Team Develops More Effective Therapeutic Antibodies – Genetic Engineering & Biotechnology News

Researchers from the University of Maryland and Rockefeller University, who previously developed a method to modify an antibody's sugar group structure, which opened the door for biochemists to create antibodies with consistent sugar groups, report that they havetaken their method a step further by determining which specific sugar combinations enhance--or suppress--an antibody's ability to signal the immune system to attack an invader.

The results ("Modulating IgG effector function by Fc glycan engineering"),published online in theProceedings of the National Academy of Sciences, are an important step toward the development of highly effective antibodies to fight cancer and other diseases, according to the investigators.

An antibody's ability to send killer signals depends on the configuration of sugar chains attached to the protein. In naturally occurring antibodies, these sugar chains have a lot of variability. Even in antibodies currently used for disease therapy, a given dose might contain a wide variety of antibody variants, also known as "glycoforms," distinguished by their sugar groups.

Although prior methods tried to sort out these glycoforms and collect the most effective ones, these methods are time-consuming, expensive and not 100 percent effective. The method used in the current study enables the researchers to create a given antibody with identical glycoforms using biochemical techniques. Each glycoform can then be tested independently to see whether it enhances or suppresses the immune response.

"Our first major step forward was to develop a method to produce homogeneous glycoforms," said Lai-Xi Wang, Ph.D., a professor of chemistry and biochemistry at UMD. "With this, we can now look at how individual different sugars affect the properties of antibodies. Until this study, we didn't have an efficient way to know how individual sugars in various glycoforms affect suppression or activation of the immune response."

Most therapeutic antibodies on the market are designed to treat cancer and autoimmune diseases. For example, Rituximab is an antibody-based drug used to treat lymphoma, leukemia and rheumatoid arthritis. Rituximab and other similar antibody drugs are usually produced in cultured cell lines.

"These processes are not optimized at all. There is no easy way to control glycosylation," noted Dr. Wang. Glycosylation is the process by which sugar groups are added to a protein such as an antibody. "Our method could be used to improve antibodies already on the market because it modifies the antibodies directly instead of working at the genetic level."

Dr. Wang's group, which specializes in the biochemistry of protein glycosylation, developed the methodology to modify the antibody sugar groups. They partnered with Jeffrey Ravetch's group at Rockefeller University, which specializes in immunology and animal models, to test the effects of various glycoforms on the immune response. The new findings will help guide the development of future antibody-based therapeutics.

"Our method would be generally applicable because it can be used on a wide variety of antibodies," explained Dr. Wang. "It's an important step forward in the effort to engineer therapeutic antibodies that can target specific cancers, inflammation and other diseases. Soon we will be able to build customized antibodies."

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Team Develops More Effective Therapeutic Antibodies - Genetic Engineering & Biotechnology News

Department of Biochemistry, University of Oxford

Welcome to the Department of Biochemistry, part of the University of Oxford's Medical Sciences Division. We are one of the largest Biochemistry departments in the world and carry out world-class research and teaching. Our researchers come from a range of disciplines and work in a collaborative environment on all aspects of modern molecular and cellular biochemistry. We hope you enjoy reading more about our activities on these pages.

Professor Mark Sansom, Head of Department

A new paper from postdoctoral fellow Stephan Uphoff in the Biochemistry department has revealed that random variation in the DNA repair capacity of cells can lead to genetic variation.

E. coli cells treated with DNA methylation damage induce the adaptive response by activating Ada protein expression. The microscopy image shows fluorescently tagged Ada in yellow. Despite identical genetic makeup and treatment, a fraction of cells fails to induce the Ada response (in grey). Scale bar: 5 m (Click to Enlarge)

The results are published in Science (1) and are the fruition of a collaborative project between Dr Uphoff in Professor David Sherratt's lab and the lab of Professor Johan Paulsson at Harvard Medical School. They provide insight into how phenotypic variation can lead to genetic variation - a new twist on studies exploring the impact of variability in gene expression between cells.

A physicist by training, Dr Uphoff has spent the last few years developing and applying live cell imaging techniques. Currently funded by a Sir Henry Wellcome Postdoctoral Fellowship from the Wellcome Trust and a Junior Research Fellowship at St John's College in Oxford, he has been using single-molecule imaging to study mechanisms of DNA repair in bacteria, in both the Sherratt and Paulsson labs.

