UVM Appoints New Dean of Agriculture and Life Sciences – UVM News

University of Vermont Provost and Senior Vice President Patricia Prelock today announced the appointment of Leslie V. Parise, Ph.D., as dean of the College of Agriculture and Life Sciences (CALS).

Parise has built a long and successful career at the University of North Carolina-Chapel Hill (UNC-CH), where she rose through the ranks from assistant to full professor. For the past decade, Parise has served as the chair of the Department of Biochemistry and Biophysics, which currently ranks fifth in the United States for National Institutes of Health-funded biochemistry departments.

Dr. Parise is a strong proponent of translating research to benefit society, said Prelock. She impressed the search committee with her understanding of the importance of UVMs land-grant mission, and the critical role CALSand UVM Extensionhave played in advancing this mission. She has a track record of working with faculty to promote inventions, patenting, and licensing agreements. And her entrepreneurial mindset resonates with the innovative spirit so central to our UVM community. I have no doubt that Dr. Parise will be an exceptional leader and member of our community.

President Garimella said of her appointment, We are delighted that Dr. Leslie Parise is joining the University of Vermont as dean of the College of Agriculture and Life Sciences. She brings an impressive skillset to the university: great prowess in basic and translational research, longtime success promoting entrepreneurship and technology transfer, a commitment to student success, and a proven track record as a leader. We very much look forward to welcoming her to the UVM community.

Parise said she is honored to join the UVM community. CALS and UVM Extension play an incredibly important role in demonstrating the power of UVMs land-grant mission, she said. I look forward to meeting and working closely with the world-class faculty, staff and students of UVM, along with residents of Vermont. Finding ways to further engage our constituents to strategically maximize the educational, research and service missions of CALS, and to increase its visibility across the state and beyond will be among my priorities. I look forward to further positioning CALS as a microcosm for positive global impact.

Widely recognized for cardiovascular and cancer research, Parises work has been continuously funded, including more than $14.5M from the NIH. She is also a strong advocate for faculty and student advancement. As department chair at UNC, she worked with faculty, students and postdoctoral fellows to reinvigorate programs through a range of approaches including enhanced internal communication and planning, and increased mentoring.

Parise helped faculty maintain and grow funding through partnerships across campus and with neighboring institutions to facilitate greater investment from foundations and government agencies such the Keck Foundation, American Heart Association, National Institutes of Health and the National Science Foundation. She also facilitated partnerships with neighboring institutions to stimulate investment in a highly transformative technology for solving molecular structures called cryo-electron microscopy.

In 2017, Parise was elected Chair of the Faculty at UNC-CH, a role she held until May 2019. In this capacity, she represented all 3,800 faculty of the UNC-CH campus, interacting closely with the chancellor, provost, deans and faculty from within the university, as well as UNCs Board of Trustees, system president, and a faculty assembly from across the states 17-campus system. She has worked closely on issues ranging from curriculum changes, to budget models, to advancing diversity.

Parise will join UVM on May 15.

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UVM Appoints New Dean of Agriculture and Life Sciences - UVM News

Biochemistry Analyzers Market Reprt Impressive Growth, Industry Size, Key Players And Forecast 2020 To 2027 – TechNews.mobi

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Biochemistry Analyzers Market Reprt Impressive Growth, Industry Size, Key Players And Forecast 2020 To 2027 - TechNews.mobi

IISc.s biochemistry department turns 100 – The Hindu

The Department of Biochemistry of the Indian Institute of Science (IISc.) stepped into its centenary year in 2020. Established in 1921, it is said to be one of the oldest departments not only in India, but in all of Asia. Around 850 students have graduated from the department so far.

P.N. Rangarajan, Chairperson, Department of Biochemistry, told The Hindu that the major achievement has been its students, many of who are now leaders in industry and academia. One of them J. Padmanabhan alumni and faculty became the director of IISc. M.R.S. Rao went on to become the president of the Jawaharlal Nehru Centre for Advanced Scientific Research, and Ram Rajasekharan became the Director of CFTRI-Mysuru, he said.

The department has planned a major conference and alumni reunion in December, as well as a centenary lecture series that will be held almost every month. On the IISc.s Open Day on Saturday, it is organising an exhibition highlighting its past and current activities.

Prof. Rangarajans own research has led to the development of the hepatitis B vaccine. At least four vaccines are currently in the market. The hepatitis B component in these vaccines came from the lab of the Department of Biochemistry, he added.

In a recent issue of the journal Current Science, Prof. Rangarajan lists out the progression of research in the department. This includes research of societal relevance in the early years which resulted in the development of methods for conversion of municipal waste into organic manure and fluoride removal from drinking water, to name a few.

The article makes note of key contributions in basic research such as the identification of yeast chromosomes and nuclear membrane.

Ongoing research

At present, a novel drug combination for extremely drug resistant and multi-drug resistant TB, as well as new blood-based biomarker signatures of host genes for diagnosis of tuberculosis and for detecting response to anti-tubercular therapy are being developed, he told The Hindu. A novel inhibitor of DNA repair enzyme called SCR7 has also been developed in our laboratory. It has the potential to develop as a cancer drug, said Prof. Rangarajan.

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Automated Biochemical Analyzers Market likely to touch new heights by end of forecast period 2020-2025 – Express Journal

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Catch and Release: MTU Biochemists Purify Proteins with a Fishing Technique – Newswise

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Newswise Biochemists developed a catch and release technique to find the specific protein theyre fishing for.

The technique is explained in a new paper published in the Journal of Biological Chemistry. A team of biochemists from Michigan Technological University, including students, did the research, which is led by Tarun Dam, associate professor of chemistry.

Protein purification is a multibillion-dollar industry, Dam said, explaining that proteins are important for studying everything from cancer to allergies to vaccines. Unless you purify a protein, you dont know what it can do. We set out to improve that process.

Go FishFor Proteins

Much like fishing, Dam and his teams technique comes down to selecting the right lure and knowing the habits and habitat of what theyre baiting. They call their system CaRe, short for capture and release, and it follows four steps.

First, the team has to capture the protein theyre looking for. They do this by picking the lure: The tackle box is full of ligands, which are molecules with pincer-like arms that can bind proteins between the prongs. Much like fish that prefer different flies, lures or live bait, different proteins bind better with different ligands.

The hook needs to be a specific capturing agent, Dam explained, adding that the second step is to isolate the bound protein. Now we need the centrifuge. Once the protein is caught, the molecules weight becomes heavier, so they come down in solution.

The third step is to remove the isolated ligand-protein complex much like getting the fish into the boat and the fourth step is to get the hook out and separate the ligand and protein. Once separated, the protein stands alone, a purified end product.

No technique is 100% perfect, Dam said, noting that isolating low levels of a protein is akin to trawling for walleye where the sunfish hang out. Also, just like real lures, some proteins are picky and some ligands attract everything; a challenge and delight that keeps many people in waders and lab coats.

What we are most excited about is the simplicity of the technique, Dam said.

CaRe can isolate and separate out proteins in a day or two compared to the greater expense in both time and cost of current protein purification systems.

Glycoproteins, Cancer and Immunotherapy

Dam and his Michigan Tech collaborators, notably research assistant professor Purnima Bandyopadhyay, were able to develop CaRe because of the nature of the proteins. Alongside carbohydrates and fats (lipids), proteins are an important building block of living organisms.

