David Cortez, Richard N. ArmstrongChairforInnovation inBiochemistryandprofessor of biochemistry, has been named interimchairintheDepartment ofBiochemistrybeginningJan. 1.

This follows the departure of John York, who was recently named chief science officer of food technology startup Impossible Foods and will be moving to California.

The investments that Dr. York directed into the infrastructure, training and people in the Department of Biochemistry have been transformative. Simply put, I want to build on this momentum, Cortez said. I look forward to working with the faculty, staff and trainees to continue our shared pursuit of excellence in science discovery and education. The people in this department and at Vanderbilt make it special, and I will do everything I can to support them as they pursue their goals.

Cortez, also associate director for basic sciences research at theVanderbilt-Ingram Cancer Center, specializes in understanding the function of DNA damage response pathways in maintaining a healthy genome, and in understanding how those pathways are activated. His labs current projects include identifying new proteins involved in DNA damage response and developing cancer therapeutics that target that response. The trans-institutional Cortez lab is connected to theGenome Maintenance Research Programwithin the VICC,the Center in Molecular Toxicology,Vanderbilt Institute of Chemical Biologyand the Department of Biochemistry.

During Yorks tenure, the Department of Biochemistry became 2019s top NIH-funded department in the nation.

During Yorks tenure, the Department of Biochemistry became 2019s top NIH-funded department in the nation. With an expanded and diversified faculty, he invigorated the graduate and development research programs, building a shared sense of purpose and community in the department. These efforts fostered an environment that supports discovery science and curiosity-driven research, saidLawrence Marnett, dean of School of Medicine Basic Sciences.

My time at Vanderbilt has been a remarkable professional experience and a tremendous privilege. Together, we have built a discovery-science environment for recruitment of diverse faculty and trainees, York said. The commitment to academic excellence and pursuit of transformative solutions to problems facing the world shared by my colleagues and students is unparalleled, and the department is well-positioned to continue its steep upward trajectory. Iintend to maintain the One Vanderbilt spirit of collaboration in the next phase of my career and will remain a friend to all the wonderful colleagues I have worked with over the past nine years.

It has been an honor to work with John, who not only significantly increased funding for the Department of Biochemistry, but has also helped to establish Vanderbilt as a top destination for world-class faculty and scholars determined to make life-changing discoveries, said Provost and Vice Chancellor for Academic AffairsSusan R. Wente. I wish him luck with his next venture and am confident that David Cortez has the dedication and the visionary leadership to continue the remarkable momentum that John has established.

Cortez graduated summa cum laude from the University of Illinois at Champaign-Urbana with highest honors in biology and biochemistry and received his Ph.D. in molecular cancer biology from Duke University. After postdoctoral training as a Jane Coffin Childs Fellow with Stephen Elledge at the Baylor College of Medicine, he joined Vanderbilt in 2002. In 2009, Cortez was named professor of biochemistry and Ingram Professor of Cancer Research. His achievements have been recognized with the Howard Temin Award from the National Cancer Institute, the Wilson S. Stone Memorial Award from the MD Anderson Cancer Center and a Pew Scholar Award from the Pew Charitable Trusts. Cortez is a member of the editorial boards of the journalsCell ReportsandScience Advances, and in 2017 he was named a fellow of the American Association for the Advancement of Science.

While the departure of an esteemed colleague is never good news, we are proud of what John has built and wish him well in this exciting new endeavor. Our biochemistry students and faculty have benefitted tremendously from the hard work and dedication that John brought to his role, Marnett said. We are also extremely fortunate to have a world-class scientist like Dave Cortez assume the leadership of the department and continue its momentum. I look forward to working with him and anticipate he will be very successful.

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Cortez named interim chair in the Department of Biochemistry; York named Impossible Foods chief science officer - Vanderbilt University News

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Adv Radiat Oncol. 2020 Aug 31;5(6):1126-1140. doi: 10.1016/j.adro.2020.07.009. eCollection 2020 Nov-Dec.

ABSTRACT

PURPOSE: There is increasing use of radical prostatectomy to treat patients with high-risk prostate cancer. This has contributed toward a pathologic stage migration, and a greater number of patients are subsequently being diagnosed with biochemical failure. There is increasing use of advanced imaging techniques in the setting of biochemical failure, including positron emission tomography-computed tomography (PET-CT).

METHODS AND MATERIALS: This critical literature review highlights the evidence for PET-CT in postprostatectomy biochemical failure and identifies sites of pelvic lymph node relapse in the setting of biochemical failure and the potential implications that the locations of these relapses may have for salvage therapies. Potential future directions are then considered.

RESULTS: The optimal PET-CT tracer remains uncertain but there is increasing use of prostate-specific membrane antigen PET-CT for investigating sites of nodal metastasis at low prostate-specific antigen levels, and this is leading to a blurring of the biochemical and radiologic recurrence phases. The optimal therapeutic approach remains undefined, with current trials investigating postoperative radiation therapy to the whole pelvis in addition to the prostatic fossa, the use of PET-CT in the setting of biochemical recurrence to guide delivery of salvage radiation therapy, and, for patients with node-only relapsed prostate cancer, the addition of whole pelvis radiation therapy to metastasis-directed therapies such as stereotactic ablative radiotherapy.

CONCLUSIONS: The most appropriate target volume for salvage radiation therapy remains uncertain, and the findings of studies using PET-CT to map nodal recurrences suggest that there could be a role for extending whole pelvis radiation therapy volumes to increase coverage of superior nodal regions. The emerging fields of radiomics and radiogenomics could provide important prognostic information and aid decision making for patients with relapsed prostate cancer.

PMID:33305073 | PMC:PMC7718540 | DOI:10.1016/j.adro.2020.07.009

Excerpt from:
Patterns of Lymph Node Failure in Patients With Recurrent Prostate Cancer Postradical Prostatectomy and Implications for Salvage Therapies - DocWire...

Overview Of Biochemistry Analyzer Industry 2020-2028:

This has brought along several changes in This report also covers the impact of COVID-19 on the global market.

The Biochemistry Analyzer Market analysis summary by Reports Insights is a thorough study of the current trends leading to this vertical trend in various regions. Research summarizes important details related to market share, market size, applications, statistics and sales. In addition, this study emphasizes thorough competition analysis on market prospects, especially growth strategies that market experts claim.

Biochemistry Analyzer Market competition by top manufacturers as follow: URIT Medical Electronic, ELITechGroup, EKF Diagnostics, Spinreact, Mindray, Danaher, Roche Diagnostics

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The global Biochemistry Analyzer market has been segmented on the basis of technology, product type, application, distribution channel, end-user, and industry vertical, along with the geography, delivering valuable insights.

The Type Coverage in the Market are:

Semi-Automatic Biochemical Analyzers

Fully Automated Biochemistry Analyzers

Market Segment by Applications, covers:

Academic Research Institutes

Biotechnology Companies

Contract Research Organizations

Diagnostic Centres

Hospitals

Pharmaceutical Companies

Others

Market segment by Regions/Countries, this report coversNorth AmericaEuropeChinaRest of Asia PacificCentral & South AmericaMiddle East & Africa

Major factors covered in the report:

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The analysis objectives of the report are:

Our report offers:

Market share assessments for the regional and country level segments. Market share analysis of the top industry players. Strategic recommendations for the new entrants. Market forecasts for a minimum of 9 years of all the mentioned segments, sub segments and the regional markets. Market Trends (Drivers, Constraints, Opportunities, Threats, Challenges, Investment Opportunities, and recommendations). Strategic recommendations in key business segments based on the market estimations. Competitive landscaping mapping the key common trends. Company profiling with detailed strategies, financials, and recent developments. Supply chain trends mapping the latest technological advancements.

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Biochemistry Analyzer Market Incredible Possibilities, Growth Analysis and Forecast To 2028 ELITechGroup, EKF Diagnostics, Spinreact, Mindray - The...

LSU CANCER RESEARCH: TheAmerican Association for the Advancement of Science has honoredSuresh Alahari, of theLSU Health New Orleans School of Medicine, as a fellow, in recognition of hiscontributions in cancer research and teaching, with a focus on signal transduction. His research interests include the biochemistry of cell adhesion and the mechanism of action of Nischarin in tumor cell migration and invasion. Nischarin is a novel protein Alahari discovered that is involved in a number of biological processes, including the regulation of breast cancer cell migration and movement. He joined the LSU Health New Orleans faculty in 2004.

LSU HEALTH GRADUATE STUDIES: TheAssociation for Research in Vision and Ophthalmology has awarded its Emerging Advocate Award to Jarrod C. Harman, a student at LSU Health New Orleans School of Graduate Studies. The award recognizes ARVO members who have made efforts to integrate advocacy as part of their professional efforts early in their careers. Harman, who is pursuing a doctorate of philosophy degree in biochemistry and molecular biology, has been active in the Student Government Association at LSU Health New Orleans. He served as vice president and interim president. His advocacy work has included lobbying in Washington, D.C., for funding for the National Eye Institute and working with the Louisiana Lions Eye Foundation to perform vision screenings at inner-city primary schools.

OCHSNER BAPTIST: TheWomens Wellness and Survivorship Center at Ochsner Baptist will be the beneficiary of the New Me Time Challenge presented by the Crescent City Classic and Ochsner Health. The virtual challenge,focused on physical and mental health, is running through Jan. 14. The entry cost for either the 30-mile individual challenge or the 100-mile team challenge is $35. For every 5 miles logged, participants will unlock health-focused tips along with special access to wellness and nutrition offers provided by Ochsner Health. To register,visit http://www.ccc10k.com. For information, email customer.service@ccc10k.com.

SURVIVORS OF SUICIDE SUPPORT GROUP:NOLA Survivors of Suicide Loss is a free, peer-led support group for adults who have lost a loved one to suicide. The usual Zoom meeting time for the group is from 6:30 p.m. to 8 p.m. on the second and fourth Wednesdays of each month; to register to attend a meeting, visitnolasurvivors.com/contact-usor email survivors.nola@gmail.com.