The newly published study explores the consequences of heterogeneity in a bacterial DNA repair process. Whilst there has been lots of discussion about noise in gene expression giving rise to phenotypic heterogeneity in genetically identical cells, there have been few studies that go beyond transient variations in gene expression. In the case of DNA repair, however, any transient heterogeneity could persist over long timescales in the form of mutations.

In the bacterium Escherichia.coli, the adaptive response protects cells against the toxic and mutagenic effects of DNA methylation damage. This requires Ada protein, which as well as directly repairing methylated DNA, also activates ada gene expression. It does this via a positive feedback mechanism - ada expression is increased a thousand-fold by methylated Ada which acts as a transcriptional activator after transfer of a methyl group from damaged DNA onto the protein during the repair process.

Another feature of the DNA damage response is that Ada protein is present in low numbers in cells before DNA damage. 'We hypothesised that there should be substantial heterogeneity in the adaptive response between cells because positive feedback tends to amplify the noise that is inherent in low molecule numbers,' says Dr Uphoff.

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Department of Biochemistry, University of Oxford

Chemistry & Biochemistry – The University of Oklahoma

Welcome to the Department of Chemistry and Biochemistry at the University of Oklahoma. Our mission is to serve the citizens of the State of Oklahoma and the nation through instructing our undergraduate majors, those in cognate disciplines and as part of the general education programs of the College of Arts and Sciences to understand the role of chemistry and biochemistry in the natural world, through professional training of graduate students and postdoctoral researchers, through creating and disseminating new research-based understanding of chemistry and biochemistry, through providing expert advice and consultation to educational, industrial and governmental units, and through participating in service to the university and professional communities.

We are pursuing this mission through our research activities, our instructional programs and our service contributions. Our research activities are housed in our spectacular Stephenson Life Sciences Research Center (SLSRC) on the research campus located south of OUs main campus. Since 2010, these research facilities house our faculty offices, faculty-led research labs, research centers, research support facilities and departmental administration offices.

As described in our faculty research pages, our outstanding and award-winning faculty contribute to the development of new scientific understanding and training of our students and professional research associates.

We are in the process of a major investment of effort and resources in the development of our undergraduate and graduate instructional programs. Our Graduate Program has just been converted to a modular course program in which we offer variable length courses. Coupled to these highly focused courses are related changes to our graduate program that should bring the time to a doctoral degree down to an average of 4.5 years. In our undergraduate instructional programs we are redesigning the curriculum from general chemistry up to the advanced courses. At the core we wish all students taking chemistry to appreciate the role of chemistry in understanding nature. These courses also develop abilities to collect scientific information, process it and reach conclusions while preparing to add to our scientific understanding of nature.

We are also committed to serving the wider community. Information on our summer academies and science-society relations can be found on our Student Lifeweb pages.

We are grateful to our strong network of supporters. For information on how you can contribute efforts or resources to the department, please visit our Supportweb pages.

I hope you find the information you are looking for on these web pages and by following us on Twitter @UOkChemBiochem. If you have additional questions, please contact us.

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Biochemistry professor continues to follow passions at 100 years old – The Maneater

Eighty years ago, professor emeritus of biochemistry Boyd ODell began taking classes at MU. Now 100 years old, ODell, who has made many discoveries and inspired generations of colleagues, can still be found in his office in Eckles Hall.

I have some questions I really would like to answer, and Id rather think about answering those questions than retiring, ODell said.

ODell technically retired in 1988, but still does part-time research on campus.

In September, a celebration honoring the 40th anniversary of the biochemistry department served as an early 100th birthday party for ODell. In December, a plaque was unveiled, naming the bridge connecting Schweitzer Hall to the Schlundt Annex the Boyd ODell Bridge of Discovery.

I hope the bridge will be a bridge to the future for all the students and progress will be made in research and learning, ODell said at the unveiling.

Over the years, ODell has served as a mentor and a friend for many of his colleagues and students. Biochemistry professor Judy Wall first met ODell when she joined the MU faculty in 1978.

Hes an incredible gentleman, very professional, a great scholar and a truly kind person, Wall said.

Wall remembers when she and ODell were assigned to evaluate a graduate students grant proposal for a comprehensive exam. This was Walls first time evaluating this type of exam, and the only other female faculty member in the department did not attend their presentations.

I was the sole female faculty member and, you know, a silly person who was in the process of thinking about impressing all of my peers and making sure they didnt think I was an idiot at the evaluations, Wall said. So I was all set for getting this guy because I didnt think his proposal was great.

ODell went first. He discussed the importance of the problem the student had addressed and the strengths of the work before introducing criticism.