About 60% of proteins are glycoproteins, meaning they have a sugar-based chain attached to them, and for decades, researchers thought the chains were junk structures. But as often happens in research over time, the sugary chains proved to be a key part of how proteins interact with their environment and the cells around them.

In his primary research, Dam explores a specific proteins interactions. Galectin-3, or simply Gal-3, is an important biomarker for thyroid cancer and a multitasking protein. Bandyopadhyay makes recombinant Gal-3 and its mutants in the lab. As Dam developed his Gal-3 research and needed to screen different proteins, he was set back by the cost and cumbersome processes of protein purification. So, he asked Bandyopadhyay, can we go fishing?

In addition to his own work, Dam is excited to see other labs apply the CaRe technique. It simply requires basic equipment and the chemistry equivalent of old fishing wisdom to know what lure catches what. Whether its sorting out cancer-related glycoproteins and proteins like Gal-3 or purifying proteins for immunotherapy treatments, luring the right molecules becomes as simple as catch and release fishing.

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Catch and Release: MTU Biochemists Purify Proteins with a Fishing Technique - Newswise

Bahamas and iguanas | News – The Bulletin

Every other December, a handful of students visit the home of the San Salvador Rock Iguana with David McKenzie, biology professor, to experience field ecology. During the last trip, one of the iguanas was killed.

There are about five hundred left in the world, said Scott Romeiser, senior biochemistry major. They are endemic to San Salvador island, however none of them really live there; they live on caysThe feral dogs and cats have essentially killed them off. One of the feral dogs got into a breeding enclosure that was on campus, which is essentially two lives lost for what is a critically endangered species.

Romeiser was one of 13 students who participated in the ten-day course over winter break alongside McKenzie and Marshall Sundberg, biology professor.

I didnt think about it too much just seeing them straight out, said Calder Klink, senior biology major. It may seem a bit insensitive, but they were just another animal.

According to Klink and Romesier, the students were all instructed not to tamper with native wildlife, given how fragile some of the ecosystems are.

I really learned to appreciate and embrace the diversity of nature and that you dont have to go to the Bahamas to appreciate biodiversity, Romesier said. We saw this squid, and it inked so that was coolThe class really enriched that experience because we had to pay attention to what we were looking at, the ecology of the living things and how they all work together.

While it was Romesier and Klinks first trip to the Bahamas, it is a routine expedition for McKenzie.

The guy I took it over from, Dr. Dwight Moore, said that he had been teaching the course for over 20 years, McKenzie said. The class is called Tropical Field EcologyI love it. Its probably my favorite class to teach because you get to go out there and see the biology rather than just reading about it.

McKenzie said the class has existed for over 35 years and is something he is excited to continue given the diversity the islands have to offer.

The iguana is a subspecies of the green iguana, so that main island and a few of the cays are the only places on Earth youll find them, McKenzie said. There is a pupfish which is just a little fish that seems to be going through rapid evolution on the islandIts found nowhere else on Earth.

According to McKenzie, there are plenty of benefits to field work that students cant get at home.

I love not having the class be research-focused but instead focusing on the field learning and having them ask why they see what they do, McKenzie said. Its so different than any of the other classes we offerEach trip is different but there are so many unique chances for immersion that students of all backgrounds can prosper from that exposure.

The class is open to all students who can afford the approximately $2,000 it costs to attend. Interested students should contact McKenzie ahead of time to get their spots for the 2021 trip at dmckenz1@emporia.edu.

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Bahamas and iguanas | News - The Bulletin

Strange New Organelle That Helps Prevent Cancer Discovered in Our Cells – SciTechDaily

P. Todd Stukenberg, PhD, of UVAs Department of Biochemistry and Molecular Genetics and the UVA Cancer Center, works in his lab. Credit: Dan Addison | UVA

Scientists at the University of Virginia School of Medicine have discovered a strange new organelle inside our cells that helps to prevent cancer by ensuring that genetic material is sorted correctly as cells divide.

The researchers have connected problems with the organelle to a subset of breast cancer tumors that make lots of mistakes when segregating chromosomes. Excitingly, they found their analysis offered a new way for doctors to sort patient tumors as they choose therapies. They hope these insights will allow doctors to better personalize treatments to best benefit patients sparing up to 40 percent of patients with breast cancer, for example, a taxing treatment that wont be effective.

Some percentage of women get chemotherapy drugs for breast cancer that are not very effective. They are poisoned, in pain and their hair falls out, so if it isnt curing their disease, then thats tragic, said researcher P. Todd Stukenberg, PhD, of UVAs Department of Biochemistry and Molecular Genetics and the UVA Cancer Center. One of our goals is to develop new tests to determine whether a patient will respond to a chemotherapeutic treatment, so they can find an effective treatment right away.

The organelle Stukenberg and his team have discovered is essential but ephemeral. It forms only when needed to ensure chromosomes are sorted correctly and disappears when its work is done. Thats one reason scientists havent discovered it before now. Another reason is its mind-bending nature: Stukenberg likens it to a droplet of liquid that condenses within other liquid. That was the big wow moment, when I saw that on the microscope, he said.

These droplets act as mixing bowls, concentrating certain cellular ingredients to allow biochemical reactions to occur in a specific location. Whats exciting is that cells have this new organelle and certain things will be recruited into it and other things will be excluded, Stukenberg said. The cells enrich things inside the droplet and, all of a sudden, new biochemical reactions appear only in that location. Its amazing.

P. Todd Stukenberg, PhD, of UVAs Department of Biochemistry and Molecular Genetics and the UVA Cancer Center, discovered an unknown organelle in our cells that helps ensure genetic material is sorted correctly when cells divide. Credit: Dan Addison | UVA

Its tempting to think of the droplet like oil in water, but its really the opposite of that. Oil is hydrophobic it repels water. This new organelle, however, is more sophisticated. Its more of a gel, where cellular components can still go in and out but it contains binding sites that concentrate a small set of the cells contents, Stukenberg explained. Our data suggests this concentration of proteins is really important. I can get complex biochemical reactions to occur inside a droplet that Ive been failing to reconstitute in a test tube for years. This is the secret sauce Ive been missing.

While its been known for about eight years that cells make such droplets for other processes, but it was unknown that they make them on chromosomes during cell division. Stukenberg believes these droplets are very common and more important than previously realized. I think this is a general paradigm, he said. Cells are using these non-membranous organelles to regulate much of their work.

In addition to helping us understand mitosis how cells divide Stukenbergs new discovery also sheds light on cancer and how it occurs. The organelles main function is to fix mistakes in tiny microtubules that pull apart chromosomes when cells are dividing. That ensures each cell winds up with the correct genetic material. In cancer, though, this repair process is defective, which can drive cancer cells to get more aggressive.

He has also developed tests to measure the amount of chromosome mis-segregation in tumors, and he hopes that this might allow doctors to pick the proper treatment to give cancer patients. We have a way to identify the tumors where the cells are mis-segregating chromosomes at a higher rate, he said. My hope is to identify the patients where treatments such as paclitaxel are going to the most effective.

Having looked at breast cancer already, he next plans to examine the strange organelles role in colorectal cancer.

