UMD researchers are using a $2.8 million grant to study spinal cord injuries and dementia – The Diamondback

Professor Steven Jay in the lab where he oversees research on the link between spinal cord injuries and cognitive degeneration. (Joe Ryan/The Diamondback)

A team of University of Maryland and University of Maryland, Baltimore researchers is investigating the connection between dementia and spinal cord injuries with the help of a $2.8 million dollar grant awarded earlier this month from the National Institutes of Health.

The project a collaborative effort between the universitys bioengineering lab and the University of Maryland medical school, which is housed at the University of Maryland, Baltimore aims to examine a link between spinal cord injuries and degeneration in the brain.

The possible link has to do with particles called extracellular vesicles, which cells use for communication, said Steven Jay, an associate bioengineering professor working on the study.

[Read more: Police encounters can be risky for people with autism. A UMD lecturer thinks VR can help.]

After a spinal cord injury, the surrounding cells become inflamed and start to release the vesicles; they travel within the central nervous system and ultimately land in the brain. And now, researchers are looking to see if the spinal cord injury can lead to degeneration in the brain, said Alan Faden, a trauma professor at the medical school.

My mission, for now going [on] four years, is to develop the science that can be translated to humans to protect the brain and the spinal cord from secondary damage, Faden said. And to get people to recover faster and better.

Somehow, the particles affect the brain in a negative way, resulting in higher instances of dementia, said Jay, who is studying extracellular vesicles. But researchers want to figure out how.

The research team is working to understand the biological process surrounding the vesicles, Jay said. With an understanding of the biology, the team can study ways to reverse their negative impacts.

Instead of having them, you know, promote the problem, Jay said. Could we program them to actually solve the problem?

[Read more: A diverse group of UMD researchers is studying the link between brain and gut health]

Junfang Wu, an associate professor at the medical school, is leading the project. She said shes eager to explore the relationship with the vesicles, which she said could improve understanding of spinal cord injuries and their cognitive effects.

Thats the exciting part, Wu said.

Wu has been researching spinal cord injuries for years and said that the average age for spinal cord injuries has increased. These injuries, she said, often come from falls. And the risk of falls increases in older people, along with the risk of spinal cord injury, Wu said.

Still, Jay said, vesicles role in cell-to-cell communication was discovered a little over a decade ago. So though the researchers could identify a key player in spinal cord injuries, there is a long way to go before they discover something concrete and applicable.

Its following up on very recent knowledge, Jay said. So its not something thats going to be leading to therapy in two years or something like that.

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UMD researchers are using a $2.8 million grant to study spinal cord injuries and dementia - The Diamondback

Julian Meeks, Ph.D. – "Transporting a Career from Bioengineering to Neuroscience" – Video


Julian Meeks, Ph.D. - "Transporting a Career from Bioengineering to Neuroscience"
Julian Meeks, Ph.D., University of Texas Southwestern Medical Center, Department of Neuroscience, gives speech entitled: "Transporting a Career from Bioengineering to Neuroscience" at the 2014...

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Illuminati Bioengineering MAN Into Robots NanoTech DNA Modification, Chemtrails, HAARP, Smart Meters – Video


Illuminati Bioengineering MAN Into Robots NanoTech DNA Modification, Chemtrails, HAARP, Smart Meters
Why would they put metals like alumunim, barium, not just in vaccines but in the atmosphere with chemtrails??? In February of 2012 the first Global Future 2045 Congress was held in Moscow....

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Advancing Science in Alternative Energy and Bioengineering with Many-Core Processors – Video


Advancing Science in Alternative Energy and Bioengineering with Many-Core Processors
In this video from the 2014 HPC User forum in Seattle, Michael Brown from Intel presents: Advancing Science in Alternative Energy and Bioengineering with Man...