That was a wonderful experience for me because I thought thats exactly the way you should do it, Wall said. You have to earn the right to criticize by showing that you understand whats going on and you have to earn the right to begin to make constructive suggestions. Dr. ODell had shown me that was the professional way of going about it.

Wall uses this same approach anytime she has to evaluate anything in a similar manner.

He didnt realize, and I dont think I realized at the time, that he was mentoring me, but he certainly was, Wall said.

ODell decided to pursue education because he admired his teachers, who were his first role models.

I always had an ambition to be a teacher, ODell said. What did a farm boy in Carroll County have as role models? There was two things that I can think of, teacher was the most obvious one, and veterinarian.

ODell was born on a farm outside of Hale, Missouri, on Oct. 14, 1916. Becoming a veterinarian wasnt an option he considered, because it wasnt a financial possibility.

My parents were just poor farmers, and they couldnt help me, he said. I had to pave my way.

The summer after he graduated high school, ODell took an examination to become a teacher.

I passed all subjects with high scores except one, and that was pedagogy, ODell said. I didnt even know what pedagogy was. I suppose its the art of teaching.

That summer, ODell took classes at the University of Central Missouri, which was known as Warrensburg Teachers College at the time. He then began working in a one-room schoolhouse, where he taught first through eighth grade.

It was kind of fun in retrospect, ODell said. And that was in the depths of the Depression, to be paid $50 a month was a very good job. A lot of people were unable to even find a job.

Because he wanted to continue his education, ODell left the grade school after four years.

After a few years I transferred to the university here and got jobs one way or another and was able to support myself, he said.

He wanted to study bacteriology, but MU didnt have a program, so ODell was advised to become a chemistry major.

I worked for Dr. A.G. Hogan, who was my mentor for my Ph.D. At that time, he was interested in a vitamin that now is known as folic acid, ODell said.

ODell went on to work for a pharmaceutical company in Detroit after receiving his degree. With the end of World War II, MU saw an increase in students and invited ODell back to become a professor.

Coming back to Mizzou was kind of an easy choice because that was home. Im a Missourian through and through, ODell said.

ODell then studied the existence of unknown vitamins as an assistant professor.

At that time, an assistant professor was really an assistant to the professor, ODell said. When I became a little further along and had the independence, I still followed the question of, are there still unknown vitamins?

ODell went on to study the role of copper and zinc in the body. Among his discoveries was the revelation that copper deficiencies in animals can cause death through the rupture of the aorta, in the heart.

The opportunity arose for me to go on a sabbatical to Australia, ODell said. And why would I want to go to Australia? If youre interested in copper, its the place to go because much of the soil in Australia is copper-deficient.

In Australia, ODell saw that copper deficiency in sheep can cause symptoms similar to Parkinsons disease. He later observed the same results in rats.

We became interested in zinc deficiency around the same time, ODell said. We found that zinc deficiency in animals stops growth and causes increased subject to disease. Diarrhea is a common complaint of zinc-deficient animals and children.

He then discovered that phytic acid, which appears in plants such as soybeans and corn, can actually impact the way the body absorbs zinc.

Scientists want to know why does zinc deficiency cause these signs and symptoms in humans and animals, ODell said. Ive been interested in trying to solve that question for quite a number of years.

ODell is currently researching the importance of zinc in maintaining calcium channels.

If you think back of all the factors that a cell does, a cell divides, a cell secretes, contracts and carries messages, ODell said. All of this is dependent on a calcium channel, and if you take away zinc, the channel fails and you get all these symptoms. I think that that is the true, fundamental function of zinc to maintain the calcium channel.

ODell and Wall, a professor of biochemistry, have since worked together on a variety of committees and both taught biochemistry to first-year medical students.

He was always incredibly prepared, just beautiful lectures and so absolutely timely, Wall said. He knew the literature and was just great.

Another of ODells colleagues, professor emerita of biochemistry Grace Sun, also spoke of ODells role as a mentor.

Right now, Ive been retired for two years only and hes been retired for many more years, Sun said. I would say that hes a role model for me, and I wish I could do half as much like him.

The two became friends in the 80s, when a colleague Sun had met while working as a visiting professor in Taiwan came to MU to study with ODell.

ODell and his wife used to throw parties around the holidays where they would serve American foods, Sun said.

We loved it because we have a lot of international students and he has always a group of them, Sun said. At the time, he was like a hub for the international students.

Sun says ODell still interacts with colleagues and former research assistants by attending seminars and events on campus.