UNIVERSITY OF HOLY CROSS:Free telecounseling is available from 11 a.m. to 8 p.m. Monday through Thursday from the University of Holy Cross. To schedule a session, call (504) 398-2168.

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LSU cancer researcher recognized, and other metro area health news - NOLA.com

IndustryGrowthInsights, one of the worlds prominent market research firms has announced a novel report on the Laboratory Biochemical Reagent market. The report is integrated with imperative insights on the market which will support the clients to make precise business decisions. This research will help both existing and new aspirants for Global Laboratory Biochemical Reagent Market to figure out and study market requirements, market size, and competition. The report incorporates data regarding the supply and demand situation, the competitive scenario, and the challenges for market growth, market opportunities, and the threats encountered by key players during the forecast period of 2020-2027.

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Impact of COVID-19

The report also incorporates the impact of the ongoing global crisis i.e. COVID-19 on the Laboratory Biochemical Reagent market and explains how the future is going to unfold for the global market. The report also provides an analysis of the effects of the pandemic on the global economy. The outbreak has directly affected production and demand disrupted the demand and supply chain. The report also computes the financial impact on firms and financial markets. IndustryGrowthInsights has accumulated insights from various delegates of the industry and got involved in the primary and secondary research to offer the clients data & strategies to combat the market challenges during and after the COVID-19 pandemic.

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Some of the major companies that are covered in this report:

Beckton, Dickinson & CompanyMerck & Co. Inc.Abbott LaboratoriesAgilent Technologies, Inc.Waters CorporationSiemens HealthineersThermo Fisher Scientific IncBio-Rad LaboratoriesRoche Holding AGJohnson & Johnson

*Note: Additional companies can be included on request

The market scenario is likely to be fairly competitive. To analyze any market with simplicity the market is fragmented into the following segments:

By Application:

HospitalsDiagnostic CentersAcademics and ResearchPharma and Biotech CompaniesCROs

By Type:

PCR Reagent KitsCell and Tissue Culture ReagentsElectrophoresis ReagentsChromatography ReagentsOthers

By Geographical Regions

Asia Pacific: China, Japan, India, and Rest of Asia PacificEurope: Germany, the UK, France, and Rest of EuropeNorth America: The US, Mexico, and CanadaLatin America: Brazil and Rest of Latin AmericaMiddle East & Africa: GCC Countries and Rest of Middle East & Africa

Segmenting the market into smaller components helps in analyzing the dynamics of the market with more clarity. Another key component that is integrated into the report is the regional analysis to assess the global presence of the Laboratory Biochemical Reagent market. You can also opt for a yearly subscription of all the updates on the Laboratory Biochemical Reagent market.

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Executive Summary

Assumptions and Acronyms Used

Research Methodology

Laboratory Biochemical Reagent Market Overview

Global Laboratory Biochemical Reagent Market Analysis and Forecast by Type

Global Laboratory Biochemical Reagent Market Analysis and Forecast by Application

Global Laboratory Biochemical Reagent Market Analysis and Forecast by Sales Channel

Global Laboratory Biochemical Reagent Market Analysis and Forecast by Region

North America Laboratory Biochemical Reagent Market Analysis and Forecast

Latin America Laboratory Biochemical Reagent Market Analysis and Forecast

Europe Laboratory Biochemical Reagent Market Analysis and Forecast

Asia Pacific Laboratory Biochemical Reagent Market Analysis and Forecast

Asia Pacific Laboratory Biochemical Reagent Market Size and Volume Forecast by Application

Middle East & Africa Laboratory Biochemical Reagent Market Analysis and Forecast

Competition Landscape

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Laboratory Biochemical Reagent Market ? What Factors Will Drive The Market In Upcoming Years And How It Is Going To Impact On Global Industry |...

DNA synthesis can be used to generate true random numbers. Credit: Isabelle Benz

ETH scientists have generated a huge true random number using DNA synthesis. It is the first time that a number of this magnitude has been created by biochemical means.

True random numbers are required in fields as diverse as slot machines and data encryption. These numbers need to be truly random, such that they cannot even be predicted by people with detailed knowledge of the method used to generate them.

As a rule, they are generated using physical methods. For instance, thanks to the tiniest high-frequency electron movements, the electrical resistance of a wire is not constant but instead fluctuates slightly in an unpredictable way. That means measurements of this background noise can be used to generate true random numbers.

Now, for the first time, a research team led by Robert Grass, Professor at the Institute of Chemical and Bioengineering, has described a non-physical method of generating such numbers: one that uses biochemical signals and actually works in practice. In the past, the ideas put forward by other scientists for generating random numbers by chemical means tended to be largely theoretical.

For this new approach, the ETH researchers apply the synthesis of DNA molecules, an established chemical research method frequently employed over many years. It is traditionally used to produce a precisely defined DNA sequence. In this case, however, the research team built DNA molecules with 64 building block positions, in which one of the four DNA bases A, C, G and T was randomly located at each position. The scientists achieved this by using a mixture of the four building blocks, rather than just one, at every step of the synthesis.

As a result, a relatively simple synthesis produced a combination of approximately three quadrillion individual molecules. The scientists subsequently used an effective method to determine the DNA sequence of five million of these molecules. This resulted in 12 megabytes of data, which the researchers stored as zeros and ones on a computer.

However, an analysis showed that the distribution of the four building blocks A, C, G and T was not completely even. Either the intricacies of nature or the synthesis method deployed led to the bases G and T being integrated more frequently in the molecules than A and C. Nonetheless, the scientists were able to correct this bias with a simple algorithm, thereby generating perfect random numbers.

The main aim of ETH Professor Grass and his team was to show that random occurrences in chemical reaction can be exploited to generate perfect random numbers. Translating the finding into a direct application was not a prime concern at first. Compared with other methods, however, ours has the advantage of being able to generate huge quantities of randomness that can be stored in an extremely small space, a single test tube, Grass says. We can read out the information and reinterpret it in digital form at a later date. This is impossible with the previous methods.

Reference: DNA synthesis for true random number generation by Linda C. Meiser, Julian Koch, Philipp L. Antkowiak, Wendelin J. Stark, Reinhard Heckel and Robert N. Grass, 18 November 2020,Nature Communications.DOI: 10.1038/s41467-020-19757-y

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Biochemical Random Number: Scientists Have Generated a Huge True Random Number Using DNA Synthesis - SciTechDaily

CLAREMONT, Calif.--(BUSINESS WIRE)--Synedgen, a biotechnology company using glycopolymer chemistry to develop drugs that enhance and control signaling in the innate immune system, today announced that UNSW in partnership with Synedgen has been awarded an A$600,633, 3-year, research grant from the Australian Research Council (ARC) to advance knowledge of the biochemical and biophysical structure of the endothelial glycocalyx. The resulting study will be the first to explore how charged glycopolymers interact with the endothelial glycocalyx with the goal of mapping the lifecycle of the network of membrane-bound proteoglycans and glycoprotein.

Synedgen is developing molecules that interact with the glycocalyx to control the movement of cells and molecules across the endothelium and we are keen to deepen the understanding of the dynamic structure of and implicit role of the endothelial glycocalyx in innate immune signaling. This ARC-funded project aims to address this knowledge deficit by mechanistically elucidating and describing the dynamic lifecycle of the endothelial glycocalyx, said Shenda Baker, Ph.D., President and Chief Executive Officer of Synedgen. We are grateful to the ARC for this grant and honored to be working with Drs. Megan Lord and John Whitelock of the University of New South Wales, experts in proteoglycan interactions and signaling. We anticipate that results of these efforts can be leveraged to inform the development of targeted molecules to treat diseases involving the endothelial glycocalyx including cardiovascular and pulmonary diseases, stroke and traumatic brain injury.

We still have much to learn about the structure and dynamics of the endothelial glycocalyx, a network of proteoglycans and glycosaminoglycans anchored at the cell surface, said Megan Lord, Ph.D., lead PI on the grant. Synedgens glycopolymers will enable us to study interactions at the endothelial interface and develop new ways to support endothelial functions.

Synedgen believes the findings of the ARC-sponsored project will inform the companys future research and development activities over the next 3-7 years.

Synedgens CEO, Shenda Baker, gave a related keynote lecture at the Pan Pacific Connective Tissue Societies Symposium on November 25, 2020, titled, Glycopolymer interactions with the glycocalyx to modulate innate immune responses after dermal injury. The 12th Pan Pacific Connective Tissue Societies Symposium, a virtual event held in November 2020, was held in conjunction with the scientific meetings of the Australian Wound & Tissue Repair Society (AWTRS) and Matrix Biology Society of Australia and New Zealand (MBSANZ).

About Synedgen

Synedgen is a biotechnology company using glycochemistry to develop drugs that enhance and mimic the innate immune system. The companys lead development candidate is SYGN305 for gastrointestinal mucositis, where a large unmet need exists to prevent intestinal radiation injury, the single most important dose-limiting factor in cancer radiotherapy. Synedgens glycopolymer platform has already generated five FDA 510(k)-cleared therapeutics, one OTC drug, one veterinary indexed drug, and an out-licensed Phase 2 program, to Synspira, for the potential treatment of pulmonary complications of cystic fibrosis. Synedgen has research and manufacturing facilities in Claremont, California. For more information please visit http://www.synedgen.com.

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Synedgen Partnership with the University of New South Wales Receives Australian Research Council (ARC) Grant - Business Wire

Market Report Summary

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The clinical use of biochemistry analyzers in measurement solutions such as latex agglutination, ion-selective potentiometry, and colorimetric & photometric testing. In addition to this, accuracy of biochemistry analyzers in analyzing blood and urine samples has benefited pathology labs and diagnostic centers across the globe. Persistence Market Research predicts that the global demand for biochemistry analyzers will continue to soar on the grounds of such factors.

