There is a little-understood realm inside cells that cell biologist Tom Maresca likes to think of as the cells dark matter, something like the largely unknown stuff that is so abundant in space.

Maresca recently received a four-year, $1.3 million grant renewal from the National Institute of General Medical Sciences to use specialized tools to learn more about this less-studied inner universe of the cell.

Its a pretty good metaphor, he says. We know theres a lot of it out there, but its difficult to study and defining its functions inside cells is complicated.

He explains that a foundational aspect of how scientists think about biology is called the structure-function paradigm, referring to how many proteins adopt specific and highly reproducible folded shapes that allow them to carry out their functions. For these, shape and function are inextricably linked. These would be analogous to regular matter and they can be studied with conventional biochemical methods and techniques like X-ray crystallography and cryo-electron microscopy, Maresca says.

But there are also many proteins that are predicted to have no specific structure, and theyre not as easy to study as well-folded proteins. Theyre called intrinsically disordered proteins, which means they are unstructured, he adds.

Sometimes referred to as the Dark Proteome, these shapeless proteins appear to be very abundant, we just dont know much about them. Theres been tremendous progress in understanding structure-function; now we hope to make progress in this other important area of how unstructured proteins function.

For the new grant, Maresca and colleagues will collaborate with biophysicist Nathan Derr at Smith College to focus on unstructured proteins in an essential structure called the kinetochore. It ensures that chromosomes are evenly split between cells when they divide. Failure to achieve this, Maresca explains, leads to cells acquiring an incorrect number of chromosomes, which is known as aneuploidy a condition that causes miscarriage, genetic disorders, tumorigenesis and possibly cancer metastasis. The long-term goal is to identify basic cell processes that can be targeted by therapies to control aneuploidy.

We are going to be using some exciting methods to look at these things, Maresca says of their planned multi-pronged approach. Force sensors inserted into kinetochores in Marescas lab measure the amount of force being applied to them during cell division. Derruses techniques on single molecules, pulling on them to see how much they extend and whether pulling on them changes their ability to bind to other proteins, Maresca explains.

The kinetochore is a particularly interesting place to study these proteins, he adds, because there are many, very large, disordered proteins in it. An added layer of complexity is that disordered proteins are very likely subjected to forces that alter their properties in interesting ways, he notes.

Through evolution, whats been conserved are these really large proteins, and we dont know why. But we suspect their unstructured nature and the fact that they can adopt a range of possible conformations and lengths in response to forces is important. Somehow the very large, unstructured nature of these proteins is essential for their function, but we dont understand how yet.

Continued here:
Exploring the 'Dark Matter' of the Cell | Office of News & Media Relations - UMass News and Media Relations

University of Victoria chemist David Leitch may be working from his home office, but that doesnt hamper his instinct to pursue scientific discovery to help produce and donate a potential life-saver in the fight against the COVID-19 pandemic.

UVic on Tuesday delivered more than 200 litres of hand sanitizerenough for about 65,000 single dosesfor use by Island Health, whose front-line workers are in the thick of responding to the health crisis.

The ingredients are basic. Its pharmaceutical grade 190 to 200 proof ethanolmuch stronger than the spirits you get at the local liquor storehydrogen peroxide and a softening agent like glycerin to make sure your hands dont get dried out to the point of seriously cracking, says Leitch, who collaborated on the project with six other researchers.

The recipe is in line with World Health Organization guidelinesso its easy, safe, useful and potentially life-saving for someone in this current climate.

The UVic research community is pulling together to address the COVID-19 crisis including digital technologies, biomedical and biochemistry, genome research, proteomics, nursing, law, mathematics, social sciences, exercise science and 3D printing of supplies. To date, there are dozens of UVic research projects linked to the COVID-19 response.

Soap and water continue to be the best bet for hand hygiene. If that is not possible, using a hand sanitizer that is at least 60 per cent alcoholor 120 proofhelps avoid people getting sick or spreading germs, according to the Centers for Disease Control and Prevention.

Leitch, who led the UVic effort, was able to leverage his prior experience in the pharmaceutical industry to plan and execute a manufacturing campaign consistent with stringent Health Canada standards. He recalls discussing with his colleagues the opportunity with simple questions: Its not like we can just whip up a solution and hand it over to a health authority. What is the regulatory process around this, and can we pull this off in time to make a difference?

Researchers used supplies already on hand. From conception, licensing approval to manufacture, the process took less than two weeks, much faster than normal, says Leitch. He adds delivery would not have been possible without extremely rapid turnaround time for Health Canada approvals, a donation of kegs by a local microbrewery to mix the sanitizer and the incredibly hard work of UVic researchers.

UVic chemistry faculty and staffKatherine Elvira, Scott McIndoe, Jeremy Wulff, David Berry, and department chair, Neil Burfordalong with Heather Buckley, cross-appointed in chemistry and civil engineering, spent a recent morning mixing up the solutions.

In uncertain and different times, researchers are also doing everything they can to use their knowledge and experience as teachers to keep the UVic community engaged with science, despite the new remote working reality, says Elvira.

Science contributes vitally to some of the worlds toughest problems including the current COVID-19 response. We are allresearchers, students, UVicadapting as a community, she says. Throughout, we need to ensure we can support our students and their research and their experiences right now.

Burford adds he is inspired by the hard work of faculty, staff and students, and their efforts under these very challenging conditions to maintain consistency. We have to be in touch with our colleagues, our students, checking in often, however we can. I am especially impressed with the resolve of the students as they adapt to the COVID conditions. We will get through this together, says Burford.

In ongoing care for COVID-19 patients, Island Health welcomes donations of personal protective equipment and medical supplies through its website.

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UVic donates hand sanitizer - UVic The Ring

Chuck Staben has returned to his roots as a university professor, but its not where he wants to finish his career in higher education.

Staben, who served as president of the University of Idaho from 2014-19 before the State Board of Education opted not to renew his contract, took a semester off and recently started teaching again as a professor of biological sciences at UI.

He is enjoying spending time with students, but ultimately he believes he can do more good at the helm of a public university.

I am continuing to look for other opportunities as a president or perhaps other opportunities, Staben said. In fact, I was a ... finalist for the job recently at the University of North Dakota.

Craig Clohessy: What are you teaching this semester and how has the transition been from the presidents office back to the classroom?

Chuck Staben: Im teaching Biochemistry 2, which is Biology 454, and its cross-listed as a graduate course, 554 primarily a senior undergraduate course. Im also doing a little bit of teaching in education leadership.