I remember one time, this must have been four or five years ago, and hes way over 90 and he wrote me an email, Sun said. He read a paper and then he said, Hey, Grace, maybe we can work together to do something on this area. I was so shocked. I was really amazed how he must be reading a lot of papers at home or in his office.

Now, ODell does experiments once or twice a week with cells that are grown in the Life Science Building.

I asked to use the equipment and I think they decided they better volunteer to do some of the work rather than trust me, ODell said with a laugh.

An undergraduate was assigned to help ODell grow and transfer the cells, Wall said.

It came holiday time, and the undergraduate was coming up on holiday, and so instead of imposing on this woman, Boyd decided he would just teach himself how to culture the human tissue culture, and so he did it, Wall said. Every day he would come over and transfer his cells and work with his cells. He walks over form Eckles to the Life Sciences Center and back again and has learned how to do this. What a terrifically fearless person he is when it comes to science.

ODell doesnt just walk across campus; he also walks from his house every time he comes to do research.

Most of my career I rode a bicycle to work, ODell said. I dont have a car, and I dont ride my bicycle anymore that leaves walking. I like walking. I think its good exercise, and I need exercise.

ODells daughter Ann, who lives in Columbia, helps drive him when he needs to go shopping and eats with him every week. ODell has a son, David, who lives in California, as well as four grandchildren and two great-grandchildren.

Outside of science, ODells hobbies include photography and bird-watching.

I was always interested in bird-watching and nature work; I guess that might fall from the science, ODell said. Even when I was teaching at the grade school, I had projects for the kids where wed collect plants.

After 100 years, ODell recognizes the importance of lifelong learning and following ones interests.

I think you should, in general even beyond science, you should pick a job or do what you have a real passion for, ODell said. I think if you really are keenly interested in it you will be successful.

Edited by Kyle LaHucik | klahucik@themaneater.com

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Biochemistry professor continues to follow passions at 100 years old - The Maneater

Amino Acids – University of Arizona

Basic Structure of Amino Acids

Acidic & Amides Aliphatic Aromatic Basic Cyclic Hydroxyl Sulfur-Containing

Test yourself Structure & Chemistry ID Structures Letter Codes

Author of 1 letter codes Dr. M.O. Dayhoff

Introduction Essential amino acids Why learn this?

Amino acids play central roles both as building blocks of proteins and as intermediates in metabolism. The 20 amino acids that are found within proteins convey a vast array of chemical versatility. The precise amino acid content, and the sequence of those amino acids, of a specific protein, is determined by the sequence of the bases in the gene that encodes that protein. The chemical properties of the amino acids of proteins determine the biological activity of the protein. Proteins not only catalyze all (or most) of the reactions in living cells, they control virtually all cellular process. In addition, proteins contain within their amino acid sequences the necessary information to determine how that protein will fold into a three dimensional structure, and the stability of the resulting structure. The field of protein folding and stability has been a critically important area of research for years, and remains today one of the great unsolved mysteries. It is, however, being actively investigated, and progress is being made every day.

As we learn about amino acids, it is important to keep in mind that one of the more important reasons to understand amino acid structure and properties is to be able to understand protein structure and properties. We will see that the vastly complex characteristics of even a small, relatively simple, protein are a composite of the properties of the amino acids which comprise the protein.

Top Essential amino acids Humans can produce 10 of the 20 amino acids. The others must be supplied in the food. Failure to obtain enough of even 1 of the 10 essential amino acids, those that we cannot make, results in degradation of the body's proteinsmuscle and so forthto obtain the one amino acid that is needed. Unlike fat and starch, the human body does not store excess amino acids for later usethe amino acids must be in the food every day.

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Amino Acids - University of Arizona

Plant Biochemistry Physiology Journals | High Impact Articles

Impact Factor: 2.28*

Journal of Plant Biochemistry & Physiology deals with the cellular and molecular biology and interaction between bimolecules along with the study of photosynthesis, respiration, plant nutrition, plant hormone functions which are associated with plant morphology, ecology and environmental effects on plants.

The journal includes a wide range of fields in its discipline to create a platform for the authors to make their contribution towards the journal and the editorial office promises a peer review process for the submitted manuscripts for the quality of publishing.