A recent report published by Persistence Market Research projects that by the end of 2024, the global market for biochemistry analyzers will reach US$ 4,625.3 Mn in terms of value.

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Company Profiles

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Key findings in the report cite that the use of chemistry analyzers spans from high-throughput clinical labs to point-of-care clinics, and its use for testing enzymes, electrolytes and proteins is gaining traction.

The report current values the globalbiochemistry analyzer marketat a little over US$ 3,000 Mn. During the forecast period, revenues generated through global sales of biochemistry analyzers are, thus, expected to soar at a steady CAGR of 5.5%.

Key Research Insights from the Report include:

The global market for biochemistry analyzers represents absolute $ opportunity of US$ 154.6 Mn in 2017 over 2016 and incremental opportunity of US$ 1,570.8 Mn between 2016 and 2024

Apart from clinical diagnostics, critical applications of biochemistry analyzers include drugs-of-abuse testing and diagnostic testing of patients metabolic functions

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Over 40% of biochemistry analyzers sold across the globe during the forecast period will be concentrated in North America

Demand for biochemistry analyzers is also expected to surge in Asia-Pacific, revenues from which will record steadfast growth at 6.1% CAGR

Leading manufacturers of biochemistry analyzers are developing multiplexing analyzers a cost-effective upgrade to existing product line

The report further reveals that fully-automated biochemistry analyzers will remain in great demand in the years to come. In 2017 and beyond, more than 85% of global biochemistry analyzer revenues will be accounted by sales of fully-automated biochemistry analyzers.

Moreover, clinical diagnostics will also remain the largest application of biochemistry analyzers throughout the forecast period. Revenues accounted by global sales of biochemistry analyzers in clinical diagnostics are anticipated to register speedy growth at 5.7% CAGR.

The report further identifies diagnostic centers as largest end-users of biochemistry analyzers in the world. On the other hand, rising number of point-of-care diagnostic labs instated in hospitals will render a key end-user of biochemistry analyzers. Together, hospitals and diagnostics centers will be responsible for procure over two-third of global biochemistry analyzers revenues through 2024.

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Persistence Market Research (PMR) is a third-platform research firm. Our research model is a unique collaboration of data analytics and market research methodology to help businesses achieve optimal performance.

To support companies in overcoming complex business challenges, we follow a multi-disciplinary approach. At PMR, we unite various data streams from multi-dimensional sources. By deploying real-time data collection, big data, and customer experience analytics, we deliver business intelligence for organizations of all sizes.

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The Biochemistry Analyser Market To Revive The Growth Indices, Reach US$ 4700 Million - Cheshire Media

The global Automotive MEMS Sensors market is broadly analyzed in this report that sheds light on critical aspects such as the vendor landscape, competitive strategies, market dynamics, and regional analysis. The report helps readers to clearly understand the current and future status of the global Automotive MEMS Sensors market. The research study comes out as a compilation of useful guidelines for players to secure a position of strength in the global Automotive MEMS Sensors market. The authors of the report profile leading companies of the global Automotive MEMS Sensors market, such as Analog Devices Inc., Delphi Automotive PLC, Denso Corporation, Freescale Semiconductor, Inc., General Electric Company, Harman International Industries, Inc., Hitachi Ltd., Infineon Technologies AG, InvenSense, Inc., Murata Manufacturing Co. Ltd., Panasonic Corporation, Robert Bosch GmbH, STMicroelectronics N.V., Sensata Technologies, Inc. They provide details about important activities of leading players in the competitive landscape.

The report predicts the size of the global Automotive MEMS Sensors market in terms of value and volume for the forecast period 2019-2026. As per the analysis provided in the report, the global Automotive MEMS Sensors market is expected to rise at a CAGR of XX % between 2019 and 2026 to reach a valuation of US$ XX million/billion by the end of 2026. In 2018, the global Automotive MEMS Sensors market attained a valuation of US$_ million/billion. The market researchers deeply analyze the global Automotive MEMS Sensors industry landscape and the future prospects it is anticipated to create.

This publication includes key segmentations of the global Automotive MEMS Sensors market on the basis of product, application, and geography (country/region). Each segment included in the report is studied in relation to different factors such as consumption, market share, value, growth rate, and production.

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The comparative results provided in the report allow readers to understand the difference between players and how they are competing against each other. The research study gives a detailed view of current and future trends and opportunities of the global Automotive MEMS Sensors market. Market dynamics such as drivers and restraints are explained in the most detailed and easiest manner possible with the use of tables and graphs. Interested parties are expected to find important recommendations to improve their business in the global Automotive MEMS Sensors market.

Readers can understand the overall profitability margin and sales volume of various products studied in the report. The report also provides the forecasted as well as historical annual growth rate and market share of the products offered in the global Automotive MEMS Sensors market. The study on end-use application of products helps to understand the market growth of the products in terms of sales.

Global Automotive MEMS Sensors Market by Product: , Pressure Sensor, Accelerometer, Gyroscope, Others

Global Automotive MEMS Sensors Market by Application: , Safety and Chassis, Powertrain, Infotainment, Body and Convenience

The report also focuses on the geographical analysis of the global Automotive MEMS Sensors market, where important regions and countries are studied in great detail.

Global Automotive MEMS Sensors Market by Geography:

Methodology

Our analysts have created the report with the use of advanced primary and secondary research methodologies.

As part of primary research, they have conducted interviews with important industry leaders and focused on market understanding and competitive analysis by reviewing relevant documents, press releases, annual reports, and key products.

For secondary research, they have taken into account the statistical data from agencies, trade associations, and government websites, internet sources, technical writings, and recent trade information.

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Table Of Contents:

1 Automotive MEMS Sensors Market Overview1.1 Automotive MEMS Sensors Product Overview1.2 Automotive MEMS Sensors Market Segment by Type1.2.1 Pressure Sensor1.2.2 Accelerometer1.2.3 Gyroscope1.2.4 Others1.3 Global Automotive MEMS Sensors Market Size by Type (2015-2026)1.3.1 Global Automotive MEMS Sensors Market Size Overview by Type (2015-2026)1.3.2 Global Automotive MEMS Sensors Historic Market Size Review by Type (2015-2020)

1.3.2.1 Global Automotive MEMS Sensors Sales Market Share Breakdown by Type (2015-2020)

1.3.2.2 Global Automotive MEMS Sensors Revenue Market Share Breakdown by Type (2015-2020)

1.3.2.3 Global Automotive MEMS Sensors Average Selling Price (ASP) by Type (2015-2020)1.3.3 Global Automotive MEMS Sensors Market Size Forecast by Type (2021-2026)