The transition has been fine. I had a one-semester leave that allowed me to prepare as well as do a few other things during that time, and I enjoy being back in the classroom. I like the contact with students. I liked contact with students when I served as president as well.

CC: Do students and faculty treat you any differently now from when you were president?

CS: I have a different role, so in that respect students and faculty and others treat me somewhat differently. Generally, in a personal sense, no, I dont think they treat me differently. And I enjoy interacting with colleagues that I knew when I was president and, as I said, I enjoy interacting with students.

CC: In addition to teaching, are you doing any research work?

CS: Im not doing any sort of laboratory research. I participated on a report for the Association of Public and Land Grant Universities on what their member universities universities like the University of Idaho are doing with respect to the opioid crisis and what opportunities they might have to do additional work on the opioid crisis. So more public impact research than what I would call traditional biological research.

CC: You continue to search out professional advancements. What are you looking for? What type of opportunities would appeal to you?

CS: What Im looking for is primarily the opportunity to contribute in higher education, and I have a particular love for public higher education, for ensuring that students of all types and backgrounds, socioeconomic status, etc., can access public higher education. I think I have more to contribute to higher education and can do more as a president than I can as a professor, although I know that I can also contribute in the classroom.

CC: What did you learn during your time as president either success or failure that you think will help you in your next position?

CS: If Im fortunate enough to get another presidency, I think one of the things that became very clear to me as I served as (UI) president is just how important communication and consistency in communication are to being successful as a president. And I think that I would put even more emphasis ... on ensuring student success. That students can come to the university and access an education, but that they also will progress from freshman to sophomore to senior and on to a great career. And I think that we have to work very conscientiously on ensuring that sort of success.

CC: UI is facing serious budget challenges with a $22 million deficit, a freeze on tuition and declining state support. Do you feel fortunate not to have to be making those tough decisions that will be coming, or do you actually miss being part of finding those solutions?

CS: I think you phrased it well. I miss being part of finding those solutions. Ive never shied from tough decisions. I feel I am imaginative and capable and would be happy to be still in charge and facing these issues.

CC: Does the current president, Scott Green, seek out your advice?

CS: I met Scott when he was a member of the U of I Foundation Board early in my presidency, around 2015. And he and I had a number of conversations leading up to the time that he became president, and weve had a few conversations afterwards, but at this point we dont confer frequently. Im sure that he has assembled his leadership team and has his initiative and, you know, has the reins at this point and wants to keep moving the university forward.

CC: In your free time you love marbling paper. Explain what that is.

CS: Marbling is an old process for making unique patterns on things like paper or fabric. Basically what you do is ... take a big flat tray, and you put a viscus sort of gelatinous solution in it and you put paints on. ... You often draw through these with a stylus or with combs or other ways. But you put a unique pattern on the top of this bath, and then you take a piece of paper and you lift the pattern off the bath. Its a one-time-only printing process. It makes these beautiful patterns of colors.

Where you might have encountered it is if you have old books. The front and end papers were typically marbled papers. Thats what its used for in bookbinding. ... I think it was first devised in the 1300s in Turkey actually.

CC: How did you come to be interested in this process?

CS: I love old books. Ive always loved to be in a library and looking at the old books and journals that one has there. I spent a lot of time in libraries, especially as a young scientist, and I always wondered how these unique and beautiful patterns were made.

I read some craft books about how you did it. It seemed really hard and I never did it, and then one Christmas I decided Im going to investigate this more closely it was about 10 years ago.

I looked around on the internet, and I found some beautiful marbling examples and this guy who sold marbling supplies and the kits. Funny enough, you couldnt order them on the internet. ... There was a phone number, so I called him up. Turns out its a guy who is president of the American Marbling Association, and he wants to talk to everyone he sells a kit to, and thats why you cant find them over the internet.

The kids and I did it, and it turns out its terrifically easy to make something that is unique and beautiful. Im kind of a klutzy nonartistic guy, and so I thought, Wow, I mean its amazing that this process works so incredibly easily and well. To really control it and be a master of the process is a little different, but to make something that is cooler than you ever thought you could make is remarkably easy.

CC: You did this as a team-building exercise with your cabinet when you were president.

CS: I think it was the most popular cabinet meeting, hands down. I think you could call almost any member of the cabinet and ask them that question, and thats probably the one cabinet meeting they would remember.

CC: Anything else youd like to add?

CS: I have a deep love of higher education. I love students I like to see them succeed. Im enjoying teaching my biochemistry class. Biochemistry has changed quite a bit since the last time I taught it in 1982. Ive taught related courses, but it has been intellectually refreshing to think about what is it that todays student needs to know about biochemistry as opposed to how has biochemistry traditionally been taught.

Clohessy is managing editor of the Lewiston Tribune. He may be contacted at cclohessy@lmtribune.com or (208) 848-2251.

Title/occupation: Professor of biological sciences; former president at the University of Idaho.

Family: Married to Mary Beth Staben, MD, a hospitalist practicing at St. Lukes, Boise; sons Mac Staben, an anesthesiology resident at University of Pennsylvania, and Cal Staben, emergency medicine resident, University of Louisville, who is married to Sarah Staben; daughter Rae is a medical student at Vanderbilt University.

Education: Grew up in Waukegan, Ill., and attended grade schools and public high school there; Bachelor of Science in biochemistry, University of Illinois in 1978; Ph.D. in biochemistry, University of California, Berkeley, 1984; postdoctoral research at Chiron Corp., 1985-86, on HIV virus sequence variation and at Stanford University, 1987-89, on fungal mating type genes.

Work history: Assistant professor, associate professor, professor of biology at University of Kentucky, 1989-2008; also served as chairman of the School of Biological Sciences, 2000-04, associate vice president for research, 2004-08, and as acting vice president for research, 2006-07; provost, University of South Dakota, 2008-14; president, University of Idaho, 2014-19; professor of biological sciences, UI, 2019-present.

Hobbies/interest: Family, skiing, biking, hiking, fitness, travel, bridge.

Hidden talents: I learned to marble paper and taught a couple of sessions on marbling for an arts class at the University of South Dakota and have used marbling as a group activity for the University of Idaho cabinet. I use the paper that I marble for bookbinding, gift wrapping, and for handmade notecards for our family and as special thank-you notes.