Plant Biochemistry and Physiology Journal is at higher echelons that enhance the intelligence and information dissemination on topics closely related to Plant Biochemistry and Physiology. It provide an unique forum dedicated to scientists to express their research articles, review articles, case reports and short communications on an array of Plant Biochemistry and Physiology research. The Plant Biochemistry and Physiology Peer Reviewed Journals are proficiently supported by universally prominent Editorial Board members. Plant Biochemistry and Physiology journal impact factors is mainly calculated based on the number of articles that undergo a double blind peer review process by competent Editorial Board so as to ensure excellence, essence of the work and number of citations received for the same published articles. Abstracts and full texts of all articles published by Plant Biochemistry and Physiology Open Access Journals are freely accessible to everyone immediately after publication.

This Plant Biochemistry & Physiology is using Editorial Manager System for quality in review process. Editorial Manager System is an online manuscript submission, review and tracking systems. Review processing is performed by the editorial board members of Journal of Plant Biochemistry & Physiology or outside experts; at least two independent reviewers approval followed by editor approval is required for acceptance of any citable manuscript. Authors may submit manuscripts and track their progress through the system, hopefully to publication. Reviewers can download manuscripts and submit their opinions to the editor. Editors can manage the whole submission/review/revise/publish process.

Submit manuscript at http://www.editorialmanager.com/biochem or send as an e-mail attachment to the Editorial Office at editor.jpbp@omicsinc.com

Plant cellular biochemistry is not only an important field of basic science explaining the molecular function of a plant, but is also an applied science that is in the position to contribute to the solution of agricultural and pharmaceutical problems.Plant cellular biochemistry, sometimes called biological chemistry, is the study of chemical processes within and relating to living organisms. By controlling information flow through biochemical signaling and the flow of chemical energy through metabolism, biochemical processes give rise to the complexity of life. Over the last 40 years, biochemistry has become so successful at explaining living processes that now almost all areas of the life sciences from botany to medicine are engaged in biochemical research. Today, the main focus of Plant cellular biochemistry Journals is in understanding how biological molecules give rise to the processes that occur within living cells, which in turn relates greatly to the study and understanding of whole organisms.

Plant Molecular and Cellular Biochemistry is a peer-reviewed scientific journal covering research in cellular biology and biochemistry. Plant Molecular and Cellular Biochemistry Journals was a successor to the journal Enzymologia and was established in 1973 to make it possible to extend the potentialities of the periodical

Molecular biology of plants is the study of biology at the molecular level. The field overlaps with other areas of biology and chemistry, particularly genetics and biochemistry. Molecular biology of plants studies the properties of cells including their physiological properties, their structure, the organelles they contain, interactions with their environment, their life cycle, division and death. Molecular and cellular biology are interrelated, since most of the properties and functions of a cell can be described at the molecular level. Molecular biology of plants Journals encompass many biological fields including: biotechnology, developmental biology, physiology, genetics and microbiology.

Plant stress physiology is a subdiscipline of botany concerned with the functioning, or physiology, of plants. Closely related fields include plant morphology (structure of plants), plant ecology (interactions with the environment), Plant stress physiology (biochemistry of plants), cell biology, genetics, biophysics and molecular biology. Fundamental processes such as photosynthesis, respiration, plant nutrition, plant hormone functions, tropisms, nastic movements, photoperiodism, photomorphogenesis, circadian rhythms, environmental stress physiology, seed germination, dormancy and stomata function and transpiration, both parts of plant water relations, are studied in Plant stress physiology Journals.

Plant biotechnology is a field that entails applying technology on life (plants). It is a vast field that entails producing new products in a larger faster way, deviating from the conventional way of doing the same. Plant biotechnology Journals can be divided into several systems depending on what each of these entails.

Plant Biochemistry, sometimes called biological chemistry, is the study of chemical processes within and relating to living organisms. By controlling information flow through biochemical signaling and the flow of chemical energy through metabolism, biochemical processes give rise to the complexity of life. Over the last 40 years, biochemistry has become so successful at explaining living processes that now almost all areas of the life sciences from botany to medicine are engaged in biochemical research. Today, the main focus of pure biochemistry is in understanding how biological molecules give rise to the processes that occur within living cells, which in turn relates greatly to the study and understanding of whole organisms. Plant Biochemistry is closely related to molecular biology, the study of the molecular mechanisms by which genetic information encoded in DNA is able to result in the processes of life. Depending on the exact definition of the terms used, molecular biology can be thought of as a branch of Plant Biochemistry Journals as a tool with which to investigate and study molecular biology.

