Life is complicated. Even the smallest cells contain a mind-blowing assortment of chemical reactions that allow them to thrive in a chaotic landscape.

If we want to know where to draw the line between life and bubbles of stale old organic soup, it helps to strip away the non-essential extras to expose the core components, and then map how each of them works.

This has been the goal of biochemists for a number of years, who have, over the years, succeeded in designing some surprisingly basic organisms that barely cling to life in a laboratory.

Now, scientists from the J. Craig Venter Institute and the University of Illinois Urbana-Champaign in the US, and the Technische Universitt Dresden in Germany, have taken the next step and constructed a detailed simulation of their latest minimalist microbe.

"What's new here is that we developed a three-dimensional, fully dynamic kinetic model of a living minimal cell that mimics what goes on in the actual cell," says University of Illinois Urbana-Champaign chemist Zaida Luthey-Schulten.

Luthey-Schulten led a team of researchers in analyzing the diverse genetic, metabolic, and structural changes that take place in a replicating culture of synthetic bacteria called JCVI-syn3A.

Simulating the workings of the most basic of organisms, such as species of Mycoplasma or the common microbe Escherichia coli, still requires a few mathematical fudge factors to broadly model the operations of numerous sub-systems. Weaving together the full range of detailed descriptions of everything from the genes up and nutrients down just hasn't been possible, even for these comparatively simple bacteria.

In the early 2000s, researchers at the J. Craig Venter Institute removed as many genes as they could from Mycoplasma mycoides, leaving a version that stood right on the brink of survival.

This synthetic life form, called JCVI-syn1.0, was soon superseded by something even more basic. JCVI-syn3.0.

This updated version contains just 531,000 bases divided among 473 genes. With all of its nutrient needs provided by the laboratory, its bare-bones genome is left to take care of replicating and growing and little else.

Still, JCVI-syn3.0 isn't exactly consistent in its growth, producing a confusing diversity of shapes in its progeny. A few genes were popped back in, resulting in the latest version of the minimal cell: JCVI-syn3A.

Its creators have a solid idea of what genes their synthetic cell contains, though are still working out exactly what each one does.

To make things even more difficult, it's vital knowing how each atom and molecule diffuses through the cell, a description that requires heavy-duty computing power to simulate.

"We developed a three-dimensional, fully dynamic kinetic model of a living minimal cell," says Luthey-Schulten.

"Our model opens a window on the inner workings of the cell, showing us how all of the components interact and change in response to internal and external cues. This model and other, more sophisticated models to come will help us better understand the fundamental principles of life."

The simulation confirmed a few suspicions, however, such as the fact most of the minimalist cell's energy went towards dragging in essential materials across the membranes.

It also gave an accurate description of the timelines of genetic and metabolic reactions, explaining relationships between the rate of production of lipids and proteins in the membrane and changes in the cell's shape.

Since JCVI-syn3A are essentially pared-down versions of a naturally occurring organism, they're just one example of how to minimalize the functions of biology. Life is nothing if not creative in how it overcomes obstacles to survival.

Now that we have a proven model for simulating JCVI-syn3A's growth and development, researchers can build up its complexity again to determine how different genes add to its function.

We might expect new 'lite' versions of not just M. mycoides, but other organisms in the near future. If not completely novel synthetic life forms.

Life might still be complicated, but it just got a whole lot easier to study.

This research was published in Cell.

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Bioengineers Have Modeled The Workings of The World's Most Basic Synthetic Life Form - ScienceAlert

Job Description

We are seeking a highly motivated Research Fellow with expertise in bioengineering, biomaterials and cellular engineering.

The candidate will be responsible for fabricating materials including nanoparticles and nano-needles for use in genetic engineering of cells. The candidate will also need to independently design and execute experiments, troubleshoot issues, interpret results and give project updates.

We provide a highly competitive remuneration package that commensurates with the qualifications and relevant experience of the successful candidate. The candidate will also be fully supported in their career development in different areas like research, industry, consulting and education.

Qualifications

To apply, please send your CV and contact details of two referees to Dr Andy Tay (bietkpa@nus.edu.sg) Only shortlisted candidates will be contacted.

More Information

Location: Kent Ridge CampusOrganization: EngineeringDepartment : Biomedical EngineeringEmployee Referral Eligible: NoJob requisition ID : 8619

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Research Fellow, Biomedical Engineering job with NATIONAL UNIVERSITY OF SINGAPORE | 279034 - Times Higher Education (THE)

While other systems that enable the visualization of protease activity exist, Pashucks method was designed to have lower background fluorescence (increasing imaging quality) and enable visualization of multiple proteases at the same time.

Pashuck aims to develop protease-responsive conjugates, incorporate them into hydrogels and visualize spatiotemporal protease activity in model tissue, including hydrogels containing both cancerous and noncancerous cells to better understand metastatic processes.

This approach is powerful because it can be easily adapted by other labs, can be used for many proteases and incorporated into most biomaterial systems, Pashuck said in the project summary. Since proteases catalyze the cleavage of a peptide bond, they are especially useful for making stimuli-responsive therapies. Thus this research can help researchers across disciplines develop more effective biomedical interventions.

Cancer is the second leading cause of death in the United States and about 40% of people will be diagnosed with cancer at some time in their lives. Understanding the complex interactions that occur within the tumor microenvironment is crucial for creating more effective therapies to inhibit the processes that lead to poor treatment options, Pashuck said.

Drugs targeting protease activity have entered clinical trials, but so far have not been successful. New protease therapies that have improved enzyme specificity have been developed. Increasing our understanding of protease activity in the tumor microenvironment is needed to bring such promising drugs to the clinic, Pashuck said.

Pashuck, the principal investigator, is working on the project with Lehigh University graduate student Sam Rozans. The total funding amount is $408,493.

Link:
NIH Funds Protease Research Advancing Understanding of Cancer Progression and Treatments - Lehigh University News

PROVIDENCE, R.I. [Brown University] The COVID-19 pandemic has disrupted activities across the globe but it hasnt stopped Brown faculty from making a positive impact through research and scholarship.

Over the last year, faculty members at Brown have been honored for outstanding research, service and leadership in their fields of study with numerous awards, fellowships and other honors. The scholars, whose fields range from literary arts and education to applied math and biostatistics, earned both national and international recognition and support for their work.

Among such distinctions were the following honors:

Dr. Jasjit Singh Ahluwalia, a professor of medicine and behavioral and social sciences, was invited to serve on the Food and Drug Law Institutes 2020 Tobacco and Nicotine Products Committee, which brings diverse stakeholders together for high-level discussions on tobacco products regulation and policy.

Ahmed Abdelfattah, an assistant professor of neuroscience, was one of 15 scientists named as Searle Scholars for 2021, an honor that came with $300,000 over three years to support his research. Abdelfattah, who is affiliated with Browns Carney Institute for Brain Science, uses bioengineering and chemical approaches to develop molecular tools to visualize and study the brain.

Ariella Azoulay, a professor of modern culture and media and comparative literature, was among 22 scholars, writers, artists and composers to receive the prestigious Berlin Prize in the 2021-22 academic year. Azoulay will spend a semester at the American Academy in Berlins lakeside Hans Arnhold Center, a historic 19-century villa, writing a series of letters as part of a larger effort to draw attention to the experiences of Algerian Jews.

Yuri Bazilevs, a professor of engineering, won the 2021 American Society of Mechanical Engineers Materials Division Centennial Mid-Career Award, which recognizes impactful work at the interface of materials and mechanics. Bazilevs work in computational mechanics addresses problems ranging from renewable energy to blood flow in the heart.

Sara Becker, an associate professor of behavioral and social sciences and psychiatry and human behavior, won the 2020 G. Alan Marlatt Mid-Career Research Award from the Association for Behavioral and Cognitive Therapies for her program of rigorous research in the field of addiction psychology.

Dr. Justin Berk, an assistant professor in the departments of medicine and pediatrics at the Warren Alpert Medical School, was among eight early-career physicians and researchers to be selected by the American Board of Medical Specialties to participate in its 202021 Visiting Scholars Program. During the yearlong, part-time scholarship and leadership development program, Berks research will focus on the role of medical education podcasts in continuing professional development.

