Unexpected Growth Seen in Medical Aesthetics Market Global Forecast to 2025 with Key Players Allergan PLC, Solta Medical, Syneron Medical, Cynosure…

Medical aesthetics is an area of medicine, dealing with aesthetics, well-being, peripheral appearance, noticeable skin changes, and image of the patient. Medical aesthetics include high-technology skin care procedures that denote the fusion of beauty and healthcare services. Procedures for these include the use of ground-breaking technologies to increase the aesthetics of the person. The demand for anti-aging products and procedures is growing significantly, owing to the growing focus of patients aged 50 years and above to look young and improve their appearance.

Growth in this market is mainly driven by the growing adoption of minimally invasive and noninvasive aesthetic procedures, rising adoption among geriatric individuals, increasing public awareness about cosmetic procedures, the availability of technologically advanced & user-friendly products, and the increasing demand for aesthetic treatments among men.

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Medical Aesthetic Devices Market Key Segments:

Medical Aesthetic Devices Market by Product:

Medical Aesthetic Devices Market by Application:

Medical Aesthetic Devices Market by End User:

Companies Profiled in this Report includes, Allergan PLC, Solta Medical Inc., Syneron Medical Ltd., Cynosure Inc., Lumenis Ltd., Johnson & Johnson, Merz Pharma GmbH & Co., Alma Lasers Ltd.

In product type segment, the aesthetic laser devices are growing at the highest CAGR. Aesthetic laser devices are growing because these lasers work for cosmetics application by a process called selective photothermolysis i.e. the modulation of the frequency of light for the generation of heat in the areas where it is intended to be applied. For achieving the desired aesthetic effect the wavelength of light should perfectly synchronize with the color of the target.

In Application segment, the anti-aging and wrinkles segment is growing with the highest CAGR, because people are more conscious about their look or appearance especially when it comes to their body and hence wrinkles and antiaging application area is dominating the medical aesthetics market as it provides better result in terms of beautiful look.

In the end user segment, the cosmetic centers segment is growing with the highest CAGR because of the high awareness of the people and exclusive cosmetics services are provided in this sector.

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Unexpected Growth Seen in Medical Aesthetics Market Global Forecast to 2025 with Key Players Allergan PLC, Solta Medical, Syneron Medical, Cynosure...

2.8 million awarded to fund projects by British and Israeli scientists – GOV.UK

The British Council and the British Embassy, Israel, have given the go-ahead to seven, new, three-year bilateral scientific projects in the field of research on ageing. The work will be carried out by top institutions in the UK and Israel.

The projects will be awarded nearly 2.8 million in total from BIRAX, a 10 million programme to support cutting edge UK-Israeli research.

BIRAX Ageing will look at the effects of ageing on human health, and the use of precision medicine and big data in ageing research. It will bring together scientists from the Hebrew University, Hadassah Medical Centre, Tel Aviv University, Tel Aviv Sourasky Medical Centre, University of Oxford, University of Cambridge, Kings College London, and Queens University Belfast.

The projects will focus on various aspects of ageing and how it affects diabetes, vascular disease, neuro-degenerative disease such as Multiple Sclerosis, brain imaging, as well as the use of technology for macular disease research.

British Ambassador to Israel, Mr. Neil Wigan said:

I am excited that seven new projects have been selected for the first call of BIRAX Ageing, the latest phase of our flagship science research programme. These cutting-edge research collaborations not only position the UK and Israel at the forefront of ageing research world-wide, but also reaffirm the close connection between British and Israeli academic communities and establishments. Through these meaningful and sustainable collaborations, we can together tackle universal ongoing challenges.

BIRAX Ageing research looks at the global challenges of ageing, bringing together world-class and complementary scientific capabilities to promote healthy ageing. It aims to establish and grow a substantial new academic community and support ground-breaking collaborative research in the field of ageing, funding both research mobility and joint research projects over the next five years. This crucial research will be generously supported by the Pears Foundation, The Israel Ministry of Science and Technology, The Parasol Foundation Trust, Charles Wolfson Charitable Trust, The Rosetrees Trust, Diabetes UK, The British Heart Foundation, and MS Society.

Sir Trevor Pears, Executive Chair of the Pears Foundation, added:

Since its establishment in 2011, the BIRAX Initiative has earned its excellent reputation for successfully nurturing UKIsrael scientific exchange for the advancement of knowledge. We are proud to have been the founding partner of this important initiative, which will have an enduring impact and legacy, and are delighted to be part of a family of committed partners.

BIRAX was initiated 8 years ago by the British Council, British Embassy in Israel and the UK Science and Innovation Network in collaboration with the Pears Foundation as a founding partner. So far, BIRAX has funded 19 research projects tackling some of the worlds most challenging health conditions and diseases by employing pioneering regenerative medicine and stem cell therapies and using the most advanced and cutting-edge technologies. The ground-breaking science has been made possible through the generous support of a broad family of partners and supporters including the Israel Ministry of Science and Technology, the British Heart Foundation, JDRF, MS Society, Parkinsons UK, Alzheimers Society, the Medical Research Council, The Parasol Foundation Trust, The Rosetrees Trust, Weizmann UK, Clore Foundation Israel, Charles Wolfson Charitable Trust, The Wolfson Foundation, The Maurice and Vivienne Wohl Philanthropic Foundation, The Kahn Foundation, UJIA, Celia and Edward Atkin, The Sheila and Denis Cohen Charitable Trust, The Barbara and Stanley Fink Foundation, and The Glycobiology Institute of Oxford University.

Principal Investigators: Professor Lynne Cox, University of Oxford Professor Rivka Dresner Pollak, Hadassah Medical Center

The overall aim of this research is to understand bone fragility in ageing patients with type 1 diabetes who are currently at high risk of bone fracture and premature death, and to develop new treatments.

Principal Investigators: Professor Heidi Johansen-Berg, University of OxfordProfessor Yaniv Assaf, Tel Aviv University

The project will explore neurodegenerative processes in age related disease such as dementia by understanding the processes behind healthy brain ageing. Owing to dramatic developments in brain imaging methods for providing quantitative measures of brain microstructure, in particular, in Prof Assafs lab in Tel Aviv, these methods could be particularly powerful ways to detect subtle changes in brain structure occurring with ageing, providing early indicators of age-related neurodegeneration. No database of microstructural imaging yet exists.

This project aims to create the first database of microstructural imaging and to initiate a brain database in Israel.

Principal Investigators: Professor Robin Franklin, University of CambridgeDr Amnon Buxboim, Hebrew University of Jerusalem

This project seeks to find answers that will provide clues as to how the effects of age might be reversed therapeutically. It will examine how the brain is able to induce harmful in central nerve system stem cells, and how are the physical signals of the brain transmitted to a central nerve system stem cell to change its function.

Principal Investigators: Professor Manuel Mayr, Kings College London Professor Eli Keshet, Hebrew University of Jerusalem

This project proposes a novel anti-ageing approach to combat age-associated deterioration of vascular function. The knowledge gained in the project will be leveraged for the development of new anti-aging treatments.

Principal Investigators: Professor Masashi Narita, University of Cambridge Professor Ittai Ben-Porath, Hebrew University of Jerusalem

This project addresses in depth the roles of beta-cell senescence in aging and diabetes. The researchers aim to uncover whether beta-cell senescence contributes to, or, alternatively acts to counteract diabetes.

Principal Investigators: Professor Tunde Peto, Queens University Belfast Professor Anat Loewenstein, Tel Aviv University

This project aims to investigate the performance of new automated software algorithms to monitor AMD and detect progression, towards implementation in routine patients management; and to investigate the potential for machine learning to identify factors and biomarkers associated with long-term AMD treatment response.

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2.8 million awarded to fund projects by British and Israeli scientists - GOV.UK

The Right Chemistry: Looking for the secrets to longevity – Montreal Gazette

We cant avoid aging. Every passing minute brings us one minute closer to the end. Not a pleasant thought. So, it is little wonder that the term anti-aging has been seized by marketers of various cosmetics, health supplements, exotic juices and dietary regimens. Anti-aging medicine is a growing field with numerous biotech companies working on drugs designed to combat the aging process.

The quest for immortality, of course, is not new. The ancient alchemists sought to turn base metals like lead into gold in order to find the secret of golds immortality. After all, the metal would not tarnish, it maintained its beautiful sheen and seemed to last forever. If they could find its magic, they could perhaps apply it to humans. But they never did find the secret. Lead is still lead and the alchemists are long dead.

This is not to say that there are not some intriguing possibilities that may help slow down the clock. As we age, an increasing number of our cells enter a stage of senescence in which they no longer divide and begin to release chemicals that cause inflammation resulting in damage to tissues. A buildup of senescent cells, sometimes called zombie cells, is a hallmark of aging. Can anything be done to prevent this buildup? Possibly. At least in mice. When researchers at the Mayo Clinic injected just a small number of senescent cells into young mice, their speed, endurance and strength eroded to that seen in a senior mouse in just a few weeks. When the mice were then treated with desatinib and quercetin, a combination of drugs known to destroy senescent cells, they recovered most of their lost physical capabilities within two weeks! Quite dramatic! But mice are not people, and while quercetin is a safe compound extracted from apple peel, desatinib is a very expensive leukemia drug with loads of side effects. Still, this experiment is a proof of principle, demonstrating that destroying senescent cells with senolytics is worthy of exploration.

However, slowing aging may not be a matter of what we do, but what we dont do. It may be that if we want to live longer, all we have to do is eat less. Calorie restriction has been the only sure-fire way that scientists have found to slow aging in animals from rodents to monkeys and now we are beginning to accumulate data that suggests this applies to humans, as well. The idea that less is more when it comes to eating is not new. Hippocrates noted that fat people were more likely to die suddenly than slender ones, and Avicenna, the famed Persian philosopher and physician, suggested that the elderly should eat less than when they were younger.

Venetian nobleman Luigi Cornaro may have been the first to put a restricted calorie diet to a test in the 17th century when he came to believe that his health was deteriorating due to excessive partaking of food, drink and sex. He then restricted himself to no more than 350 grams of food a day and 400 mL of wine and lived to the ripe old age of 98. He documented his regimen in his book Discourses On the Temperate Life and described how the changes he made in his lifestyle allowed him to remain in vigorous health well into old age.

