A journal regarded as the leader in its field is without editors after they resigned as a group earlier this month in a dispute over their workload and compensation.

On August 11, the four editors-in-chief of Aging Cell tendered their resignations to Wiley and the Anatomical Society, which together publish the monthly periodical. Explaining their decision in a letter dated August 23 and posted to Twitter by an account unrelated to the journal, the editors Peter Adams, Julie Andersen, Adam Antobi, Vera Gorbunova, along with John Sedivy, the reviews editor said they had reached the breaking point after trying to work with the publishers for the last 2-3 years on serious issues in running the journal.

We were unable to immediately reach the editors or Wiley, but Adams retweeted the letter and asked his followers to Please distribute.

Many of those problems, the editors wrote, involved fallout from a steep increase in workload as the journals stature has risen. According to the letter, the journal handled 874 papers in 2021; by early August 2022 alone, that figure was 540 or an estimated 950 for the year. The group writes that they were flooded with submissions after the journals Impact Factor grew, but does not provide data on the number of submissions before 2021.

One solution was to pay the volunteer section editors based on the number of manuscripts they handle. That fix, according to the group, was ignored, with a counter-offer of relying instead on early career scientists.

Meanwhile, the editors-in-chief said they were still being paid for their time at a rate set in 2006: 2,000 GBP, or about $2,619, per year.

The letter also points out that Wiley eliminated the editors modest budget to travel to meetings in 2022 an important part of the job, they said because they missed the deadline to apply for the funds last year.

According to the letter:

As noted at the beginning of this letter, we have reached an impasse with the Anatomical Society and Wiley. There has simply been no meaningful or considered response to our requests. Thus, in good faith we felt the proper thing to do was to resign. We were hopeful that this would convey the seriousness of our concerns, solicit a good faith response, and that Humpty Dumpty could somehow be put back together again.

The move came a few weeks before the Biden White House announced yesterday that all federally funded research would need to be published open access, which some observers have predicted could harm small scientific societies that often rely on subscriptions that are part of membership instead of article processing charges.

In the end, the editors wrote, their mission and the publishers goals were too far apart:

Unfortunately, our common interests are not shared by Wiley and the Anatomical Society, who are driven largely by profit. They would be happy to publish more papers (and make more profit) even at the cost of bringing down the Impact Factor. Over the years we have steadily resisted this, which might in part explain why they are quite willing to be rid of us.

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Editors-in-chief of aging journal resign en masse after 'impasse with the Anatomical Society and Wiley' - Retraction Watch

Every year in January, politicians in both the Dil and Seanad must sit down and fill out a detailed statement disclosing any interests, whether it be land, contracts or shares. The rules are clear. Any income above 2,600 in the previous year means that the trade or profession it came from must be declared.

For example, Sinn Fin Senator Fintan Warfield declared in his returns that he is also a barista in Rialto in Dublin as well as being a musician.

Any investment in a company worth more than 13,000 must be declared, as well as any interest in land above the same value, though not the family or personal home. Any gift worth more than 650 must be revealed.

The same goes for any contract for the supply of goods or services above the value of 6,500.

TDs are even supplied with a code of conduct document which impresses upon them the importance of fostering and sustaining public confidence and maintaining trust. They are told it is up to them to ensure theyve read the guidelines and laws properly, and they are given plenty of detailed documents to help them understand what is required.

To some politicians, it might well have looked like just another admin job to be ticked off the to-do list until now.

For Fianna Fils Robert Troy, who resigned on Wednesday night as minister of state for company regulation, the roots of his downfall go all the way back to those January days down through the years when he sat down to fill out those very same forms.

For the first summer since the onset of the pandemic it has been relatively quiet, politically speaking. In the middle of this lull, on August 10th, The Ditch website began a series of articles which started with a story about a house Troy had sold in 2018, but which was never mentioned on his declaration of interests.

Along with this was an unreserved apology, which was never going to cut it with the Opposition

When the TD went on RT Radio the day after the first story was published, he apologised and said he was under the mistaken impression that only a property in your possession on the date of the return had to be declared. He said he would amend the register following his error.

The reprieve was short-lived, however, because it immediately emerged that the same thing had happened in 2019, and also that he had failed to declare a company directorship in 2021. His explanation for the issue with the company in question, RMT management, was that he thought it had been wound up by the time he made his declarations that year.

Suddenly one error had become two and then three, with more to come.

[Troys biggest mistake was being unable to see that owning one property is a privilege never mind 11]

[Trifecta of tribulations ahead for Coalition in autumn]

[Residents complained to Robert Troy about dangerous conditions at Dublin property]

At this stage, the story had the attention of Taoiseach Michel Martin and Tnaiste Leo Varadkar who were being peppered with questions about it during summer doorsteps with journalists. There was a certain sense within Government that there was nothing worth panicking about just yet, as long as Troy got his affairs together and put out a comprehensive statement.