Originally posted here:
Back in the classroom, with eyes toward the future - Lewiston Morning Tribune

Metoprolol (Met) is widely applied in the treatment ofmyocardial infarctionand coronary heart disease in clinic. However, the metabolic network in vivo affected by Met manipulation is still unclear and its therapeutic molecular mechanisms were remained to be furthered elucidated except 1 adrenergic receptor.Myocardial infarction(MI) was induced by permanent CAL for 24 h in ICR mice.Myocardialinfarct size, biochemical indicators such as creatine kinase (CK), lactate dehydrogenase (LDH), C-reactive Protein (CRP), tumor necrosis factor- (TNF-) and cardiac troponin I(cTn-I), cardiac function andmyocardialpathological changes were detected to ensure the improvement of Met on MI. Subsequently, the significantly changed endogenous metabolites and the network in both serum and urine were screened and constructed through metabolomics by using HPLC-Q-TOF/MS. Finally, the potential regulatory enzymes that could be the possible new therapeutic targets of Met were selected and validated by western blotting and immunohistochemistry based on the screened differential metabolites and the enrichment analysis.

Met effectively reduced the infarct size ofmyocardial infarctionmice, improved the biochemical indicators, and ameliorated the cardiac function and pathological conditions. Our study further found that Met could regulate the pathways of glycine, serine and threonine metabolism, cysteine and methionine metabolism, purine and pyrimidine metabolism under the pathological conditions of MI. Moreover, several regulatory enzymes involved GATM, CSE and NT5E were demonstrated to be regulated by Met. This study constructed the regulatory metabolic network map of Met, elucidated the endogenous metabolic pathway regulated by Met, and validated the new potential therapeutic targets of Met in MI, which might provide a further reference for the clinical application of Met.

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Metabolomic Profiling of Metoprolol-Induced Cardioprotection in a Murine Model of Acute Myocardial Ischemia - DocWire News

Kate Ptashnik is a second-year distance free swimmer on the Case Western Reserve University swim team. With the season still young, she looks to improve on a stellar first year that featured an 18:21.88 in the 1,650 free. Swimming provides Ptashnik with countless memories, including getting punched in the face. Ptashnik is currently majoring in nutritional biochemistry and likes to spend time with her friends.

What is your favorite part of being on the swim team? Why?

My favorite part of being on the swim team is being surrounded by people who have similar work ethics, but different passions than I do. I enjoy hearing and seeing my teammates/friends being excited about things they are doing while we get to bond through something we all love.

Do you have any meets that you remember being particularly special? Why?

The Wooster Invitational meet last year, I was accidentally punched in the face by another athlete right before my race (the mile), but then proceeded to swim my best time of the season.

Aside from swimming, what other activities are you involved in on campus? Can you explain what you do in them?

I am the Greek Games chair and the executive assistant in Kappa Alpha Theta. I am also a tour guide at the CWRU Office of Admissions. Additionally, I am a part of research within the nutrition department, where we are trying to teach children with family members who have diabetes how to make healthy and nutritious foods.

Why are you majoring in nutritional biochemistry? What about it interests you?

I am majoring in nutritional biochemistry because I liked both biology and chemistry, and then got early exposure to a nutrition course my first semester here and absolutely loved it. I am interested in nutritional biochemistry because I think it is really applicable to a student athlete as well as just a person.

What are your favorite free time activities? Why?

Spending time with my friends, both on and not on the swim team, because we can always have fun no matter what else is happening in our stressful CWRU life.

What is your favorite quote or what inspires you?

Be the hammer Doug Milliken.

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Second-year swimmer excited for new season - The Observer

David DeMarini 72, M.S. 74, Ph.D. 80, accepts the 2019 Distinguished Alumni Award.

Each yearIllinois State Universitys Alumni Association recognizes alumni for their outstanding contributions to their fields, their impact on society, and their passion for Illinois State through the Alumni Awards program. This year seven individuals will be honored at the Annual Awards Dinner:

Distinguished Alumni AwardJay D. Bergman 70CEO and chairman, Petco Petroleum Corp.Major/College: Business administration, College of Business

Alumni Achievement AwardDaniel Wagner 89, M.S. 94Senior vice president of government relations, Inland Real Estate GroupMajor/College: Political science, College of Arts and Science

Senator John W. Maitland Jr. Commitment to Education AwardDamian K. GregoryFounder and executive director, Gridiron Group

E. Burton Mercier Alumni Service AwardBeverly Grimes 60Retired nurseMajor/College: Nursing, Mennonite College of Nursing

Outstanding Young Alumni AwardPaul DeJong 15Shortstop, St. Louis CardinalsMajor/College: Biochemistry, College of Arts and Science

Jenna Goldsmith 08, M.S. 10Instructor of Writing, Oregon State University-CascadesMajor/College: English, College of Arts and Science

Griffin Hammond 07, M.S. 09Documentary Filmmaker, Recount MediaMajor/College: Television/Communication, College of Arts and Science

Nominations are also being sought for the 2021 Alumni Awards. The deadline to submit is May 31, 2020.

A quick summary how to recognize outstanding alumni.

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Seven to receive 2020 Alumni Awards - News - Illinois State University News

UHS approves affiliation of 29 institutes

LAHORE: The syndicate of University of Health Sciences (UHS) has approved the affiliation of 29 institutes for start of 56 new postgraduate and undergraduate programmes.

The 58th meeting of UHS Syndicate was held here on Monday with Vice Chancellor Prof Javed Akram in the chair. The other members who were present included Prof Talat Naseer Pasha, Prof Khawaja Sadiq Hussain, Prof Humaira Akram, Prof Nadia Naseem, Prof Nasir Shah, Dr Asad Zaheer and representatives of Punjab Specialized Healthcare and Medical Education (SHC&ME) and Finance departments.

The syndicate approved affiliation, extension in affiliation and enhancement of seats in various institutions after considering inspection reports of the affiliation committee. It approved Doctor of Medicine (MD) in the disciplines of psychiatry, radiology, gastroenterology, nephrology, cardiology, medicine, and paediatrics to be offered in different public sector institutions of the province.

Similarly, recommendations of the affiliation committee were approved for start of Master of Surgery (MS) in cardiac surgery, ophthalmology, neurosurgery, urology, and paediatric surgery.

The body also approved BSc programmes in the disciplines of nursing, Doctor of Physical Therapy (DPT), medical laboratory technology, dental technology, dental hygiene, nutrition, cardiac perfusion, medical imaging technology, orthotics and prosthetics, optometry and Orthoptics, and audiology to be started in different public and private sector institutions of Punjab.

Moreover, approval was also granted for start of MPhil Biochemistry, MSc Nursing, Diploma in Anaesthesia, and Diploma in Child Health.

The syndicate also approved the recommendations of MD/MS/MDS Reforms Committee to conduct intermediate examination on completion of 18 months of training rather than 24 months.