###

Stukenberg and his colleagues have described their discovery in the scientific journal Nature Cell Biology. The research team consisted of Prasad Trivedi, Francesco Palomba, Ewa Niedzialkowska, Michelle A. Digman, Enrico Gratton and Stukenberg.

Reference: The inner centromere is a biomolecular condensate scaffolded by the chromosomal passenger complex by Prasad Trivedi, Francesco Palomba, Ewa Niedzialkowska, Michelle A. Digman, Enrico Gratton and P. Todd Stukenberg, 3 September 2019, Nature Cell Biology.DOI: 10.1038/s41556-019-0376-4

The research was supported by the National Institutes of Health, grants R01GM124042, R24OD023697 and P41-GM103540; and the National Science Foundation, grant MCB-1615701.

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Strange New Organelle That Helps Prevent Cancer Discovered in Our Cells - SciTechDaily

A new method to study nanoparticles – ChemEngOnline

By Paul Grad | January 1, 2020

Researchers from the Singapore-MIT Alliance for Research and Technology (Singapore; https://smart.mit.edu) have discovered a way to study the properties of a nanoparticle without damaging it, which has not been possible so far. The work was led by Michael Strano, a professor at MIT (Cambridge, Mass.; http://www.mit.edu), and a principal investigator of DiSTAP the Disruptive & Sustainable Technologies for Agricultural Precision Interdisciplinary Research Group which is a part of Smart. DiSTAP develops new technologies to enable Singapore to improve its agriculture yield to reduce its dependence on imported food and produce.

The researchers method, called molecular probe adsorption (MPA), is based on a non-invasive adsorption of a fluorescent probe on the surface of colloidal nanoparticles in aqueous phase.

The corona phase the adsorbed layer of polymer, surfactant, or stabilizer molecules around a nanoparticle is typically used to disperse nanoparticles into a solution or solid phase. However, this phase also controls molecular access to the nanoparticle surface. The MPA method allows measuring the accessible nanoparticle surface using a titration of a quenchable fluorescent molecule.

A material balance on the titration yields certain surface coverage parameters, including the ratio of the surface area (q) to the dissociation constant (Kd) of the fluorophore, q/Kd, as well as Kd itself. Using MPA across a series of corona phases, the researchers found that the Gibbs free energy of probe binding scales inversely with the cubic root of the surface area, q.

The researchers say MPA is the only technique to date capable of discerning critical structure-property relationships for such nanoparticle surface phases. They say the MPA method is also able to characterize a nanoparticle within minutes compared with several hours that the best chemical methods require today. Because it uses only fluorescent light, the MPA method is also substantially cheaper than other methods.

DiSTAP is using the MPA method for nanoparticle sensors in plants and nanocarriers for delivery of molecular cargo into plants. Strano says with better data and insight into plant biochemistry, we can provide optimal nutrient levels for healthier plants and higher yields.

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A new method to study nanoparticles - ChemEngOnline

Automated Biochemical Analyzers Market 2019 Analysis & Forecast To 2025 By Key Players, Share, Trend, Segmentation – Food & Beverage Herald

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Semester in the sun – Gazette

Part of a special feature highlighting the student voice, student experience and the range of student supports and opportunities available at Memorial.

Nov. 22, 2019

Amelia Lacey will likely spend some time studying on an Aloha State beach during the winter 2020 semester.

The fourth-year biochemistry (nutrition) major and St. Johns resident will study at the University of Hawaii at Mnoa as one of 20 top Canadian students receiving a Killam Fellowship from Fulbright Canada this year.

The scholarship program allows exceptional undergraduate students to participate in a bi-national academic exchange between Canada and the United States.

I wont be able to come home for a visit while Im there, and Ive never lived away from home for that long before, so its definitely going to be a new experience for me, said Ms. Lacey about the upcoming experience.

But, Im looking forward to all of the adventurous activities there and I hope to explore the islands of Hawaii as much as I can.

Ms. Lacey says her success in receiving the fellowship is an example of what can happen when you dont give up. She applied for the Killam Fellowship twice before being successful this year let alone in the highly coveted Paradise of the Pacific spot.

You have to choose the university that best matches the courses you need to take for your degree, and Hawaii has a great nutrition program, said Ms. Lacey. I recognized that and highlighted it in my application. They also offer a lot of courses we dont have at Memorial, so Im hoping to take a few courses I wouldnt otherwise get to take.

Photo: Submitted

In September she travelled to Ottawa, Ont., for an orientation session. There, she met the other Canadian and American Killam fellows, along with the American Fulbright students and scholars who are studying and conducting research in Canada this year. This spring Ms. Lacey will gather with them once again for a seminar in Washington, D.C.

It was great to meet people who were very different from me, but who also had similar values, she continued. I only spent three days with them, but were still talking regularly. I know well be keeping in touch.

It showed her, as many past Memorial fellowship recipients have found, that the Killam network is a strong one.

Once you get a Killam, youre considered a Killam fellow for life. So, you will continue to get emails, event invitations and other opportunities from them. It certainly opens up doors, thats for sure.

A focus on health and well-being has guided Ms. Laceys academic and personal pursuits.

She has been awarded several research awards, including three MUCEPs, a Natural Sciences and Engineering Research Council of Canada Undergraduate Student Research Award and a Faculty of Medicine Summer Undergraduate Research Award.

A Deans List student for the past three years, she has also been supported by several generous scholarships. Currently, she is the vice-president (social) for the Biochemistry Society, executive director of communications with the Women in Science and Engineering Undergraduate Society and a member of the Quintessential Vocal Ensemble. Past volunteer work with Global Brigades in Honduras also inspired Ms. Lacey to become more involved in global health.

Kelly Foss is a communications advisor with the Faculty of Science. She can be reached at kfoss@mun.ca.

Originally posted here:
Semester in the sun - Gazette

The promise of terpenoids in human health – Varsity

Mangoes contain high quantities of Vitamin A, which is a type of terpenoid. BRIGITTE TOHM/UNSPLASH | IMAGE HAS BEEN CROPPED

The word terpenoid is not only limited to rhyming with words such as meteoroid, avoid, and steroid it also symbolizes organic compounds produced by plants that offer significant medicinal and pharmacological benefits to humans.

In a review paper, U of T scientists explored the vast role that these chemicals play in our everyday lives.

Co-authors Dr. Michael Phillips, an assistant professor at UTMs Department of Biology; and Matthew Bergman, a graduate student at the same department, discussed thefindings of this review with The Varsity.

Relevance of terpenoids

The presence of terpenoids can be found all around us. Vitamin A is an example, along with the chemical that is key to the unique smell of pine.

The review explained that terpenoids can attract pollinators, repel herbivores, or attract herbivore predators. This has broad impacts on fields such as agriculture.

Terpenoids also feature heavily in cannabis. Specialized terpenoids include well-known compounds such as cannabidiol also known as CBD and tetrahydrocannabinol THC.The compounds have been used for their psychoactive, anxiolytic and anesthetic effects for thousands of years, according to the co-authors.

The ability to make these terpenoids evolved as a result of selective pressures imposed by animals on plants. A great sense of irony lies in the fact that these chemical compounds, which often serve as plant defence compounds against herbivorous insects, possess fortuitous uses in medicine.

The reason that these compounds are biologically active in humans is in part due to the fact that our proteins are made up of exactly the same amino acids as the plant proteins, noted Phillips.