1.3.3.1 Global Automotive MEMS Sensors Sales Market Share Breakdown by Type (2021-2026)

1.3.3.2 Global Automotive MEMS Sensors Revenue Market Share Breakdown by Type (2021-2026)

1.3.3.3 Global Automotive MEMS Sensors Average Selling Price (ASP) by Type (2021-2026)1.4 Key Regions Market Size Segment by Type (2015-2020)1.4.1 North America Automotive MEMS Sensors Sales Breakdown by Type (2015-2020)1.4.2 Europe Automotive MEMS Sensors Sales Breakdown by Type (2015-2020)1.4.3 Asia-Pacific Automotive MEMS Sensors Sales Breakdown by Type (2015-2020)1.4.4 Latin America Automotive MEMS Sensors Sales Breakdown by Type (2015-2020)1.4.5 Middle East and Africa Automotive MEMS Sensors Sales Breakdown by Type (2015-2020) 2 Global Automotive MEMS Sensors Market Competition by Company2.1 Global Top Players by Automotive MEMS Sensors Sales (2015-2020)2.2 Global Top Players by Automotive MEMS Sensors Revenue (2015-2020)2.3 Global Top Players Automotive MEMS Sensors Average Selling Price (ASP) (2015-2020)2.4 Global Top Manufacturers Automotive MEMS Sensors Manufacturing Base Distribution, Sales Area, Product Type2.5 Automotive MEMS Sensors Market Competitive Situation and Trends2.5.1 Automotive MEMS Sensors Market Concentration Rate (2015-2020)2.5.2 Global 5 and 10 Largest Manufacturers by Automotive MEMS Sensors Sales and Revenue in 20192.6 Global Top Manufacturers by Company Type (Tier 1, Tier 2 and Tier 3) (based on the Revenue in Automotive MEMS Sensors as of 2019)2.7 Date of Key Manufacturers Enter into Automotive MEMS Sensors Market2.8 Key Manufacturers Automotive MEMS Sensors Product Offered2.9 Mergers & Acquisitions, Expansion 3 Global Automotive MEMS Sensors by Region (2015-2026)3.1 Global Automotive MEMS Sensors Market Size and CAGR by Region: 2015 VS 2020 VS 20263.2 Global Automotive MEMS Sensors Market Size Market Share by Region (2015-2020)3.2.1 Global Automotive MEMS Sensors Sales Market Share by Region (2015-2020)3.2.2 Global Automotive MEMS Sensors Revenue Market Share by Region (2015-2020)3.2.3 Global Automotive MEMS Sensors Sales, Revenue, Price and Gross Margin (2015-2020)3.3 Global Automotive MEMS Sensors Market Size Market Share by Region (2021-2026)3.3.1 Global Automotive MEMS Sensors Sales Market Share by Region (2021-2026)3.3.2 Global Automotive MEMS Sensors Revenue Market Share by Region (2021-2026)3.3.3 Global Automotive MEMS Sensors Sales, Revenue, Price and Gross Margin (2021-2026) 4 Global Automotive MEMS Sensors by Application4.1 Automotive MEMS Sensors Segment by Application4.1.1 Safety and Chassis4.1.2 Powertrain4.1.3 Infotainment4.1.4 Body and Convenience4.2 Global Automotive MEMS Sensors Sales by Application: 2015 VS 2020 VS 20264.3 Global Automotive MEMS Sensors Historic Sales by Application (2015-2020)4.4 Global Automotive MEMS Sensors Forecasted Sales by Application (2021-2026)4.5 Key Regions Automotive MEMS Sensors Market Size by Application4.5.1 North America Automotive MEMS Sensors by Application4.5.2 Europe Automotive MEMS Sensors by Application4.5.3 Asia-Pacific Automotive MEMS Sensors by Application4.5.4 Latin America Automotive MEMS Sensors by Application4.5.5 Middle East and Africa Automotive MEMS Sensors by Application 5 North America Automotive MEMS Sensors Market Size by Country (2015-2026)5.1 North America Market Size Market Share by Country (2015-2020)5.1.1 North America Automotive MEMS Sensors Sales Market Share by Country (2015-2020)5.1.2 North America Automotive MEMS Sensors Revenue Market Share by Country (2015-2020)5.2 North America Market Size Market Share by Country (2021-2026)5.2.1 North America Automotive MEMS Sensors Sales Market Share by Country (2021-2026)5.2.2 North America Automotive MEMS Sensors Revenue Market Share by Country (2021-2026) 6 Europe Automotive MEMS Sensors Market Size by Country (2015-2026)6.1 Europe Market Size Market Share by Country (2015-2020)6.1.1 Europe Automotive MEMS Sensors Sales Market Share by Country (2015-2020)6.1.2 Europe Automotive MEMS Sensors Revenue Market Share by Country (2015-2020)6.2 Europe Market Size Market Share by Country (2021-2026)6.2.1 Europe Automotive MEMS Sensors Sales Market Share by Country (2021-2026)6.2.2 Europe Automotive MEMS Sensors Revenue Market Share by Country (2021-2026) 7 Asia-Pacific Automotive MEMS Sensors Market Size by Region (2015-2026)7.1 Asia-Pacific Market Size Market Share by Region (2015-2020)7.1.1 Asia-Pacific Automotive MEMS Sensors Sales Market Share by Region (2015-2020)7.1.2 Asia-Pacific Automotive MEMS Sensors Revenue Market Share by Region (2015-2020)7.2 Asia-Pacific Market Size Market Share by Region (2021-2026)7.2.1 Asia-Pacific Automotive MEMS Sensors Sales Market Share by Region (2021-2026)7.2.2 Asia-Pacific Automotive MEMS Sensors Revenue Market Share by Region (2021-2026) 8 Latin America Automotive MEMS Sensors Market Size by Country (2015-2026)8.1 Latin America Market Size Market Share by Country (2015-2020)8.1.1 Latin America Automotive MEMS Sensors Sales Market Share by Country (2015-2020)8.1.2 Latin America Automotive MEMS Sensors Revenue Market Share by Country (2015-2020)8.2 Latin America Market Size Market Share by Country (2021-2026)8.2.1 Latin America Automotive MEMS Sensors Sales Market Share by Country (2021-2026)8.2.2 Latin America Automotive MEMS Sensors Revenue Market Share by Country (2021-2026) 9 Middle East and Africa Automotive MEMS Sensors Market Size by Country (2015-2026)9.1 Middle East and Africa Market Size Market Share by Country (2015-2020)9.1.1 Middle East and Africa Automotive MEMS Sensors Sales Market Share by Country (2015-2020)9.1.2 Middle East and Africa Automotive MEMS Sensors Revenue Market Share by Country (2015-2020)9.2 Middle East and Africa Market Size Market Share by Country (2021-2026)9.2.1 Middle East and Africa Automotive MEMS Sensors Sales Market Share by Country (2021-2026)9.2.2 Middle East and Africa Automotive MEMS Sensors Revenue Market Share by Country (2021-2026) 10 Company Profiles and Key Figures in Automotive MEMS Sensors Business10.1 Analog Devices Inc.10.1.1 Analog Devices Inc. Corporation Information10.1.2 Analog Devices Inc. Description, Business Overview10.1.3 Analog Devices Inc. Automotive MEMS Sensors Sales, Revenue and Gross Margin (2015-2020)10.1.4 Analog Devices Inc. Automotive MEMS Sensors Products Offered10.1.5 Analog Devices Inc. Recent Developments10.2 Delphi Automotive PLC10.2.1 Delphi Automotive PLC Corporation Information10.2.2 Delphi Automotive PLC Description, Business Overview10.2.3 Delphi Automotive PLC Automotive MEMS Sensors Sales, Revenue and Gross Margin (2015-2020)10.2.4 Analog Devices Inc. Automotive MEMS Sensors Products Offered10.2.5 Delphi Automotive PLC Recent Developments10.3 Denso Corporation10.3.1 Denso Corporation Corporation Information10.3.2 Denso Corporation Description, Business Overview10.3.3 Denso Corporation Automotive MEMS Sensors Sales, Revenue and Gross Margin (2015-2020)10.3.4 Denso Corporation Automotive MEMS Sensors Products Offered10.3.5 Denso Corporation Recent Developments10.4 Freescale Semiconductor, Inc.10.4.1 Freescale Semiconductor, Inc. Corporation Information10.4.2 Freescale Semiconductor, Inc. Description, Business Overview10.4.3 Freescale Semiconductor, Inc. Automotive MEMS Sensors Sales, Revenue and Gross Margin (2015-2020)10.4.4 Freescale Semiconductor, Inc. Automotive MEMS Sensors Products Offered10.4.5 Freescale Semiconductor, Inc. Recent Developments10.5 General Electric Company10.5.1 General Electric Company Corporation Information10.5.2 General Electric Company Description, Business Overview10.5.3 General Electric Company Automotive MEMS Sensors Sales, Revenue and Gross Margin (2015-2020)10.5.4 General Electric Company Automotive MEMS Sensors Products Offered10.5.5 General Electric Company Recent Developments10.6 Harman International Industries, Inc.10.6.1 Harman International Industries, Inc. Corporation Information10.6.2 Harman International Industries, Inc. Description, Business Overview10.6.3 Harman International Industries, Inc. Automotive MEMS Sensors Sales, Revenue and Gross Margin (2015-2020)10.6.4 Harman International Industries, Inc. Automotive MEMS Sensors Products Offered10.6.5 Harman International Industries, Inc. Recent Developments10.7 Hitachi Ltd.10.7.1 Hitachi Ltd. Corporation Information10.7.2 Hitachi Ltd. Description, Business Overview10.7.3 Hitachi Ltd. Automotive MEMS Sensors Sales, Revenue and Gross Margin (2015-2020)10.7.4 Hitachi Ltd. Automotive MEMS Sensors Products Offered10.7.5 Hitachi Ltd. Recent Developments10.8 Infineon Technologies AG10.8.1 Infineon Technologies AG Corporation Information10.8.2 Infineon Technologies AG Description, Business Overview10.8.3 Infineon Technologies AG Automotive MEMS Sensors Sales, Revenue and Gross Margin (2015-2020)10.8.4 Infineon Technologies AG Automotive MEMS Sensors Products Offered10.8.5 Infineon Technologies AG Recent Developments10.9 InvenSense, Inc.10.9.1 InvenSense, Inc. Corporation Information10.9.2 InvenSense, Inc. Description, Business Overview10.9.3 InvenSense, Inc. Automotive MEMS Sensors Sales, Revenue and Gross Margin (2015-2020)10.9.4 InvenSense, Inc. Automotive MEMS Sensors Products Offered10.9.5 InvenSense, Inc. Recent Developments10.10 Murata Manufacturing Co. Ltd.10.10.1 Company Basic Information, Manufacturing Base and Competitors10.10.2 Automotive MEMS Sensors Product Category, Application and Specification10.10.3 Murata Manufacturing Co. Ltd. Automotive MEMS Sensors Sales, Revenue, Price and Gross Margin (2015-2020)10.10.4 Main Business Overview10.10.5 Murata Manufacturing Co. Ltd. Recent Developments10.11 Panasonic Corporation10.11.1 Panasonic Corporation Corporation Information10.11.2 Panasonic Corporation Description, Business Overview10.11.3 Panasonic Corporation Automotive MEMS Sensors Sales, Revenue and Gross Margin (2015-2020)10.11.4 Panasonic Corporation Automotive MEMS Sensors Products Offered10.11.5 Panasonic Corporation Recent Developments10.12 Robert Bosch GmbH10.12.1 Robert Bosch GmbH Corporation Information10.12.2 Robert Bosch GmbH Description, Business Overview10.12.3 Robert Bosch GmbH Automotive MEMS Sensors Sales, Revenue and Gross Margin (2015-2020)10.12.4 Robert Bosch GmbH Automotive MEMS Sensors Products Offered10.12.5 Robert Bosch GmbH Recent Developments10.13 STMicroelectronics N.V.10.13.1 STMicroelectronics N.V. Corporation Information10.13.2 STMicroelectronics N.V. Description, Business Overview10.13.3 STMicroelectronics N.V. Automotive MEMS Sensors Sales, Revenue and Gross Margin (2015-2020)10.13.4 STMicroelectronics N.V. Automotive MEMS Sensors Products Offered10.13.5 STMicroelectronics N.V. Recent Developments10.14 Sensata Technologies, Inc.10.14.1 Sensata Technologies, Inc. Corporation Information10.14.2 Sensata Technologies, Inc. Description, Business Overview10.14.3 Sensata Technologies, Inc. Automotive MEMS Sensors Sales, Revenue and Gross Margin (2015-2020)10.14.4 Sensata Technologies, Inc. Automotive MEMS Sensors Products Offered10.14.5 Sensata Technologies, Inc. Recent Developments 11 Automotive MEMS Sensors Upstream, Opportunities, Challenges, Risks and Influences Factors Analysis11.1 Automotive MEMS Sensors Key Raw Materials11.1.1 Key Raw Materials11.1.2 Key Raw Materials Price11.1.3 Raw Materials Key Suppliers11.2 Manufacturing Cost Structure11.2.1 Raw Materials11.2.2 Labor Cost11.2.3 Manufacturing Expenses11.3 Automotive MEMS Sensors Industrial Chain Analysis11.4 Market Opportunities, Challenges, Risks and Influences Factors Analysis11.4.1 Automotive MEMS Sensors Industry Trends11.4.2 Automotive MEMS Sensors Market Drivers11.4.3 Automotive MEMS Sensors Market Challenges11.4.4 Porters Five Forces Analysis 12 Market Strategy Analysis, Distributors12.1 Sales Channel12.2 Distributors12.3 Downstream Customers 13 Research Findings and Conclusion 14 Appendix14.1 Methodology/Research Approach14.1.1 Research Programs/Design14.1.2 Market Size Estimation14.1.3 Market Breakdown and Data Triangulation14.2 Data Source14.2.1 Secondary Sources14.2.2 Primary Sources14.3 Author Details14.4 Disclaimer

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Biochemical Sensor Market to Witness an Outstanding Growth by 2026| Honeywell, TE Connectivity, NovaSensor - The Market Feed

Biochemistry Analyser is a medical device that uses the pale yellow supernatant portion (serum) of a centrifuged blood sample or a urine sample and contains reactions using reagents to measure various components, such as sugar, cholesterol, protein, enzyme, etc.