Dr. Richard W. Besdine, a professor of medicine and health services, policy and practice, received the Charles Bud Kahn, M.D., Lifetime Leadership Award from the Miriam Hospital Medical Staff Association for "outstanding leadership over a lifetime of service." Besdineretired from his position as director of the division of geriatrics and palliative medicine in the department of medicine, and chief of geriatrics, for Lifespan after 20 years of service.

Melody Chan, an associate professor of mathematics, was named a 2022 fellow of the American Mathematical Society, a designation that recognizes people who have made outstanding contributions to the creation, exposition, advancement, communication and utilization of mathematics. Chan was honored for her research at the interface of algebraic geometry and combinatorics, and for mentorship and mathematical exposition.

Associate Professor of Behavioral and Social Sciences Patricia Cioe was named by the University of Rhode Island College of Nursing as one of 75 luminaries representing the best nurses and nurse scientists to have come through its nursing program over the years, excelling in professional practice, education, research and advancement of the college, and making lasting contributions to the profession of nursing.

Professor of Modern Culture and Media Anthony Cokes has been selected to participate in the 2022 Whitney Biennial, which features a constellation of some of the most relevant art and ideas produced by Americans in the last two years. Work by Cokes will be on display at New Yorks Whitney Museum of American Art from April to September 2022.

Pradeep Guduru, a professor of engineering, won the 2020 James R. Rice medal from the Society of Engineering Science. Named for a former Brown professor, the award celebrates pioneering contributions to the field of engineering sciences. Guduru was honored for his work in energy storage, catalysis, surface adhesion and other areas.

David Henann, an associate professor of engineering, received the 2020 Eshelby Mechanics Award for Young Faculty from the American Society of Mechanical Engineers. Henann, who studies the physics of granular materials, was honored for creative use and development of mechanics in his research.

Tim Herbert, a professor of Earth, environmental and planetary sciences, was named a 2020 fellow of the American Geophysical Union, an honor bestowed on 0.1% of the AGUs 60,000 members. Herbert reconstructs ocean temperature and biological production through time.

Professor of Literary Arts Laird Hunt was a finalist for a National Book Award in the fiction category for his novel Zorrie. Hunts novel follows a woman searching for her place in the world and finding it in the daily rhythms of life in rural Indiana. Since 1950, the National Book Award has celebrated much of the best writing in the United States.

Sorin Istrail, a professor of computer science, was one of 13 top researchers elected as 2021 Fellows of the International Society for Computational Biology. Before coming to Brown, Istrail was head of informatics research at Celera Genomics, where his group played a central role in the construction of the sequence of the human genome. At Brown, he develops computational methods for cutting edge genomic research.

Dr. Ashish K. Jha, dean of the School of Public Health, was honored with the Meeting the Moment in Public Health Award from Johnson & Johnson Research! America. Jha was recognized for playing a key role in communicating public health information and developments to members of the public and for his masterful ability and tireless commitment to conveying key information about COVID-19 to a wide array of audiences.

George Karniadakis, a professor of applied math and engineering, received the SIAM/ACM Prize in Computational Science and Engineering in March 2021 for pushing applications to extreme computational scales and mentoring many leaders in the field of computational modeling. The award is given biennially by the Society for Industrial and Applied Mathematics and the Association for Computing Machinery.

Associate Professor of Education Matthew Kraft was given the Society for Research on Educational Effectiveness Early Career Award for his research on efforts to improve teacher and organizational effectiveness in K-12 public schools. Matt has become a leading national voice on education policy, read a statement from a colleague who nominated Kraft for the award. His research and public engagement has helped shape the national dialogue on how best to design and implement effective teacher evaluation systems.

Greg Landsberg, a professor of physics, was named chair of the publications committee for the CMS Collaboration, one of the major particle physics experiments happening at the Large Hadron Collider in Geneva, Switzerland. The publications committee assures the quality of around 100 research papers produced by the CMS Collaboration each year.

Dr. Tracy Madsen, an associate professor of epidemiology and emergency medicine, was selected by the National Academy of Medicine as the 2021 American Board of Emergency Medicine Fellow. During her two-year fellowship, Madsen will collaborate with eminent researchers, policy experts and clinicians from across the country and will help facilitate initiatives convened by the National Academies to provide nonpartisan and evidence-based guidance to policymakers, academic leaders, health care administrators and the public.

Francesca Mari, a visiting lecturer in literary arts, was awarded a fellowship by the organization New America, which gives new generations of policy experts and public intellectuals the time, space and resources to confront societys most pressing problems through research, reporting and analysis. As a New America Fellow, Mari is writing a book about why housing in the U.S. is so expensive, charting the consequences of financialization on the lives of neighbors on a single block in Los Angeles.

Associate Professor of Brain Science Kate O'Connor-Giles was one of five recipients of the 2021 National Institute of Neurological Disorders and Stroke Landis Award for Outstanding Mentorship by an NINDS Investigator. The award recognizes faculty members who have shown dedication to superior mentorship and training in neuroscience research, and includes a $100,000 grant supplement to support efforts to foster the career advancement of additional trainees.

Iris Montero Sobrevilla, an assistant professor of Hispanic studies, won the 2021 Robert F. Heizer Article Award for The Disguise of the Hummingbird: On the Natural History of Huitzilopochtli in the Florentine Codex. The award, granted by the American Society for Ethnohistory, recognizes the best article in the field of ethnohistory and seeks to feature cross-disciplinary approaches to Indigenous histories.

Dr. Christine Montross, an associate professor of psychiatry and human behavior, and medical science, was a finalist for a 2020 L.A. Times Book Prize in the current interest category for her nonfiction book, Waiting for an Echo: The Madness of American Incarceration. In what the L.A. Times called a riveting glimpse into Americas prison system, Montross, a practicing inpatient psychiatrist, illuminates the human cost of mass incarceration and mental illness.

Elias Muhanna, an associate professor of comparative literature and history, was awarded the 2022 John Nicholas Brown Prize for his monograph The World in a Book: Al-Nuwayri and the Islamic Encyclopedic Tradition. Awarded by the Medieval Academy of America, the prize is awarded annually for a first book or monograph on a medieval subject judged by the selection committee to be of outstanding quality.

Assistant Professor of Literary Arts Sawako Nakayasu received a $35,000 fellowship for digital publication from the National Endowment for the Humanities and the Andrew W. Mellon Foundation. The fellowship will enable Nakayasu to conduct research for a digital monograph on the reception and legacy of modernist Japanese poet Chika Sagawa.

Jayanti Owens, an assistant professor of international and public affairs and sociology, was selected as a 2020 William T. Grant scholar. With a $350,000 award, Owens will develop different aspects of an ongoing project investigating what drives racial and ethnic disparities in school discipline. Launched in 1982, the prestigious William T. Grant scholars program supports the professional development of early career researchers in the social, behavioral and health sciences.

Owens also received the Promising Scholar Award from the Foundation for Child Development for her research on school discipline disparities. The foundation seeks to help researchers, policymakers and advocates develop high-quality, evidence-based early childhood systems to serve the needs of all children.

Applied mathematics professor Kavita Ramanan was named a 2021 Vannevar-Bush Faculty Fellow, the most prestigious research award from the U.S. Department of Defense. The $3 million award supports supports out-of-the-box ideas where researcher creativity intersects with the unknown. Ramanans research in probability theory and stochastic processes investigates the uncertain outcomes and random effects that pervade science, engineering and everyday life.

Dr. Ranna Rozenfeld, a professor of pediatrics who specializes in pediatric critical care medicine, is one of 55 new members of the American Pediatric Society. New members are nominated by current members through a process that recognizes individuals who have distinguished themselves as child health leaders, teachers, scholars, policymakers and/or clinicians.