Today, members of the Calorie Restriction Society that has the goal of increasing longevity are following in Cornaros footsteps and are acting as human guinea pigs. They consume no more than 2,000 calories per day, which is just over half of what an average North American wolfs down. They dont do this, though, by eating half servings of hamburger, fries or pizza. They do it by following a diet high in whole grains, fruits, vegetables, beans and fish. And according to a study published in the Journal of the American College of Cardiology, the austere regimen is paying off. Researchers examined the heart function of 25 members of the Calorie Restriction Society, and to their amazement found that the hearts functioned like those of people 15 years younger. But permanent hunger is not appealing.

What is appealing, however, is taking a deep dive into the science of aging. That is just what we will do this year at our annual Trottier Public Science Symposium, one of McGills largest annual public events. We have invited three expert speakers to address humans Longing for Longevity. On Tuesday, Oct. 22, Harvard Professor of Genetics David Sinclair, a world leader in aging research, will discuss how aging may be a treatable disease, and cosmetic chemist Kelly Dobos will scrutinize claims made by producers of anti-aging cosmetics. On Wednesday, Oct. 23, Ruth Westheimer, psychosexual therapist, author and pioneer of radio and television programs dealing with sexual issues will speak on Sex After 50. (Spoiler: there is.)

The symposium will take place at 7 p.m. both days at the Centre Mont Royal, 1000 Sherbrooke St. West. Admission is free. Arrive early.

joe.schwarcz@mcgill.ca

Joe Schwarcz is director of McGill Universitys Office for Science & Society (mcgill.ca/oss). He hosts The Dr. Joe Show on CJAD Radio 800 AM every Sunday from 3 to 4 p.m.

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The Right Chemistry: Looking for the secrets to longevity - Montreal Gazette

Methylation Clocks and True Biological Age – ScienceBlog.com

The good news is that the DataBETA project has found a home. After several months of seeking a university partner, I am thrilled to be working with Moshe Szyfs lab at McGill School of Medicine. DataBETA is a broad survey of things people do to try to extend life expectancy, combined with evaluation of these strategies (and their interactions!) using the latest epigenetic clocks. Szyf was a true pioneer of epigenetic science, back in an era when epigenetics was not yet on any of our radar screens. No one has more experience extracting information from methylation data.

DataBETA is just the kind of study that is newly possible, now that methylation clocks have come of age. Studies of anti-aging interventions had been impractical in the past, because as long as the study depends on people dying of old age, it is going to take decades and cost $ tens of millions. Using methylation clocks to evaluate biological age shortcuts that process, potentially slashing the time by a factor of 10 and the cost by a factor of 100. But it depends critically on the assumption that the methylation clocks remain true predictors of disease and death when unnatural interventions are imposed. Is methylation an indicator, a passive marker of age? Or do changing methylation patterns cause aging?

Two types of methylation changes with age

Everyone agrees that methylation changes with age are the most accurate measure we have, by far, of a persons chronological ageand beyond this, the GrimAge clock and PhenoAge clock are actually better indications of a persons life expectancy and future morbidity than his chronological age.

Everyone agrees that methylation is a program under the bodys control. Epigenetic signals control gene expression, and gene expression is central to every aspect of the bodys metabolism, every stage of life history. Sure, there is a loss of focus in methylation patterns with age, sometimes called epigenetic drift. But there is also clearly directed change, and it is on the directed changes that methylation clocks are based.

But there are two interpretations of what this means. (1) There is the theory that aging is fundamentally an epigenetic program. Senescence and death proceed on an evolutionarily-determined time schedule, just as growth and development unfold via epigenetic programming at an earlier stage in life. Several prominent articles were written even before the first Horvath clock proposing this ideas [ref, ref], and I have been a proponent of this view from early on [ref]. If you think this way, then methylation changes are a root cause of aging, and restoring the body to a younger epigenetic state is likely to make the body younger.

(2) The other view, based on an evolutionary paradigm of purely individual selection, denies that programmed self-destruciton is a biological possibility. Since there is a program in late-life epigenetic changes, it must be a response and not a cause of aging. Aging is damage to the body at the molecular and cellular level. In response to this threat, the body is ramping up its repair and defense mechanisms, and this accounts for consistency of the methylation clock. In this view, setting back the methylation pattern to a younger state would be counter-productive. To do so is to shut off the bodys repair mechanisms and to shorten life expectancy.

So, if you believe (1) then setting back the bodys methylation clock leads to longer life, but if you believe (2) then setting back the bodys methylation clock leads to shorter life.

I think there is good reason to support the first interpretation (1). Epigenetics is fundamentally about gene expression. If you drill down to specific changes in gene expression with age, you find that glutathione, CoQ10=ubiquinone, SOD and other antioxidant defenses are actually dialed down in late life when we need them more. You find that inflammatory cytokines like NFB are ramped up, worsening the chronic inflammation that is our prominent enemy with age. You find that protective hormones like pregnenolone are shut off, while damaging hormones like LH and FSH are sky high in women when, past menopause, they have no use for them. There is a method in this madness, and the method appears to be self-destruction.

Until this year, I have been very comfortable with this argument, and comfortable promoting the DataBETA study, which is founded in the premise that setting back the methylation clock is our best indicator of enhanced life expectancy. The thing that made me start to question was the story of Lu and Horvaths GrimAge clock, which I blogged about back in March.

The GrimAge clock is the best predictor of mortality and morbidity currently available, and it was built not directly on a purely statistical analysis of direct associations with m&m, but based on indirect associations with such things as inflammatory markers and smoking history. (This is a really interesting story, and I suggest you go back and read the March entry if you have not already. The story has been told in this way nowhere else.)

(Please be patient, Im getting to the point.) Years of smoking leave an imprint on the bodys methylation patterns, and this imprint (but not the smoking history itself) is part of the GrimAge clock. I asked myself, How does smoking shorten life expectancy? I have always assumed that smoking damages the lungs, damages the arteries, damages the bodys chemistry. Smoking shortens lifespan not through instructions imprinted in the epigenetic program, but quite directly through damaging the bodys tissues. Therefore, the epigenetic shadow of smoker-years that contributes to the GrimAge clock is not likely to be programmed aging of type (1), but rather programmed protection, type (2).

For me, this realization marked a crisis. I have begun to worry that setting back the methylation clock does not always contribute positively to life expectancy. The canonical example is that if we erased the bodys protective response to the damage incurred by smoking, we would not expect the smoker to live longer.

The bottom line

I now believe there are two types of methylation changes with age. I remain convinced that type (1) predominates, and that setting these markers to a younger state is a healthy thing to do, and that it offers genuine rejuvenation. But there are also some type (2) changes with agehow common they are, I do not knowand we want to be careful not to set these back to a younger, less protected state.

The methylation clocks promise a new era in medical research on aging, an era in which we can know what works without waiting decades to detect mortality differences between test and control groups. But it is only type (1) methylation changes that can be used in this way. So it is an urgent research priority to distinguish between these two types of directed changes.

This is a difficult problem, because the obvious research method would be to follow many people with many different methylation patterns for many decadesexactly the slow and costly process that the methylation clocks were going to help us avoid. My first hunch is that we might find a shortcut experimenting with cell cultures. Using CRISPR, we can induce methylation changes one-at-a-time in cell lines and then assess changes in the transcriptome, and with known metabolic chemistry, make an educated guess whether these changes are likely to be beneficial or the opposite. As stated, this probably will not work because methylation on CpGs tends to work not via individual sites but on islands that are typically ~1,000 base pairs in length. Perhaps changes in the transcriptome can be detected when we intervene to methylate or demethylate an entire CpG island.

Perhaps there is a better way. I invite suggestions from people who know more biology than I know for experimental ways to distinguish type (1) from type (2) methylation changes with age.

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Methylation Clocks and True Biological Age - ScienceBlog.com

Pick Up the Pace: Walking More Quickly May Improve Your Health – Healthline

Share on PinterestResearchers say people who walk more quickly tend to have better cognitive and overall health. Getty Images

When it comes to long-term health of the body and the brain, that old nudge Grandma used to give you may just have powerful implications: Put a little pep in your step.

A 40-year research study published in the journal JAMA Network Open finds that lifelong walking speed may have a direct link to overall health and cognitive function.

In the study, slower walkers were shown to have accelerated aging on a 19-measure scale devised by researchers.

In addition, their lungs, teeth, and immune systems tended to be in worse shape than the people who walked more quickly.

Cognitive function and deterioration was linked to slower walking as well.

The data is from a study of nearly 1,000 people who were born during a single year in Dunedin, New Zealand.

The research participants have been tested, quizzed, and measured their entire lives, mostly recently from April 2017 to April 2019 at age 45.

According to Line J.H. Rasmussen, PhD, a postdoctoral researcher in the Duke University Department of Psychology & Neuroscience and the Clinical Research Centre at Copenhagen University Hospital Amager and Hvidovre in Copenhagen, Denmark, and a lead researcher on the study, what fascinated the team most was that long-term cognitive outcomes seem to connect directly to gait speed in children as young as 3 years old.

Since childhood brain health already at the age of 3 years was associated with walking speed at midlife, it looks like the early life function of the brain could affect the long-term function of the body and thus the walking speed, Rasmussen told Healthline.

A most remarkable finding was that we could predict how fast they walked at midlife by a childhood assessment of their neurocognitive functions at age 3. There was a difference of 12 IQ points on average between children who grew up to be the slowest (mean gait speed 1.21 meters per second) and fastest (mean gait speed 1.75 meters per second) walkers 4 decades later. Gait speed is not only an indicator of aging, but also an indicator of lifelong brain health, she said.

What does this mean?

For the research community and those who study and treat both the aging population and all ages of neurological patients, its a little bit of we knew this and a lot of lets look at this more.

For Rasmussen and her co-researchers, the next step is to dig deeper, specifically looking at the chicken-or-the-egg aspect of all this.

Did a less healthy brain cause slower gait in life, or does having a slower gait lead to the decreased health?

[We want to] find out if poor cognitive function causes the slow walking speed and accelerated aging, she said.

They also want to link with other researchers to find ways to apply this knowledge to current practices.

We would like to see whether gait could be used as a simple way to test the effect of anti-aging treatments, she said.

Rasmussen notes there are randomized trials of preventive treatments for middle-aged people who are still well.

Those trials could use gait as a test to see if the experimental treatments are helping, she said.

So, whats a person to do with this information?

Its not a huge surprise that your lifelong habits influence your lifelong physical function, Michael J. Ormsbee, PhD, FACSM, FISSN, CSCS, associate professor in the department of nutrition, food, and exercise sciences and associate director of the Institute of Sports Sciences & Medicine at Florida State University, told Healthline.

The bottom line to me is one, be active; two, start early; and three, never stop. Lets work on using exercise as medicine and applying this to the early years, rather than later in life, he said.