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AgeX Therapeutics Announces Drawdown of Second Tranche of Loan Facility from Juvenescence Ltd. – BioSpace

Juvenescence is pleased to continue its commitment to AgeX through this additional drawdown under the loan facility, commented Gregory Bailey, MD, Chairman of AgeX and CEO of Juvenescence. Juvenescence remains committed to funding the future development plans of AgeX through further advancements under the loan facility or otherwise. Since Juvenescences initial investment in AgeX in June 2018, AgeX has been an important element in the Juvenescence mission and strategy. Juvenescence is also investing its time and personnel to support AgeXs business development initiatives which have impressive potential. We look forward to AgeX announcing its plans for 2020 as it pursues tissue regeneration in Reverse Bioengineering, while advancing the development of BAT and VASC 1, the coupling of HLA-G with PureStem-derived cells for transplant therapies, and exploring partnerships with third parties.

This round of funding will allow us to continue to execute on our strategic plan to provide therapies for certain chronic and degenerative diseases through cellular regeneration and replacement, commented AgeXs founder and CEO Michael D. West, PhD.

As announced in the companys news release on August 14, 2019, AgeX has obtained a $2 million credit facility from Juvenescence to finance AgeXs operations and advance its product development programs.

About AgeX Therapeutics

AgeX Therapeutics, Inc. (NYSE American: AGE) is focused on developing and commercializing innovative therapeutics for human aging. Its PureStem and UniverCyte manufacturing and immunotolerance technologies are designed to work together to generate highly-defined, universal, allogeneic, off-the-shelf pluripotent stem cell-derived young cells of any type for application in a variety of diseases with a high unmet medical need. AgeX has two preclinical cell therapy programs: AGEX-VASC1 (vascular progenitor cells) for tissue ischemia and AGEX-BAT1 (brown fat cells) for Type II diabetes. AgeXs revolutionary longevity platform induced Tissue Regeneration (iTR) aims to unlock cellular immortality and regenerative capacity to reverse age-related changes within tissues. AGEX-iTR1547 is an iTR-based formulation in preclinical development. HyStem is AgeXs delivery technology to stably engraft PureStem cell therapies in the body. AgeX is developing its core product pipeline for use in the clinic to extend human healthspan and is seeking opportunities to establish licensing and collaboration agreements around its broad IP estate and proprietary technology platforms.

For more information, please visit http://www.agexinc.com or connect with the company on Twitter, LinkedIn, Facebook, and YouTube.

Forward-Looking Statements

Certain statements contained in this release are forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Any statements that are not historical fact including, but not limited to statements that contain words such as will, believes, plans, anticipates, expects, estimates should also be considered forward-looking statements. Forward-looking statements involve risks and uncertainties. Actual results may differ materially from the results anticipated in these forward-looking statements and as such should be evaluated together with the many uncertainties that affect the business of AgeX Therapeutics, Inc. and its subsidiaries, particularly those mentioned in the cautionary statements found in more detail in the Risk Factors section of AgeXs Annual Report on Form 10-K and Quarterly Reports on Form 10-Q filed with the Securities and Exchange Commissions (copies of which may be obtained at http://www.sec.gov). Subsequent events and developments may cause these forward-looking statements to change. AgeX specifically disclaims any obligation or intention to update or revise these forward-looking statements as a result of changed events or circumstances that occur after the date of this release, except as required by applicable law.

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AgeX Therapeutics Announces Drawdown of Second Tranche of Loan Facility from Juvenescence Ltd. - BioSpace

The Latest: Justice Dept. files brief supporting travel ban – WIAT 42

WASHINGTON (AP) The Latest on the lawsuit involving President Donald Trumps executive order restraining immigration (all times local):

6:15 p.m.

The Justice Department has filed a brief with a federal appeals court in support of President Donald Trumps travel and refugee ban.

The document was filed Monday with the San Francisco-based 9th U.S. Circuit Court of Appeals.

The filing says the Trump administration executive order that bans travelers from seven predominantly Muslim nations is a lawful exercise of presidential authority. A federal judge in Washington state put the order on hold Friday.

Federal government lawyers say the ruling by the judge, James Robart, was overly broad and should be overruled.