Due to the pandemic, we have included a special section on the Impact of COVID 19 on the Biochemistry Analysers Market which would mention How the Covid-19 is affecting the Biochemistry Analysers Industry, Market Trends and Potential Opportunities in the COVID-19 Landscape, Covid-19 Impact on Key Regions and Proposal for Biochemistry Analysers Players to Combat Covid-19 Impact

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The Biochemistry Analysers Market report covers all the elements and offerings quantitative and qualitative statistics about its basics on a global as well as provincial level. It offers a comprehensive overview of the global market along with the market influencing factors. Furthermore, it offers an in-depth description of the global market with respect to the dynamics of the market such as internal and external driving forces, restraining factors, risks, challenges, threats, and opportunities.

In addition, the report is wide-ranging of information on key pillars such as propellers and restraints which also help to understand the changeable trends of industries. The report further also underlines highlights recent trends, tools, and technology platforms that are facilitating to upsurge the performance of the companies.

The Top Key players of Biochemistry Analysers Market:

URIT Medical Electronic, ELITechGroup, Danaher, EKF Diagnostics, Roche Diagnostics, Spinreact, Mindray

The Biochemistry Analysers Market segmentation by Type:

The Biochemistry Analysers Market segmentation by Application:

The Biochemistry Analysers Market segmentation by Region:

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It also offers a comparative study of the Biochemistry Analysers Market to recognize the difference in performance among global competitors. Also, it represents how those competitors competing against each others to drive the trades rapidly. Researchers present enlightening information in a flawless and professional manner. Historical growth rate, as well as forecasted rate, is also mentioned in the report.

Table of Contents:

Chapter 1. Biochemistry Analysers Market Overview

Chapter 2. Market Competition by Players / Suppliers

Chapter 3. Sales and Revenue by Regions

Chapter 4. Sales and Revenue by Type

Chapter 5. Biochemistry Analysers Market Sales and revenue by Application

Chapter 6. Market Players profiles and sales data

Chapter 7. Manufacturing Cost Analysis

Chapter 8. Industrial Chain, Sourcing Strategy and Down Stream Buyers

Chapter 9. Market Strategy Analysis, Distributors/Traders

Chapter 10. Biochemistry Analysers Market effective factors Analysis

Chapter 11. Market Size and Forecast

Chapter12. Conclusion

Chapter13. Appendix

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Biochemistry Analysers Market Thriving Growth during Forecast 2020-2028 with Leading Players Vetter Pharma, Ypsomed, SCHOTT, Nipro, Lyophilization...

Semi-automated Biochemical Urine Analyzer Industry Market

UpMarketResearch, 27-11-2020: The research report on the Semi-automated Biochemical Urine Analyzer Industry Market is a deep analysis of the market. This is a latest report, covering the current COVID-19 impact on the market. The pandemic of Coronavirus (COVID-19) has affected every aspect of life globally. This has brought along several changes in market conditions. The rapidly changing market scenario and initial and future assessment of the impact is covered in the report. Experts have studied the historical data and compared it with the changing market situations. The report covers all the necessary information required by new entrants as well as the existing players to gain deeper insight.

Furthermore, the statistical survey in the report focuses on product specifications, costs, production capacities, marketing channels, and market players. Upstream raw materials, downstream demand analysis, and a list of end-user industries have been studied systematically, along with the suppliers in this market. The product flow and distribution channel have also been presented in this research report.

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The Major Manufacturers Covered in this Report:company 1company 2company 3company 4company 5company 6company 7company 8company 9

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By Types:Type 1Type 2Type 3

By Applications:Application 1Application 2Application 3

By Regions:

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The Semi-automated Biochemical Urine Analyzer Industry Market Report Consists of the Following Points:

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In conclusion, the Semi-automated Biochemical Urine Analyzer Industry Market report is a reliable source for accessing the research data that is projected to exponentially accelerate your business. The report provides information such as economic scenarios, benefits, limits, trends, market growth rate, and figures. SWOT analysis is also incorporated in the report along with speculation attainability investigation and venture return investigation.

About UpMarketResearch:Up Market Research (https://www.upmarketresearch.com) is a leading distributor of market research report with more than 800+ global clients. As a market research company, we take pride in equipping our clients with insights and data that holds the power to truly make a difference to their business. Our mission is singular and well-defined we want to help our clients envisage their business environment so that they are able to make informed, strategic and therefore successful decisions for themselves.

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Semi-automated Biochemical Urine Analyzer Industry Market Industry Perspective, Comprehensive Analysis, Size, Share, Growth, Segment, Trends And...

The Biochemical Diagnostic Reagent market study added by Market Study Report, LLC, exhibits a comprehensive analysis of the growth trends present in the global business scenario. The study further presents conclusive data referring to the commercialization aspects, industry size and profit estimation of the market. The study also illustrates the competitive standing of leading manufacturers in the projection timeline whilst incorporating their diverse portfolio and regional expansion endeavors.

Executive Summary:

The recent study on Biochemical Diagnostic Reagent market contains a descriptive study of this business sphere with regards to key growth drivers, opportunities, and constraints.

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The Biochemical Diagnostic Reagent market is estimated to register a robust CAGR of xx% over the forecast period.

Crucial information pertaining to the regional terrain and competitive landscape along with factors influencing the numerous market segmentations are highlighted in the document. Additionally, the report examines the influence of the COVID-19 pandemic on the growth matrix and suggests strategies for stakeholders to adapt effectively to industry fluctuations.

Market Rundown:

Regional analysis:

Product terrain outline:

.

Application scope overview:

.

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Competitive landscape Review:

.

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Some of the Major Highlights of TOC covers:

Development Trend of Analysis of Biochemical Diagnostic Reagent Market

Marketing Channel

Market Dynamics

Methodology/Research Approach

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Biochemical Diagnostic Reagent Market Analysis, Size, Regional Outlook, Competitive Strategies and Forecasts to 2025 - Murphy's Hockey Law

LOS ANGELES, United States:The report titled Global Bench-top Veterinary Biochemistry Analyzers Market is one of the most comprehensive and important additions to QY Researchs archive of market research studies. It offers detailed research and analysis of key aspects of the global Bench-top Veterinary Biochemistry Analyzers market. The market analysts authoring this report have provided in-depth information on leading growth drivers, restraints, challenges, trends, and opportunities to offer a complete analysis of the global Bench-top Veterinary Biochemistry Analyzers market. Market participants can use the analysis on market dynamics to plan effective growth strategies and prepare for future challenges beforehand. Each trend of the global Bench-top Veterinary Biochemistry Analyzers market is carefully analyzed and researched about by the market analysts.The market analysts and researchers have done extensive analysis of the global Bench-top Veterinary Biochemistry Analyzers market with the help of research methodologies such as PESTLE and Porters Five Forces analysis. They have provided accurate and reliable market data and useful recommendations with an aim to help the players gain an insight into the overall present and future market scenario. The Bench-top Veterinary Biochemistry Analyzers report comprises in-depth study of the potential segments including product type, application, and end user and their contribution to the overall market size.

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In addition, market revenues based on region and country are provided in the Bench-top Veterinary Biochemistry Analyzers report. The authors of the report have also shed light on the common business tactics adopted by players. The leading players of the global Bench-top Veterinary Biochemistry Analyzers market and their complete profiles are included in the report. Besides that, investment opportunities, recommendations, and trends that are trending at present in the global Bench-top Veterinary Biochemistry Analyzers market are mapped by the report. With the help of this report, the key players of the global Bench-top Veterinary Biochemistry Analyzers market will be able to make sound decisions and plan their strategies accordingly to stay ahead of the curve.

Competitive landscape is a critical aspect every key player needs to be familiar with. The report throws light on the competitive scenario of the global Bench-top Veterinary Biochemistry Analyzers market to know the competition at both the domestic and global levels. Market experts have also offered the outline of every leading player of the global Bench-top Veterinary Biochemistry Analyzers market, considering the key aspects such as areas of operation, production, and product portfolio. Additionally, companies in the report are studied based on the key factors such as company size, market share, market growth, revenue, production volume, and profits.

Key Players Mentioned: Idexx Laboratories, Abaxis, Heska, Fuji Film, DiaSys Diagnostic Systems, Randox Laboratories, LITEON, URIT Medical Electronic, Scil Animal Care, BPC BioSed, AMS Alliance, Carolina Liquid Chemistries, Crony Instruments, iCubio, etc.