Ormsbee sees a possible immediate actionable item from this study as well.

It is also interesting that perhaps gait speed could be used as a very easy (at-home even) test to do and gauge health, he said.

Walking speed has long been used as a measure of health and aging in older patients, but whats new in this study is the relative youth of these study participants and the ability to see how walking speed matches up with health measures the study has collected during their lives.

Applying this to testing, both in home and medical offices, could help pinpoint possible issues and bring in intervention sooner.

Predicting future health would be huge for overall health and economic burden, Ormsbee said.

While the study authors work to dig deeper and look at things such as socioeconomic background, lifestyle habits, and other issues, the general public can take easy action, Ormsbee says.

He says its never a bad idea to move more, and move more quickly, at any age.

Its never too late (or too soon) to move more, he said.

But he also adds that people should still remember to stop and smell the roses.

In other words, move at a healthy pace but remember to savor this life as well.

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Pick Up the Pace: Walking More Quickly May Improve Your Health - Healthline

Everything you need to know about Bakuchiol a smart alternative to Retinol – Dazed

In our on-going quest for perfect skin, Retinol has been considered a bit of a hero product. A derivative of vitamin A, Retinol helps boost collagen production and aids in cell turnover thus helping reduce everything from wrinkles and sunspots to acne and uneven skin, making it a favourite of everyone fromFrank Oceanto AOC.

However, Retinol can also often cause irritation and dryness, especially for those with sensitive skin, and those who suffer from rosacea, eczema, or psoriasis are advised to steer clear. Not to worry though, there is a new ingredient in town which boasts all of the benefits of Retinol without any of the irritants. Introducing: Bakuchiol.

Pronounced buh-koo-chee-ol, Bakuchiol is a plant-based derivative of the babchi plant (psoralea corylifolia). For years, the babchi plant has been widely used in Ayurvedic medicine (a thousands year old holistic healing system originating in India) to treat a variety of illnesses from indigestion to scorpion poisoning, and now new research has emerged that shows Bakuchiol mimics the effects of Vitamin A when used in skincare.

In 2018, a study published by the British Journal of Dermatology reported that: Bakuchiol is comparable with retinol in its ability to improve photoageing and is better tolerated than retinol. Concluding that: Bakuchiol is promising as a more tolerable alternative to retinol.

Not only is Bakuchiol is anti-aging, anti-bacterial and anti-inflammatory, with the potential to treat acne and hyper-pigmentation, critically, it also does without the less than ideal side effects of Retinol such as redness, burning, skin irritation and dryness.

With all those benefits plus a few additional ones Bakuchiol is suitable for vegans and safe for use during pregnancy, unlike Retinol this new hero ingredient is on its way to holy grail status. Here weve rounded up some of the best products on the market right now.

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Everything you need to know about Bakuchiol a smart alternative to Retinol - Dazed

Dr. Monica Jacob Obesity Consultant and Anti-Aging Physician in Mumbai – The India Saga

By TIS Staffer 09 Oct 2019

Dr. Monica Jacob is MBBS, M.D (Bom), She is an Aesthetic physician, Obesity Consultant, and Anti-Aging Physician.

She has been practicing for 16 years. She completed her M.B.B.S from J.J Group of hospitals, Grant medical college (Mumbai) in 1999, M.D. from TNMC, Nair medical college (Mumbai).

DPB from C.P.S in 2002.Diploma in aesthetic dermatology (American academy of aesthetic medicines), Nutrition & Diet planning (Australia, gold coast academy), Hair transplantation (American Acadamy of Aesthetic medicines), Anti-ageing medicine- hormones.

Her clinic offers the latest technologies for the treatment of various skin and hair ailments.

Dr. Monica Jacob is an amazing doctor. She is so vibrant and her good attitude is infectious. She is thorough and meticulous in her job. She is very friendly & equally professional. She helped her patients in understanding the reasons for the skin issues & also explained in detail various treatment procedures to address the same. In fact, Various patients highly recommended her.

Easy Remedies that she tells to Follow

1.Protect your skin from the sun every day. ...

2.Apply self-tanner rather than get a tan. ...

3.If you smoke, stop. ...

4.Avoid repetitive facial expressions. ...

5.Eat a healthy, well-balanced diet. ...

6.Drink less alcohol. ...

7.Exercise most days of the week. ...

8.Cleanse your skin gently.

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Dr. Monica Jacob Obesity Consultant and Anti-Aging Physician in Mumbai - The India Saga

Push-ups? Here’s what can really help you live to a ripe old age – The Australian Financial Review

The problem with any of these approaches is that you would just be training for a particular test, which misses the point. It's not the push-up itself that makes you live longer; it's that you are still strong and nimble enough to execute one.

What these tests have in common is they're good shorthand of things that matter for longevity: overall health, fitness and muscle strength. A fit person walks faster than someone out of shape, and getting up off the floor is tricky for people with weak bones and muscles.

"Frailty is a really bad thing starting in middle age, and even worse as you get older," says Michael Joyner, a physician and human physiology researcher at the Mayo Clinic.

One way to think of longevity is "not as some magic property of a body, but as the lucky state of not having a fatal disease", says Steve Cole, professor of medicine and psychiatry and bio-behaviouralsciences at the UCLA School of Medicine. "By and large, people don't die of being old; they die of disease." Therefore, the study of longevity is a way of looking at disease risk or the rate of disease development, he says.

Over the years, various drugs and nutritional supplements have been studied for their potential to help us live longer, but nothing has been shown to work in humans to the extent that would be required for the Food and Drug Administration's approval, says Gordon Lithgow, chief academic officer at the California-based Buck Institute for Research on Aging.

While researchers continue searching for a pill to extend life, you'll have to try these verified methods.

The most powerful way to promote longevity and improve your long-term health is also simple and, depending on how you do it, free.

"There's no question that exercise is the biggest anti-ageing medicine there's ever going to be - it's really huge," Lithgow says.

"Hands down, nothing compares to exercise," says Laura Carstensen, founding director of the Stanford Center on Longevity. "The great thing is that most people can do it, and you don't need 10,000 steps per day to get the benefits." It takes remarkably little exercise to get longevity benefits.

Even 10 to 15 minutes a day provides measurable rewards, says Michael Joyner, a physician and human physiology researcher at the Mayo Clinic. Going from sedentary to even just a bit of exercise is where you get the biggest payoffs. The health benefits - such as reducing your risk of heart disease and diabetes - increase with greater amounts of exercise, until you get to about an hour of exercise per day. After that, the rewards start to level off.

"Almost anyone doing more than that is doing it for things other than health," Joyner says.

Go ahead and train for that Ironman if that's what you want, but if you're exercising for health and longevity, you don't need to run a marathon. Work by Iowa State University epidemiologist Duck-Chul Lee suggests that even running a little less than 10 minutes a day could decrease your mortality risk by about 30 per cent.

But you don't have to run. Walking or other moderate activities are just as good if you're looking for a longevity boost.

Some of the early evidence for the heart benefits of moderate exercise came from studies in the 1950s by British epidemiologist Jeremy Morris showing that conductors on double-decker buses, who spent their shifts walking up and down, had lower rates of coronary heart disease and thus lived longer than bus drivers who spent their workday sitting. Since then, studies showing the cardiovascular benefits of exercise have been "incredibly consistent", Joyner says.

But there's more. Physical activity also reduces the risk of diabetes, which one study found shaved six years off life expectancy.

And it keeps your brain healthy, too. "Exercise has better effects on cognitive performance than sitting around playing brain games," Carstensen says. A 2006 study in Neuroscience found that exercise spurs the brain to release growth factors that promote new connections between neurons, keeping the brain healthy. There's even research suggesting that strength training can reverse some age-related changes in your muscles.

There seems to be something about keeping an active lifestyle, too.

When you look at centenarians as a group, they might not be Arnold Schwarzeneggers, but they typically maintain a high level of physical function, says author Bill Gifford, who interviewed quite a few of them while writing his book, Spring Chicken: Stay Young Forever (Or Die Trying). "They can go up and down stairs, probably because they never stopped going up and down stairs," Gifford says.

His research for the book spurred him to make sure he was exercising at least a little bit every day.

Extend your life span while you sleep. It sounds like a bad infomercial, but it turns out that sleeping well is a good way to keep your body healthy for the long haul. Sleep is a time when your brain gets caught up on maintenance. In 2013, a team led by Maiken Nedergaard at the University of Rochester Medical Center published a study in Science concluding that sleep helps the brain clear out metabolic waste that accumulated during waking hours, providing a kind of restorative maintenance.

Skimp on sleep, and you hinder this important work.

If you've ever missed a night of slumber, you know that sleep deprivation hampers your mood and makes it hard to think clearly, but it can have severe consequences for your metabolic health, as well. Take someone who needs seven hours of sleep a night and restrict them to only five hours of shut-eye for five nights and they experience metabolic changes that look a lot like diabetes, says Satchidananda Panda, who studies circadian biology at the Salk Institute for Biological Studies.

Indeed, numerous studies have shown that sleep deprivation can decrease insulin sensitivity - a measure of how well your body regulates blood sugar - and increase your risk of diabetes. A 2015 meta-analysis found that Type 2 diabetes risk was higher in people who sleep less than seven hours or more than nine hours, compared with people who got seven to eight hours a night.

So why is sleeping more than nine hours associated with greater mortality? "People who sleep 14 hours per day are probably not healthy," Carstensen says, but it's hard to say right now whether it's possible to get too much sleep. Most people are on the other end of the spectrum.

Regularly sleeping too long may indicate a health problem

The consensus among sleep researchers is that seven to eight hours of sleep is ideal, but that's just a best guess based on the current data, Carstensen says.

"The biggest problem is that most of the data is self-reported and people are really bad at that," Carstensen says.

The advent of sleep trackers can help with the measurements, but they aren't always accurate, so avoid fixating too much on the exact numbers or you may end up in a cycle of anxiety that prevents you from sleeping. The problem is common enough that researchers have coined a term for it - orthosomnia.

Don't make a habit of skimping on sleep during the week with the idea that you'll catch up on the weekends. It doesn't take many nights of short sleep to reduce insulin sensitivity, and a small study published this year in Current Biology found that recouping on sleep over the weekend didn't entirely make up for the metabolic problems that developed during sleep deprivation. Furthermore, when volunteers in the study were given the opportunity to catch up on sleep over the weekend, they ended up shifting their body clocks so that it became harder to get up on Monday morning.