Brenda Rubenstein, a professor of chemistry, won a 2021 Teacher-Scholar Award from the Camille and Henry Dreyfus Foundation. She was one of 16 people nationwide to win the award, which goes to faculty within the first five years of their academic careers who have created an outstanding body of scholarship and are deeply committed to education. Rubenstein was also named one of Popular Sciences Brilliant 10, the magazines list of the most innovative up-and-coming minds in science.

Jim Russell, a professor and chair of Earth, environmental and planetary sciences, won the Willi Dansgaard Medal from the American Geophysical Union, which honors high-impact, interdisciplinary work in paleoceanography and paleoclimatology. Russell uses key indicators trapped in lake and ocean sediments to reconstruct past climate conditions.

Dr. Samir A. Shah, a clinical professor of medicine at Brown and chief of gastroenterology at the Miriam Hospital, was elected the 2021-22 president of the American College of Gastroenterology, a national medical organization representing more than 17,000 clinical gastroenterologists and other specialists in digestive diseases. Shah will direct ACGs programs, which include continuing medical education in the clinical, scientific and patient-related skills of gastroenterology; activities involving national and state medical affairs; health policy issues; and clinical investigation.

Chi-Wang Shu, a professor of applied mathematics, was awarded the 2021 John von Neumann Prize by the Society for Industrial and Applied Mathematics. The prize is awarded for outstanding and distinguished contributions to the field of applied mathematical sciences and for the effective communication of these ideas to the community.

Anita Shukla, an associate professor of engineering, won a Dr. Ralph and Marian Falk Medical Research Trust Transformational Award. The $1 million award is intended to provide the bridge to the technology transfer process for moving an exciting health care innovation to the next step in commercial development. Shukla is investigating the antibacterial potential of hydrogels, with the expectation that these materials will greatly improve treatment options for difficult to treat wounds prone to infection, such as diabetic ulcers and burns.

Chemistry professor Richard Stratt won the 2021 Joel Henry Hildebrand Award in the Theoretical and Experimental Chemistry of Liquids from the American Chemical Society. Stratts research group studies molecular mechanisms of events such as solvation and vibrational relaxation the elementary steps that determine the course of chemical reactions in liquids.

Adam Teller, a professor of history and Judaic studies, was named a National Jewish Book Awards finalist in the history category for his book Rescue the Surviving Souls: The Great Jewish Refugee Crisis of the Seventeenth Century. The National Jewish Book Awards were established by Jewish Book Council in 1950 to recognize outstanding works of Jewish literature.

Associate Professor of Health Services, Policy and Practice Kali Thomas was the inaugural recipient of the Terrie Fox Wetle Rising Star Award in Health Services and Aging Research from the American Federation for Aging Research for her work applying health services research to inform policies and practices that improve health and quality of life for older adults. The award is name for the founding dean of Browns School of Public Health.

Kimani Toussaint, a professor and associate dean of engineering, was elected to the American Institute for Medical and Biological Engineering College of Fellows, a select group of the top two percent of medical and biological engineering professionals. Toussaint was elected for his outstanding contributions to biomedical engineering using both novel photonic materials and optical imaging systems.

Assistant Professor of Humanities Daniel Vaca received an honorable mention in the Modern Language Associations Matei Calinescu Prize announcement for his book Evangelicals Incorporated. The prize committee shared that Vacas book uncovers a new archive for the history of religion in the United States: the flourishing for-profit business of evangelical publishing.

Lai-Sheng Wang, professor and chair of chemistry, won the 2020 E. Bright Wilson Award in Spectroscopy from the American Chemical Society. Wangs lab creates new forms of matter called nanoclusters, then uses a technique called photoelectron spectroscopy to study their properties one atom at a time. His discoveries include boron analogs to the carbon nanomaterials graphene and fullerene.

Ian Wong, an associate professor of engineering, was one of 60 of the most promising early career engineers from the United States and Japan chosen to participate in the National Academy of Engineerings 2021 Japan-America Frontiers of Engineering Symposium. Wong engineers new miniaturized technologies based on biomaterials and microfluidics to investigate cancer cell invasion, drug resistance and heterogeneity.

Kenneth Wong, a professor of international and public affairs, education policy and political science, was among 39 leaders who were elected as new fellows of the National Academy of Public Administration in 2021. As a NAPA fellow, Wong joins a cadre of former cabinet officers, members of Congress, governors, mayors and state legislators, prominent scholars, business executives, nonprofit leaders and prominent public administrators.

Samuel Zipp, an associate professor of American studies and urban studies, was awarded the Robert H. Ferrell Prize for his book The Idealist: Wendell Willkies Longtime Quest to Build One World. The prize, given annually by the Society for Historians of American Foreign Relations, is designed to reward distinguished scholarship in the history of American foreign relations, broadly defined. Members of the prize committee heralded Zipps book as enormously inventive richly researched and written with verve and artfulness.

Andrew R. Zullo, an assistant professor of health services, policy and practice and epidemiology, was named a 2020 Health in Aging Foundation New Investigator Awardee by the American Geriatrics Society for his original research reflecting new insights in geriatrics and his commitment to the disciplines role in academia.

In early January 2022, six faculty members from Brown were among 200 American scholars recognized by Education Week for their highly influential educational research. The annual Edu-Scholar Public Influence Rankings seek to spotlight United States researchers who did the most to shape educational practice and policy in the last year. Among those listed were Professor of Economics Emily Oster; Director of the Annenberg Institute for School Reform Susanna Loeb; Associate Professor of Education Matthew Kraft; Professor of Sociology Prudence Carter; Associate Professor of Education Policy Lindsay Page; and Associate Professor of Education John Papay.

Originally posted here:
Faculty at Brown earn prestigious awards, distinctions - Brown University

MarketsandResearch.biz has just released Global Bovine-based Collagen for Biomedical Applications Market from 2021 to 2027, a global study report that combines industry expertise, unique ideas, practical solutions, and cutting-edge technology to improve the user experience. The research is a great way to learn about the global Bovine-based Collagen for Biomedical Applications market, emerging trends, product applications, customer and competitor motivators, brand positioning, and consumer behaviour.

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Global Bovine-based Collagen for Biomedical Applications Market likely to touch new heights by end of forecast period 2021-2027 Share and Future...

ATLANTAAn influenza vaccine administered through the nose and constructed with nanoparticles that enhance immune response offers strong protection against different influenza virus strains, according to researchers in the Institute for Biomedical Sciences at Georgia State University.

The intranasal vaccine contributed to multifaceted immune responses, leading to robust cross protection against influenza in mice. The vaccine consists of PEI-HA/CpG nanoparticles. PEI (polyethyleneimine), a robust and versatile delivery system, can simultaneously carry antigens (hemagglutinin, HA) that induce an immune response in the body, and adjuvants (CpG) that enhance the bodys immune response to an antigen for optimal immunoenhancement.

These comprehensive immune responses and cross protection were long lasting, exhibiting defense from influenza virus over six months after immunization. The findings are published in the journal ACS Applied Materials & Interfaces.

Intranasal vaccination is an ideal approach for infectious respiratory diseases such as influenza. Seasonal influenza vaccines generally induce narrow immune responses that rapidly decline, which leaves populations vulnerable to novel influenza strains. Advancements in influenza vaccine technology are needed to protect against a wide range of influenza viruses. Intranasal vaccination can improve local mucosal immune responses by preventing influenza infection at the portal of virus entry.

In the influenza virus, HA is a protein that plays a crucial role in the early stages of virus infection. Influenza HA has a head region and stalk region. Current influenza vaccines elicit immune responses against the HA head, but this head region is highly changeable and accounts for lowered efficiency against different strains. The HA stalk region is more conservative across different strains of influenza viruses.

Protein antigens that are administered intranasally are usually less able to provoke an immune response, so adjuvants are needed to have highly efficient intranasal vaccines. Adjuvants, such as CpG, can enhance and manipulate immune responses, thus improving the potency and breadth of protection.