Applications of the review

Phillips hopes to use his review partly as a teaching tool but also [to] summarize the literature that is important for [his] field.

Bergman also spoke aboutthe implications that his research would have on non-specialists in biology. Theres a lot of interest right now in medicinal plants and theres a lot of confusion surrounding what are the active constituents, he said.

By conducting the review, Bergman hopes to eliminate some of this confusion.This is important because theres a connection between [our research] and what [consumers] find in the grocery store, added Phillips.

The future of terpenoid research

In many cases, terpenoid-based medications could hold promise in health care, by virtue of the fact of how much common ancestry we share with herbivores that terpenoids evolved to affect, noted Phillips.

While many terpenoids represent potentially beneficial compounds for humans, the testing process is painstaking and resource intensive, according to the review. This process is further obstructed by the fact that many [terpenoids] are produced in small amounts, and only in response to elicitation.

Additionally, while the amount of plant terpenoids that can be screened for therapeutic applications is still unknown, it likely surpasses over 100,000 variants, according to the co-authors. With a review of terpenoids completed, researchers now have a tool to develop plans for further research in the field of plant biochemistry.

Tags: Biochemistry, botany, Chemistry, medicine, organic chemistry, Science

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The promise of terpenoids in human health - Varsity

pabmb – Panamerican Association for Biochemistry and …

MINUTES OF THE PABMB COUNCIL MEETING

July 20, 2016

Vancouver (Canada)

PABMB officers and delegates met for the Council Meeting on Wednesday 20, July 2016 at 2:00 PM in Vancouver Convention Center during the joint XVI IUBMB Conference / XIII PABMB Congress / 59th CSMB Congress, in Vancouver (Canada).PABMB Chairman, Hugo Maccioni, chaired the meeting.

MEMBERS PRESENT:

Hugo Maccioni (Chairman PABMB); Sergio Grinstein (Vice-Chairman PABMB), Jorge Babul (Past Chairman PABMB), Carlos Argaraa (Treasurer PABMB), Bianca Zingales (Secretary General PABMB), Jos Luis Daniotti (Delegate of Sociedad Argentina de Investigacin en Bioqumica y Biologa Molecular), Sergio Lavandero (Past President of Sociedad de Bioqumica y Biologa Molecular de Chile), Alicia Kowaltowski (Delegate of Sociedade Brasileira de Bioqumica e Biologa Molecular), Ana Cristina Rego (Delegate of Sociedad Portuguesa de Bioqumica) and Federico Mayor Menndez (President of Sociedad Espaola de Bioquimica y Biologa Molecular).

MEMBERS ABSENT:

Representatives of the Canadian Society for Biochemistry, Molecular and Cellular Biology; Sociedad Mexicana de Bioqumica; Asociacin Panamea de Bioqumica y Biologa Molecular; Sociedad Qumica del Per; American Society of Biochemistry and Molecular Biology; American Chemical Society/Division of Biological Chemistry; Sociedad Uruguaya de Bioqumica y Biologa Molecular; Seccin Cubana de Bioqumica y Biologia Molecular; Sociedad Cubana de Qumica.

The Committee Meeting Agenda was informed on April 25, 2016 (see ANNEX I).

MEETING:

Bianca Zingales presented the initiatives undertaken by the PABMB Executive Committee in the period November 2013 December 2014, under the presidency of Jorge Babul and in the period January 2015 June 2016, under the presidency of Hugo Maccioni.

The support to PABMB Plenary lectures held in annual meetings of PABMB Constituent and Adherent Societies and in IUBMB and FEBS meetings was discriminated as well as support to fellowships for young scientists to attend meetings, courses and workshops (see ANNEX II).

In the years 2011, 2012, 2013 and 2015 PABMB participated together with IUBMB and ASBMB in the PROLAB (Promoting Research Opportunities for Latin American Biochemists) program aimed at fostering interactions among biochemists in Latin America, Portugal and Spain with those in the United States. The specific objective of PROLAB is the support of graduate and post-doctoral students and young investigators from countries active in the PABMB, to spend short stays (1-6 months) in the laboratory of a scientist affiliated with ASBMB (average stipend 5,000 USD/fellowship). The list of 2016 fellowships winners is given in ANNEX III.

Additional actions in the period:

The participants commended the activities and asked additional information on some topics.

Carlos Argaraa presented (ANNEX IV) the Financial Report of PABMB (December 2013 June 2016).

The Chairman commented that some PABMB Constituent Societies such as Sociedad Mexicana de Bioqumica; Asociacin Panamea de Bioqumica y Biologa Molecular and Sociedad Qumica of Per, and the Associated Society Seccin Cubana de Bioqumica y Biologia Molecular and Sociedad Cubana de Qumica have a low participation in PABMB activities. He pointed out the need of promoting greater engagement of these Societies as well as the enrolment of additional Latin American Societies of Biochemistry and related sciences in PABMB. The attendants agreed with the suggestions and Jorge Babul offered to collaborate in these activities.

The Chairman inquired the attendants if the Societies they represent had suggested candidates for this position. Given the negative response, the Chairman informed that the Sociedad Uruguaya de Bioqumica y Biologa Molecular had indicated Dr. Jos Sotelo Silveira (Instituto de Investigaciones Biolgicas Clemente Estable, Montevideo, Uruguay), former president of this Society, as a candidate for PABMB Secretary General. The election was opened and Dr. Sotelo was elected by unanimous vote of the delegates present.

The Chairman summarized the proposal and comments and suggestions that were provided by the attendees of IUBMB Executive Committee Meeting.

ANNEX 1

ANNEX II

PABMB Lecturers

Year 2013

Year 2014

Year 2015

Year 2016 (Forthcoming Lecturers)

Travel Fellowships for young scientists

Year 2013

Year 2014

Year 2015

ANNEX III

2016 PROLAB Fellowship Winners

ANNEX IV

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Fulcrum Therapeutics to Host Key Opinion Leader Breakfast Symposium on Facioscapulohumeral Dystrophy (FSHD), on November 7, 2019 – GlobeNewswire

CAMBRIDGE,Mass., Oct. 31, 2019 (GLOBE NEWSWIRE) -- Fulcrum Therapeutics, Inc.(Nasdaq: FULC), a clinical-stage biopharmaceutical company focused on improving the lives of patients with genetically defined rare diseases, today announced that it will host a key opinion leader (KOL) breakfast symposium focused on understanding Facioscapulohumeral Dystrophy (FSHD) genetics, biology, and clinical implications, on Thursday, November 7, 2019 from 8:30 a.m. to 10:30 a.m. ET in New York, NY. Fulcrum is currently conducting Phase 2 trials investigating the safety, tolerability, and efficacy of losmapimod to treat the root cause of FSHD.

Guest speakers scheduled to present at the event include:

A live webcast of the presentation will be available through the investor relations section of the Company's website at https://ir.fulcrumtx.com/events-and-presentations. Following the live webcast, an archived replay will also be available.

About FSHDFSHD is characterized by progressive skeletal muscle loss that initially causes weakness in muscles in the face, shoulders, arms and trunk, and progresses to weakness throughout the lower body. Skeletal muscle weakness results in significant physical limitations, including an inability to smile and difficulty using arms for activities, with many patients ultimately becoming dependent upon the use of a wheelchair for daily mobility.