It was not immediately clear when the 9th Circuit might rule, but the legal fight may ultimately reach the U.S. Supreme Court.

___

4:35 p.m.

White House Press Secretary Sean Spicer says the Trump administration is not rethinking its strategy over the presidents ban on refugees and travelers from seven predominantly Muslim countries from entering the United States.

He says the administration remains confident it will prevail in the lawsuit.

Spicer tells reporters traveling aboard Air Force One the president has huge discretion to protect the safety of Americans. He says clearly the law is on the presidents side, the Constitutions on the presidents side.

An appellate court this weekend denied the Trump administrations request to immediately set aside a Seattle judges ruling that put a hold on the ban nationwide. Both sides face a Monday afternoon deadline to file court motions.

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4:10 p.m.

Attorneys general from 15 states and the District of Columbia are urging a federal appeals court to uphold a lower court judges stay on President Donald Trumps immigration order.

The friend of the court brief was filed Monday with the 9th U.S. Circuit Court of Appeals in San Francisco.

The 23-page filing was signed by AGs from California, Connecticut, Delaware, Washington, D.C., Illinois, Iowa, Maine, Maryland, Massachusetts, New Mexico, New York, Oregon, Pennsylvania, Rhode Island, Vermont and Virginia.

The officials say Trumps executive order targeting refugees and nationals from seven predominantly Muslim countries hurts their states economies. They say it also disrupts education and medical services and violates First Amendment-protected religious liberties.

Trump has argued the U.S. must protect its borders from would-be foreign terrorists.

Government lawyers are expected to file court papers later Monday.

___

2:40 p.m.

Two Democrat-appointed judges and one Republican appointee will weigh the appeal involving President Donald Trumps recent immigration order.

David Madden, a spokesman for the 9th U.S. Circuit Court of Appeals, says the courts randomly assigned motions panel for this month will rule on the federal governments appeal of a Seattle judges order temporarily blocking the travel ban.

The judges on the panel are Senior Judge William C. Canby Jr., appointed by President Jimmy Carter in 1980; Senior Judge Richard Clifton, appointed by President George W. Bush in 2002; and Michelle T. Friedland, appointed by President Barack Obama in 2014.

Washington state, Minnesota and Hawaii are arguing that the San Francisco-based court should allow a temporary restraining order blocking the travel ban to stand. The Justice Department was expected to file its brief Monday afternoon.

___

10:35 a.m.

Two Yemeni brothers denied entry into the U.S. under President Donald Trumps travel ban have been reunited with their family at Dulles International Airport.

Ammar Aqel Mohammed Aziz and Tareq Aqel Mohammed Aziz are green-card holders who were traveling through Dulles on their way to Flint, Michigan, when the ban took effect. A federal lawsuit alleges they were coerced into signing away their status and sent to Ethiopia. The brothers arrived at the airport Monday morning.

Attorney Paul Hughes says an agreement was reached with the government to allow their re-entry, as well as that of another Yemeni family under similar circumstances. That family also arrived Monday.

Without the agreement, Hughes says they may not have been allowed entry since their visas were marked by prominent canceled stamps.

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10 a.m.

An Iraqi couple whose plans to resettle in the U.S. were dashed by President Donald Trumps travel ban are now on their way to New York.

Mariam Ali Hussein waited months for a visa in order to be reunited with her husband, Samah Yousef, who has a U.S. passport. The visa finally came through just days before Trump ordered a ban on travelers from Iraq and six other Muslim-majority nations.

Hussein said she had resigned her job, expecting to move, but then suddenly our lives turned upside down after the surprise ban. She was overjoyed when she received word that a U.S. judge had suspended the order.

She and her husband flew out of Baghdad on Monday, with plans to transit in Cairo. There are no direct flights from Baghdad to the United States, but flights to the usual transit hubs of Cairo, Amman and Istanbul are booked solid.

__

9:55 a.m.