(Getting enough sleep every night might also improve your work life. In the throes of writing his book, Gifford made a decision to start prioritising sleep over work. His deadline was fast approaching, and he'd been getting up early and staying up late. Allowing his body to sleep as long as it needed to led to a "radical transformation in my ability to write", Gifford says. "I'd been trying to work 14 hours per day, and then suddenly I was getting twice as much done in six or seven hours.")

Forget all those headlines you've seen about "anti-ageing diets" and anti-aging "superfoods".

"These notions are generally not supported by science," Lithgow says. That's not to say diet isn't important, only that "nutrition is just a very difficult science", he says.

Severely restricting calories in lab animals makes them live longer, but "it's not clear that it works in humans", Lithgow says. Although there's plenty of evidence that it's not good to overeat, he says, whether drastically limiting food intake can extend life in people remains an open question. The joke, of course, is that calorie restriction will surely make your life seem longer.

It might be possible to get some of the benefits of calorie restriction without giving up so much food. Intriguing work by Panda suggests that restricting the timing of when you eat, rather than the amount, might provoke some of the healthy metabolic changes that reduce the risk of diabetes. Most of these studies have been done in mice, however, and Panda acknowledges that the human studies are small.

Although Panda is confident enough in the results to have written a book, The Circadian Code, which includes instructions on how to try it, some scepticism is warranted, Joyner says.

"Time-restricted eating has shown some interesting results in small studies," Joyner says, but "will it be sustainable over time in the real world? This is important because most dietary strategies work only if they are adhered to."

He says he wonders whether the metabolic benefits that Panda has found with time-restricted eating is really about the timing or simply related to people eating less when their dining hours are restricted. One thing shown repeatedly in anti-ageing studies is that things that initially look like magic bullets never live up to their initial hype, Joyner says.

What does seem clear, however, is that metabolic health is important for long-term health, because it keeps diabetes in check and that insulin sensitivity in particular appears crucial.

Given what we know right now, a Mediterranean diet - with its heart-healthy emphasis on fish, vegetables, fruits, nuts, healthy fats like olive oil, whole grains and limited consumption of red meat - "is probably the best approach for improving longevity", Carstensen says.

But the benefits are pretty modest. If you hate eating that way, then the payoff probably won't feel worth it to you, she says. At least try to eat a diet rich in fruits and vegetables.

The idea of red wine as a health elixir became popular in the 1980s with the observation that rates of coronary heart disease were low in France, despite the predominance of a diet relatively high in fat and cholesterol. The French penchant for a glass of red wine with dinner was proposed as an explanation for this "French Paradox", popularisingthe notion of red wine as heart helper.

Subsequent studies have indeed found that moderate alcohol consumption may reduce the risk of coronary heart disease, and a two-year randomisedclinical trial in Israel showed that people with Type 2 diabetes who were assigned to drink a glass of red wine with dinner every night experienced some improvements in blood markers associated with cardiovascular disease risk.

But other studies suggest that alcohol may raise the risk of many cancers, and a report published last year in the journal Lancet concluded that there's no amount of alcohol that improves health. What gives?

"Alcohol studies are very much like nutrition studies - based almost exclusively on self-reports, and we know that people are really bad at self-reporting," Carstensen says. "Most people, when they say they're drinking two drinks per day, are probably consuming more. We don't know the amounts that people are consuming nor do we know what else they do."

There's some evidence that people who abstain from alcohol are sicker or less healthy than those who imbibe a little.

"That probably reflects not a lack of alcohol in their system, but something about their world - that they're sick or isolated or don't have friends to meet at the pub," Carstensen says. "I've never seen a study that's really controlled for all of those factors." Which means that the studies calculating the health consequences of alcohol consumption depend on consumption figures that are inherently unreliable and may fail to account for other factors that could be at play.

Drinking to excess - more than one or two drinks a day - is unhealthy, and will take a toll on your longevity - no doubt about it. But taking the published studies together, "I don't think we have a lot of evidence that moderate alcohol is bad for you," Carstensen says. At the same time, she'd "be very hesitant to recommend that people who don't drink should start".

In today's world, it's easy to live in a state of chronic stress, and the problem isn't just that stress feels lousy. It also makes you more susceptible to diseases that could shorten your life.

Researchers are now learning that many conditions associated with older age - such as cancer, heart attacks and Alzheimer's disease - share a common ingredient: inflammation.

Under normal conditions, inflammation is simply the body's response to injury - it's how the body heals cuts and wounds and other insults, Cole says. "Inflammation by itself is not inherently evil." But when we're feeling chronically threatened or under siege, our bodies amp up their inflammatory machinery to ready our biological response to injury, and that inadvertently fuels the development of an array of age-related diseases, where inflammation is a common fertiliser, Cole says.

Research has identified chronic stresses that can provoke harmful biological changes, including living in poverty, caregiving for a dying spouse, losing a loved one, suffering post-traumatic stress disorder, and experiencing prejudice.

"Any way of feeling threatened or insecure seems to be enough to activate the body to produce more inflammation," Cole says. "This is one of the best defined connections between the world as we experience it and how we end up generating a body that's a fertile ground for the development of these diseases."

Your chance of developing chronic inflammation also rises with the passing years. "Inflammation seems to be a general sign of aging, where our inflammatory processes are being turned on or accumulated," Lithgow says. "Age-related inflammation is very much like inflammation from an injury, but now it's coming on without a source of infection."

What's the antidote? "Obviously we should all just be happy," Cole says with a laugh, as if it were that easy. He knows that it's not and says you probably can't eliminate stress from your life, but you can find ways to manage it. Identify the recurring stressors in your life, and work on a plan to diffuse them.

Wellness strategies such as yoga, tai chi and meditation can reliably help diffuse stress, Cole says, although he acknowledges that they often don't make a huge difference.

Forging connections with other people has been found to be a powerful way to manage stress and improve your overall wellbeing.

"People who report having stronger relationships live longer than people who are socially isolated," Carstensen says. A meta-analysis published in 2015 calculated that loneliness and social isolation were associated with 29 per cent and 26 per cent increases in mortality risk, respectively, and living alone was linked to a 32 per cent increase risk of dying.

What's clear is that people who have a strong sense of purpose and meaning in their lives have a markedly lower risk of death than those who don't.

"How we can bottle that and make it useful is more of a challenge," says Cole, who has studied loneliness and longevity.

Telling a lonely person to stop being lonely doesn't work, Cole says, "but if you can go to the lonely person and say, 'Hey, we really need your help. Is there anything you can do to help others?' - that is incredibly powerful. The mechanism here seems to be turning attention away from yourself and your own suffering and toward a community or cause greater than yourself."

Centenarians tend to have a sense of purpose in their lives.

"It's really important that people who are entering the later phases of life have a clear purpose, something to get up for every day," Lithgow says. That thing can be anything from looking after a grandchild or working or tending a garden.

Many centenarians continued working into their 80s, 90s and beyond, Lithgow says, and usually these jobs are in environments where they interact with younger people.

Interacting with other generations can keep older people engaged, and some retirement communities and nursing facilities are now taking steps to give their residents opportunities to connect with kids - for instance, placing kindergarten classrooms in nursing homes.

Most of the proven tips for living a long, healthy life are not products that you buy, but good lifestyle habits that you adopt (or bad ones, such as smoking, that you either quit or never take up and are clearly associated with diminished longevity).

Even something as simple as always wearing a seat belt can reduce your chances of dying early. Most of the things that make up a longevity lifestyle are simple - exercise, eat (and drink) healthily, sleep adequately, stay engaged - if only people would do them.

"To me, the bottom line is: Live a reasonably moderate life and you'll be OK," Carstensen says.

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Teresa Sievers: The life behind the murder victim – Wink News

FORT MYERS

While you may know her face and you probably know the name, who was Dr. Teresa Sievers before she was a murder victim?

Ladies, remember when walking into a room meant turning heads? said Teresa in a YouTube video. You had that glowing skin, in-shape body. Didnt you feel sexy and confident?

Teresa was used to commanding attention. She was always dressed to perfection, always in heels and her middle name was literally Grace.

She was a tiny thing like you and just as cute as a bugs ear, said a former patient, Marian Ziegler-McAfee. Uplifting, positive, full of energy, a dynamo, a dynamo in a tiny package.

Teresa was only 411. When patients like Marian got to know her, they appreciated her, even loved her.

Several people said that she was like the Oprah Winfrey of Florida, Marian said. That she was that popular.

MORE:Teresa Sievers murder trial pushed back, date undecided

Teresa grew up in Connecticut. She was her high school valedictorian and later on graduated medical school with honors. When the new doctor moved to Charleston, she met her first husband, Kenny Cousins.

I believe this is the sort of person you might meet once in your life, Kenny said. When I met Theresa, she was doing clinical research in South Carolina. Some of the ways that we connected certainly love of the outdoors, the ocean, music, food and really having a good time. The real kind of a work hard, play hard ethic.

The pair moved to Saint Pete where Teresa worked at an outpatient clinic in a disadvantaged part of town.

She didnt think it was fair that she would have to have two or 3,000 patients, Kenny said. She could literally only spend 15 minutes with each of those patients.

MORE:Attorneys motion contains disturbing detail of Sievers murder

Three years after they married, Teresa and Kenny divorced. But Kenny said they remained dear friends. Even when Teresa remarried to Mark Sievers a few months later, they kept in touch, emailing monthly a couple of short lines with life updates.

She really felt restricted to be a doctor and thats one of the reasons when she got remarried to Mark, Kenny said. They bought a practice in the Fort Myers area where she wasnt taking medical insurance because it sort of lifted that burden.

It was a calling she had and she fulfilled it in an exceptional way. It was not a 15-minute visit; it was an hour and a half a visit, Marian said. Im grateful that I got that in this lifetime. Thats how rare she is.

For her patients, her medicine lives on in a series of videos on a YouTube channel, which focuses mainly on anti-aging. Many women turned to her for help through menopause. It was a group of women she was talking to when she said something that now has the kind of irony that makes you think.

I dont know about you, but Im not ready for post-mortem, said Teresa in a YouTube video. I want to enjoy my life like it is now.

MORE:From dreams to nightmare, key witness describes life before, after Sievers killing

Teresa had a beautiful life or at least that is how it looked.

Almost a year to the day after that video was uploaded, Teresa was murdered. She came back early from a family trip while Mark and their two daughters stayed in Connecticut.

Teresa rolled her suitcase into an attack in her kitchen.

Is she awake? the dispatcher said.

No she is dead on the floor, the caller said. Shes cold. The back of her head is bashed in and there is blood everywhere.