FSHD is caused by mis-expression of DUX4 in skeletal muscle, resulting in the presence of DUX4 proteins that are toxic to muscle tissue. Normally, DUX4-driven gene expression is limited to early embryonic development, after which time the DUX4 gene is silenced. In people with FSHD, the DUX4 gene is turned on as a result of a genetic mutation. The result is death of muscle and its replacement by fat, leading to skeletal muscle weakness and progressive disability. There are no approved therapies for FSHD, one of the most common forms of muscular dystrophy, with an estimated patient population of 16,000 to 38,000 in the United States alone.

About LosmapimodLosmapimod is a selective p38/ mitogen activated protein kinase (MAPK) inhibitor that was exclusively in-licensed by Fulcrum Therapeutics following Fulcrums discovery of the role of p38/ inhibitors in the reduction of DUX4 expression and an extensive review of known compounds. Utilizing its internal product engine, Fulcrum discovered that inhibition of p38/ reduced expression of the DUX4 gene in muscle cells derived from patients with FSHD. Although losmapimod has never previously been explored in muscular dystrophies, it has been evaluated in more than 3,500 subjects in clinical trials across multiple other indications, including in several Phase 2 trials and a Phase 3 trial. No safety signals were attributed to losmapimod in any of these trials. Fulcrum is currently conducting Phase 2 trials investigating the safety, tolerability, and efficacy of losmapimod to treat the root cause of FSHD.

About Fulcrum TherapeuticsFulcrum Therapeutics is a clinical-stage biopharmaceutical company focused on improving the lives of patients with genetically defined diseases in areas of high unmet medical need, with an initial focus on rare diseases. Fulcrums proprietary product engine identifies drug targets which can modulate gene expression to treat the known root cause of gene mis-expression. Please visit http://www.fulcrumtx.com.

Investor Contact:Christina TartagliaStern Investor Relations, Inc.212.362.1200christina@sternir.com

Media Contact: Lynn GranitoBerry & Company Public Relationslgranito@berrypr.com212-253-8881

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Fulcrum Therapeutics to Host Key Opinion Leader Breakfast Symposium on Facioscapulohumeral Dystrophy (FSHD), on November 7, 2019 - GlobeNewswire

UGA scientist revolutionized biochemical research – Online Athens

EDITOR'S NOTE: This story is part of a series, called Georgia Groundbreakers, that celebrates innovative and visionary faculty, students, alumni and leaders throughout the history of the University of Georgiaand their profound, enduring impact on our state, our nation and the world.

Biochemist Marion Bradford spent most of his career developing new ways to use a common item found in kitchens and nurseries around the world cornstarch.

For decades, Bradford worked to convert cornstarch into a renewable energy source that could replace fossil fuels and produce everyday products ranging from food, feed and fiber to chemicals and industrial fuels.

He was part of a team recognized in 2003 by the U.S. Environmental Protection Agency and the American Chemical Society for creating an organic compound from corn sugar used in carpet fibers, cosmetics and liquid detergents that helped reduce the global economys reliance on petroleum-based materials. The organizations praised the teams contributions to the welfare and progress of humanity.

But it is his research on the seventh floor of the Boyd Graduate Studies Research Center at the University of Georgia in the 1970s that will be his legacy. A theory he pursued because he thought it would save scientists time in the laboratory turned part of his doctoral dissertation into one of the most cited scientific papers in history and invented an analytic process that revolutionized biochemical research.

I look back and say, yep, that is what I am known for, said Bradford, 72, who developed the Bradford protein assay, a process that is still being used in laboratories around the world to detect proteins in tissue samples. It made life a lot simpler.

One of the most cited research papers in history

According to an article published in Nature in 2014, if you put a printout of the first page of every paper listed on Thomson Reuters Web of Science that cited Bradfords research paper and stacked them up, the pile would almost reach the summit of Mount Kilimanjaro.

Five years ago, Bradfords paper had been cited by other scientists 157,683 times and was one of only three to achieve more than 100,000 citations. Today, it has jumped to 206,088 citations and counting, which makes Bradford one of only a few scientists in the world whose work has been recognized at this rate and used by others in the evolution of science to provide credibility for their research and scientific knowledge.

Looking back more than 40 years, Bradford, who is retired and living in Hendersonville, North Carolina, talks matter-of-factly about how the discovery which is done in a test tube in one simple step came about. His friend, a postdoc working next to him, was reading a published paper on a dye, Coomassie Brilliant Blue, and how it changes colors when it binds to a protein.

He asked me what I thought it would be good for, Bradford said. I said I thought it would be an instant protein assay.

At the time, an assay that could provide an instantaneous reading on proteins seemed out of reach. Proteins are important because they do most of the work in cells and can either help fight infection and keep people healthy or cause damage and serious illness.

The method being used at the time was a multi-step chemical reaction, Bradford said, and it took up to two hours to complete.

But, he thought, if Coomassie Brilliant Blue first developed for use in the textile industry could be used to stain wool sweaters instantly, it should be able to stain proteins in a solution as well.

I took the concept that was being used and changed it to a liquid form, came up with a new formulation that would allow it to stay in the solution, bind to the protein, and change colors instantaneously, he said.

The discovery led to a patent

Bradfords discovery using Coomassie Brilliant Blue G-250 was patented in 1976. The professor working with Bradford told him that he could be the sole author on the research paper since he was doing it outside of his fieldwork of reproductive biochemistry -- but the professor wanted to be included on any patent.

Christopher West, who chairs the department of biochemistry and molecular biology at UGAs Franklin College of Arts and Sciences, was a graduate student at the California Institute of Technology when Bradford developed his assay. Suzanne Barbour, dean of the graduate school at the University of North Carolina and a professor of biochemistry and biophysics, was in junior high school.

Barbour calls the Bradford assay the gold standard. West says it is a critical research tool that provides scientists with a quick reading on the concentration of proteins in any sample a necessary procedure for researchers, whether using it to detect illness, for drug development or to study the relationship between plant protein and human nutrition.

Anytime you do an experiment, you need to know how many proteins you have, West said. Its like looking at the fuel gauge before going on a trip or deciding how much flour to buy before baking a cake. There are things you need to do first before you move on to what comes next.

Both scientists suspect that Bradford didnt realize the impact his discovery would have when he published his paper in 1976.

For him it was probably a means to an end, said Barbour, a former dean of UGAs Graduate School. I dont think he realized that a gazillion scientists would be using this assay every day and that it would be something that revolutionized the way we do molecular biochemistry.

Research was always his passion

Bradford always wanted to be a researcher, but it didnt happen right away. After obtaining his Bachelor of Arts degree in chemistry from Shorter College in Rome, Georgia, in 1967, he taught middle school science and math for a few years. He also worked for the Georgia Department of Public Health in its clinical tuberculosis laboratory.

What Bradford realized during his time outside the lab was that pure scientific research was his passion. And he knew that to move forward, graduate school was a must.

The research I wanted to do could have been in almost anything, said Bradford. But I knew that for the work that I wanted to do, I first needed a graduate degree. It was like getting a permission slip.

So Bradford left public school teaching behind and spent his first wedding anniversary in 1972 standing in line at UGA signing up for graduate courses in foreign languages and biochemistry an area of study in which he had never taken a single course as an undergraduate.