The policy of negative marking was also abolished for both intermediate and abridged examination in all disciplines in Central Induction Policy (CIP) scheme of MD/MS/MDS programmes.

It was also decided that the candidates who would pass written component of an examination in MD/MS/MDS, but fail in clinical and oral component, would be allowed a maximum of three attempts to clear clinical and oral component of that examination, failing which they would have to take the entire examination, including written component, afresh.

The syndicate also endorsed the VCs proposal to invite online applications for grant of affiliation in future besides creation of a dedicated directorate of affiliation in the University to deal with matters related to affiliation.

The members also approved award of PhD degree to Dr Rabiea Munir in the subject of pharmacology.

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UHS approves affiliation of 29 institutes - The News International

The Department of Biochemistry was founded in 1959 when Arthur Kornberg was recruited as a fundamental part of the move of the Stanford Medical School from San Francisco to the main Stanford campus. Innovations established at that time included the mixing of students and postdoctoral fellows in common laboratories so that the different research groups would be familiar with each other's research work and cross-fertilization would be inevitable. Specialized reagents were shared and major instruments were made available to everyone. Benches were not owned by a particular faculty member, but fair and equitable sharing of space was enjoyed in an unprecedented way of carrying out research in a department setting. We have embraced and maintained these approaches over time, and everyone in the department continues to prosper under this unusual innovative mode of operation, rarely found anywhere else in the world.

In the first decade of the department, there was a nearly complete focus on DNA and RNA biochemistry, and methodologies were also focused on hard-core biochemical approaches of enzyme purification and characterization. The current department is now enormously diverse with nearly everyone using interdisciplinary approaches of biochemistry, genetics, biophysics, structural biology, high-resolution light microscopy, and other innovative methodologies, often developed by Biochemistry students and postdoctoral fellows during the course of their work. Thus, genetic engineering, high-throughput RNA expression analysis, and single molecule analysis all came out of the Biochemistry Department and are fueling current advances in biosciences, biotechnology and medicine.

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Stanford Biochemistry

Infectious diseases are caused by pathogenic microorganisms capable of entering, colonising and growing within a host organism, thus producing an infection. Bacterial infections have been on the rise worldwide in recent years, but many mechanisms underlying bacterial pathogenesis are still poorly understood. This is highly relevant given the fact that the development of new antimicrobial therapies is largely based on current knowledge of the mechanisms behind these infections. The proteins coded by the bacterial genes are responsible for the thousands of biochemical processes essential for the efficient propagation of the pathogen. Many studies demonstrate, however, that in order to identify these genes, in vivo information is needed on what happens with the bacteria in a real case of an infected host. The in vitro studies, i.e., those recreated in laboratories with cell and bacterial cultures, later do not always correlate with data from in vivo studies. This is due to the fact that pathogenic bacterial genes essential for producing the infections depend on the environment of the colonised organism.A team of researchers from the Department of Biochemistry and Molecular Biology of the Universitat Autnoma de Barcelona and from the Centre of Genomic Regulation (CRG) has created the BacFITBase database. Based on the results of the in vivo experiments, researchers systematically characterised the bacterial genes relevant for host cell invasion and infection. All the experiments performed were based on a technique named transposon mutagenesis, where the DNA fragments called transposons are transferred to the organism's pathogenic genes, thereby inactivating them. By doing so, their role in the infection can be observed directly and researchers can determine which are essential for a specific host organism to become infected. Therefore, this database will make it easier to identify target proteins that can help in fighting infectious diseases and accelerate the development of new antimicrobial agents.The database contains over 90,000 entries with information on specific pathogenic bacterial genes and their contribution to in vivo infectious conditions in five different host species. It includes information on a total of 15 bacteria (two variants ofSalmonella enterica, Haemophilus influenzae, Streptococcus pyogenes, Porphyromonas gingivalis, Mycobacterium avium,three variants ofEscherichia coli, Vibrio cholerae, Campylobacter jejuni, Klebsiella pneumoniae, Acinetobacter baumannii, Serratia marcescensandVibrio parahaemolyticus) and 5 model vertebrates (cow, pig, hen, mouse and rabbit), with information across 10 different tissues.BacFITBase, published in the journal Nucleic Acids Research, was developed by researchers from the UAB Department of Biochemistry and Molecular Biology Javier Macho and Marc Torrent, alongside researchers from the Centre for Genomic Regulation (CRG) Benjamin Lang and Gian Gaetano Tartaglia.

Reference:Rendn,et al. (2019) BacFITBase: a database to assess the relevance of bacterial genes during host infection.Nucleic Acids ResearchDOI: https://doi.org/10.1093/nar/gkz931

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

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New Database Could Help Identify Therapeutic Targets for the Creation of Antibiotics - Technology Networks

Wesleyan Connection (blog)

Students Inducted into Honor Society, Win Awards At American ... Wesleyan Connection (blog) Julianne Riggs '17 in Chicago last month, where she attended the American Society for Biochemistry and Molecular Biology meeting. Five Wesleyan seniors ... Prebiotic Qualities of Dried Plums Identified as a Colon Cancer ...Oncology Nurse Advisor all 2 news articles »

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Students Inducted into Honor Society, Win Awards At American ... - Wesleyan Connection (blog)

MEET YOUR NEIGHBOR: Carlos Romagosa, 17

If there is one common theme among high school valedictorians, its the fact that, when they look back at their high school careers, they often find something they think they could improve upon.

Despite his 3.98 (5.33 weighted) GPA and the achievement of finishing high school ranked No. 1 in his class, Carlos Romagosa is no different.

I was doing it for the wrong reasons, Romagosa said of his quest to become valedictorian of Royal Palm Beach High. I should have been doing it because it was something that could make me a better student and better person. Instead, when I look back, I was just doing it because it was an academic achievement. I wanted to be No. 1 and that was it.

Regardless of the reasoning, Romagosas is an amazing achievement. Especially when you consider the only B that figured into his GPA was one he received before he began high school.

I had always wanted to take AP calculus so I thought Id take on online geometry class before my freshman year began, he said. That was my B. That taught me never to procrastinate.

Of course, he later took the geometry class in person and got an A.

Avoiding procrastination may have been the biggest life lesson that Romagosa took from high school. Applying himself to get work done turned out to be the key to his rising from No. 2 after his sophomore year to No. 1 when he graduated.

During his junior year, Romagosa took only Advanced Placement and Advanced International Certificate of Education courses as he pursued his quest to become valedictorian.

I just had to start taking my time on things. Take care with everything I do and do everything well. Challenge myself, he said. I really wouldnt change a thing. Everything that happened to me has molded me to be in this position. But I would tell students to try new things. Try things youre uncomfortable with as well.