The PEI-HA/CpG nanoparticles show good potential as a cross-protective influenza vaccine candidate, said Dr. Baozhong Wang, corresponding author of the study and a professor in the Institute for Biomedical Sciences at Georgia State. The combination of PEI and CpG in the PEI-HA/CpG nanoparticle group contributed to the multifaceted immune responses, leading to vigorous cross protection. The incorporation of CpG and antigens into the same nanoparticle enhanced cellular immune responses.

Our results revealed that the nanoparticles significantly enhanced HA immunogenicity, or the ability to provoke an immune response, providing cross protection against different influenza virus strains. The conserved HA stalk region induced substantial antibodies in the nanoparticle immunization groups.

Nanoparticle platforms have shown intriguing characteristics and great potentials in thedevelopment of next-generation cross-protective influenza vaccines, said Dr. Chunhong Dong, the first author of the study and a postdoctoral fellow in theInstitute for Biomedical Sciences. However, challenges exist to the successful research and development of nanoparticle vaccines. Though no apparent adverse effects were observed in the study, a more comprehensive safety evaluation of the nanoparticle adjuvant system is needed before clinical trials.

Co-authors of the study include Baozhong Wang, Chunhong Dong (first author), Ye Wang, Wandi Zhu, Yao Ma, Joo Kim, Lai Wei and Gilbert X. Gonzalez.

The study was funded by the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health.

To read the study, visit https://pubs.acs.org/doi/10.1021/acsami.1c19192.

Read more from the original source:
Intranasal Flu Vaccine with Nanoparticles to Enhance Immunity Offers Robust Protection, Biomedical Sciences Researchers Find - Georgia State...

SINGAPORE - Scientists from Nanyang Technological University (NTU) have developed a therapy that uses a gel and infrared light to burn fat - a possible safer treatment for people working to control their weight.

Drugs that tackle obesity are meant to accompany exercise and a healthy diet in helping people who are severely obese, including those who have metabolic disorders, but many in the market come with side effects.

Laboratory trials by the NTU team from the School of Chemical and Biomedical Engineering show that mice on a high-fat diet that underwent its therapy weighed 5.5 per cent lighter after two weeks, and lost between 40 per cent and 50 per cent of body fat.

In the therapy, a transparent gel - called a hydrogel - developed by the scientists, is injected into a layer of fat under the mice's skin.

Aninfrared light is then shone on the injection site for five minutes a few times a day to trigger the hydrogel's fat-burning ability.

Infrared light refers to wavelengths of light that are not visible to the human eye, but can be felt as heat.

When exposed to the infrared light, nanoparticles in the hydrogel convert light into heat to activate a protein in the body that kick-starts the fat-burning process.

In this process, white fat - which stores excess calories and leads to weight gain - is converted into calorie-burning tissue.

"Fat cells become energy-burning instead of energy-storing," said bioengineering professor Chen Peng, who led the study.

After two weeks of the treatment - which includes eight days of rest - the mice lost 40 per cent of the fat under their skin and 54 per cent of the fat surrounding their internal organs.

The rodents also had lower cholesterol levels and reduced resistance to insulin, suggesting that the procedure has the potential to reduce the risk of metabolic disorders, said NTU in a statement on Tuesday (Jan 25).

Touching on the therapy's safety, the research team said the hydrogel nanoparticles - made of copper sulphide - have negligible toxic effects on vital organs and tissues.

And although the process uses heat converted from the infrared light to burn fat under the skin, the team found no thermal injury to the mice's skin, said Prof Chen.

The hydrogel also contains substances that are approved by the United States Food and Drug Administration (FDA). For instance, the gel contains an FDA-approved drug for people with overactive bladders, which the NTU team repurposed for its therapy.

The team envisions the therapy being used as a home treatment one day.

Read the original here:
New therapy to tackle obesity by NTU team uses gel and infrared light, safety shown in trials on mice - The Straits Times

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Histidine Market Growth, Future Prospects And Competitive Analysis 2021 to 2027 Kyowa Hakko Bio, Ajinomoto, Shine Star Biological Engineering,...

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Dishman, Weleda, Deutsche Lanolin Gesellschaft, Zhejiang Garden Biochemical, NK Ingredients, Nippon Fine Chemical, Heyang Suntech Bioengineering

The report emphasizes the regional sector analysis:

North America (United States, Canada and Mexico), Europe (Germany, France, United Kingdom, Russia, Italy, and Rest of Europe), Asia-Pacific (China, Japan, Korea, India, Southeast Asia, and Australia), South America (Brazil, Argentina, Colombia, and Rest of South America), Middle East & Africa (Saudi Arabia, UAE, Egypt, South Africa, and Rest of Middle East & Africa)

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The following market parameters were investigated in the study:

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Global Cosmetic Grade Lanolin Alcohol Market to Experience Significant Growth during the Forecast Period 2021-2027 The Oxford Spokesman - The Oxford...

Clinical stage oncology company Prescient Therapeutics (ASX: PTX) has made plans to advance and accelerate its proprietary OmniCAR platform after unveiling two high-profile additions to its scientific advisory board.

In a statement to the market, the oncology company said it had appointed physician-scientist, Dr Marco Davila from the Moffitt Cancer Center and bioengineering expert Professor Andrew Tsourkas from the University of Pennsylvania, effective immediately.

The dual appointments are expected to bring unsurpassed expertise to Prescients ongoing development work on CAR-T therapies and binder protein engineering.

The company explained the rationale behind the move by stating that Dr Davila and Professor Tsourkas would bring deep complementary expertise to its operations and would compliment an existing team of highly credentialed personnel on the scientific board.

Currently, the broader team is comprised of CAR-T expert Professor Phil Darcy, hematologist and CAR-T researcher Professor H. Miles Prince and brain cancer specialist and cell therapy researcher Professor Don ORourke.

As a highly experienced clinical developer of CAR-T, Dr Davila is currently regarded as a leading figure in the field and is often invited to address global oncology conferences.

Dr Davila currently works at the Department of Blood and Marrow Transplantation at the Moffitt Cancer Center one of the largest cancer centres in the US treating patients with hematologic malignancies with various cell therapies.

Dr Davilas current research includes pre-clinical development and clinical translation of gene-engineered cell therapies, including CAR-T therapies, for patients with hematologic and solid tumour malignancies.

Moreover, Dr Davilas research has received widespread acclaim including generous grants and awards from the American Society of Hematology, Damon Runyon Cancer Research Foundation, the American Society of Clinical Oncology and the American Society for Clinical Investigation, respectively.

From my clinical experience with CAR-T therapies, as well as their pre-clinical development, I have seen both the early success of this revolutionary therapy in B cell malignancies and also the challenges in translating it to other cancers, said Dr Davila.

I am excited by the capabilities of OmniCAR to overcome many of these obstacles and bring gene-engineered cell therapies to many more patients. I am delighted to be appointed to Prescients SAB to help guide the development of OmniCAR, he added.

According to Prescient Therapeutics, OmniCAR is a universal immune receptor platform enabling controllable T-cell activity and multi-antigen targeting with a single cell product.

The company says it is the first of its kind: the first universal immune receptor allowing post-translational covalent loading of binders to T-cells.

As well as the addition of Dr Davila to its scientific board to help advance OmniCAR, Prescient is also bolstering its ranks from the University of Pennsylvania and an original co-founder of the technology.

Professor Tsourkas is a co-inventor of the patents developed at Penn and licensed by Prescient to form OmniCAR.

OmniCAR is based on technology first licensed from Penn as well as the so-called SpyTag/SpyCatcher binding system licensed from Oxford University. Given OmniCARs development path and close collaboration with Penns researchers, Prescient acquired the services of Professor Tsourkas as an organic fit.

Professor Tsourkas particular expertise in the conjugation of proteins is especially relevant to the development of OmniCARs binders, which involves incorporating SpyTag into antibodies and other antigen-binding molecules, the company said.

It has been wonderful to see the rapid progress of development of OmniCAR since Prescient licensed the underlying patent from Penn last year, said Professor Tsourkas.

The rapid, covalent nature of OmniCARs binding confers many unique capabilities and advantages over conventional CAR-T approaches. I look forward to assisting Prescient in the development of OmniCAR and its associated binders to address a variety of different cancers, Professor Tsourkas added.