After Bradford received his doctoral degree in 1975, he stayed at UGA as a research biochemist until 1981 when the postdoc who first asked him about his thoughts on the use of Coomassie Blue told him that A.E. Staley Manufacturing Co. in Decatur, Illinois, was looking to hire.

Bradford got the job and worked for A.E. Staley one of the largest processors of corn in the United States that merged with the British company Tate & Lyle in 1988 for the next 21 years. Afterward, he spent 17 years as a consultant with the Iowa Corn Promotion Board developing new uses and improving the sustainable production of corn.

He was part of the green, or sustainable, chemistry movement and patented new methods of converting carbohydrates from corn into materials that would replace the petrochemicals being used to develop drugs, preserve foods, create plastics, resins and fibers, and make pesticides and fertilizers.

His last hurrah, he said, was being part of that Tate & Lyle and DuPont team that discovered the renewably sourced plant-based textiles.

Still, it is the Bradford assay, he knows, that will be at the top of his scientific accomplishments long after he is gone.

Well, gee, Bradford said. Its nice to have made an impact.

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UGA scientist revolutionized biochemical research - Online Athens

Biochemistry & Analytical Biochemistry – OMICS International

Index Copernicus Value: 85.79

Journal of Biochemistry & Analytical Biochemistry is an academic journal providing an opportunity to researchers and scientist to explore the advanced and latest research developments in the field of Biochemistry. Journal of Biochemistry & Analytical Biochemistry is of highest standards in terms of quality and concentrates on the biological chemistry that are prevalent in unique chemical processes. This Journal covers all areas of the life sciences from botany to medicine that are engaged in biochemical research. Biochemistry deals with the structures, functions and interactions of biological macromolecules, such as proteins, nucleic acids, carbohydrates and lipids, which provide the structure of cells and perform many of the functions associated with life.

Journal of Biochemistry & Analytical Biochemistry is a scholarly Open Access journal and aims to publish the most complete and reliable source of information on the advanced and very latest research topics.

Biochemistry & Analytical Biochemistry is a peer reviewed scientific journal known for rapid dissemination of high-quality research. This Biochemistry Journal with high impact factor offers an open access platform to the authors in academia and industry to publish their novel research. It serves the International Scientific Community with its standard research publications.

The journal is using Editorial Manager System for quality in review process. Editorial Manager is an online manuscript submission, review and tracking systems. Review process is performed by the editorial board members of Journal of Biochemistry and Analytical Biochemistry or outside experts; at least two independent reviewers approval followed by editor approval is required for acceptance of any citable manuscript. Authors may submit manuscripts and track their progress through the system, hopefully to publication. Reviewers can download manuscripts and submit their opinions to the editor. Editors can manage the whole submission/review/revise/publish process.

Biochemistry is for everyone. It is the central science to both fish biology and fish processing. Fishery biochemistry is considered a branch under veterinary biochemistry providing Proper knowledge on the biochemical composition of fish finds application in several The Biochemistry of Fish - Annual Reviews,The Journal of Fish Biology - fsbi.org.uk, Fish Physiology and Biochemistry,areas. Fish is an easily perishable commodity and deterioration in quality is due to the changes taking place to the various constituents likeproteins, lipids etc.

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Preparative biochemistry deals with all aspects of preparative techniques in biochemistry, including synthetic methods, production or manufacturing, separation,isolation, and purification of materials of biochemical at the laboratory, pilot, and production scale levels.

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Soil Biochemistry is the branch of soil science which ceals with formation and decomposition of soil organic matter, biochemical reactions of Carbon, nitrogen, sulphur, Phosphorous, metals andxenobioticsin soils, and biochemistry of the plant-root rhizosphere. Soil Biochemical reactions mainly concern on the organic fraction, though it is made up of 55 of total soil volume.

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Biochemistry of the blood gives us an indication of what is happening with in the body. When different tissues are damaged the damaged cells release specific enzymes which our equipment detects as abnormal levels. This then helps localise the problem. Also if certain organs are not eliminating certain waste products this can tell us they are not functioning properly.

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The Food Biochemistry gathering plans to enhance understanding of detailed composition of foods, especially food components that have beneficial effects on human health.The Food Biochemistry include utilization of modern chemical and biochemical analytical methods offoodcomponents and their reactions, model systems to study their reactions and efficient statistical tools for data analysis to get the maximum informative value.

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Carbohydrates are carbon compounds that contain large quantities of hydroxyl groups. Carbohydrates also can combine with lipid to form glycolipids or with protein to form glycoproteins. Carbohydrates are made up of a 1:2:1 ratio of Carbon, Hydrogen, and Oxygen (CH2O)n. carbohydrates are for structural purposes, such ascellulose(which composes plants' cell walls) and chitin (a major component of insect exoskeletons).

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Proteins are composed of a linear polymer of amino acids. Amino acids are molecules containing an amine group (NH3), a carboxylic acid group(R-C=O-OH) and a side-chain (usually denoted as R) that varies between different amino acids. They are particularly important in biochemistry, where the term usually refers to alpha-amino acids. Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form in a biologically functional way.

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Pesticide Biochemistry deals with the mode of action of plant protection agents such as insecticides, fungicides, herbicides, and similar compounds, including nonlethal pest control agents, biosynthesis of pheromones, hormones, and plant resistance agents. It mainly emphasizes on Biochemistry and Physiology of Comparative toxicity, Mode of action,Pathophysiology, Plant growth regulators, Resistance, Other effects of pesticides on both parasites and hosts.

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Cellular and Molecular Biology Biochemistry is the study of the molecular nature of living organisms leading to an understanding of the biochemical control of life processes. It mainly focuses on the rapid changes in cytoskeletal proteins, protein kinases, membrane lipids, and small ions that accompany extracellular signals. This includes a wide range of topics from the structure and function of single molecules to the integrated molecular control of entire cells and organisms.

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The membranes form the barriers that separate the inside from the outside of living cells and that define organelles within cells. It focuses simplified self-assembled model membranes of lipids and proteins to membranes of living cells, and by using different complementary approaches, including molecular biology, chemical synthesis, analytical tools and advanced biophysical methods.

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Abiomoleculeis any molecule that is present in living organisms, including large macromolecules such as proteins, polysaccharides, lipids, and nucleic acids, as well as small molecules such as primary metabolites, secondary metabolites, and natural products. There are thousands of different types of molecules in a cell. A diverse range of biomolecules exist, including Small molecules Monomers, oligomers and polymers.

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Biochemistry & Analytical Biochemistry - OMICS International

Stumping for science: Rock Falls grad student takes her passion to the Hill – SaukValley.com

BY MAGGIE ROTERMUD Media Relations Specialist Medical Center Communications Saint Louis University

A Saint Louis University student researcher and one of Rock Falls' brainiest natives recently spent a day on Capitol Hill, advocating for the importance of biomedical research.

Celine Hartman, 24, is a fourth-year graduate student at Saint Louis University, working in its Department of Biochemistry and Molecular Biology.

On April 6, she and the rest of a team of student researchers from the American Society for Biochemistry and Molecular Biology took their passion for their science out of the lab and did their best to use it to convey to federal legislators the importance of continuing to fund agencies such as the National Institutes of Health and the National Science Foundation.

Hartman, who is a 2010 Rock Falls High School graduate and the daughter of Jim and Dawn Hartman, took part in the society's Hill Day, meeting with lawmakers and congressional staff to talk about the work they are doing.