Jordans national airline is drumming up business for U.S.-bound flights in a light-hearted advertisement. It follows a U.S. judges temporary suspension of President Donald Trumps travel ban targeting those from seven Muslim-majority countries.

Airline spokesman Basel Kilani said Monday that Royal Jordanian is offering discounts of up to 20 percent for flights to Chicago, New York and Detroit. The ad reads: Fly to the U.S. now that youre allowed to and had the word ban edited graphically to read bon in bon voyage.

Jordan is not one of the black-listed countries, but serves as a regional travel hub.

Kilani says RJ blocked four passengers from boarding after Trumps initial Jan. 29 ban, and that there were also some cancellations. He did not provide figures.

The spokesman says the ban was bad for business.

__

8:45 a.m.

John Kerry and Madeleine Albright, both former secretaries of state, are joining former top U.S. national security officials in asking the courts to continue blocking President Donald Trumps recent immigration order.

Most of the former officials served under President Barack Obama. They said travel restrictions on seven Muslim-majority nations would disrupt thousands of lives, while likely endangering U.S. troops in the field and hurting partnerships with other countries to combat terrorism.

The group wrote that the order will aid the Islamic State groups propaganda effort and serve its recruitment message by feeding into the narrative that the United States is at war with Islam. They add: Blanket bans of certain countries or classes of people are beneath the dignity of the nation and Constitution that we each took oaths to protect.

The six-page document was provided to the United States Court of Appeals for the 9th Circuit. The San Francisco-based appeals court has already turned down a Justice Department request to set aside immediately a Seattle judges ruling that put a temporary hold on the ban nationwide.

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4:30 a.m.

Lawyers for Washington state and Minnesota have told a federal appellate court it would unleash chaos again if it lifted an order temporarily halting President Donald Trumps ban on refugees and travelers from seven predominantly Muslim countries from entering the United States.

In briefs filed early Monday morning with the San Francisco-based 9th U.S. Circuit Court of Appeals, Washington state and Minnesota said Trumps travel ban harmed residents, businesses and universities and was unconstitutional.

The appellate court this weekend denied the Trump administrations request to immediately set aside a Seattle judges ruling that put a hold on the ban nationwide but sought briefs from both Washington state and the federal government. The Justice Department has until Monday afternoon to file its court motion.

Trumps order a caused confusion for many foreigners trying to reach the United States, prompted nationwide airport protests and led to multiple court challenges.

The federal government has until later today to respond to the states briefs.

___

3:32 a.m.

Dozens of tech companies, including giants like Apple, Google, and Uber, are siding with Washington state as it fights President Donald Trumps ban on refugees and travelers from seven predominantly Muslim countries from entering the United States.

The companies filed briefs late Sunday with a federal appellate court saying the Trump executive order hurts their businesses by making it harder to recruit employees. The companies also said the travel ban would prompt businesses to build operations outside the United States.

Washington state is suing Trump, saying the ban harmed residents and effectively mandated discrimination.

The 9th U.S. Circuit Court of Appeals this weekend denied the administrations request to immediately set aside a Seattle judges ruling that put a hold on the ban nationwide.

___

3:15 a.m.

The White House says it expects the courts to restore President Donald Trumps ban on refugees and travelers from seven predominantly Muslim countries, an executive order founded on a claim of national security.

The next opportunity for the presidents team to argue in favor of the ban will come in the form of a response to a lawsuit by Washington state and Minnesota contending that Trumps order harms residents and effectively mandates discrimination. The 9th U.S. Circuit Court of Appeal has ordered the Justice Department to file its briefs by 6 p.m. EST Monday.

The San Francisco-based appeals court has already turned down a Justice Department request to set aside immediately a Seattle judges ruling that put a temporary hold on the ban nationwide. That ruling last Friday prompted an ongoing Twitter rant by Trump, who dismissed U.S. District Court Judge James Robart as a so-called judge and his decision as ridiculous.

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The Latest: Justice Dept. files brief supporting travel ban - WIAT 42