WINK News Anchor Amanda Hall first interviewed Kenny in 2015, shortly after the killing.

I mean my God shes 411 and defenseless and by herself, Kenny said. If there were problems in their marriage, why couldnt they just get divorced?

As Mark awaits trial for plotting his wifes murder, Kenny wants people to focus on how special she was.

This is the Teresa. This is the person that I know. This is the person that I care about and respect and honor, Kenny said. I really want people to understand this is a loving, kind, caring nurturing mother and physician. This is a person that wanted to and I believe made an impact on everyones life that she touched.

Will he ever find peace? Teresa may have answered that best in one of her YouTube videos.

Is it a guarantee? Teresa said. No. Theres no guarantees in life.

Its hard to find peace knowing that somebody that you know and love and care about and you always want the best for has been taken this way, Kenny said. I havent been able to get my arms around any of that yet. I dont know if I ever will.

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Ingredient Spotlight on Snow Mushroom – Truth In Aging

Snow mushroom or tremella fuciformis (also known as snow fungus, snow ear, silver ear fungus and white jelly mushroom) starts out as a slimy, mucous-like film until it encounters its preferred hosts. Then it grows into an ethereally pretty white cloud that is gaining a well-deserved reputation in anti-aging skincare.

Tremella is one of natures natural sponges. It is said that it can hold 500 times its weight in water.This is about half as much as hyaluronic acid, which behaves in a similar way to draw in moisture and retain it. But snow mushroom has so much more going for it than hyaluronic.

For a start, snow mushroom can create a flexible hydration film that helps to restore dry skin to its optimally hydrated state. The molecular size of the extract is smaller than hyaluronic acid (a notoriously clunky molecule) and this means it can penetrate the skin more easily.

Then this shroom just keeps getting better. Scientists have demonstrated that it exhibits potent antioxidative, anti-inflammatory and anti-aging effects. Wondering why, they discovered that snow mushroom protects fibroblasts via the upregulation of SIRT1 expression. This has to do with sirtuins, which regulate the activity of the genes responsible for metabolism, cell defense and reproduction. When food is scarce, the body's sirtuins go into self-preservation mode. So giving your sirtuins a boost is a good thing.

Tremella fuciformis is a traditional nutritional food in China and is used as a traditional Chinese medicine and dietary supplement. Recent studies have indicated that the medicinal and tonic properties of tremella fuciformisare due to its polysaccharides, which are anti-inflammatory. Polysaccharides in skincare also reduce transepidermal water loss, protecting the skin barrier function.

Researchers have also demonstrated that snow mushroom oxidative stress and apoptosis in skin fibroblasts in a concentration-dependent manner and possessed excellent antioxidative properties. (source). It also efficiently reduced water and collagen loss in the skin and inhibited the increase of glycosaminoglycans.

A few other claims are less well documented (at least not that I can find), but Ill record that snow mushroom has also been shown to inhibit melanin production by 59.7%. It is also said to be comprised of over 18 kinds of amino acids and is a source of vitamin D.

Find tremella in hMSC Skincare Amplify ($160 in the shop), Cannatera Renew Facial Moisturizer ($69 in the shop), Cannatera Revive Serum ($79 in the shop), and Dr. Dennis Gross Alpha Beta Pore Perfecting Cleansing Gel ($32 in the shop)

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EastGate Biotech Announces Expansion and Restructuring of Joint Venture with its Partner in Pakistan – GlobeNewswire

Key products to be tested, registered and marketed include Insugin for diabetes application, alternative insulin for Alzheimers application, and Blood Plasma Derived Products, Human Serum Albumin 20%

WEST CALDWELL, NJ and TORONTO, ON, Oct. 09, 2019 (GLOBE NEWSWIRE) -- via NEWMEDIAWIRE -- EastGate Biotech Corp. (OTC: PINK: ETBI), a pharmaceutical company that focuses on innovative technological developments specifically in insulin drug delivery for the treatment of Type 2 diabetes, announced today that it has restructured its Joint Venture Agreement in Pakistan. The rationale behind the restructuring was to initiate a branding campaign that expanded the purpose of the Joint Venture beyond Insugin. An independent company called EastGate Biotech Pakistan was established by the local partner with the same ownership structure of 51% held by EastGate Biotech and 49% held by EastGate Biotech Pakistan.

The objectives and activities of the Joint Venture Agreement include:

Human Serum Albumin (HSA) is made of plasma proteins from human blood. It is one of the primary components of blood and typically extracted from expired blood. This medicine works by increasing plasma volume or levels of albumin in the blood. HSA is used to replace blood volume loss resulting from trauma or an injury that causes blood loss.

The global plasma fractionation market is projected to reach $29.5 Billion by 2023 from $21.23 billion in 2018. Blood Fractionation is a critical, essential, and even a matter of national security to every country that wants to be independent of import and reliance on a single local producer.

We are pleased to solidify our relationship with our local JV partner, said Anna Gluskin, CEO of EastGate Biotech. Our local partner initially approached us with the idea of branding the EastGates name for our innovative delivery of Insugin for diabetes treatment, but then wanted to expand it to include the Alzheimers indication. Both parties realized there is greater value in developing a brand versus just one product. So the inclusion of the opportunity to register blood plasma derived products to the Joint Venture pipeline fits our strategy of creating greater shareholder value. This restructuring has increased the revenue potential for EastGate and long term profitability for all of our stakeholders.

EastGate has an incredible delivery platform, said COO, Bill Abajian. Once this proprietary technology is demonstrated on a commercial scale there is little doubt that many large and territorial pharmaceutical companies will want to possess it. Licensing has always been a key part of our strategy and formulating new methods of delivery is a key maneuver in big pharmas playbook for their own product pipeline. The Pakistani JV Agreement has clear objectives which focus on products with massive potential, but only require a small market penetration rate in order for EastGate to recognize substantial revenues which lead to greater valuations. We ultimately look to strengthen our pathways for both a robust financial scenario for EastGate or for strategic M&A partnerships.

We look forward to boosting the awareness of EastGate Biotech as an innovative company, said CEO of EastGate Biotech Pakistan, Nasir Irfat. Our overall plan is to start with our own alternative insulin products and build a solid foundation and brand name. We believe the oral insulin mouth rinse could reach blockbuster status at which point we would hope to attract other innovative products that are in high demand. It gives me great pleasure to introduce EastGate Biotech to the Blood Plasma-derived product space through my own license with JV Pharmaland of Belarus, which is one example of a product with critical use.

About EastGate Biotech

EastGate Biotech focuses on innovative technological developments and produces and distributes innovative drug compounds and healthy nutraceuticals that are based on natural therapies absorbed by the body. We utilize advanced nanotechnologies and alternative delivery systems that take difficult to deliver compounds and deliver them using our nanotechnology platform which ultimately increase the bioavailability to the body. Using our methods of delivery provides healthy alternatives to conventional pharmaceuticals that all-too-often create dangerous side-effects and unexpected consequences for those trying to attain and maintain a healthy lifestyle. EastGate's wholly owned subsidiary Omni Surgery and Anti-Aging Centre is the first of many surgery centers to come under the Omni umbrella as we plan to roll up existing business under the Omni brand and expand our footprint globally.

Cautionary statement on forward-looking information

All statements, other than statements of historical fact, contained or incorporated by reference in this news release constitute "forward-looking information" or "forward-looking statements" within the meaning of certain securities laws, including the provisions for "safe harbor" under the United States Private Securities Litigation Reform Act of 1995 and are based on expectations, estimates and projections as of the date of this news release.

The words "anticipates", "plans", "expects", "indicate", "intend", "scheduled", "estimates", "forecasts", "focus", "guidance", "initiative", "model", "methodology", "outlook", "potential", "projected", "pursue", "strategy", "study", "targets", or "believes", or variations of or similar such words and phrases or statements that certain actions, events or results "may", "could", "would", or "should", "might", or "way forward", "will be taken", "will occur" or "will be achieved" and similar expressions identify forward-looking statements. Forward-looking statements are necessarily based upon a number of estimates and assumptions that are inherently subject to significant business, economic and competitive risks, uncertainties and contingencies. The risks, estimates, models and assumptions contained or incorporated by reference in this release, include those identified from time to time in the reports filed by EastGate with the SEC, which should be considered together with any forward-looking statement. EastGate undertakes no obligation to update publicly any forward-looking statements, whether as a result of new information, future events or otherwise.

CONTACT:

Rose Perri1-647-692-0652Email: information@eastgatepharmaceuticals.comWebsite: http://www.EastGateBiotech.com

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EastGate Biotech Announces Expansion and Restructuring of Joint Venture with its Partner in Pakistan - GlobeNewswire

Aesthetic Medicine & Anti-Aging Clinic | Baton Rouge …

FACIALS, HAIR REMOVAL AND MICRODERMABRASION IN BATON ROUGE AND LAFAYETTE, LA

You can achieve many of the anti-aging results you seek through non-invasive, relaxing spa treatments in Baton Rouge and Lafayette, LA, from The Aesthetic Medicine & Anti-Aging Clinics of Louisiana. Facials, peels and microdermabrasion purify the skin and accentuate your natural beauty while waxing and laser hair removal effectively eliminate unsightly hair.

We also sell many beneficial skin care products so you can maintain your vibrant, healthy appearance in the comfort of your home. Call today to learn more about our beautifying spa services, skin care products and anti-aging treatments in Baton Rouge and Lafayette, LA and schedule your free consultation.

Botox and Vaser liposuction will make you look great, but if you have a hormone imbalance, you likely wont feel as good as you look. If you are suffering from lower energy and libido, increased weight gain and other seemingly unexplainable issues, it may be due to a hormone imbalance. We specialize in hormone replacement therapy, including testosterone replacement. Call today to schedule your free consultation with a hormone replacement therapist and discover if hormone replacement therapy is the solution to the issues that affect your quality of life.

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Aesthetic Medicine & Anti-Aging Clinic | Baton Rouge ...

Anti-Aging Medicine | Pagdin Health

Please ensure you complete the registration form and questionnaire with as much detail as possible. Dr. Pagdin will be utilizing many of your answers to create a tailored and comprehensive lab requisition for you.

*In order to reduce the duplication of ordered lab testing, please forward any recent lab results that you have had within the last 3-6 months, to us along with your completed forms.

Get your lab results online! Visithttp://www.myehealth.ca/ to find out more.

Once the questionnaire and registration form are complete, return all documents to us either by email, fax, or you may drop them off in person. You will then be contacted by our office to arrange a brief 15-minute interview, either by phone or in person, with the doctor to establish and arrange your lab testing.