World history taught him that lesson, Romagosa said. He took the class not thinking he would enjoy it, but it ended up being one of his favorite subjects in high school. So much so that, after his trip to the Dominican Republic later this summer, he has places like Africa and Europe on his radar as future destinations.

Romagosa will head to Florida International University, where he will pursue a degree in biochemistry. The hope is to soak up the culture Miami has to offer and finish college with the goal of working in a lab.

I want to study the cellular membrane, he said. See how we might be able to apply photosynthesis to other applications.

Q&A

What are your hobbies?

Reading, writing, I love the game of basketball. Im not good at it but I try to play it. I love watching it. My favorite team is the Golden State Warriors, but Im not a bandwagon fan, Ive been watching them since 2012.

What would you do if you were invisible for a day?

I would love to go into our government and learn all their secrets. Im just so curious. I want to know what theyre hiding from us. What are they keeping from us?

If you could have dinner with anyone in history, who would it be?

This is kind of hard for me, so Im going to say its a tie between FDR and JFK. They were both so progressive, so ahead of their times. Especially FDR and how he could inspire hope in such a weak time in our history. And JFK, every time you see him in a debate, he just looked so lively and full of life.

What is the best advice you ever received?

Be yourself. Its short and sweet. I heard it a lot, but I think the first time it was from a manager at Chick-fil-A. He told me the most important advice is to be yourself. Dont get caught up with people.

What event in history would you have liked to have witnessed?

The rise of the Romans. They were such a dominant group of individuals. I like that when they conquered enemies, they learned their enemies strengths to make them stronger.

What is your favorite childhood memory?

Going to Disney World. There is nothing that beats that for the first time. I was 4 or 5, but I remember Mickey Mouse and all that. It was so cheerful and bright. Universal is exciting, but Disney has that special thing to it.

Who is your hero, someone who inspires you?

Hemingway. He struggled with all these mental breakdowns, but fought through it all and succeeded. For a period of time he pushed through it and excelled. He would write for hours and hours on end. Then he would go out and drink.

What is something most people dont know about you?

I think everyone views me as very serious, but I have a really good sense of humor. All my friends know. I mean, nerds can go crazy too!

What three things would you bring with you if you were stuck on a desert island?

A desalinization machine, a beach umbrella, and a book just to relax. Any book would work, but if I could list one, I would say The Old Man and the Sea, since Im stuck on an island and all.

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Royal Palm valedictorian plans to study biochemistry - Palm Beach Post

In chemistry residue is whatever remains or acts as a contaminant after a given class of events.

Residue may be the material remaining after a process of preparation, separation, or purification, such as distillation, evaporation, or filtration. It may also denote the undesired by-products of a chemical reaction.

Toxic chemical residues, wastes or contamination from other processes, are a concern in food safety. For example, the U.S. Food and Drug Administration (FDA) and the Canadian Food Inspection Agency (CFIA) have guidelines for detecting chemical residues that are possibly dangerous to consume.[1][2]

Residue may refer to an atom or a group of atoms that forms part of a molecule, such as a methyl group.

In biochemistry and molecular biology, a residue refers to a specific monomer within the polymeric chain of a polysaccharide, protein or nucleic acid. One might say, "This protein consists of 118 amino acid residues" or "The histidine residue is considered to be basic because it contains an imidazole ring." Note that a residue is different from a moiety, which, in the above example would be constituted by the imidazole ring or the imidazole moiety.

The concept that suggested this term is presumably the nature of the condensation reaction by which such classes of monomeric building blocks, such as amino acids or monosaccharides, are strung together to form a polymeric chain, such as a polysaccharide or a peptide; some atoms, typically in the form of a water molecule, are discarded from each building block, leaving only a "residue" of the building block, that ends up in the finished product. A residue might be one amino acid in a polypeptide or one monosaccharide in a starch molecule.

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Residue (chemistry) - Wikipedia

Cyrus Moulton Telegram & Gazette Staff @MoultonCyrus

WORCESTER - Researchers have moved from the back row to the orchestra seats for the ballet of the cell, now that a new cryo-electron microscope is up and running at University of Massachusetts Medical School and attracting use and attention from all over the region.

Prior to this CryoEMtechnology, it was like we were at the back of the arena with very poor vision, said Brian A. Kelch, assistant professor of biochemistry and molecular pharmacology at UMass Medical School. These microscopes now allow us to get 20/20 vision and move to the orchestra seats so we can now see all the dancers and see how they interact with each other. Then also when the dance gets out of synchrony, which could lead to disease, we can see how to bring those dancers back to synchrony which can fix that disease.

UMass Medical School held a ribbon cutting in October for a $12 million facility housing two powerful, high-resolution cryo-electron microscopes. The two microscopes - the roughly $5 million Titan Krios and the roughly $4 million Talos Arctica - will be the most advanced electron microscopes in New England and two of fewer than 50 such cryo-EM microscopes worldwide, according to Chen Xu, associate professor of biochemistry and molecular pharmacology and the core director of the Cryo-EM Facility at UMass Medical School.

The Titan Krios was acquired in collaboration with Harvard Medical School, supported by a grant of $5 million from the Massachusetts Life Sciences Center. The Talos-Arctica system was acquired with funding from the Howard Hughes Medical Institute. UMass Medical School has invested $3 million in renovations on its main campus to house the facility.

Now after lots of testing, calibration and training for staff, the Talos Arctica microscope is operational, and the Titan Krios is scheduled to come online this month.

The technology, known as cryo-EM, uses electron energy to produce images of samples that are cryogenically frozen with liquid nitrogen.

The technology not only allows scientists to see an object closer and more clearly than before but also allows scientists to see a sample frozen in many different positions.

Previous technology called X-ray crystallography required that samples be frozen in crystals that only allowed one position for samples. That process was also more time-consuming - it could take years to develop a sample, Mr. Xu said - and there was no guarantee that a sample that took so long to develop would be usable.

The new technology, however, can cut the time to develop a sample down to a few months, Mr. Xu said. It also requires less of a sample than the X-ray crystallography, according to Mr. Kelch.

Seeing the sample in multiple positions also enables two important developments.

It enables scientists to better reconstruct the sample in three dimensions and understand its function.

This is crucial for Mr. Kelch, whose lab is working on two projects.

In the first, he is studying the part of the cell that copies DNA and how that relates to cancer.