Over the next 12 months, Prescient expects to expand the cohort read-out for its PTX-100 drug, as well as complete enrolment in the expansion cohort by Q3 2022. Prescient is confident of announcing several further value-adding milestones for each OmniCAR program throughout 2022.

In addition, Prescient has confirmed it expects to receive results for its PTX-200 Ph1b AML trial early next year with several cell therapy enhancements expected to come out of stealth mode in the first half of 2022.

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Prescient Therapeutics bolsters scientific advisory board with CAR-T and bioengineering experts - Small Caps

ST. LOUIS Just as there often exists an urban-rural divide in political and environmental landscapes, urban and rural education systems share the common issue of being under-resourced, especially for science education.

Kristine Callis-Duehl, the Sally and Derick Driemeyer director of education research and outreach at the Donald Danforth Plant Science Center, and her collaborators at the Jackie Joyner-Kersee Foundation and University of Illinois Extension were awarded a three-year $685,000 grant from the U.S. Department of Agriculture to create a synergistic partnership between urban and rural communities in southern Illinois to establish a cross-regional curriculum that introduces bioengineering and plant monitoring technology to middle school aged youth in summer programs.

Young people at the Jackie Joyner-Kersee Foundation in East St. Louis, Illinois, and at the U of I Extension program in Waterloo, Illinois, will monitor corn growth in both regions by using in-demand technology including drones and a microclimate field monitoring system developed by Danforth Center scientist Nadia Shakoor.

By growing and comparing sweet corn, GMO commodity corn and non-GMO commodity corn, students will see firsthand how bioengineering improves plant health and crop yield.

By conducting joint fieldwork and presenting their ideas at a mini-conference, urban and rural youth will establish a collaboration that generates culturally mindful activities, as well as authentic data that can help shed light on the impact of climate change on corn harvests.

This collaboration will allow rural students to experience FarmBot robotics at work in smaller, urban plots and allow urban students to experience the use of drones used in precision agriculture on larger, rural farms.

Ultimately, through this informal authentic research experience, participants will help develop a culturally informed curriculum that can be launched nationwide to establish a network of urban-rural authentic research hubs for non-formal summer programs.

Young people participating in the project will gain an understanding of gene editing and hands-on experience using robotics to plant corn, as well as experience using drone and microclimate monitoring systems to assess corn growth and the microclimate, Callis-Duehl said.

It will also provide technological training, and exposure to data analysis to prepare them for the future, as big data analysis has become increasingly critical in agricultural science.

Youth also will gain leadership experience by providing feedback on the curriculum so that it evolves and by teaching the youth the partner program how to use the agricultural technology unique to their urban or rural research area.

Co-project directors include Lisa Walsh, Danforth Plant Science Center; Mark Fryer, Jackie Joyner-Kersee Foundation; and Amy Cope, U of I Extension.

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Collaboration aims to shrink the urban-rural divide - Agri-News

The lease for CBREs Richardson facility was announced last year. The company took over an existing building at 2375 N. Glenville Drive. (Olivia Lueckemeyer/Community Impact Newspaper)

The lease for CBREs Richardson facility was announced last year, according to a spokesperson with the real estate and investment firm. The company took over an existing building at 2375 N. Glenville Drive.

So far, there are 700 CBRE employees based in Richardson with about 300 more to be added by early next year, the spokesperson said. The companys Dallas headquarters will also add another 460 new jobs and more than $29 million in capital investment, according to Abbotts release.

"CBRE's expansion in the Dallas-Fort Worth metroplex will bring over one thousand high-paying jobs and greater opportunities for the hardworking people of North Texas, Abbott said in the release. I look forward to a strong relationship with the company as we work together to keep Texas the national model for economic prosperity."

CBRE will receive grants of $3.3 million and $3.5 million from the Texas Enterprise Fund, Abbott said in the release. The fund awards deal-closing grants to companies considering a new project for which one Texas site is competing with other out-of-state sites, according to the states economic development office.

Mayor Paul Voelker said the company made a strategic choice in choosing Richardson, which is regarded as a center for innovation.

"As the heart of the Telecom Corridor area and home to the Richardson IQ, we are proud CBRE has made the strategic choice to locate its operations center in this innovative ecosystem," Voelker said in the release. "The 550 new jobs that come with this project have good neighbors in an area especially designed for collaboration, and we are excited about the possibilities CBRE has here in Richardson."

The addition of CBRE to the citys corporate landscape comes with many benefits for residents, said Bill Sproull, president and CEO of the Richardson Chamber of Commerce.

CBREs expansion into Richardson provides high-paying job opportunities for our citizens, an enhanced tax base and further involvement of a Fortune 50 company in our community, he said.

For more information on CBREs presence in Dallas-Fort Worth, visit this link.

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CBRE operations hub to bring more than 500 new jobs in Richardson - Community Impact Newspaper

Adroit Market Research published a new research study on Global Cysteine Market 2021 by Manufacturers, Regions, Type and Application, Forecast to 2028 that promises a complete review of the marketplace, clarifying the previous experience and trends. On the basis of these previous experiences, it offers the future prediction considering other factors influencing the growth rate. The report covers the crucial elements of the global Cysteine market and elements such as drivers, current trends of the past and present times, supervisory scenario & technological growth. The research document presents in-depth evaluation of the market. It shows a detailed observation of several aspects, including the rate of growth, technological advances and various strategies implemented by the main current market players.

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The Cysteine marketplace contrasts the historical data with the present market gain, manufacturing array, and market cost. A normal monitoring of the net Cysteine industry manufacturing process, leading players that are important, sequential arrangement and the demand and supply scenario of this Cysteine market are siphoned in this report. The data methodically analyses the current situation of the worldwide Cysteine industry groups together side the forthcoming sections that might project the Cysteine market growth on the forecast interval.

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Leading players of Cysteine Market including:

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Competitive Landscape:

Competitive landscape of a market explains the competition in the Cysteine Market taking into consideration price, revenue, sales, and market share by company, market concentration rate, competitive situations, trends, and market shares of top companies. Strategies incorporated by key vendors of the market such as investment strategies, marketing strategies, and product development plans are also further included in the report. The research integrates data regarding the producers product range, top product applications, and product specifications.

Cysteine market Segmentation by Type:

Based on source, l- cysteine is segmented into (Natural through feathers and human hair, Synthetic through microbial fermentation), Based on the grade, l- cysteine is segmented into (Food grade, Tech grade, Pharma grade), Based on the Industrial use, l- cysteine is segmented into(Food, Pharmaceuticals, Cosmetics)

Cysteine market Segmentation by Application:

Based on Applications, l- cysteine is segmented into (Conditioner, Flavor enhancer, Reducing agent, Radical scavenger)

Marketing Communication and Sales Channel

Understanding marketing effectiveness on a continual basis help determine the potential of advertising and marketing communications and allow to use best practices to utilize untapped audience. In order to make marketers make effective strategies and identify why target market is not giving attention we ensure Study is Segmented with appropriate marketing & sales channels to identify potential market size by value & Volume* (if Applicable).

SWOT Analysis on COVID-19 Outbreak- Cysteine Players

In additional Market Share analysis of players, in-depth profiling, product/service and business overview, the study also concentrates on BCG matrix, heat map analysis, FPNV positioning along with SWOT analysis to better correlate market competitiveness.

Demand from top notch companies and government agencies is expected to rise as they seek more information on latest scenario. Check Demand Determinants section for more information.

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* It offers an analysis of changing competitive scenarios.* For making informed decisions in the businesses, it offers analytical data with strategic planning methodologies.* It offers a six-year assessment of Cysteine Market.* It helps in understanding the major key product segments.* Researchers throw light on the dynamics of the market such as drivers, restraints, trends, and opportunities.* It offers a regional analysis of Cysteine Market along with the business profiles of several stakeholders.* It offers massive data about trending factors that will influence the progress of the Cysteine Market.