Our services are not covered by medical insurance therefore, full payment is required prior to the services rendered.

An Anti-Aging consultation is 45 minutes in length and $350. 30-minute quarterly appointments are recommended for the first year ($250). Additional 15-minute follow-up appointments are $125. Our goal is to have you feeling optimal and balanced such that we will see you once or twice a year. As an added convenience for our patients, follow-up appointments can be done over the phone.

Please note that seeing Dr. Pagdin for Anti-Aging treatments does not make him your "family doctor". He will be acting as an Anti-Agent Consultant. All other medical concerns should be followed-up with your family doctor or at a walk-in clinic.

Please feel free to call or email if you have any further questions. We look forward to being in touch with you soon.

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Novus Anti-Aging Center Los Angeles | Erectile Dysfunction …

Novus Anti-Aging Center Los Angeles | Erectile Dysfunction Clinic

Welcome to the orgasm clinic! If your sex life is anything short of amazing, come see us for a free consultation. We offer innovative and non-invasive procedures that are proven to be effective up to 90% without the use of medications or risky surgeries.

Stephanie is the nations leading sexual wellness expert, the co-founder of Launch Medical, co-inventor of The Phoenix, a Board Certified Anti-Aging Specialist, Hormone Expert, and Peptide Expert with the American Academy of Anti-Aging Medicine,a Board Certified Physicians Assistant, and aCertified Weight Loss Specialist with the National Academy Of Sports Medicine.She graduated from Arizona State University in 2000 with her Bachelor of Science in Life Sciences and continued on to Midwestern University where she obtained her degree as a Physician Assistant.

At Novus Anti-Aging Center, we provide treatments for male and female hormone mastery for our Los Angeles patients. Our specialists have helped harmonize hormones and happiness for hundreds of mature patients who are now living the high life (with a revived love life).

The Novus Center Answers Your Most Asked Questions about Sexual Performance

If you've suffered from vaginal laxity for quite some time, you may have thought revival was impossible. In the past, women had no choice but to bear the effects of childbirth and make the most of it, but those days are long gone - now, Viveve is empowering women to take back their vibrant sexuality on their own terms.

Your sex life - regardless of your age - might have taken a nosedive because sex has become painful or unexciting due to lack of arousal. The O-Shot is a revolutionary nonsurgical treatment that uses a patient's own blood platelets to activate growth factors that rejuvenate the female orgasm system.

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2020 | MIT Technology Review

Novel drugs are being designed to treatunique genetic mutations.

Heres a definition of a hopeless case: a child with a fatal disease so exceedingly rare that not only is there no treatment, theres not even anyone in a lab coat studying it. Too rare to care, goes the saying.

Thats about to change, thanks to new classes of drugs that can be tailored to a persons genes. If an extremely rare disease is caused by a specific DNA mistakeas several thousand aretheres now at least a fighting chance for a genetic fix.

One such case is that of Mila Makovec, a little girl suffering from a devastating illness caused by a unique genetic mutation, who got a drug manufactured just for her. Her case made the New England Journal of Medicine in October, after doctors moved from a readout of her genetic error to a treatment in just a year. They called the drug milasen, after her.

The treatment hasnt cured Mila. But it seems to have stabilized her condition: it has reduced her seizures, and she has begun to stand and walk with assistance.

Milas treatment was possible because creating a gene medicine has never been faster or had a better chance of working. The new medicines might take the form of gene replacement, gene editing, or antisense (the type Mila received), a sort of molecular eraser, which erases or fixes erroneous genetic messages. What the treatments have in common is that they can be programmed, in digital fashion and with digital speed, to correct or compensate for inherited diseases, letter for DNA letter.

How many stories like Milas are there? So far, just a handful.

But more are on the way. Where researchers would have once seen obstacles and said Im sorry, they now see solutions in DNA and think maybe they can help.

The real challenge for n-of-1 treatments (a reference to the number of people who get the drug) is that they defy just about every accepted notion of how pharmaceuticals should be developed, tested, and sold. Who will pay for these drugs when they help one person, but still take large teams to design and manufacture?

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2020 | MIT Technology Review

The Dog Aging Project digs deeper than ever to help our best friends live better longer and the findings could help us, too – The Spokesman Review

SEATTLE If it werent for squirrels, Bagel probably wouldnt be here today at Washington State Universitys College of Veterinary Medicine. The yellow Labrador was destined to be a guide dog for the blind but flunked out because she was distracted by small animals. Now, this otherwise very good girl has a second chance to be of service by participating in the most comprehensive study ever conducted of health and aging in dogs.

Bagels owner, Brenda Voght, volunteered her to join a research pack that already includes more than 37,000 pet dogs across the country and is expected to swell to 100,000. Called the Dog Aging Project, the ambitious undertaking seeks to answer many of the questions dog owners ask and often anguish over: Why do some breeds live longer than others? How do genetics, environment and lifestyle affect longevity and the risk of disease? And, above all: How can we ensure our beloved companions stay healthy, happy and active for as long as possible?

I would like to know if there is something we can do as humans, as their partners, to extend their lives a little longer, says Voght. After her last dog died, it was a year before she was able to open her heart to another puppy.

She fostered Bagel for about a year, then adopted her after the canines career change the gentle euphemism used when guide dogs dont make the cut.

On average, yellow Labs live 10 to 12 years.

Bagel is 9.

The project welcomes dogs of all types and ages and plans to track them for at least 10 years, says Daniel Promislow, an evolutionary geneticist at UW Medicine who co-founded the initiative and helped assemble a national team of more than 80 researchers, veterinarians and data scientists to coordinate the massive undertaking.

No one has ever investigated such a large number of dogs over such a long period of time, especially at the level of detail Promislow and his colleagues envision. One branch of the study is sequencing the genomes of at least 10,000 dogs. Another zeros in on the oldest dogs in the pack the supercentenarians to look for keys to their longevity.

All of us are really excited about what will come out of it, says Elaine Ostrander, who pioneered genetic analysis of dogs more than two decades ago in Seattle at the Fred Hutchinson Cancer Research Center. She now works at the National Human Genome Research Institute.

Its long been clear that big dogs have shorter lifespans than small dogs, and that different breeds are predisposed to different ailments, says Ostrander, who is not involved in the project. Golden retrievers are prone to cancers. German shepherds often develop hip dysplasia. Doberman pinschers have a high prevalence of heart disease. The Dog Aging Project will help reveal more about the mechanisms behind those links, she says.

Theyre going to be able to make those connections pretty tightly because their data set is the biggest one out there.

The researchers also hope to gain insights into normal aging, along with the entire spectrum of ailments that plague older dogs, from arthritis and hearing loss to cataracts and cognitive decline. Discovering ways to help dogs live longer would be wonderful, says Promislow. But the primary goal is to prolong health span that golden period of well-being when dogs can leap and dive and fetch and snuggle free from pain or disability.

We want to help each dog live the longest, healthiest lifespan that it can, he says.

The findings could be relevant to human health as well.

Dogs suffer from many of the same diseases we do. And unlike mice and other animals used in laboratory studies, dogs are genetically diverse. They live in our homes, breathe the same air and experience the same conditions.

The sad fact that dogs lives are shorter than ours means its possible to gain that knowledge more quickly by focusing on humanitys best friends.

Most of the animals enrolled in the Dog Aging Project never have to leave their home turf. Owners fill out an annual, 116-page questionnaire that covers everything from diet and mobility to temperament, favorite types of toys, bowel habits, pesticide exposure, health status and sleeping arrangements. Environmental data, like air and water quality, is correlated to each dogs geographic location. Participants also can upload their dogs veterinary records, and more than 15,000 already have done so.

Dog owners are integral to the project, which keeps them in the loop with blog posts and a dedicated social media platform called the Dog Park. Its the kind of science that cuts across politics, demographics and geography because so many Americans are crazy about dogs, Promislow says.

Im really excited about the ability to bring science to the lives of people in a way thats fun and informative and educational.

A small subset of canines are candidates for more intensive study, which is why Voght made the drive from her home in Bothell to the other side of the state. Bagel is being evaluated for the most high-profile arm of the project: a clinical trial of a potential anti-aging drug.

Called rapamycin, the medication is used in human transplant patients to prevent organ rejection. But studies in yeast, worms and mice show that low doses can extend lifespan by up to 25%. Rapamycin also delays age-related maladies such as cognitive decline and cancer, and boosts heart health in mice.

Dr. Kate Creevy, chief veterinary officer for the project, is optimistic it might do the same for dogs. In one small trial, dogs who got the drug showed improved heart function. In another, owners said their dogs seemed more active.

Now, the team is recruiting 500 senior dogs for a year of treatment and two years of follow-up. Half the dogs will get rapamycin, and half will get a placebo. Neither owners nor scientists will know which until the end.

Even if we dont actually change lifespan, if we improve the experience of aging, that will be really, really valuable to dogs and the people who love them, says Creevy, of Texas A&M University.

The dogs in the study need to be healthy, so Bagel is getting the type of checkup available only in a veterinary teaching hospital such as WSUs. Staff leads her into an exam room, where she obligingly hops on the table and rolls onto her side.

Technicians shave a small patch of fur for analysis, draw blood, measure blood pressure and attach electrodes to monitor her heartbeat. Dr. Ryan Baumwart, a veterinary cardiologist, checks Bagels eyes and probes her heart with ultrasound, displaying the image of the beating organ on a wall-mounted computer screen.

The study is just getting started, and, so far, only about half of dogs examined have qualified. Bagels scans look promising, Baumwart says. Now, its a matter of waiting on the blood tests.

The dog aging project reflects a new approach to the most common causes of death in canines and people, says co-director and UW Medicine pathologist Matt Kaeberlein, who studies the basic biology of aging. Most research focuses on specific diseases, such as cancer or Alzheimers. But nearly all of the major killers are strongly linked with age, so Kaeberlein argues that it makes sense to focus on the aging process itself.

If we can understand aging biology and what it is at a cellular, molecular, mechanistic level, then maybe it will be feasible to target that biology with interventions, he says. Those might be nutritional strategies, drugs or gene therapy, with the goal of lowering the risk of all age-related diseases.

For example, rapamycin seems to work at least in part by reducing inflammation, which increases with age and impairs immune function. Older animals also accumulate more cellular debris, and rapamycin revs up the process of clearing it away.

Another arm of the project, called the Precision Cohort, will delve in unprecedented detail into biochemical changes and shifts in gene expression over time in 1,000 dogs.