But without the cryo-EM, Mr. Kelch would not be able to look at the guardian proteins that are the target of the research. Although the study is in its infancy, Mr. Kelch hopes that understanding the structure of these proteins can lead to the development of chemotherapeutic drugs that work by interacting with the proteins.

In the second project, Mr. Kelchs lab is investigating how viruses become infectious particles. Again, being able to see the shape of proteins containing the virus is crucial to developing antiviral drugs.

Seeing the sample in multiple positions also enables scientists to discover how the sample can move.

Andrei A. Korostelev, associate professor of RNA therapeutics at UMass Medical School, described the process as like taking a picture of thousands of running horses and then arranging each horse in a sequence to show movement.

Here you freeze 1,000 horses, each of them moving differently, Mr. Korostelev said, continuing the analogy (the scientists actually freeze molecules). And then from that we try to reconstruct a smooth pathway of the movement.

Understanding movement is key to Mr. Korostelevs work studying the ribosome, the key machine in the cell that reads genetic code and converts it to proteins.

He has used cryo-EM to see how the parts of the ribosome move with respect to each other so the ribosome can perform its complex function.

Whats brand-new is that you can see the movements in such detail, said Mr. Korostelev, whose work has created movies of the ribosome in the process of making proteins.

But aside from their own research applications, scientists see the microscopes as a way to spark future collaborations among the different institutions and companies using the machines.

So far in addition to UMass Medical School, Harvard Medical School, Massachusetts General Hospital, biotechnology company Sanofi Genzyme and pharmaceutical company Vertex are some of the clients that are lining up to use the machine. The rates range from roughly $120 per hour for internal users to $300 an hour for industry partners, Mr. Xu said.

In addition, Mr. Korostelev said the microscopes are an attraction for students who are looking for the latest technology.

Mr. Kelch said the microscopes being at UMass is a boon for the entire state.

This whole facility can be an economic engine not just for academic science in Massachusetts, but also for the biotech industry as well, Mr. Kelch said. We get from them some money to help run the facility as well as make partnerships with those companies which helps our students and trainees to find new jobs once they leave here. The biotech industry gets access to the worlds state-of the art microscopes without having the burden of running that facility on their own. And all of that means a lot of growth, economic growth for the commonwealth.

Robert K. Coughlin, president and CEO of the Massachusetts Biotechnology Council, agreed.

It gives us a huge competitive advantage because this is state-of-the-art technology that is open source for many scientists to utilize, said Mr. Coughlin, whose organization represents more than 1,000 other organizations in the life-sciences cluster. If were going to continue in this region to be the best place for innovation, we need to stay ahead of the curve and constantly have access to cutting-edge equipment and technology.

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Cryo-electron microscopes view 'ballet of the cell' at UMass Med School - Worcester Telegram

On July 1, 2017, Memorial University will mark a special milestone.

On that date, the Department of Biochemistry, Faculty of Science, which first opened on July 1, 1967, will turn 50 years old. To commemorate, the department is hosting a reunion weekend Sept. 8-10 and hopes to reconnect with many former students, staff and faculty.

Dr. Mark Berry is the current head of the department. He says details about the reunion are still being finalized, but plans include a dinner and reception, and an open house.

We will be opening our labs to visitors on Sept. 9, and students will display posters and share their research, he said.

This will provide our alumni the chance to see new research space that has been added to the department since their time, especially the Biotechnology building facilities which came online in the early 90s, and learn about the research of some of our newer department members.

Photo: Submitted

The reunion dinner and reception will take place on Friday, Sept. 8, at the Johnson Geo Centre, with tickets on sale at $50 per person. The evening has been designed to provide ample opportunity to reconnect and reminisce with old classmates, staff and faculty. The location also provides easy access to the downtown district for those that wish to continue into the later hours.

Things are changing and in five years the department is likely going to look very different. Dr. Mark Berry

Dr. Berry estimates more than 2,200 students have passed through the departments doors over the last 50 years and hes looking forward to the opportunity to meet as many of them as possible.

The great thing about a reunion is it will allow us to get a handle on who our alumni are, he said. We know they feel a great affinity for the Department of Biochemistry, but in the past we havent been great at keeping in touch with them. Also, if anyone has old memorabilia or photos from their time in the department that they are willing to share, wed love to hear from them.

Photo: Submitted

With some of the departments longtime faculty members set to retire in the next few years, Dr. Berry notes this may be one of the last chances for alumni to come back and see some of those familiar faces.

Things are changing and in five years the department is likely going to look very different, he said. Alumni who were here in the 80s and 90s will still recognize most of the people around here, but I suspect not for much longer.

The first course in biochemistry at Memorial was given in the Department of Biology by Dr. Woodrow (Woody) Feltham, who was chief clinical chemist at the General Hospital at the time.

The idea that a Department of Biochemistry shouldbe created was at first rejected by one of the committees looking at thepossibility of establishing a new medical school at Memorial.

They suggested thatthree basic science departments biochemistry, physiology and microbiology should be established before the admission of the first class of medical students. Thesedepartments were to be hosted by the Faculty of Arts and Science untilsuch time as the medical school should be established; they would then become partof the medical school.

This work, in my opinion,was among the most consequential ever carried out at Memorial. Dr. Sean Brosnan

Of these three, only the Department of Biochemistry was established, with Dr.Feltham as its head. A professorof physiology, Ken Roberts, was appointed and also became associate deanof Basic Medical Sciences.

Ken was philosophically opposed to the idea of departments; he felt that theycaused artificial divisions in what should be a seamless body ofknowledge and scholarly enquiry, said Dr. Sean Brosnan, the longest serving member of the biochemistry departments faculty.

He established the Division of Basic Medical Sciences, which has sincebecome the Division of Biomedical Sciences, within the medical school.Woody Feltham decided that biochemistry should remain within the Facultyof Arts and Science, soon to become the Faculty of Science.

When Dr. Brosnan arrived at Memorial in January of 1972, the department had four faculty members: Dr. Feltham, Peter OBrien,Clive Little and John Wheldrake. They were joined by Dr. Brosnan and another assistantprofessor, Peter Penner.

However, Profs. Little and Wheldrake left soon after. Kevin Keough joined inSeptember of 1972; Choi Hew and Margaret Brosnan joined in the fallof 1974.

At the time, research areas included biological oxidation, metabolism, membranes and molecular biology.

Choi Hew teamed up with Garth Fletcher of the Ocean Sciences Centre, then the Marine Sciences Research Laboratory, to pioneer ways ofintroducing foreign genes into salmon, said Dr. Brosnan.This work, which, in my opinion,was among the most consequential ever carried out at Memorial, directlyled to the first genetically modified animal approved for humanconsumption by the FDA.