Key questions answered in the report:

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Table of Contents:

Table of Contents1 Bench-top Veterinary Biochemistry Analyzers Market Overview

1.1 Product Overview and Scope of Bench-top Veterinary Biochemistry Analyzers

1.2 Bench-top Veterinary Biochemistry Analyzers Segment by Type

1.2.1 Global Bench-top Veterinary Biochemistry Analyzers Production Growth Rate Comparison by Type 2020 VS 2026

1.2.2 Automatic

1.2.3 Semi-automatic

1.3 Bench-top Veterinary Biochemistry Analyzers Segment by Application

1.3.1 Bench-top Veterinary Biochemistry Analyzers Consumption Comparison by Application: 2020 VS 2026

1.3.2 Veterinary Hospitals

1.3.3 Veterinary Clinics

1.4 Global Bench-top Veterinary Biochemistry Analyzers Market by Region

1.4.1 Global Bench-top Veterinary Biochemistry Analyzers Market Size Estimates and Forecasts by Region: 2020 VS 2026

1.4.2 North America Estimates and Forecasts (2015-2026)

1.4.3 Europe Estimates and Forecasts (2015-2026)

1.4.4 China Estimates and Forecasts (2015-2026)

1.4.5 Japan Estimates and Forecasts (2015-2026)

1.5 Global Bench-top Veterinary Biochemistry Analyzers Growth Prospects

1.5.1 Global Bench-top Veterinary Biochemistry Analyzers Revenue Estimates and Forecasts (2015-2026)

1.5.2 Global Bench-top Veterinary Biochemistry Analyzers Production Capacity Estimates and Forecasts (2015-2026)

1.5.3 Global Bench-top Veterinary Biochemistry Analyzers Production Estimates and Forecasts (2015-2026)2 Market Competition by Manufacturers

2.1 Global Bench-top Veterinary Biochemistry Analyzers Production Capacity Market Share by Manufacturers (2015-2020)

2.2 Global Bench-top Veterinary Biochemistry Analyzers Revenue Share by Manufacturers (2015-2020)

2.3 Market Share by Company Type (Tier 1, Tier 2 and Tier 3)

2.4 Global Bench-top Veterinary Biochemistry Analyzers Average Price by Manufacturers (2015-2020)

2.5 Manufacturers Bench-top Veterinary Biochemistry Analyzers Production Sites, Area Served, Product Types

2.6 Bench-top Veterinary Biochemistry Analyzers Market Competitive Situation and Trends

2.6.1 Bench-top Veterinary Biochemistry Analyzers Market Concentration Rate

2.6.2 Global Top 3 and Top 5 Players Market Share by Revenue

2.6.3 Mergers & Acquisitions, Expansion3 Production Capacity by Region

3.1 Global Production Capacity of Bench-top Veterinary Biochemistry Analyzers Market Share by Regions (2015-2020)

3.2 Global Bench-top Veterinary Biochemistry Analyzers Revenue Market Share by Regions (2015-2020)

3.3 Global Bench-top Veterinary Biochemistry Analyzers Production Capacity, Revenue, Price and Gross Margin (2015-2020)

3.4 North America Bench-top Veterinary Biochemistry Analyzers Production

3.4.1 North America Bench-top Veterinary Biochemistry Analyzers Production Growth Rate (2015-2020)

3.4.2 North America Bench-top Veterinary Biochemistry Analyzers Production Capacity, Revenue, Price and Gross Margin (2015-2020)

3.5 Europe Bench-top Veterinary Biochemistry Analyzers Production

3.5.1 Europe Bench-top Veterinary Biochemistry Analyzers Production Growth Rate (2015-2020)

3.5.2 Europe Bench-top Veterinary Biochemistry Analyzers Production Capacity, Revenue, Price and Gross Margin (2015-2020)

3.6 China Bench-top Veterinary Biochemistry Analyzers Production

3.6.1 China Bench-top Veterinary Biochemistry Analyzers Production Growth Rate (2015-2020)

3.6.2 China Bench-top Veterinary Biochemistry Analyzers Production Capacity, Revenue, Price and Gross Margin (2015-2020)

3.7 Japan Bench-top Veterinary Biochemistry Analyzers Production

3.7.1 Japan Bench-top Veterinary Biochemistry Analyzers Production Growth Rate (2015-2020)

3.7.2 Japan Bench-top Veterinary Biochemistry Analyzers Production Capacity, Revenue, Price and Gross Margin (2015-2020)4 Global Bench-top Veterinary Biochemistry Analyzers Consumption by Regions

4.1 Global Bench-top Veterinary Biochemistry Analyzers Consumption by Regions

4.1.1 Global Bench-top Veterinary Biochemistry Analyzers Consumption by Region

4.1.2 Global Bench-top Veterinary Biochemistry Analyzers Consumption Market Share by Region

4.2 North America

4.2.1 North America Bench-top Veterinary Biochemistry Analyzers Consumption by Countries 4.2.2 U.S. 4.2.3 Canada

4.3 Europe

4.3.1 Europe Bench-top Veterinary Biochemistry Analyzers Consumption by Countries 4.3.2 Germany 4.3.3 France 4.3.4 U.K. 4.3.5 Italy 4.3.6 Russia

4.4 Asia Pacific

4.4.1 Asia Pacific Bench-top Veterinary Biochemistry Analyzers Consumption by Region 4.4.2 China 4.4.3 Japan 4.4.4 South Korea 4.4.5 Taiwan 4.4.6 Southeast Asia 4.4.7 India 4.4.8 Australia

4.5 Latin America

4.5.1 Latin America Bench-top Veterinary Biochemistry Analyzers Consumption by Countries 4.5.2 Mexico 4.5.3 Brazil5 Production, Revenue, Price Trend by Type

5.1 Global Bench-top Veterinary Biochemistry Analyzers Production Market Share by Type (2015-2020)

5.2 Global Bench-top Veterinary Biochemistry Analyzers Revenue Market Share by Type (2015-2020)

5.3 Global Bench-top Veterinary Biochemistry Analyzers Price by Type (2015-2020)

5.4 Global Bench-top Veterinary Biochemistry Analyzers Market Share by Price Tier (2015-2020): Low-End, Mid-Range and High-End6 Global Bench-top Veterinary Biochemistry Analyzers Market Analysis by Application

6.1 Global Bench-top Veterinary Biochemistry Analyzers Consumption Market Share by Application (2015-2020)

6.2 Global Bench-top Veterinary Biochemistry Analyzers Consumption Growth Rate by Application (2015-2020)7 Company Profiles and Key Figures in Bench-top Veterinary Biochemistry Analyzers Business

7.1 Idexx Laboratories

7.1.1 Idexx Laboratories Bench-top Veterinary Biochemistry Analyzers Production Sites and Area Served

7.1.2 Bench-top Veterinary Biochemistry Analyzers Product Introduction, Application and Specification

7.1.3 Idexx Laboratories Bench-top Veterinary Biochemistry Analyzers Production Capacity, Revenue, Price and Gross Margin (2015-2020)

7.1.4 Main Business and Markets Served

7.2 Abaxis

7.2.1 Abaxis Bench-top Veterinary Biochemistry Analyzers Production Sites and Area Served

7.2.2 Bench-top Veterinary Biochemistry Analyzers Product Introduction, Application and Specification

7.2.3 Abaxis Bench-top Veterinary Biochemistry Analyzers Production Capacity, Revenue, Price and Gross Margin (2015-2020)

7.2.4 Main Business and Markets Served

7.3 Heska

7.3.1 Heska Bench-top Veterinary Biochemistry Analyzers Production Sites and Area Served

7.3.2 Bench-top Veterinary Biochemistry Analyzers Product Introduction, Application and Specification

7.3.3 Heska Bench-top Veterinary Biochemistry Analyzers Production Capacity, Revenue, Price and Gross Margin (2015-2020)

7.3.4 Main Business and Markets Served

7.4 Fuji Film

7.4.1 Fuji Film Bench-top Veterinary Biochemistry Analyzers Production Sites and Area Served

7.4.2 Bench-top Veterinary Biochemistry Analyzers Product Introduction, Application and Specification

7.4.3 Fuji Film Bench-top Veterinary Biochemistry Analyzers Production Capacity, Revenue, Price and Gross Margin (2015-2020)

7.4.4 Main Business and Markets Served

7.5 DiaSys Diagnostic Systems

7.5.1 DiaSys Diagnostic Systems Bench-top Veterinary Biochemistry Analyzers Production Sites and Area Served

7.5.2 Bench-top Veterinary Biochemistry Analyzers Product Introduction, Application and Specification

7.5.3 DiaSys Diagnostic Systems Bench-top Veterinary Biochemistry Analyzers Production Capacity, Revenue, Price and Gross Margin (2015-2020)

7.5.4 Main Business and Markets Served

7.6 Randox Laboratories

7.6.1 Randox Laboratories Bench-top Veterinary Biochemistry Analyzers Production Sites and Area Served

7.6.2 Bench-top Veterinary Biochemistry Analyzers Product Introduction, Application and Specification

7.6.3 Randox Laboratories Bench-top Veterinary Biochemistry Analyzers Production Capacity, Revenue, Price and Gross Margin (2015-2020)

7.6.4 Main Business and Markets Served

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Bench-top Veterinary Biochemistry Analyzers Market Size, Growth Trends, Top Players, Application Potential and Forecast to 2026 | Idexx Laboratories,...

Researchers demonstrate molecular binding mechanism that could change approach to designing influenza treatments

There is no hole-in-one drug treatment when it comes to the flu, but that doesnt stop scientists from trying to sink one. Especially since as many as one in five Americans gets the flu. The reported estimated cost of this illness is $10 billion each year in medical expenses and another $16 billion in lost earnings in America alone, according to researchers at UC San Diego.

Rommie Amaro, Professor of Chemistry and Biochemistry, University of California, San Diego.