We will know more about the biology and physiology of those dogs than probably anybody has ever known about dogs before, Kaeberlein says. We will be collecting very high-resolution data to try to understand the relationship between their unique genetic makeup and their unique environment thats influencing the aging process.

One of those dogs is Hana, a 3-year-old Cavalier King Charles spaniel with long, silky ears who lives on Bainbridge Island. Her owner, Masami Shimizu-Albergine, is a researcher herself and was eager to help.

Once a year, Hanas vet collects blood, urine, feces and hair samples for analysis at specialized labs. Its a level of medical monitoring few humans receive, and it will help pin down the role of gut microbes, metabolic function, toxin exposure and a host of other factors.

Theres really no end to what we can discover, Promislow says.

Analyzing the genomes of 10,000 dogs will uncover the genetic basis for a large swath of canine diseases, says Joshua Akey, a geneticist who started working on the dog project at the University of Washington and is now at Princeton Universitys Lewis-Sigler Institute for Integrative Genomics.

As in humans, though, its not likely to be simple. Most diseases result from multiple genes and environmental factors. But Akey says it should be possible to develop risk scores to alert owners to their dogs genetic predispositions. One UW researcher is focused on dogs with lymphoma, looking for a genetic biomarker for early diagnosis.

The link between a dogs size and lifespan appears to have a strong genetic basis. Big breeds have higher levels of a protein called IGF-1 (insulin-like growth factor), which is involved in regulating growth. In mouse studies, dialing down that protein can extend life and improve health.

So even though it might be possible to improve health for all dogs, a 150-pound Great Dane likely will never match the longevity of a 15-pound Chihuahua, Creevy says.

Distinct breeds were developed only in the past few centuries, and the trove of genetic information compiled for the project will help retrace that process. It could even settle the debate over when wolves were first domesticated and morphed from Canis lupus to Canis familiaris.

Some people say it was 10,000 years ago, and others have argued it was much longer, Akey says. I think well have a data set that can definitively answer some of these evolutionary questions.

Promislow, Creevy and Kaeberlein started kicking around the idea of a major dog study more than a decade ago. It took years to lay the groundwork and convince federal funders of its worth. Their first major grant $25 million from the National Institutes of Aging was awarded in 2018. The team also has funding from foundations, tech entrepreneurs and small donors such as the Irish wolfhound Association of New England.

All of the data will be freely shared online. The first batch, from about 25,000 dogs, was recently posted and already is showing some intriguing correlations. For example, dogs fed once a day appear to have higher cognitive scores and fewer health problems than dogs who eat multiple times a day.

That doesnt prove cause and effect, Kaeberlein cautions, but its a place to start digging deeper.

The project also has the potential to provide some of the best comparisons of dog diets, which now come in a dizzying array, from dry kibble to small-batch artisan concoctions. Promislow, who never imagined he would be cooking for a dog, started preparing a mix of sweet potatoes, oats, ground chicken and kibble for Frisbee, his 16-year-old mixed-breed female, after she was stricken with severe diarrhea.

We can do the careful science to evaluate the effects of raw-food diets, home-cooked diets, et cetera, he says. We will soon have more data than any other study on the consequences of a grain-free diet.

The project is nonprofit, but entrepreneurs are keen to apply the information it generates. Americans spent almost $104 billion on pet care in 2020, and the trendline points up, according to the American Pet Products Association.

Startups already are chasing more sophisticated genetic testing and anti-aging drugs for dogs. But they cant generate the massive amounts of data or conduct large-scale clinical trials like the Dog Aging Project does, says Celine Halioua, founder and CEO of Loyal. Kaeberlein is a scientific adviser to the Bay Area biotech, which is testing two drugs to increase health span in dogs.

The dog-aging database will be an invaluable resource, Halioua says.

Its a gift to the aging field for them to be doing this.

A week after the visit to WSU, Voght got the news: Bagel qualified for the rapamycin trial. Shell get a once-a-week dose, either real or placebo, for the next year, and physical exams every six months through 2025. Voght wont know until then whether Bagels pills are real. Either way, shes willing to keep making the trip to Pullman in hopes that the project will benefit Bagel, other dogs or even people.

Shes not expecting miracles, though.

Bagel is already slowing down a bit, and her face is frosted with white. If Labs can make it into the double digits, youre lucky, Voght says.

So she recently adopted what she calls her transition dog a 2-year-old black Lab named Delray.

Its nice to have another dog in the house to help you a little bit, she says. For when that time comes.

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The Dog Aging Project digs deeper than ever to help our best friends live better longer and the findings could help us, too - The Spokesman Review

Health and Wellness Market to Exceed US$ 6.94 Trn by 2031; Companies Expanding Range of Skincare Products to Capture Steady Revenues, Observes TMR…

ALBANY, N.Y., April 26, 2022 (GLOBE NEWSWIRE) -- Relentless focus on expanding the portfolio of skincare and anti-aging products have pivoted several lucrative avenues in the health and wellness market. In recent years, especially after the outbreaks of COVID-19 pandemic, the emphasis on wellness has gained strong momentum, spurring industry stakeholders to tap into new revenue streams. The global health and wellness market valuation was pegged at more than US$ 4.1 Trn in 2020, and is projected to exceed US$ 6.94 Trn by 2031.

The growing commercialization of multi-functional personal care products such as for skincare and hand care has propelled revenue possibilities, finds an in-depth TMR study on the health and wellness market. The authors of the study also assert that hand care premiumization is a trend that has picked up enormous pace in emerging markets such as in Asia Pacific. Furthermore, the upsurge in sales of alcohol-based hand sanitizers and skincare products for all demographics has contributed to the rapidly expanding size of the health and wellness market.

Personal care product manufacturers over the years have geared toward adopting eco-friendly packaging materials and sustainable sourcing and manufacturing processes, thus expanding lucrative frontiers in the health and wellness market. Further, in several of the hygiene products, health-promoting ingredients are expanding the avenue for these players.

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Key Findings of Health and Wellness Market Study

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Health and Wellness Market: Key Drivers

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Health and Wellness Market: Regional Growth Dynamics

Health and Wellness Market: Key Players

Some of the key players in the health and wellness market are Healing Holidays (Cleveland Travel Ltd.), BodyHoliday Saint Lucia, Lift Brands, Anytime Fitness LLC, Herbalife Nutrition Ltd., Abbott Laboratories, BioThrive Sciences, Unilever plc., L'Oral S.A., The Este Lauder Companies Inc., and Anti-ageing Facial Tools.

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Global Health and Wellness Market: Segmentation

Modernization of healthcare in terms of both infrastructure and services have pushed the healthcare industry to new heights, Stay Updated with Latest Healthcare Industry Research Reports by Transparency Market Research:

Sexual Wellness Market: Global health organizations and efforts of voluntary organizations for the betterment of women health in underdeveloped countries are also stoking the demand for sexual wellness products, especially sex toys. These organizations conduct adult health awareness workshops periodically for preventive care.

Wellness Tourism Market: The rising demand for services from the global wellness tourism market can be attributed to rising demand for healthy living, stress reduction, gaining authentic experiences, preventing diseases, and managing and changing poor or toxic lifestyle habits or choices.

Health & Wellness Services Market: Rise in awareness about health and wellness services among employers, increase in health care costs, and surge in incidence of chronic diseases are driving demand for health and wellness services in the corporate segment and increasing investments in corporate wellness programs. These factors are expected to drive the global health & wellness services market during the forecast period.

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Health and Wellness Market to Exceed US$ 6.94 Trn by 2031; Companies Expanding Range of Skincare Products to Capture Steady Revenues, Observes TMR...

Seek health and well-being at wellness tourism destinations – The Korea Herald

A View from Seolhaeone Resorts infinity pool in Yangyang, Gangwon Province (KTO)

In 2020, the global wellness tourism market was estimated at 908 trillion won ($735.8 billion), according to the GWIs Wellness Tourism-Global Market Trajectory and Analytics report, published in April 2021. This is a 15 percent increase from some 790 trillion won recorded in 2017.

The report also forecasts the wellness tourism market to reach 1,479 trillion won by 2027.

So-called retreat centers are freshly gaining popularity in Korea after the pandemic, Choi Hee-jeong, professor at Cha Universitys Graduate School of Integrative Medicine, told The Korea Herald.

Jeju 901, a brunch cafe and guest house, offers regular yoga sessions in Jeju City, Jeju Island. (KTO)

The wellness tourism recommendation project, which was initiated in 2017, reflects travelers growing demand for tourism that links to themes of enhancing physical, mental, and emotional health.

This years list consists of 59 locations recommended for wellness tourism.

The selected sites fall under one of four main categories: beauty and spas, nature and forest, healing and meditation as well as Asian medicine.

The beauty and spa category includes beauty therapy programs and facilities such as hot springs. This year, the East Coast Energy Hot Springs Convention Hotel in Donghae, Gangwon Province, Seolhaeone Resort in Yangyang, Gangwon Province, and S2 Beau Tech Lounge in Daegu were chosen.

Jeju Hwansang Forest Gotjawal Park, a farm-turned-forest park located on Jeju Island (KTO)

Added to the Asian medicine category list is Lee Moon Won Medical Clinic, located in Seouls Cheongdam-dong. The clinic offers not only Asian medicine treatments, but also operates scalp immune enhancement programs and aroma massage therapy services.

Mayfield Hotel in western Seoul, Taekwondowon in Muju, North Jeolla Province, and Jeju 901, a brunch cafe and guest house with yoga programs in Jeju City, Jeju Island, are listed in the healing and meditation category.

By Kim Hae-yeon (hykim@heraldcorp.com)

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Seek health and well-being at wellness tourism destinations - The Korea Herald

South Florida Walk-In Orthopedics & Sports Medicine – SFWIO

Dr. Fabian Morales is one of only a handful of physicians in the United States to be double board-certified in both Sports Medicine and Emergency Medicine and certified to practice Age Management Medicine. In addition to the acute management of orthopedic injuries and illnesses, Dr. Morales provides a full spectrum of orthopedic care including diagnostic musculoskeletal ultrasound, fracture management and regenerative non-surgical orthopedics. Dr. Morales has significant experience at the highest levels of professional sports including serving as Medical Director for Event Medical Services at the National Basketball Association. He provides medical coverage for elite level athletes domestically and internationally including NBA Global Games, NBA finals, All Star Games and NBA basketball camps. He has also served as medical director for USA Boxing where he provided medical coverage at ringside for youth and adult boxing matches.