Table of Content:

1 Scope of the Report1.1 Market Introduction1.2 Research Objectives1.3 Years Considered1.4 Market Research Methodology1.5 Economic Indicators1.6 Currency Considered2 Executive Summary3 Global Cysteine by Players4 Cysteine by Regions4.1 Cysteine Market Size by Regions4.2 Americas Cysteine Market Size Growth4.3 APAC Cysteine Market Size Growth4.4 Europe Cysteine Market Size Growth4.5 Middle East & Africa Cysteine Market Size Growth5 Americas6 APAC7 Europe8 Middle East & Africa9 Market Drivers, Challenges and Trends9.1 Market Drivers and Impact9.1.1 Growing Demand from Key Regions9.1.2 Growing Demand from Key Applications and Potential Industries9.2 Market Challenges and Impact9.3 Market Trends10 Global Cysteine Market Forecast11 Key Players Analysis12 Research Findings and Conclusion

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Cysteine Market Technological Innovations and Pandemic Analysis Till 2026: Wacker Chemie AG, Ajinomoto Pte.Ltd, Donboo Amino Acid Co. Ltd, Wuxi Bikang...

Newswise Among the many devastating impacts of Alzheimers disease and other types of dementia is the risk that patients will wander and become lost. Indeed, according to the Alzheimers Association, six in 10 people with the disease will wander at least once over the course of their illness and many do so repeatedly.

For researchers who study and treat people with neurodegenerative disorders, understanding the human neural circuitry that leads to such behavior is among the highest-priority goals. But to better study these and other neurological conditions, the work needs to begin with effective, accessible animal models.

Thats where researchers at the NeuroBat lab led by Michael Yartsev, assistant professor of bioengineering and of neurobiology come in. Their studies of the neural circuitry of navigation in Egyptian fruit bats are yielding insights that might one day help explain and prevent dangerous situations for humans.

Egyptian fruit bats are one of the most superior navigators that exist on our planet, Yartsev says. He describes how these diminutive, highly social creatures in the wild will travel tens of kilometers, even through dark and stormy nights, seldom if ever getting lost in their search for food. The bats complex travel through 3D space, he says, could shed light on the complexity of human behavior in navigating from place to place.

But understanding the neuronal processes at the root of behavior in appropriate animal models goes well beyond studies of navigation. We have a huge number of questions that we want to understand about the brain, Yartsev says. And one of his goals as a neuroscientist is to advocate for an expansion of the diversity of animal models researchers have available for their work.

In the current landscape of neuroscience research, Yartsev says, 75% or more of the work focuses on a handful of standard organisms, such as rats and mice. The reasons often come down to accessibility of tools and ease of maintenance in laboratory environments. But this overwhelming convergence is not without cost, as it limits the type of questions asked, the discoveries made and the degree to which scientific findings can be generalized beyond those species.

With bats, Yartsev says, their ability to fly, complex social behaviors, patterns of vocalization, long lives and more set them apart as animal models for studying a specific set of basic research problems in neuroscience such as how the brain processes skills like navigation, sociality and language.

Yartsevs first encounter with bats as a subject for neuroscience took place some 15 years ago during his Ph.D. studies at the Weizmann Institute of Science in Israel. Yartsev says it was a risky move, then, to pursue a Ph.D. in neuroscience by studying a non-traditional animal. But this work helped establish bats as an important model system for a variety of new research topics.

As befits Yartsevs biomedical engineering background, the work has included the opportunity to develop new research tools for neuroscience for example, the first wireless electrophysiology system for recording and studying a bats brain activity during flight.

This was the first single-cell neural recording from a freely flying animal, Yartsev says, referring to experimental work behind a 2013 Science paper on navigation-related bat neural activity. Bats obviously cannot fly around freely with a cable attached, so we had to develop the tools needed to do this work we still do, he adds, citing, as another example, a piezoelectric device for recording vocalizations that is lightweight enough for the bats to wear as a necklace while communicating with one another.

In 2015, Yartsev brought his pioneering research with Egyptian fruit bats to UC Berkeley, where he has established his own group, the NeuroBat Lab. Studying the neural circuitry of these diminutive creatures, the group continues to build and publish a rich trove of basic research data and neuroscience insight with more to come.

In a continuation of his research work on navigation using bats, the NeuroBat Lab has recently focused on neural mechanisms that could underlie goal-directed navigation, which Alzheimer patients often struggle with. To carry out the study, the Yartsev team used a specialized facility they created called the fully automated flight room. It is a human-free space used to obtain detailed, quantitative understanding of bat navigation and flight behavior by recording activity in relevant neural circuits.

Bioengineering graduate student Madeleine Snyder, one of Yartsevs team members who also studies the neural mechanisms of navigation in bats, says bats make a good research subject because theyre both highly social and highly navigationally adept, and thats very similar to humans in many ways. They will go kilometers and kilometers to forage in a specific tree and then come home together.

She describes the flight room as about the size of a large living room that is outfitted with cameras and other recording devices. Researchers can situate perches for the bats at various places in the room. The perches might be outfitted with beam breakers that, when triggered by a bat alighting on the perch, will trigger some action like the introduction of food. Lights can be programmed to turn on and off, sounds can be introduced and researchers can simply step back, watch and record how the bats interact with their environment.

In comparison to studies with other animal models, she says, with bats in the human-free flight room, were not constraining the animal but just letting them do what they want to do and seeing what happens.

As with many animal-model studies, Yartsev says, subtracting humans from the study environment can heighten fidelity of results. Thats because the presence of human investigators may introduce experimental biases, reduce reproducibility of the experiment, prevent the animals from engaging freely in self-paced navigational behavior and limit the complexity of tasks that could be utilized to study neural circuits.

For the navigation study, the team looked at the activity of place cells, specialized cells in the brain that act as a sort of internal global positioning system. Studies of place cells in rats had indicated that the cells primarily encode the animals location at the time the cell is firing.

What we are showing in this paper is that if you align all the place cells that you are recording as they are firing in the hippocampus, there is a continuum of space and time, Yartsev says, referring to their paperpublished in Scienceearlier this year. The cells are representing where the animal has been, where it will be a half a second into the future, a second into the future and so on.

One of the hallmarks of Alzheimers disease, Yartsev notes, is that people get lost all the time, even in their own neighborhoods. Understanding how the brain represents the environment, how a person knows the route to take to get from one place to another remains unknown, he says. The NeuroBat Lab study suggests that the reason a person might get lost is that their brain somehow loses that continuum of space and time the ability to hold and follow a planned trajectory.

He says the data from their fast-moving bat animal model reveals dynamics of neuronal activity that would be difficult to observe so cleanly by only studying, for example, a slower-moving rodent in a 2D maze.

We can sometimes make very significant progress with just one experiment with bats, no matter that it can at times be very difficult, Yartsev says. Thats because the animals can be a highly relevant model system for a specific scientific question that could also be important for humans. For example, bats are specialized for communication at the group level. They have developed behavioral capacities for group living and the underlying neural circuits that serve those capacities.

In another recent study from the lab, the team became the first to observe synchronized brain activity in a nonhuman species engaging in natural social interactions like grooming, fighting or sniffing each other.

For the study,published in Cell,Yartsev and postdoctoral fellow Wujie Zhang used simultaneous wireless neural recording devices to measure brain activity while multiple bats freely interacted. The specialized recording devices allowed them to capture what modalities like functional MRI and EEG cannot the full scope of neural activity from brain oscillations to the firing of individual neurons, all at the same time.

The researchers found surprisingly strong correlations between the bats brains. That is, as they engaged with one another in social behaviors in the same environment, their brain wave and neuronal electrical activity began to look the same in each bat, even when the bats performed very different actions. The correlations were present whenever the bats shared a social environment and increased before and during their social interactions, Yartsev says.

Their detailed analysis of social interactions allowed them to rule out other possible explanations for the synced-up brain activity, such as that bats were simply reacting to the same environment or engaging in the same activity. For example, bats placed in identical but separate chambers and that were both busy grooming did not show the same synchronization.