Drs. Sean and Margaret Brosnan are conservatively estimated to have taught 90-95 per cent of the departments 2,200 alumni in some capacity, and are still going strong.

Photo: Submitted

Its impossible for me to calculate how many undergraduates I may havetaught, said Dr. Sean Brosnan.Certainly, enrolment in the third-year metabolism course hasincreased from about 15 per year to more than 200. I calculate that morethan 100 students have received research training in mylaboratory, as summer/honours students, graduate students orpost-doctoral fellows.

My most pleasant and memorable events have allhad to do with the success of the students, he added.

The department has seen four Rhodes Scholars, Tim Whalen, Ann Colbourne, Paul Boland and Luke Pike; two future Canada Research Chairs, Tim Whalen and Jason Treberg; and twofuture heads of nutrition departments, Jim House and Mark Jois. Manyothers have gone on to careers in academia or the professions,particularly in medicine.

Online registration for the reunion recently opened and alumni, staff, faculty and friends of the department can register here.

The department has also created a dedicated reunion email address, biochem50@mun.ca, for alumni who wish to send in memorabilia, such as photos or copies of old mixer posters and exams, or stories about the department. Sponsorship opportunities are also available and full details can be requested through the biochem50 email address.

To learn more about the Department of Biochemistry, visit their website, or Facebook page.

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PortCityDaily.com is your source for free news and information in the Wilmington area.

WILMINGTON The University of North Carolina Wilmington received a multi-million dollar gift today.

Quality Chemical Laboratories pledged a $5 million gift, to be donated over the next five years. The donation is the largest corporate philanthropic gift in the Universitys history. Quality Chemical Laboratories founder, Dr. Yousry Sayed is a longtime UNCW faculty member in the chemistry department. His wife, Linda Sayed, is a graduate of the University.

UNCW Chancellor Jose Sartarelli said the announcement was some time in the making.

We have been working on this for about a year, Sartarelli said. I have become involved more recently. Aswani Volety, our Dean of the College of Arts and Sciences, was very involved. This was a confluence of good things and good timing.

The Sayeds donation to UNCW will support new programs aimed at advancing study in pharmaceutical and chemistry. According to the administration hopes the gift will help the University further develop recent advances in chemistry, biochemistry, biology and marine biology. Over the coming years, the gift will provide funding for establishing distinguished professorships and research, and may also help support scholarships, faculty research and travel grants.

Sartarelli said the programs will help the school meet the current needs of the state and the growing health care market.

The programs will be under the department of chemistry and biochemistry. Were starting with a Masters program, and we hope to develop a Ph.D. program as well. The goal, of course, is to help connect our students with the growing field of health sciences, with clinical research organizations and testing.

Quality Chemical Laboratories employs many UNCW graduates from the chemisty and biochemistry programs, according to Sartarelli. He hopes the Sayeds gift will help prepare future graduates for similar jobs across the state.

In a press release, Dr. Sayed said he and his wife were happy to be able to give back to their University.

It is an honor to be able to make this small contribution to this great university we love and appreciate, and to invest in the future of this important area of study and the students we serve, said Sayed. My wife and I have been a part of the Seahawk family and have grown together with UNCW for decades, and to know we are contributing to the universitys mission and outcomes in some small way is very rewarding for us.

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UNCW receives largest ever donation, gift will support pharmaceutical and chemistry programs - Port City Daily

The clinical biochemistry department at one of the countrys largest hospitals says it is unable to provide clinical advice or interpretation of test results due to a lack of consultant cover.

In a clinical advisory to GPs, seen by the Irish Examiner, consultant haematologist at Cork University Hospital (CUH), Mary Cahill, said that, as a consequence, they had sought to voluntarily suspend accreditation for the department.

Accreditation provides the assurance that organisations are adhering to internationally recognised standards.

Prof Cahill said they are working with our medical manpower service to rectify this situation and hope to be able to return to providing a clinical advisory service again in the near future.

In the meantime, she said, patient specimens will still be processed as before to a high-quality standard and by the same highly trained medical scientists.

GPs were advised of the difficulties at the laboratory by the HSE earlier this week. The inability to provide a clinical advisory service took effect on March 31.

John Sheehan, a Cork City GP, said that in the short-term the lack of a clinical advisory service will not make a huge difference because GPs rarely need to utilise it.

However, loss of accreditation is potentially a more serious problem, he said.

Its a worrying sign, said Dr Sheehan. It doesnt sound encouraging. For instance, you may not have anyone looking at new assays [laboratory tests to find and measure a specific substance]; or it could mean the lab will function without certain key personnel that would be required for accreditation. If they no longer fulfil the accreditation criteria, it means they cant meet certain standards.

Despite the staffing problems, Prof Cahill said test results will be available in the same timeframe as previously and available through normal channels, such as electronic means.

She said if the interpretation of a laboratory result falls outside the users experience, then staff should seek any additional necessary information or interpretation prior to applying a result to patient care.

If a laboratory result appears to be discordant with the clinical situation, initial discussion with senior clinical laboratory personnel in biochemistry and/or with the patients consultant is warranted, she said.

The letter to GPs is also signed by Brendan OReilly, laboratory manager at CUH.

Last year, the head of the department of clinical biochemistry, consultant clinical biochemist John OMullane, retired. A replacement has yet to be appointed.

In 2014, the Irish Examiner reported that CUH had written to GPs saying the hospital could not stand over test results for some patients because of a major IT glitch.

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Cork University Hospital biochem lab hampered by staff shortage - Irish Examiner

Contact Us: (855) 325-0894 | Email our Staff

UNE Academic Calendars| UNE Academic Catalog|Technical Requirements

This is a one-semester online Biochemistry course designed for individuals who need first semester Biochemistry as a prerequisite to apply for admission to a program in the health professions.

Graduate programs that may require a CHEM 1005 Medical Biochemistry class include:

Medical Biochemistry is a four credit hour course designed to lay the foundation for other basic and clinical medical sciences. The goal of this course is to learn the core concepts of biochemistry that apply to human health and disease and to cite specific examples of their application. You will be able to analyze and evaluate the most common biochemistry cited in medical literature. Furthermore, these basics will facilitate further learning in biochemistry and the health sciences.Click here for the online Biochemistry course syllabus.More detailed readings are available on Blackboard.

The typical student will complete this online Biochemistry course in approximately 16 weeks. Many students are nontraditional students who have elected an online course for flexibility. Since the course is self-paced, you may complete the course in fewerthan 16 weeks.