Dr. Morales has a special interest in regenerative nonsurgical orthopedics and Age Management for patients and athletes throughout their lives. He is a pioneer in the use of Platelet Rich Plasma and Stem Cell treatments for a variety of orthopedic conditions.

A graduate of the Rutgers Medical School, Dr. Morales completed a residency at Jacobi Medical Center at Albert Einstein College of Medicine and a fellowship at Allegheny General Hospital in Pittsburgh, PA where he served as a team physician for Major League Baseballs Pittsburgh Pirates.

Dr. Morales has been core faculty at the Sports Medicine fellowship at North Shore/LIJ Hofstra School of Medicine in New York and is the current supervisor of the Orthopedic and Sports Medicine rotation at the Emergency Medicine residency program at Kendall Regional Hospital in Miami. He has done multiple presentations and lectures on sports medicine and anti-aging as well as having multiple publications in the field. He has also been interviewed multiple times in television and print on topics relating to sports medicine.

Dr. Morales has been a life long athlete and participates in Mixed Martial Arts and CrossFit/Interval Training.

Dr. Morales is a native Spanish speaker and fluent in both English and Spanish.

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South Florida Walk-In Orthopedics & Sports Medicine - SFWIO

Schisandra chinensis – Wikipedia

Species of flowering plant

Schisandra chinensis (common name: magnolia-vine, Chinese magnolia-vine, schisandra),[1] whose fruit is called magnolia berry[3] or five-flavor-fruit[1] (from Chinese wwizi), is a vine plant native to forests of Northern China and the Russian Far East and Korea.[4] Wild varieties of Schisandra chinensis are also found in Japan.[5] It is hardy in USDA Zone 4. The fruits are red berries in dense clusters around 10 centimetres (3.9in) long.

The genus Schisandra was first published by Andr Michaux in 1803, the name deriving from the Greek words schizein ('to split') and andros ('man'), referring to the separate anther cells on the stamens.[6][7]

In the 21st century, Schisandra chinensis belongs to the family of Schisandraceae. In earlier years, it was assumed that the species belonged to the family of Magnoliaceae, hence the name Chinese magnolia-vine. However, many differences in plant phenology between Schisandraand members of Magnoliaceae led to the formation of Schisandraceae.[8]

Its Chinese name comes from the fact that its berries possess five basic flavors: salty, sweet, sour, pungent (spicy), and bitter.[citation needed] Sometimes, it is more specifically called bi wwizi (literally "northern five-flavor berry") to distinguish it from another schisandraceous plant, Kadsura japonica, that grows only in subtropical areas.[citation needed] Another species of schisandra berry, Schisandra sphenanthera, has a similar but different biochemical profile, the Chinese Pharmacopeia distinguishes between S. chinensis ( bi wwizi) and S. sphenanthera ( nn wwizi).[5]

Vegetative plant organs

Schisandra chinensis is a perennial, deciduous woody vine plant found at high latitudes and in cool climatic conditions. It commonly grows in natural coniferous or mixed forests or along streams and climbs up other trees or shrubs to reach optimal light conditions.[9] In Russia, Schisandra chinensis is also called Limonnik or Maximowich's red grape. The name Limonnik comes from the lemony smell of different plant organs, especially the leaves.[4] The prostrate woody stems usually grow 89 metres (2630ft) tall,[9] but can reach a length of up to 25m.[4] They are dark brown in colour and can reach 1.52cm in thickness.[10]

New shoots are typically short, but they continue their growth after flowering until late in the season.[6] The leaves are simple, oval-shaped (511cm long and 37cm wide) and alternating and the petioles have a slight red colouring.[10][9] Multicellular trichomes are located on the abaxial leaf lamina. Stomata show a irregular, random distribution.[6]

The roots of Schisandra chinensis are branched and stay close to the soil surface.[7] Nodes located on the stems can also produce roots.[6]

Generative plant organs

The flowers of Schisandra are unisexual and the species itself is dioecious.[9] The plant is therefore not self-fertile, hence flowers on a female plant will only produce fruit when fertilized with pollen from a male plant. However, a hybrid selection titled 'Eastern Prince' has perfect flowers and is self-fertile. Seedlings of 'Eastern Prince' are sometimes sold under the same name, but are typically single-sex plants.

The female flowers are white or cream-coloured and turn slightly reddish to the end of the flowering season.[10] They have 512 waxy, spirally arranged tepals forming the perianth and 12120 pistils.[9] The tepals show a transition in colour from green for the outer tepals to more pigmentation for the inner ones.[9] The flowers typically grow out of the leaf axils in clusters, later forming grape clusters with berries, but can also be found solitary.[6][11] The male flower has 5 stamens with filaments of different lengths[9][11] The flowers of S. chinensis are important for various pollinators such as bees, beetles and small moths.[6] The fruits of Schisandra chinensis are red berries which are smooth and shiny, have a spherical shape and reach 510mm in diameter.[10][12][11] They grow in dense hanging clusters of 25 berries which reach a length of about 68cm. Each berry usually contains 12 brownish yellow kidney-shaped seeds.[10][12][11] The seeds have the capacity to stay dormant and to form seed banks. Distribution of seeds mainly occurs through birds.[6]

Wild plants of Schisandra chinensis mostly grow in mixed forests, valleys and open forest spaces. The plant can grow in wet environments and tolerates cold temperatures to 30C. Its optimal growing temperature is at 2025C. Schisandra grows in acidic (pH of 6.5 6.8), deep and loose sandy loam soils.[13] Furthermore, Schisandra cannot withstand dense and compact soils and prefers soils rich in humus.[14] The plant grows in shade with moist, well-drained soil.

Schisandra is native to northern and northeastern China (Manchuria).[citation needed] Major cultivation of Schisandra is located in Korea and China. The production however declined continuously due to the increased deforestation in Asia.[13] Schisandra can be integrated in agroforestry farming systems as it climbs up trees to get better light conditions.[15] On a large-scale production Schisandra plants are grown similar to grape vines and are tied up on stakes in vertical columns. Therefore, cultivation requirements are thought to be similar to those of grapes.[16]

The species itself is dioecious, requiring flowers of a female plant to be fertilized with pollen from a male plant.[17] A hybrid selection titled 'Eastern Prince' has flowers and is self-fertile (monoecious). Seedlings of 'Eastern Prince' are sometimes sold under the same name, but are typically single-sex plants. Another monoecious cultivar mainly planted in China is "Hong-zhen-zhu". This cultivar is next to "Bai Wu-wei-zi", "Chang-bai-hong", and "Da-chuan-hong" one of the main cultivars in China used for germplasm resources.[18]

Plants can be propagated by seed or by layering in spring or autumn, or in the summer time by using semi-ripe cuttings.[17] Schisandra seeds are planted in early May (the seasons mentioned in here refer to China), sprout after 1520 days and the plants grow until late September. The seeds are sown at a density of 30 g/m2 and are then covered with fine soil and straw, pine needles or a grass mat. Alternatively, the seeds can be cultivated in pots and then transplanted to the field. The soil should be kept humid for the seeds to soak up with water.[19] Three years after sowing, the plants will blossom for the first time. Normally, the plants start flowering from middle or late May to early June. As the flowers are prone to frost damage, they are best grown in areas where the chances for frost in May and June are low. Starting from June to July the fruits develop and ripen from August to September.[18] In spring, summer or fall pruning of Schisandra vines is necessary to improve ventilation and light conditions, ensure an endogenous nutrition status and increase the number of female flowers and thus overall fruit yield. Furthermore, sprouting tillers that compete for nutrition with the main Schisandra vine should be cut away.[20]

The first fruit harvest of the Schisandra plant usually takes place 45 years after planting.[citation needed] In China, the ripe fruits are harvested in September.[8][21] The berries in Europe may ripen earlier, possibly in August.[12]

Schisandra chinensis is affected by many different diseases and pests, which some of them are mentioned in this section.

Temperature dependent damage to Schisandra involve sun scald or frost damage.[20] Sun scald from heat can lead to pathogenic infections. Sun scald can be controlled by applying more organic fertilizers, promoting vertical rooting, keeping an appropriate branch-fruit ratio and leaf-fruit ratio. These prevention measures enhance the plant's tolerance to drought and prevent the direct exposure of the fruits to the sun. Furthermore, irrigation can help to lower surface temperatures on the fruits. Frost damages can cause necrotic leaves and weakens the vitality of the plant. Frost damages can be prevented by covering the roots, maintaining temperatures through smoke or irrigation, applying antifreeze fluid and P-K fertilizers (i.e. phosphorus and potassium fertilizers).

To control weeds, the herbicides paraquat, pendimethalin and glufosinate can be applied.[25]

To control fungal diseases on Schisandra different fungicides are applied such as pyraclostrobin, fluquinconazole, triforine, fenarimol, fenbuconazole, thiophanate-methyl, mancozeb, metalaxyl, benomyl and hexaconazole.[25]

Prior to fungicidal application, prevention measures should be applied to lower the risk for fungal outbreaks. Only if economic thresholds are exceeded one should apply fungicides. Prevention measures in Schisandra cultivation could be:

Insects such as wireworms and nematodes can be controlled with e.g. ethoprophos and aphids can be controlled with e.g. endosulfan.[25]

Prevention measures to control insects in Schisandra cultures could be:

To lower infections of soil-borne diseases carbendazol hydratable powder or amobam can be applied after sowing.[19]

For the cultivation of young Schisandra plants a nutrient rich soil is required, wherefore mostly manure is applied as organic fertilizer. Organic high-N and high-H fertilizer should be applied at the embryonic stage and later on it should be fertilized with high-P and high-K. During key growth stages it is best to undertake a foliar fertilization to ensure normal fruit production.[26] As the quantity of female flowers is a key point to increase Schisandra berry yields, barax, ammonium molybdate, and lanthanum nitrate fertilizers can be applied in July as foliar fertilizer.[27]

Its berries are used in traditional medicine. Chemical constituents include the lignans schisandrin, deoxyschizandrin, gomisins, and pregomisin.[5] When crushed, the leaves release a lemony smell and can be used as a vegetable.[28][29]

In Korean, the berries are known as omija ( (hangul) five flavours). The cordial drink made from the berries is called omija-cha, meaning "omija tea"; see Korean tea. In Japanese, they are called gomishi. The Ainu people used this plant, called repnihat, as a remedy for colds and sea-sickness.[30]

Interest in limonnik (S. chinensis) in Russia was associated with investigations by Soviet scientists on berries and seeds.[4]

In 1998, Russia released a postage stamp depicting S. chinensis.[31]

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Schisandra chinensis - Wikipedia