Plant cell physiology are eukaryotic cells that differ in several key aspects from the cells of other eukaryotic organisms. Their distinctive features include: A large central vacuole, a water-filled volume enclosed by a membrane known as the tonoplast that maintains the cell's turgor, controls movement of molecules between the cytosol and sap, stores useful material and digests wasteproteins and organelles. A cell wall composed of cellulose and hemicellulose, pectin and in many cases lignin, is secreted by the protoplast on the outside of the cell membrane. Plant cell physiology Journals contrasts with the cell walls of fungi (which are made of chitin), and of bacteria, which are made of peptidoglycan. Specialized cell-to-cell communication pathways known as plasmodesmata pores in the primary cell wall through which the plasmalemma and endoplasmic reticulum of adjacent cells are continuous.

Genetics of plant physiology, known as plant growth regulators (PGRs) or phytohormones, are chemicals that regulate a plant's growth. According to a standard animal definition, hormones are signal molecules produced at specific locations, that occur in very low concentrations, and cause altered processes in target cells at other locations. Unlike animals, plants lack specific hormone-producing tissues or organs. Plant hormones are often not transported to other parts of the plant and production is not limited to specific locations. Genetics of plant physiology are chemicals that in small amounts promote and influence the growth, development and differentiation of cells and tissues. Hormones are vital to plant growth; affecting processes in plants from flowering to seed development, dormancy, and germination. They regulate which tissues grow upwards and which grow downwards, leaf formation and stem growth, fruit development and ripening, as well as leaf abscission and even plant death.Genetics of plant physiology Journals deals with the above topics.

Phytochemical Analysis are chemical compounds that occur naturally in plants (phyto means "plant" in Greek). Some are responsible for colour and other organoleptic properties, such as the deep purple of blueberries and the smell of garlic.Phytochemical Analysis may have biological significance, for example carotenoids or flavonoids, but are not established as essential nutrients.There may be as many as 4,000 different phytochemicals.The above all topics are covered in Phytochemical Analysis Journals.

Green chemistry Journals, is also called sustainable chemistry, is a philosophy of chemical research and engineering that encourages the design of products and processes that minimize the use and generation of hazardous substances.

Theoretical Chemistry is an exciting, contemporary and broad field: rooted inchemistry.Theoretical Chemistry Journals straddles the vibrant interfaces between chemistry, physics, materials science and biology, and encompasses any application of mathematical and computational techniques to problems and systems ofchemical and related interest.

Electrochemistry is the study of electricity and how it relates to chemical reactions. In electrochemistry, electricity can be generated by movements of electrons from one element to another in a reaction known as redox reaction, or oxidation-reduction reaction.Electrochemistry Journals deals with electricity and chemical reactions.

Heterocyclic chemistry is the branch of chemistry dealing with the synthesis, properties and applications of these heterocycles. In contrast, the rings of homocyclic compounds consist entirely of atoms of the same element. Although heterocyclic compounds may be inorganic, most contain at least one carbon.Heterocyclic chemistry Journals deals with the synthesisand properties of heterocycles.

Biotechnology-2015 aims to promote the international and national exchange of ideas, promote collaborative research network among academia and industry. Besides this dissemination of knowledge this world congress brings an opportunity for professionals to build up a scientific and professional network as well.

The Young researchers, postdoctoral researchers, graduate students and other professionals are warmly welcome to the Workshop entitled NIH Research Resources in Biotechnology which I plan to organize to explore the research possibilities in future in the field of Biotechnology.

OMICS International organizes 1000+ conferences every year across USA, Europe & Asia with support from 1000 more scientific societies and Publishes 700+ leading-edge peer-reviewed Open access journals with 10 million readers and it contains over 50000 eminent personalities, reputed scientists as editorial board members.

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Plant Biochemistry Physiology Journals | High Impact Articles

UCSD Chemistry and Biochemistry

Thank you for visiting the Department of Chemistry and Biochemistry. Ours is a vibrant and dynamic Department that combines research on the most consequential and revelatory scientific areas with education aimed at building our future leaders and informed citizens.

The research we engage in is marked by its breadth from atomic to cellular, from origins of life to climate change, from single molecules to systems level, from sustainable energy to cancer cures, from nanomaterials to solar systems, from infectious diseases to semiconductors, from RNA splicing to condensed phases, from protein structure to three-body problems, from lipid maps to stable carbenes, and so on. Along with these areas, we also engage in understanding how best to communicate scientific knowledge to our students. All these research efforts are made possible by the approximately $33M of sponsored research funds raised yearly by our faculty, and the array of advanced technologies acquired by our faculty to probe ever deeper into fundamental questions. Our faculty has been acknowledged for their creativity. We have Nobel Prize winners, members of the National Academy of Sciences, and HHMI Investigators among others.