One semester of college level biology, and one year of chemistry that includes one semester of organic chemistry.All prerequisite courses must have been completed successfully within the past seven years.

To learn more about the technical requirements for this and other Post-Baccalaureate courses, click here.

Credits: 4 Tuition: $1320 Registration: $25 Total: $1345

The cost of the materials is not included in this total.

All exams are taken online. Major exams are required to be proctored. For instructions on how to take your exams online, visit Online Learning's ProctorU site.

You may enroll at any time via our self-service registration portal.Please keep in mind that courses start on the 1st and 3rd Wednesdays of the month. Payment is due in full atthe time of registration. Your official start date is the date that the course opens, and you will have 16 weeks from that date to complete your course.

You must be registered for yourclass by 12:00 noon EST on the Mondaybefore the class starts.See the UNEAcademic Calendarfor more details.

If you have any questions or need help with registering for your class, please callan Enrollment Counselorat1-855-325-0894, email prehealth@une.edu, or view the online FlexReg course registration tutorial.

If you intend to useVA Benefits or Military Tuition Assistance, please do not usethe self-registration portal. Please call 1-855-325-0894 to be directed to the appropriate office for assistance.

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Online Medical Biochemistry: Online Biochemistry Course

Thursday, April 6, 2017

By Nicholas Snow

The Rose Mercadante Chemistry Seminar series is pleased to present the final PhD seminar of Mariana Phillips, entitled "B7H6 Derived Peptides Trigger TNF- Dependent Immunostimulatory Activity of Lymphocytic NK92-MI Cells."

The seminar will be held at 5:45 p.m. on Tuesday April 11, 2017 in the Helen Lerner Amphitheater, McNulty Hall, Science and Technology Center, Seton Hall University. The University Community is invited.

Mariana Phillips was born in Mexico City, Mexico where she received her BSc in Food Chemistry from Universidad LaSalle, Mexico, in 1998. Phillips's academic career began as a science teacher of Physics and Chemistry, focusing particularly on developing a stimulating scientific learning environment for middle school students. Phillips relocated to the United States in 2005 with her family to pursue new scientific career goals. In 2012, she joined the Department of Chemistry and Biochemistry at Seton Hall University, to work on her PhD under the supervision of Profs. David Sabatino and Constantine Bitsaktsis. During her PhD studies, Phillips has developed methods in chemical biology for the production of novel immunstimulatory peptides. Phillips has also gained expertise in working with protein biologics, including antibody mimics for cancer-targeting immunotherapy applications. In 2015, Phillips received her MS degree in Biochemistry following her successful matriculation into the PhD program. In 2016-17, Phillips initiated a productive research collaboration with Dr. Robert Korngold at Hackensack UMC to investigate the biological properties of immunstimualtory constructs in vitro and in vivo. Taken together, Phillips accomplishments during her PhD studies have led to the generation of two publications, a book chapter currently in press, a research grant approved for funding, a travel grant award for attending the American Peptide Symposium in 2015 and more than five presentations and proceedings at local and national conferences. Phillips expects to receive her PhD in Biochemsitry in May 2017.

B7H6 has been identified as a cellular membrane protein expressed exclusively on tumor cells. Interestingly, B7H6 was found to bind selectively to NKp30, an activating receptor expressed on NK cells. B7H6:NKp30 binding stimulates NK cells' antitumor immune responses through the release of cytotoxic cytokines and chemokines, leading to tumor cell death. However, lower levels or the absence of cell surface B7H6 have correlated with the evolution of tumor resistance towards NK cells' immunosurveillance. Therefore, new B7H6 derived ligands that can bind and activate NK cells are expected to improve NK-dependent killing of resilient tumors. Towards this goal, this thesis work describes the rational design of a novel class of immunostimulatory peptides (IPs) derived from the binding site interface of B7H6:NKp30. The IPs were synthesized by conventional Fmoc solid phase peptide synthesis which also facilitated the incorporation of N-terminal fluorescein isothiocyanate (FITC) for structure-activity relationship studies. The secondary structures of the peptides were examined by CD spectroscopy which revealed versatile peptide structures which transitioned from random coil to -helical and turn-type conformations. Their biological properties were evaluated by flow cytometry, enzyme-linked immunosorbent assays (ELISAs) and cell death assays. The immunostimulatory effects of the IPs on the human NK92-MI cells were assessed by the production of TNF- alone as IFN- was undetectable. In a cell death assay, the IPs were found to be non-toxic, without any observable evidence of early or late stage apoptosis within the NK92-MI cells. Therefore, B7H6 derived peptides encompass an interesting class of ligands for activating NK cells' immune activities. The latter is a current focus of our on-going research program in cancer immunotherapy applications.

The Department of Chemistry and Biochemistry offers BS, MS and PhD degrees with specializations in all areas of chemistry. Our unique research environment, including traditional full-time students and part-time students is designed to foster collaborations with industry and colleagues in other disciplines. The Rose Mercadante Seminar Series is named for Rose Mercadante, the departmental secretary for over 40 years, in honor of our alumni, her "boys and girls".

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Chemistry - Final PhD Seminar - Mariana Phillips - Seton Hall University News & Events

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The family of a 20-year-old student who died after he was hit by a car in Lenton have paid tribute to their 'fun-loving' son.

Andrew Robertson, of Berkshire, died at the scene of the crash on Derby Road at around 4.45pm last Thursday (March 30).

He was in his second year studying biochemistry at the University of Nottingham.

A statement from his family said: "He had a bright future ahead of him. He was a loving son, grandson, brother, nephew, cousin and boyfriend.

"He had many friends both at university and at home. Words cannot express how much he will be missed and we are extremely saddened by his death.

"Andrew was caring, fun-loving, sociable, supportive and very easy-going. He was a team player who always kept his word and looked out for others.

"We would appreciate privacy during this difficult time to allow us to grieve and come to terms with our loss."

Police are investigating and are appealing to anyone who might have seen anything in the area around the time of the collision, which happened between Clifton Boulevard and Priory Island.

Officers are particularly keen to speak to drivers with dashcam footage.

Hundreds of motorists were caught in gridlocked traffic after the incident occurred.

Retired Michael Fisher, who lives in Charles Avenue, said he was not surprised to hear that an incident had occurred on what he describes as a "dangerous road."

The 64-year-old told the Post: "That is sad to hear. It is a very busy road and I won't cross it without pressing the button.

"It does not surprise me at all but it is a shame."

A large section of the road was cordoned off for several hours while investigations were carried out at the scene.

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Family pay tribute to student who died in Derby Road crash - Nottingham Post