This study is really laying the groundwork for studying inter-brain correlation in animals, Zhang says. We didnt know if this is something thats only observed in humans. If we have the same phenomenon in animals, then theres a lot more experimental techniques we can use to really understand the mechanisms of this phenomenon, including its function.

This is a very core phenomenon that, for two decades, people have been excited about in humans, Yartsev says. Now that weve observed it in an animal model, it opens the door to very detailed research of it. Importantly, this phenomenon also relates to how humans socialize with one another in social groups and is impacted during diseases such as autism and other neurological disorders. Understanding the neural mechanisms behind it and how it mediates natural group social behavior could lead to future therapeutics in humans.

And this is exactly where we are going with this, Yartsev says. In another paper,published in Sciencethis fall, the lab studied social communication among groups of bats for the first time. Led by graduate student Maimon Rose and postdoctoral fellow Boaz Styr, the researchers discovered a rich repertoire of neural signals that represent key components in group communication, findings that could also have significant implications for understanding aspects of human mental health.

Another future area of research interest, Yartsev says, is language the crown jewel of humanity. Humans are the only mammals capable of learning and using language, but they are joined by bats, elephants and cetaceans (whales, dolphins) out of some 5,400 species of mammals in the ability to learn new sounds. This process, also known as vocal learning, is the basis for language learning.

First of all, just understanding that fact about learning language is really important, he says. How does our brain allow us to learn a language? It becomes even more important when we think that about 10 percent of the people in the world suffer from language disorders. And this affects them dramatically. These disorders relate to autism, dyslexia and a whole variety of problems related to brain functioning.

Unfortunately, in the world of neuroscience today, Yartsev says, we still do not understand the detailed neurobiological mechanisms that allow us to learn a language.

And beyond biology and human health, the research into complex neurobiological processes in bats might also power new technology development, Yartsev says. For example, insights from the bats might aid development of new machine learning algorithms and sensing technologies critical to the development of fully self-driving cars. Such autonomous vehicles must be able to safely maneuver roadways by sensing and reacting to other moving vehicles, random obstacles and constantly changing environmental conditions. For some questions, the bats provide us very unique advantages that you simply cant find in other animal model system and these are the questions we focus on, Yartsev says.

Articleby William Schulz

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Right off the bats - Newswise

Bioengineering Professors X. Frank Zhang and Wonpil Im have discovered a way to prevent the COVID-19 virus from sticking to receptors on human cells.

Im and Zhang both had experience studying proteins, but when the pandemic hit they shifted their focus. They were inspired to start their research on SARS-CoV-2 spike receptor proteins to contribute to the fight against the pandemic.

Professor Im and I were interested in this new virus and how it worked, Zhang said. We wanted to know why it was so dangerous and infectious.

While Im and Zhang were trying to find a way to prevent the virus, they also faced challenges associated with the pandemic, including a three month partial pause to their research due to lockdowns.

Once they were given permission to start working again in June, they had to pick up the pace of their research in a race against the spread of the virus.

As (scientists) we ask the question: how can our expertise help this issue, Zhang said.

Im and Zhangs research focuses on spike receptors which are branches stemming from the center of the viruss body. These parts of the cell are responsible for bonding with the cells in the human body, and once they have bonded, humans are able to spread and feel the effects of the virus.

Im and Zhangs research prevents the spike receptor from binding to the cells in our body. In their experiments, they would use a COVID-19 spike receptor and would bind it to a human cell. They would then measure how much force it would take to decouple to a receptor from the cell.

What makes Im and Zhangs research unique is that they used an experimental technique created by Zhang.

His technique can measure the strength (of the bond) between the viruss spike protein and the human receptor, Im said.

Along with Zhangs experimental technique, Im used a computational modeling simulation to provide detailed on Zhangs experiment.

Because of their teamwork, their findings have a greater significance and you can come to understand the issues and get a deeper answer, said Biology Professor Vassie Ware.

The results of the experiment would not be possible without Ims expertise in computational model simulations and Zhangs novel single molecule detection method.

Because Im and Zhang were experimenting on how to detach the virus from the cell, their research will most likely be used as a cure to COVID-19 for those who currently have the virus, rather than a preventative method.

Although the study could have groundbreaking implications, Zhang believes that with the time it takes to develop and manufacture a new drug, their study will likely not have a tangible impact on the current pandemic.

The time it takes to create a drug and have it pass through the FDA means that this discovery may not be able to catch this pandemic, but it will be helpful for future outbreaks, Zhang said.

In the meantime, Im and Zhang plan on continuing their research and move onto more infectious and dangerous variants of the COVID-19 virus.

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Professors discover way to keep COVID-19 virus from sticking to human cells - The Brown and White

Centrifugation-free Sperm Separation Systems market research report provides detailed information on the following aspects: industry size, share, growth, segmentation, manufacturers and progress, main trends, market drivers, challenges, standardization, deployment models, opportunities, strategies, future roadmaps, and Annual forecast till 2027, etc. The report conducted a professional and in-depth analysis of the current situation of the Centrifugation-free Sperm Separation Systems market, including major players such as manufacturers, suppliers, distributors, traders, customers, and investors. The report also helps you understand the dynamic structure of the Centrifugation-free Sperm Separation Systems market by identifying and analyzing market segments.

Combined with important market challenges, the potential of this industry field has been fully explored. The current market conditions and prospects of this segment have also been checked. In addition, key market strategies including product development, partnerships, mergers, and acquisitions will also be studied. Upstream raw materials and equipment and downstream demand analysis are also conducted.

Have a Need More Info, Request Sample PDF of This Research Report:https://www.worldwidemarketreports.com/sample/696097

The major players profiled in this report include

CooperSurgical, Inc., Koek Biotechnology Bioengineering and Medical Services Industry & Trade, Inc., Memphasys Ltd., DxNow, SAR Healthline Pvt. Ltd., Lotus Bio, other prominent players

Market Segments and Sub-segments Covered in the Report are as per below:

Based on Product Type Centrifugation-free Sperm Separation Systems market is segmented into

Migration-sedimentation (MS), Microfluidic Sperm Sorters (MFSSs), Others

Based on the Application Centrifugation-free Sperm Separation Systems market is segmented into

Hospitals & Clinics, Cryobanks, IVF Centers, Others

Regional Coverage of the Centrifugation-free Sperm Separation Systems Market:

Europe, Asia Pacific, Africa, and the Middle East, North America, Latin America

Impact of COVID-19:

The industry is mainly driven by increasing financial incentives and regulatory support from governments around the world. The current Centrifugation-free Sperm Separation Systems market is mainly affected by the COVID-19 pandemic. Most projects in China, the United States, Germany, and South Korea have been postponed. These companies are facing short-term operational problems due to supply chain constraints and the inaccessibility of factories due to the COVID-19 outbreak. Due to the pandemic impact in China, Japan, and India, the spread of COVID-19 is expected to severely affect the Asia-Pacific region.

Get the Covid-19 Impact Analysis, And All updates on Centrifugation-free Sperm Separation SystemsIndustry:https://www.worldwidemarketreports.com/covidimpact/696097

Frequently Asked Questions

What does the report cover?The report incorporates an analysis of factors that promote market growth. The report introduces the competitive landscape of the global market. This also provides a range of different market segments and applications that may affect the market in the future. The analysis is based on current market trends and historical growth data. It includes detailed market segmentation, regional analysis, and industry competition pattern.

Does the report estimate the current market size?The report effectively assesses the current market size and provides industry forecasts. The value of this market in 2019 is $XXX million, and the compound annual growth rate during 2021-2027 is expected to be XX%.(*Note: XX values will be given in final report)

How does the report provide the market size of the market?The report effectively assesses the current market size and provides forecasts for the industry in the form of Value (millions USD) and transaction Volume (Thousands Units)

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Centrifugation-free Sperm Separation Systems Market 2021-2027: Main Highlights

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Centrifugation-free Sperm Separation Systems Market to witness increasing venture capital investment in Segment: CooperSurgical, Inc., Koek...