Research is but one facet of our efforts. The other central facet is teaching. In this, we seek not only to convey the wisdom of ages but also the excitement of new scientific findings. The changes in our daily lives that these discoveries are making are enormous, and the pace at which these discoveries are being made is ever increasing. This means that one of our fundamental tasks is to help students understand what lies at the forefront of knowledge, so that they can understand how best to address current and future problems. We find the daily engagement with students to be energizing, and view scientific breakthroughs to be on equal footing with those moments in which we are able to convey an idea so that a student gets it. We teach 22,000 undergraduates and 2,000 graduate students in our courses. We have 1,000 undergraduate majors along with 40 Masters and 200 PhD students, and we train more than 100 Postdoctoral Researchers.

The Department recognizes that science is carried out in a societal context, and values diversity, equity, and inclusion among its faculty, researchers, and students. Indeed, our faculty is one of the most diverse among Chemistry departments. However, we recognize much work remains to be done and we continue to work towards increasing diversity throughout the Department.

I hope you will take some time to look around and learn about the superb research and teaching going on in the Department of Chemistry and Biochemistry.

Partho Ghosh, Chair

Macromolecular, cryoelectron microscopy and three-dimensional, image-reconstruction techniques.

Chemical Education: Development of context-rich curriculum; Use of collaborative learning strategies in large lectures; Communication of chemistry

Natural product synthesis/biosynthesis, Biological chemistry and enzymology, Metabolic engineering.

Chemical Education: Visual Literacy in Science, Biochemistry Education, Nano Science Education, K-20 Professional Development, and STEM Career Development

Bioinorganic and coordination chemistry. Metalloprotein inhibitors and supramolecular materials.

Dissociation dynamics of transient species, three-body reaction dynamics, novel mass-spectrometric methods

Materials chemistry, surface kinetics of metals/semiconductors, CVD, photo-induced deposition, thin-film spectroscopy.

Biochemistry: phospholipase A2, signal transduction in macrophages, lipid maps, prostaglandin regulation, mass spec of lipids and proteins.

Biomimetic Chemistry, Molecular Imaging, Electrochemistry

Protein Tyrosine Phosphatase, Dual=specific Phosphatase, PTEN

Inorganic and Organometallic Chemistry: Synthesis, Small Molecule Activation and New Transformations.

Electron Transport in Condensed Phases. Dissipation and Relaxation Processes. Non-equilibrium Open Quantum Systems. Molecular Electronics.

Biochemistry and biophysics: transcription, signaling, pre-mRNA splicing, mRNA transport, protein-protein, protein-DNA and protein-RNA interactions

Mechanisms of bacterial and protozoan pathogenesis, and host response against infectious microbes.

Bioorganic chemistry, Supramolecular Chemistry, Bionanotechnology, Materials, Synthesis

Nanotechnologies for analysis of glycan function during development. Glycomaterials for stem cell-based tissue regeneration.

Biophysical chemistry: protein structure, dynamics and folding; 2, 3 and 4D NMR spectroscopy; PCR; equilibrium and kinetic-fluorescence, absorbance and circular dichroism spectroscopies

Biophysical chemistry: Spectroscopic studies of membrane protein folding and dynamics

Structure, function, dynamics and thermodynamics of protein-protein interactions: NMR, mass spectrometry and kinetics

Inorganic, materials, and physical chemistry: electron transfer, catalysis, fixation and utilization of carbon dioxide.

STM/STS of gate oxides on compound semiconductors and adsorbates on organic semiconductor

Theoretical chemical physics: non-equilibrium statistical mechanics; stochastic processes; nonlinear phenomena; complex systems; condensed matter.

Statistical mechanics and computational chemistry, with applications to biological systems

Physical Chemistry: Gas Phase Chemical Kinetics and Photochemistry; Chemistry of Atmospheric Aerosols; Air Pollution in Megacities of the Developing World

Organic chemistry of marine natural products, synthesis, NMR, and biomedical applications

Evolution of catalytic RNAs, and the Origin of Life

Organotransition metal; organic; physical organic; bioorganometallic; synthetic; and inorganic chemistry

NMR structural studies of proteins in membranes and other supramolecular assemblies

Theoretical chemical physics of complex interfaces of relevance to the environment

Physical-organic chemistry: stereoelectronic effects; hydrogen bonding; isotope effects; ionic solvation; naked anions; malonic anhydrides

The application of analytical chemistry to forensic, environmental and industrial chemistry, then bridge these experiences into the classroom. This also includes the role technology and instrumentation play in discovery and problem solving.