Teeing up on the science behind the flu virus is Rommie Amaro and J. Andrew McCammon, both professors of chemistry and biochemistry, and graduate student Christian Seitz. Together with co-workers Lorenzo Casalino, Robert Konecny and Gary Huber, they studied the effect of glycansgroups of sugar moleculeson the binding of antiviral drugs to viral neuraminidase. An enzyme found on the surface of flu viruses, neuraminidase enables the viruses to exit their diseased host cells and infect and replicate in new, previously healthy host cells. The glycans help to prevent large antibody molecules from binding to the enzyme.

The researchers findings, published in Biophysical Journal, likely apply more generallyincluding to the SARS-CoV-2 virus that causes COVID-19. Amaro will soon be releasing new findings about her latest research on the virus spike protein.

According to the scientists, influenza neuraminidase is the target for three FDA-approved influenza drugs in the U.S., but drug resistance and low drug effectiveness merit more drug development. Generally, however, drug developers do not include glycans in their development pipelines. They know glycans exist, but they have ignored glycans when designing new drugs without a basis for doing so and without evidence that glycans do not affect drug binding.

With their focus on glycans, the team thought it would be prudent to test the assumption about glycans in drug design relative to neuraminidase. Their results show that their proposed binding mechanism can help shed light on the complexity of the interplay between glycans and ligand binding.

Traditionally, glycans have been difficult to study experimentally or theoretically due to a number of technological constraints, which are beginning to be lifted, explained Seitz, first author of the study. Because of this recent emergence of glycans, we still have a lot to learn about them.

The superposition of four glycan conformations onto the static neuraminidase structure shows the conformational variability of the glycans, partially blocking binding site access. Metaphorically, the glycans are the rocks on the mini-golf course and the binding sites are the holes. The glycans are in blue, red, green and gray; the binding sites are in purple and orange, and neuraminidase is in teal. This representation is simplified to emphasize the relationship between the glycans and the binding sites, showing half of the neuraminidase structure and less than one-fifth of the glycans present in the full study. Figure by Christian Seitz, Amaro Lab and McCammon Lab, UC San Diego.

To better understand glycans in the context of this particular study, the team created all-atom in silico systems of influenza neuraminidase, consisting of four different glycan configurations and one glycan-free system. They observed a two- to eight-fold decrease in the rate of ligand binding to the primary binding site of neuraminidase After examining neuraminidases binding sites, the scientists noted that drugs prefer the primary binding site over the secondary binding site.

Personally, I found two things to be quite surprising. Glycans are flexible and can reside very close to the drug binding sites, so I thought that the glycans would completely block drug binding. However, we found the glycans acted more like a screen or a curtainthings can get through, it will just take a bit longer, said Seitz. Secondly, there are two binding sites on influenza neuraminidase; one is the primary (catalytic) site needed for the viral replication cycle to continue, and the other, secondary site, is not well understood. Some previous studies had initially concluded that ligands would reach the secondary site significantly faster than the primary site.

Seitz noted that McCammon was the first person to run a molecular dynamics study with a protein, and the Brownian dynamics software used in this study was developed in his lab. Additionally, Amaro is known as a world-leading expert in molecular dynamics virus simulations, and her virus work has recently been covered in The New York Times.

Combining these rich basins of knowledge we are able to gain new insights into a global disease right here in San Diego, said Seitz.

The graduate student likened the study to a mini-golf course. We have the obvious goal of wanting to get the ball in the hole except, in our study, the golf ball is an influenza drug and the hole is the protein receptor the drug must find to kill the virus. One can often find large rocks on the greens acting as gatekeepers to make it more difficult to get the ball in the hole. In our flu analogy, these rocks are the tiny sugars called glycans.

Just as a groundskeeper can change the position of the rocks near the hole, glycans can change position on the protein. So, the researchers wanted to know if changing the position of the glycans would change how easy or difficult it is for the influenza drug to find its target.

To start, we found common positions of these glycans. However, just as you would not change the position of the rocks on a mini-golf course and do one putt before declaring it easier or harder, we knew we would have to repeat this process many times (600 million, actually) to reach a statistically significant conclusion. Each Brownian dynamics trajectory in our study represented one putt on our mini-golf course, and we simply measured if the ball reached the hole, Seitz explained.

The scientists found that changing the positions of the glycans did make it somewhat harder for the drug to reach the target, but not as much as expected. This means that drug developers do not need to account for glycans when designing new small-molecule drugs for influenzasomething that was unclear before.

For a long time, I thought this couldn't be true and ran numerous tests to disprove it, but all these tests consistently said the same thing, that most small ligands are able to evade the glycans and bind to the enzyme, Seitz said. Thus, this work is one small step in helping to ameliorate the yearly human and economic cost in our nation and our world. This is paid for by our own taxes so each of us has made a tiny contribution to this progress.

This research was supported in part by grants from the National Institutes of Health, USA (NIH grant nos. T32EB009380 and GM031749 and the National Science Foundation Graduate Research Fellowship Program (grant no. DGE-1650112). The researchers used the Extreme Science and Engineering Discovery Environment (XSEDE), which is supported by National Science Foundation (grant no. ACI-1548562) and the XSEDE Comet at the San Diego Supercomputer Center (allocation csd373).

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Clearing the Course for Glycans in Development of Flu Drugs - UC San Diego Health

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Global Automatic Biochemistry Analyzers Market Status Analysis, Scope, Trend, Capacity and Forecast 2020-2025 - The Think Curiouser

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Semi Automatic Biochemistry Analyzer Market Analysis and Global Outlook During 2020 to 2026 - The Think Curiouser

Vanderbilt researchersincludingCharles Sanders, associate dean for research and professor of biochemistry, and graduate studentJustin Marinkohave illuminated the cause of Charcot-Marie-Tooth disease, putting them on the road to developing therapeutic approaches for the disease that affects one in 2,500 people.

The discovery was published in the article Direct Relationship Between Increased Expression andMistraffickingof the Charcot-Marie-Tooth-Associated Protein PMP22 published in theJournal of Biological Chemistryon July 9. The significance and overall importance of the findings within the article earned it the rare distinction of Editors Pick.

Charcot-Marie-Tooth disease is known to cause the peripheral nerves to stop working, causing loss of dexterity and the sense of touch in the hands and feet. Over two decades, Sanders has been studying a targeted approach to treat Charcot-Marie-Tooth disease and other neuropathies by looking at rarely examined proteins.

The lab shutdown brought on by COVID-19 afforded Marinko time to more deeply analyze data previously collected in the lab. Marinkos work with this data showed that overproduction of the membrane protein PMP22 is too much of a good thing; it turns individual cells into traps.

During the safer-at-home period, we started to think about our large dataset and the layers within that data that could be analyzed in ways that we had not previously considered, said Marinko, who also is winner of theAnne Karpay Award. A very positive outcome came as a result of having some time to think about the data more thoroughly.

In healthy cells, there are two copies of the gene encoding PMP22, a protein that snakes through the lipid bilayer of the cell several times until it reaches the cell surface. Under disease conditions, a third copy adds more PMP22 to the cell in a way that overloads its pathway to the exterior of the cell, leading to most of the protein getting trapped within the cellwhere it becomes toxic and disease-causing. This research is the first experimental evidence that definitively points to this mechanism as the cause of the most common form of Charcot-Marie-Tooth disease. A similar phenomenon likely occurs for other proteins in other disorders involving unregulated cell behavior, including some forms of cancer.

The investigation is the outcome of a continuing collaboration between the Sanders Lab and that ofBruce Carter, professor of biochemistry and an associate director of theVanderbilt Brain Institute.

Discovering this relatively new phenomenon was an important step and a highlight for our lab, said Sanders, also the Aileen M. Lange & Annie Mary Lyle Chair in Cardiovascular Research.I am thrilledabout the future of this workwith our friends in the Carter Lab, translating our data and model cell line work to nervous system cells.

The work was supported by NIH grants R01 NS095989 and R01 NS107456, NIH fellowship F31 NS113494 and NIH training grant T32 NS00749.

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Vanderbilt biochemists reveal the cause of Charcot-Marie-Tooth diseasetoo much of a good thing - Vanderbilt University News

TheNational Institutes of Health(NIH) has awarded nearly $3 million to a University ofHawaiiat Mnoa-led project expanding COVID-19 testing in schools statewide. The funding supports thePacific Alliance Against COVID-19(PAAC) pilot project, which establishes a novel protocol for rapid testing at schools, collecting behavioral data, and disseminating information on mitigation procedures and vaccination.

The consortium effort is led byUHMnoasJohn A. Burns School of Medicine(JABSOM),College of Social Sciencesand the Accountable Healthcare Alliance of RuralOahu(AHARO).

PAACs goal is to empower educators, students and the community-at-large with education tools and connections with public health services, including those provided by theAHAROCommunity Health Centers, said Associate Professor in Pediatrics and co-investigatorMay Okihiro. The plan is for free antigen testing of school teachers and staff to be expanded to schools inWaianaeand Waimnalo onOahu, Hmkua-Kohala and Hilo onHawaiiIsland, and onMolokai.

PAACs novel protocol wassuccessfully tested this springin partnership with Kamaile Academy (K-12) inWaianae. The project offered free weekly SARS-CoV-2 antigen testing of teachers and staff.

About 87% of participants reported their participation led to a better understanding of the need for antigen testing, and 52% were more likely to be vaccinated as a result of the pilot testing and education program, said project co-investigatorRuben Juarez, a professor of economics and research fellow in theUHEconomic Research Organizationin the College of Social Sciences.

The project reaffirms that schools are an asset in preventing the spread of COVID-19 into our communities, added project co-investigatorAlika Maunakea, an associate professor inJABSOMs Department of Anatomy, Biochemistry & Physiology and the Institute for Biogenesis Research.

UHMnoa is one of 15 institutions to receive aNIHaward through theRADx-Underserved Populations(RADx-UP) Safe Return to School Diagnostic Testing initiative, a part of theRapid Acceleration of Diagnostics(RADx) initiative.