Researchers at the University of Texas at Dallas have developed a sensor that could detect a COVID-19 infection from your breath.

The portable, reusable breath test device, designed to provide results in less than 30 seconds, is being developed by Dallas-based SOTECH Health, which licensed the sensor technology developed by Dr. Shalini Prasad, department head and professor of bioengineering in the Erik Jonsson School of Engineering and Computer Science.

The device detects chemical markers of the bodys response to the virus.

It is not a diagnostic test for COVID, instead would be used as a screening tool and followed up with diagnostic testing, like a molecular PCR test.

The latest news from around North Texas.

"This test is revolutionary and paradigm shifting primarily because it is looking for human body's response or host response to the coronavirus," said Prasad.

SOTECH'S founding CEO Craig Micklich says the device could be used as a screening tool at places like large entertainment venues, airlines and ballparks.

"The value of the device is actually the high throughput of finding negative individuals, to push them through, to be able to get on airlines get in venues, any kind of venue," said Micklich.

SOTECH has already applied for FDA emergency authorization now it waits to see if the COVID-19 breath analyzer will become the next weapon in ending the pandemic.

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Rapid Breath Test for COVID-19 Developed in Dallas - NBC 5 Dallas-Fort Worth

Under the terms of the agreement, I2Cure future products would be incubated at IIT-Kanpur

The Indian Institute of Technology-Kanpur (IIT-K) has collaborated with I2Cure (P) Ltd, a Make in India for the world biotech company for all future research on molecular iodine-based products that would be undertaken by the Biological Sciences & Bioengineering wing of IIT-K.

I2Cure is the first biotechnology company in the world to produce molecular iodine-based i2cure BioShield, which is a broad-spectrum antimicrobial with proven efficacy of 99.999 per cent against SARS-CoV-2.

Under the terms of the agreement, I2Cure future products would be incubated at IIT-Kanpur. The relationship would be of the equity partners, and validations of Dr Jack Kessler's global research would be done for Indian conditions at IIT-K.

IIT-K would also work with I2Cure to develop new Made in India' products for global markets, especially in tackling long-term problems in the space of human preventive health, veterinary science (FMD, Bovine mastitis, dermatitis), and agri products.

Stating on this momentous occasion, Anil Kejriwal, Founder, Chairman, I2Cureshared, We would jointly be happy to contribute towards the vision of the Prime Minister of India to double agricultural income as well as become a $5 trillion economy.

Adding to it,(Prof) Dr Ashok Kumar, Biological Sciences & Bioengineering at IIT Kanpur (BSBE), added, Were excited about the prospects of IIT-K researched and curated solutions getting global attention.

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IIT-K, I2Cure to advance research on molecular iodine-based products - BSI bureau

Apex Market Research has released a detailed report on Global L- Cysteine and Its Hydrochloride Market Research Report with Opportunities and Strategies to Drive Growth COVID-19 Impact and Recovery for clients who wish to explore new market avenues, obtain In-depth information on the products of the market, maximize their revenue and review the strategies implemented by the major market players.

The coronavirus pandemic disrupted market dynamics as it imposed restrictions on the opening of offices and manufacturing facilities. This, in turn, persuaded employees to work from home and halted the production of goods across the world. In addition, it had widened the gap between supply and demand due to the restriction of business in the world. However, it has created lucrative opportunities for major players in some regions.

Get a sample of the L- Cysteine and Its Hydrochloride Report :@https://www.apexmarketsresearch.com/sample/963243

The report covers key market players and provides information about their product portfolio and deployment strategies regarding the market. This Market report includes the technological advancements in products by key players. It presents information on collaborations, partnerships, mergers and agreements made by industry players over the years in the market. In addition, it covers the factors that have created opportunities and challenges for them.

Key Players:

Wacker, Nippon Rika, Shine Star (Hubei) Biological Engineering, Donboo Amino Acid, Ajinomoto, Wuxi Bikang Bioengineering, Wuhan Grand Hoyo, Huaheng Biologgical Technology, Ningbo Zhenhai Haide Biochem

Global L- Cysteine and Its Hydrochloride Market Report 2021-2026 Attributes:

Segmentation provides the estimated reader with a comprehensive regional analysis, which indicates whether the region / country has investment potential. This analysis is prepared taking into account the socio-economic development and government regulations and policies of the country.

Types of products:

L-Cysteine, L-Cysteine Hydrochloride

Types of applications:

Food Industry, Pharmaceutical Industry, Cosmetics Industry, Animal Feed, Other

The regions

North AmericaAsia PacificEuropeMiddle East and AfricaLatin America

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This report includes Porters five forces analysis to understand market dynamics.All data and figures are included in the Report in an easy to understand format. Plus, it features infographics to save time for the esteemed reader.Quarterly or yearly market updates straight to the inbox.The L- Cysteine and Its Hydrochloride Report is prepared by interviewing Vice Presidents, CEOs, Directors and other prominent market representatives.Any doubts regarding the specifics of the Report can be resolved before and after purchasing the Report. (Yes, Apex Market Research also provides great after-sales service).The Report can be completely customized according to the needs of the client.Data collected from reputable paid sources. (No compromise on data insights)

TOC for the Global L- Cysteine and Its Hydrochloride Market:

Chapter 1: Market Overview, Drivers, Restraints and Opportunities, Segmentation OverviewChapter 2: Market Competition by ManufacturersChapter 3: Production by RegionsChapter 4: Consumption by RegionsChapter 5: Production, By Types, Revenue and Market share by TypesChapter 6: Consumption, By Applications, Market share (%) and Growth Rate by ApplicationsChapter 7: Complete profiling and analysis of ManufacturersChapter 8: Manufacturing cost analysis, Raw materials analysis, Region-wise Manufacturing expensesChapter 9: Industrial Chain, Sourcing Strategy and Downstream BuyersChapter 10: Marketing Strategy Analysis, Distributors/TradersChapter 11: Market Effect Factors AnalysisChapter 12: Market ForecastChapter 13: L- Cysteine and Its Hydrochloride Research Findings and Conclusion, Appendix, methodology and data source

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We at Apex Market Research aim to be global leaders in qualitative and predictive analysis as we put ourselves in the front seat for identifying worldwide industrial trends and opportunities and mapping them out for you on a silver platter. We specialize in identifying the calibers of the markets robust activities and constantly pushing out the areas which allow our clientele base in making the most innovative, optimized, integrated and strategic business decisions in order to put them ahead of their competition by leaps and bounds. Our researchers achieve this mammoth of a task by conducting sound research through many data points scattered through carefully placed equatorial regions.

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L- Cysteine and Its Hydrochloride Market 2021 Projections, Size, Share, Trends and Forecast by 2026 | Wacker, Nippon Rika, Shine Star (Hubei)...

Hong Kong

After completing my citation in French sophomore year, I knew that I wanted to pick up just one more foreign language before I graduated. Despite having long had an interest in Japanese and Japanese history, the distance from Dunster House to Northwest Labs where Japanese courses are typically held on campus was just great enough to dissuade me from committing to a 9 a.m. class that met five times a week. Unexpectedly, and abruptly, the pandemic-necessitated shift to online learning removed this constraint. By simply clicking into the same Zoom meeting every day, I was able to learn about Japanese customs and dissect short stories with a group of warm, motivated classmates who have all become good friends. Together, we built a pandemic-era community that helped sustain me through an academic year like none other.

I miss the warm hugs and short, 10-minute conversations you might share with an old friend from a first-year seminar or even pre-orientation as you find yourselves in the basement of Memorial Hall lining up for Fly-By together. These are also the kinds of interactions that have been the hardest to replicate in our virtual social world of late.

When conditions improve and circumstances allow, I look forward to returning to reading rooms and perhaps even having the opportunity to engage with some of the primary sources that I wish I could have accessed as I was finishing my thesis earlier this semester. Of course, when international travel permits, I am also incredibly excited at the prospect of gathering offline with friends I have not been able to see these past 15 months or so.

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The cap (and gown) on a most unusual senior year - Harvard Gazette