Celine had the initiative to apply for this wonderful program, said David Ford, who runs the department's lab. Beyond performing exciting and cutting-edge research, it is great that this opportunity is available to students, which allows themto understand the importance of science as an important investment by our government and to advocate science to politicians.

She and the other participants emphasized the critical role that federal investments in research plays in supporting the nations scientific enterprise and how those investments lead to improvements in Americans' quality of life and well-being.

I think people may not realize how cutting the NIH will affect the general public, Hartman said. By cutting basic biomedical research funding, pharmaceutical companies will now have to perform the same fundamental research we are working on, instead of finding drugs to push through to clinical trials. This will, in turn, increase the price of the pharmaceutical drugs even more.

Hartman came to SLU in 2013 after graduating cum laude from Bradley University in Peoria with a biology degree.Herthesis project is focusing on determining the biochemical mechanisms that a pro-inflammatory family of lipids, chlorinated lipids, cause endothelial dysfunction leading to multi-organ failure during sepsis.

She joined the American Society for Biochemistry and Molecular Biology last year.

Why this field of research?

Ive always had an interest in cardiovascular research, after having some heart problems when I was a kid. My mom (and many other family members) is a nurse (in the cath lab at CGH Medical Center), so Ive been exposed to the medical field all my life.

I knew I didnt want to become a medical doctor, but I wanted to continue my education after Bradley to have more job options. After meeting and talking to Dr. Ford about the research in his lab, it was an easy decision to join his lab.

What do you do in the lab?

Our lab studies biochemical mediators of sepsis and cardiovascular disease. Specifically, we study a class of lipids (fats) which are chlorinated. We are working on utilizing these lipids as a new diagnostic marker to identify these inflammatory diseases sooner, as well as finding new targets for drug therapies.

As a graduate student in the lab, I design, perform, and analyze the results of experiments, so every day is a new adventure.

Why was it important for you to do this?

With the recent political events in our country, conversations with policymakers regarding the importance of STEM research (science, technology, engineering and math) are more important than ever.

The proposed 20 percent cut to the NIH budget in FY18 is shocking. The proposed cut would essentially prevent any new grants from being funded, which would be devastating to all biomedical research.

As a young scientist preparing to enter the work force in the next 1 to 2 years, I wanted the opportunity to tell policymakers my story and why we need sustainable funding to the NIH. I was able to advocate on behalf of all young scientists in Missouri and beyond.

What did you do on Capitol Hill?

In preparation for Hill Day, we had a webinar training where we discussed the basics of the federal budget, how NIH/NSF are funded, and what the proposed budget cuts could mean.

We also received a lot of information about each member of Congress that we would be meeting with. We prepared by reviewing each persons story, voting history and participation in committees.

On Hill Day, we were paired into groups with one other student and one faculty member who is on the Public Affairs Advisory Committee. My group met with Congressional members (both senators and representatives) from Missouri, Pennsylvania and West Virginia.

What was your main message to legislators?

During each meeting, we discussed our own research and why we participated in the Hill Day.

The main message that we wanted to discuss was about the proposed budget cuts.

We would reiterate that we greatly appreciate the support to the NIH thus far, as all of our research progress is possible due to the federal funding of the NIH. We also discussed how we hoped to continue to see sustainable funding over the next few years and how detrimental the proposed budget cuts would be to our own research.

What did you learn on the Hill?

It was very interesting to see the other side of research funding that we dont think of normally. Funding the NIH has strong bipartisan support, so the conversations were very supportive of our research and the potential implications.

Moving forward, I believe conversations like the ones that I had will help support NIH funding and continue to provide jobs for young scientists like myself.

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Founded in 1906, the American Society for Biochemistry and Molecular Biology is a nonprofit scientific and educational organization with more than 12,000 members.Go to http://www.asbmb.org to learn more.

Established in 1836, Saint Louis University School of Medicine has the distinction of awarding the first medical degree west of the Mississippi River. The school educates physicians and biomedical scientists, conducts medical research, and provides health care on a local, national and international level. Research at the school seeks new cures and treatments in five key areas: infectious disease, liver disease, cancer, heart/lung disease, and aging and brain disorders.

Go to http://www.slu.edu to learn more about the school and all it has to offer.

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Stumping for science: Rock Falls grad student takes her passion to the Hill - SaukValley.com

Doctor offers solution to biochem staff issue – Irish Examiner

A Dublin-based doctor has offered what he says is a solution to a staffing shortage at the biochemistry department in Cork University Hospital (CUH) which has led to the withdrawal of its clinical advisory service and a decision to voluntarily suspend accreditation.

Bill Tormey, a consultant chemical pathologist at Beaumont Hospital, said he and three colleagues are prepared to offer the clinical advisory service while CUH continues efforts to recruit consultant cover for the lab.

Professor Tormey said he is awaiting a response to his offer from the CEO of CUH. He said four chemical pathologists are willing, pro tem, to provide a comprehensive service to CUH.

His colleagues include Dr Vivion Crowley, biochemistry department, St James Hospital; Dr Gerard Boran of the School of Medicine, Trinity College Dublin and Dr Patrick Twomey, consultant chemical pathologist at St Vincents University Hospital.

Prof Tormey said by providing consultant cover, the lab would meet the requirements for accreditation. His offer would give CUH breathing space to continue its hunt for a new consultant following the retirement last year of biochemistry department chief, Dr John OMullane.

When asked about Prof Tormeys offer, a hospital spokesperson said they are looking at a number of options in relation to the provision of the service.

Prof Tormey said he is not offering a free service but would not be looking for agency rates.

Earlier this month, the HSE advertised for a locum consultant chemical pathologist. The hospital has said it is actively recruiting both a locum replacement and a permanent replacement but that as available candidates are not plentiful, it is difficult to put a timeframe on either competition.

A spokesperson said yesterday that a locum post was advertised pending the filling of the post on a permanent basis through the Public Appointments Service.

The hospital has advised GPs that its biochemistry department is currently unable to provide clinical advice and interpretation of lab results due to a lack of consultant cover.

The situation has also prompted the lab to seek voluntary suspension of its accreditation. Accreditation is an external, independent verification of the extent to which an organisation meets a pre-determined set of quality standards.

The hospital has said regardless of the lack of consultant cover, the same scientists will process patient specimens to a high quality standard, as before, and within the same timeframe. And while it cannot directly provide a clinical advisory service at this time, it can advise service users to seek appropriate advice from various other sources.

If a laboratory result appears to be discordant with the clinical situation, initial discussion with senior clinical laboratory personnel in biochemistry and/or with the patients consultant is warranted, it said.

The biochemistry department at CUH processed approximately eight million tests last year, including tests for liver function, renal function, cardiac function, hormones, and general chemistries.

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Hendrix Students Share Chemistry Research at National ACS Meeting – Hendrix College Events and News

CONWAY, Ark. (April 12, 2017) Twenty-three Hendrix College students recently presented their research at the national meeting of the American Chemical Society in San Francisco.

The students, accompanied by Hendrix chemistry faculty and staff members, prepared research posters and shared their research with conference attendees from throughout the world. Student research projects ranged from the chemical physics of protein folding to mechanisms of water adsorption on mineral dust.