The new awards reaffirmNIHs commitment to use evidence-based research to inform policy makers of the safest ways to return to schools in vulnerable and underserved communities, said Eliseo J. Prez-Stable, director ofNIHs National Institute on Minority Health and Health Disparities and co-chair of theRADx-UPprogram.

The initiative will specifically focus on schools with racially and ethnically diverse populations, including African-Americans, Latinos/Latinas, Native Hawaiians and other Pacific Islanders and Asian Americans. It will also impact socio-economically disadvantaged populations and school districts where many students are receiving free or reduced price lunch; and students with medical complexities and developmental disabilities.

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UH Mnoa Gets $3M Boost to Expand - Big Island Now

Newswise Chemists studying how life started often focus on how modern biopolymers like peptides and nucleic acids contributed, but modern biopolymers don't form easily without help from living organisms. A possible solution to this paradox is that life started using different components, and many non-biological chemicals were likely abundant in the environment. A new survey conducted by an international team of chemists from the Earth-Life Science Institute (ELSI) at Tokyo Institute of Technology and other institutes from Malaysia, the Czech Republic, the US and India, has found that a diverse set of such compounds easily form polymers under primitive environmental conditions, and some even spontaneously form cell-like structures.

Understanding how life started on Earth is one of the most challenging questions modern science attempts to explain. Scientists presently study modern organisms and try to see what aspects of their biochemistry are universal, and thus were probably present in the organisms from which they descended. The best guess is that life has thrived on Earth for at least 3.5 billion of Earth's 4.5 billion year history since the planet formed, and most scientists would say life likely began before there is good evidence for its existence. Problematically, since Earth's surface is dynamic, the earliest traces of life on Earth have not been preserved in the geological record. However, the earliest evidence for life on Earth tells us little about what the earliest organisms were made of, or what was going on inside their cells. "There is clearly a lot left to learn from prebiotic chemistry about how life may have arisen," says the study's co-author Jim Cleaves.

A hallmark of life is evolution, and the mechanisms of evolution suggest that common traits can suddenly be displaced by rare and novel mutations which allow mutant organisms to survive better and proliferate, often replacing previously common organisms very rapidly. Paleontological, ecological and laboratory evidence suggests this occurs commonly and quickly. One example is an invasive organism like the dandelion, which was introduced to the Americas from Europe and is now a common weed causing lawn-concerned homeowners to spend countless hours of effort and dollars to eradicate. Another less whimsical example is COVID-19, a virus (technically not living, but technically an organism) which was probably confined to a small population of bats for years, but suddenly spread among humans around the world. Organisms which reproduce faster than their competitors, even only slightly faster, quickly send their competitors to what Leon Trotsky termed the "ash heap of history." As most organisms which have ever existed are extinct, co-author Tony Z. Jia suggests that "to understand how modern biology emerged, it is important to study plausible non-biological chemistries or structures not currently present in modern biology which potentially went extinct as life complexified."

This idea of evolutionary replacement is pushed to an extreme when scientists try to understand the origins of life. All modern organisms have a few core commonalities: all life is cellular, life uses DNA as an information storage molecule, and uses DNA to make ribonucleic RNA as an intermediary way to make proteins. Proteins perform most of the catalysis in modern biochemistry, and they are created using a very nearly universal "code" to make them from RNA. How this code came to be is in itself enigmatic, but these deep questions point to their possibly having been a very murky period in early biological evolution ~ 4 billion years ago during which almost none of the molecular features observed in modern biochemistry were present, and few if any of the ones that were present have been carried forward.

Proteins are linear polymers of amino acids. These floppy strings of polymerised amino acids fold into unique three-dimensional shapes, forming extremely efficient catalysts which foster precise chemical reactions. In principle, many types of polymerised molecules could form similar strings and fold to form similar catalytic shapes, and synthetic chemists have already discovered many examples. "The point of this kind of study is finding functional polymers in plausibly prebiotic systems without the assistance of biology, including grad students," says co-author Irena Mamajanov.

Scientists have found many ways to make biological organic compounds without the intervention of biology, and these mechanisms help explain these compounds' presence in samples like carbonaceous meteorites, which are relics of the early solar system, and which scientists don't think ever hosted life. These primordial meteorite samples also contain many other types of molecules which could have formed complex folded polymers like proteins, which could have helped steer primitive chemistry. Proteins, by virtue of their folding and catalysis mediate much of the complex biochemical evolution observed in living systems. The ELSI team reasoned that alternative polymers could have helped this occur before the coding between DNA and protein evolved. "Perhaps we cannot reverse-engineer the origin of life; it may be more productive to try and build it from scratch, and not necessarily using modern biomolecules. There were large reservoirs of non-biological chemicals that existed on the primeval Earth. How they helped in the formation of life-as-we-know-it is what we are interested in," says co-author Kuhan Chandru.

The ELSI team did something simple yet profound: they took a large set of structurally diverse small organic molecules which could plausibly be made by prebiotic processes and tried to see if they could form polymers when evaporated from dilute solution. To their surprise, they found many of the primitive compounds could, though they also found some of them decomposed rapidly. This simple criterion, whether a compound is able to be dried without decomposing, may have been one of the earliest evolutionary selection pressures for primordial molecules.

The team conducted one further simple test. They took these dried reactions, added water and looked at them under a microscope. To their surprise, some of the products of these reaction formed cell-sized compartments. That simple starting materials containing 10 to 20 atoms can be converted to self-organised cell-like aggregates containing millions of atoms provides startling insight into how simple chemistry may have led to complex chemistry bordering on the kind of complexity associated with living systems, while not using modern biochemicals.

"We didn't test every possible compound, but we tested a lot of possible compounds. The diversity of chemical behaviors we found was surprising, and suggests this kind of small-molecule to functional-aggregate behavior is a common feature of organic chemistry, which may make the origin of life a more common phenomenon than previously thought," concludes co-author Niraja Bapat.

###

Tokyo Institute of Technology (Tokyo Tech)stands at the forefront of research and higher education as the leading university for science and technology in Japan. Tokyo Tech researchers excel in fields ranging from materials science to biology, computer science, and physics. Founded in 1881, Tokyo Tech hosts over 10,000 undergraduate and graduate students per year, who develop into scientific leaders and some of the most sought-after engineers in industry. Embodying the Japanese philosophy of "monotsukuri," meaning "technical ingenuity and innovation," the Tokyo Tech community strives to contribute to society through high-impact research.

The Earth-Life Science Institute (ELSI)is one of Japan's ambitious World Premiere International research centers, whose aim is to achieve progress in broadly inter-disciplinary scientific areas by inspiring the world's greatest minds to come to Japan and collaborate on the most challenging scientific problems. ELSI's primary aim is to address the origin and co-evolution of the Earth and life.

The World Premier International Research Center Initiative (WPI)was launched in 2007 by the Ministry of Education, Culture, Sports, Science and Technology (MEXT) to help build globally visible research centers in Japan. These institutes promote high research standards and outstanding research environments that attract frontline researchers from around the world. These centers are highly autonomous, allowing them to revolutionise conventional modes of research operation and administration in Japan.

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Scientists discover new organic compounds that could have helped form the first cells - Newswise

Suhaili Shamsi,1 Addison Alvin Alagan,1 Seri Narti Edayu Sarchio,2 Faizah Md Yasin3,4

1Laboratory of Animal Biochemistry and Biotechnology, Department of Biochemistry, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Serdang, Selangor 43400, Malaysia; 2Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor 43400, Malaysia; 3Department of Chemical and Environmental Engineering, Faculty of Engineering, Universiti Putra Malaysia, Serdang, Selangor 43400, Malaysia; 4Institute of Advanced Technology, Faculty of Engineering, Universiti Putra Malaysia, Serdang, Selangor 43400, Malaysia

Correspondence: Suhaili ShamsiLaboratory of Animal Biochemistry and Biotechnology, Department of Biochemistry, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, Serdang, Selangor 43400, MalaysiaTel +603-9769 7964Fax +603-9769 7590Email sh_suhaili@upm.edu.my

Background: In the current literature, there are ongoing debates on the toxicity of graphene oxide (GO) that demonstrate contradictory findings regarding its toxicity profile. As a potential drug carrier, these findings are very concerning due to the safety concerns in humans, as well as the dramatic rise of GO being excreted into the environment. Therefore, there is an imperative need to mitigate the potential toxicity of GO to allow for a safer application in the future.Purpose: The present study aims to address this issue by functionalizing GO with Pluronic F127 (PF) as a means to mitigate toxicity and resolve the biocompatibility of GO. Although results from previous studies generally indicated that Pluronic functionalized GO exhibits relatively low toxicity to living organisms, reports that emphasize on its toxicity, particularly during embryonic developmental stage, are still scarce.Methods: In the present study, two different sizes of native GO samples, GO and NanoGO, as well as PF-functionalized GO, GO-PF and NanoGO-PF, were prepared and characterized using DLS, UV-Vis, Raman spectroscopy, FTIR, and FESEM analyses. Toxicological assessment of all GO samples (0 100 g/mL) on zebrafish embryonic developmental stages (survival, hatching and heart rates, and morphological changes) was recorded daily for up to 96 hours post-fertilization (hpf).Results: The toxicity effects of each GO sample were observed to be higher at increasing concentrations and upon prolonged exposure. NanoGO demonstrated lower toxicity effects compared to GO. GO-PF and NanoGO-PF were also found to have lower toxicity effects compared to native GO samples. GO-PF showed the lowest toxicity response on zebrafish embryo.Conclusion: These findings highlight that toxicity is dependent on the concentration, size, and exposure period of GO. Functionalization of GO with PF through surface coating could potentially mitigate the toxicity effects of GO in embryonic developmental stages, but further investigation is warranted for broader future applications.

Keywords: graphene oxide, pluronic, nanomaterial, toxicity, embryogenesis

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License.By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

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Synthesis, Characterization, and Toxicity Assessment of Pluronic F127- | IJN - Dove Medical Press