Environmental, physical/analytical chemistry: gas/particle processes of tropospheric significance; mass spectrometry; laser-based analysis techniques.

Inorganic chemistry: Small-molecule crystallography, synthesis of transition metal/p-block clusters

Nanomaterials: porous silicon, chemical and biological sensors, biomaterials, electrochemistry

Chemical education: development of computer-based multimedia to assist student learning of complex scientific processes and concepts

Experimental physical chemistry: photochemistry; laser spectroscopy; reaction dynamics of vibrationally excited molecules

Physical chemistry; Optical and magnetic spectroscopy; Fundamental studies of charge transport and solvation; Applications to energy conversion and energy storage.

Structure, Function, Dynamics, and Localization of PKA as a Prototype for the Protein Kinase Superfamily.

Bioinorganic and biophysical chemistry; Metalloprotein structure, function and biosynthesis; Biomaterials

Synthetic, Medicinal, Bioorganic and Biological Chemistry, Methods and Strategies in Natural Products Chemistry

Atmospheric chemistry: physical chemistry of isotope effects; solar system formation

Structure and Function of Introns and Retroelements

Ligand-nucleic acid interactions; Antiviral and antibacterial agents; Fluorescent nucleosides and nucleotides; Cellular delivery vehicles

Chemical biology; design, synthesis, and application of molecular probes of biological function

Environmental toxicology: The role of environmental and chemical toxicants on gene expression

epigenomics, cellular reprogramming, protein recognition, computational biology, systems biology

Physical chemistry: calculations of the dynamics of complex systems; theoretical geochemistry

Spatio-temporal signaling control of biological self-organization. Signaling networks in innate immunity. Microscopy; Mathematical modeling; Computational image analysis; Systems Biology.

Investigation of charge transfer mechanism in nanomaterials with novel ultrafast spectroscopies

Bioorganic Chemistry, Molecular Self-Assembly, Molecular Synthesis, Materials Chemistry, Bionanotechnology

Theory at the interface of chemistry, condensed matter, and materials physics

Gene Expression Control During Stress; mRNA Localization to Membrane-Less Compartments

Professor Ryan P. Steele

Dr. Charles W. Machan

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UCSD Chemistry and Biochemistry

Chemistry and Biochemistry Club: College Royal Magic Show 2015 V2 – Video


Chemistry and Biochemistry Club: College Royal Magic Show 2015 V2
The Chemistry and Biochemistry Club Magic Show for College Royal 2015. Winner of 1st place CPES exhibit, and 1st place overall exhibit! Guelph is in danger! The dastardly Senor Sulphur has...

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Chemistry and Biochemistry Club: College Royal Magic Show 2015 V2 - Video

Biochemistry Graduate Programs Webinar, Faculty of Medicine – Video


Biochemistry Graduate Programs Webinar, Faculty of Medicine
First Annual Interactive Graduate School Webinar hosted by Graduate and Life Sciences Education. Learn more about the graduate programs in the department of Biochemistry at the Faculty of...

By: Graduate and Life Sciences Education GLSE

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Biochemistry Graduate Programs Webinar, Faculty of Medicine - Video

Roy J. Carver Department of Biochemistry, Biophysics …

BBMBConference RoomReservations News & Events Andreotti and Oldham Featured on Women Impacting ISU Calendar

Amy Andreotti, Roy J. Carver Charitable Trust professor of BBMBand director of the Roy J. Carver Initiative in Biomolecular Structure and Function, and Anne Oldham, academic adviser in Food Science and Human Nutrition and director of the Didactic Program in Dietetics, are two of 12 women who will befeatured in the 2016 Women Impacting ISU calendar.

TheDecember 15, 2015 issue ofE-News for ResearcherslistsGuru Rao among the faculty and staff of CALS recognizedby the Office of the Vice President for Research for volunteering their time and expertise to provide agraduate course in the conduct of responsible research (GR ST 565).

Donald Beitzhas been awarded the Marvin A. Pomerantz Award in recognition for hisaccomplishments in teaching and research. As part of thePomerantz Award, Dr. Beitz will receive$3,500 to support his scholarly work.

ISU faculty and staff recipients of the universitys most distinguished awards were honored on Monday, September 21 at a ceremony held in the Memorial Union Great Hall. The College of Liberal Arts & Sciences, as well asInside Iowa State for Faculty and Staff,have the complete listing of the award winners.

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Roy J. Carver Department of Biochemistry, Biophysics ...