Students and their presentations included:

About the American Chemical Society

With nearly 157,000 members, the American Chemical Society (ACS) is the worlds largest scientific society and one of the worlds leading sources of authoritative scientific information. A nonprofit organization, chartered by Congress, ACS is at the forefront of the evolving worldwide chemical enterprise and the premier professional home for chemists, chemical engineers, and related professions around the globe.

About Hendrix College

Hendrix College is a private liberal arts college in Conway, Arkansas. Founded in 1876 and affiliated with the United Methodist Church since 1884, Hendrix is featured in Colleges That Change Lives: 40 Schools That Will Change the Way You Think about Colleges and is nationally recognized in numerous college guides, lists, and rankings for academic quality, community, innovation, and value. For more information, visit http://www.hendrix.edu.

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Job Dekker receives inaugural International Award from British … – News from the University of Massachusetts

Job Dekker, PhD

Job Dekker, PhD, has been recognized by the Biochemical Society, based in London, as the inaugural recipient of the International Award. One of 11 eminent scientists honored overall by the Biochemical Society, Dr. Dekker, Howard Hughes Medical Institute investigator, professor of biochemistry & molecular pharmacology, and co-director of the Program in Systems Biology, was recognized for his distinguished and independent interdisciplinary research that illustrates the importance of the molecular biosciences in the advancement of life sciences research. Recipients of the International Award conduct research outside of the UK and Ireland and may be of any nationality.

I am extremely delighted to have been selected for this award, said Dekker. This really honors the work of my students, postdocs, collaborators and colleagues in this field that was started to uncover how cells fold their chromosomes.

Colin D Bingle, PhD, acting chair of the Biochemical Society award committee, said, The Biochemical Society awards are the perfect way to honor exceptional scientists within the bioscience community. As ever, the entry criteria are tough and the standards high and the awards are a real tribute to the talent within our community.

A pioneer in the study of the three-dimensional structure of the genome, Dekker developed the now widely used chromosome conformation technologies used to map the topography of the genome. Although DNA is comprised of a linear sequence of bases, it doesnt exist inside the cell nucleus in a simple, straight form. More like a ball of cooked spaghetti, the genome folds and loops back on itself so it can fit inside the tight confines of the nucleus. How the genome is packed inside the nucleus is tightly controlled and varies from cell type to cell type. And each unique shape has a profound influence on which genes in a cell are turned on or turned off.

Seeking tools and technology for mapping the three-dimensional structure of the genome in detail, Dekker developed a biochemical technique for determining how DNA segments interact and are linked to one another. The result, akin to a molecular microscope, can be used to detect physical interactions between DNA segments. The more interactions between segments, the more closely associated in space they are, due to chromosome folding. This breakthrough discovery was the genesis of what are now termed 3C, 5C and Hi-C tools, used by researchers worldwide interested in mapping the structure and organization of chromosomes inside cells.

Since joining UMMS, Dekker has refined and enhanced the initial chromosome conformation techniques to visualize whole genomes, combining it with next-generation sequencing to create high through put versions. A member of the UMMS faculty since 2003, Dekker received his doctoral degree in biochemistry from Utrecht University in the Netherlands. He trained as a postdoctoral fellow at Harvard University with Nancy Kleckner, PhD, studying chromosome structure and developing the techniques that led to the 3C technology.

Dekker was elected to the American Association for the Advancement of Science in 2014. In 2007, he was named a Keck Foundation Distinguished Young Scholar in Biomedical Research, and he received the 2011 Young Investigator Award from the American Society of Biochemistry and Molecular Biology.

The recipient of the International Award, which is new for 2018, will act as an ambassador for the Biochemical Societys international activities. The award aims to recognize the achievements of early to mid-career scientists who are within 20 years of PhD completion. Dekker is invited to deliver a lecture at the 24th International Union of Biochemistry and Molecular Biology/15th Federation of Asian and Oceanian Biochemists and Molecular Biologists Congress in Seoul, Korea, June 4 to 8, 2018, or at a society conference.

Related stories on UMassMedNow: Job Dekker explains DNA organization in New York Times article STAT: UMMS study of 3D genome may reveal hidden world of folding diseases Job Dekker becomes seventh Howard Hughes Medical Institute investigator at UMass Medical School Center for 3D Structure and Physics of the Genome established at UMMS

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In an Industry Shaped by Decades of Decisions, Dala Wellness Seeks to Challenge the Status Quo: A Conversation With Founder Fahed Al Essa – Yahoo…

SEATTLE, WA / ACCESSWIRE / February 2, 2020 / The crux of Dala's mission is to address rheumatoid arthritis (RA) from a holistic perspective. Traditionally, the US healthcare industry has sought to diagnose and prescribe as necessary. Consequently, it may be a source of global medical innovation but also is burdened with the highest costs globally that achieve mediocre to poor health outcomes.

We have grown to become a nation that is looking for quick fixes, bandaids, or a pill to solve a problem. This complements the healthcare system that addresses highly variable medical conditions with the conventional paradigm of biochemistry and medicine; we treat symptoms, not the underlying problem.

"America's health-care system focuses on curing acute problems but does far too little to support patients with chronic maladies" - Arthur Kleinman (WSJ article).

At Dala Wellness, founders have thoroughly researched current "fixes" for RA and developed their own solution via a modular program which includes a supplement, topical solution, and live community board so their members can receive support during their treatment. They are focused on the mind, body, and soul. Fahed Al Essa, founder of Dala Wellness, contributes to this conversation.

How Dala Wellness is challenging the status quo

While many self-focusing treatments leave a myriad of decisions up to the patient, Dala seeks to remove this burden and provide a gentle guide in his/her treatment. While empowering the patient is important, creating a vague, self-guided treatment can lead to decision paralysis and often results in unintended effects and/or no improvement. "Dala Wellness is not this type of company. We plan to complement the patient's medical journey, not replace it," Essa states.

"For example, outside of pharmaceutical interventions, we employ numerous evidence-based complementary therapies that can improve a patient's quality of life and ability to manage symptoms, from nutrition support and elimination diets for inflammation to mindfulness and cognitive behavioral therapy approaches that reframe pain and build resilience. This is in addition to our natural supplements."

Dala Wellness Pioneering an Industry

The short answer is: no, there are no comprehensive treatment programs like Dala that are currently in the market for RA. While the internet postulates the applications of herbal medicine to treat RA, there are no modules that combine natural medicine with mindfulness as specifically to the RA patient subset like Dala does. Dala provides a pathway for patients to combine various facets of integrative medicine to attack RA head-on.

US Expansion for Dala Wellness

The US, as a developed nation, has had notable rates of chronic condition prevalence. This has burdened the system with elevated healthcare costs, epidemics (e.g. opioid crisis in treating chronic pain), and inefficiencies in the healthcare chain. Dala is a pioneer in this realm, seeking to address life with chronic pain. As mentioned by founder Fahed Al Essa, "We're supporting the health system in the US rather than adding cost to it. We're hoping to line up efficiencies in care for the patient, which then leads to cost-effectiveness within the system."

The Future of Dala Wellness

"Ultimately, the future is providing access to care - whatever that means. We want to make our platform affordable and accessible to any RA patient. Wherever that path leads!" according to Essa.

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In an Industry Shaped by Decades of Decisions, Dala Wellness Seeks to Challenge the Status Quo: A Conversation With Founder Fahed Al Essa - Yahoo...