This came at the direction of the Taoiseach who told him to put out all relevant information, in the interests of transparency but also no doubt in the hopes of putting a halt to the gallop of a story that was threatening to become the story of the summer something no politician wants in the dog days of August.

What was not foreseen was the scale of the amendments to the declaration of interests that Troy published on August 18th.

It included the sale of the properties in 2018 and 2019; another property in Mullingar which had been omitted in 2020; information that his former private dwelling at Main Street in Ballynacargy in Co Westmeath had been rented out since November 2021; the sale of a garden at 25a Rathdown Road in Phibsborough, Dublin 7 as well as new information about two Rental Accommodation Scheme (RAS) contracts he had with Westmeath County Council.

Along with this was an unreserved apology, which was never going to cut it with the Opposition.

On Wednesday, Fianna Fil TD Robert Troy stepped down from his role as Minister of State after weeks of controversy over his failure to properly declare business interests, including rental properties and company directorships. To discuss the affair and what's been learned from it, Hugh is joined by Fintan O'Toole, Jennifer Bray and Pat Leahy. 

People Before Profit TD Paul Murphy lodged a complaint with the Standards in Public Office Commission (Sipo) and by the end of last weekend it had also emerged, via the Sunday Times, that Troy had not registered a rental with the Residential Tenancies Board, as he is legally required to do.

At this point, anxiety levels among members of Fianna Fil began to shoot up. His fellow TDs, who until this point had believed he would weather the summer storm, began to have doubts. Journalists began to receive texts from the worried factions asking: How bad is this going to get?

The answer was: significantly worse.

The weekly news cycle kicked off this week with a front-page headline in the Irish Independent revealing that the Fianna Fil TD had used Dil speaking time to call for more funding for the RAS, at a time when he had such a contract with the council. What made the atmosphere even more febrile was the fact that Troy and his team were not taking questions from individual journalists. Instead, queries were left hanging in the air and so they multiplied.

His contention that he would instead address the Dil about the matter when it returned in September went down like a lead balloon.

Sensing the heat in the air, the Longford Westmeath TD took to the airwaves on Tuesday to tell RT's Bryan Dobson that he was embarrassed and sorry but that he was not trying to conceal anything. For the first time, he revealed that he owns or co-owns 11 properties, nine of which are rented out, and that he has five Housing Assistance Payment (HAP) contracts.

One veteran Fianna Fil TD was listening in to the interview.

I was cringing. I really was cringing for him. Speaking privately, another senior TD said: This definitely wont cut it. There was a steady drip-feed of information which was causing a deep level of discomfort in the Coalition, even if the party leaders continued to voice their support in public.

There comes a tipping point with every political controversy it arrived on Wednesday.

Sources around Troy say he went into the day ready to fight and ready to refute new claims that his Phibsborough property, which he co-owns, did not have appropriate fire certification. Even though some of his staff were due to go on holidays that day, they stayed on to make sure the relevant statements got out.

Green Party leader Eamon Ryan then went on radio and suggested not one but two potential investigations that could be carried out on the matter by both Sipo and the Dils oversight committee. Depending on who you talk to in the Coalition, it was either Ryan stating the blindingly obvious, or Ryan putting the boot in.

In the meantime, a myriad of questions continued to be asked by journalists, including from The Irish Times which had learned of complaints made in 2019 by residents about the condition of the aforementioned Phibsborough property. There was no response from Troy on Wednesday evening to queries about how the complaints were handled.

To all intents and purposes, the shutters were pulled down until Troy announced just after 9pm that he was stepping down. He apologised again but hit out at the media, saying he was not embarrassed to be a landlord. He said the number of errors he made had led him to the conclusion that it was time to go; he resigned from his ministerial position, but is still a TD.

That was a fact, but it is also likely that the questions were still coming in, and the scrutiny was becoming unbe
arably intense. And while he has asked for time, space and privacy, the fallout from the debacle will likely endure with questions raised about the judgment of both Martin and Varadkar.

Read more here:
The fall of Troy: Anatomy of a political downfall which left Coalition exposed - The Irish Times

For 18 seasons Greys Anatomy has been thrilling and breaking the hearts of countless diehard fans. With 401 episodes and counting, the show is currently the longest running primetime medical dramaon television, giving it an outsize impact on American pop culture. Even those who have never seen an episode have probably heard someone reference Dr. McDreamy (a reference to Patrick Dempseys character) or watched one of the many shows creator Shonda Rhimes has helmed since her Greys Anatomy breakout. It may have even changed the way some people view health care and doctors in the real world.

This rich history makes it extremely difficult to narrow down the shows best hours. After all, this is a show thats featured Post-It note weddings, hospital proms, and enough freak accidents to make any sane person think twice before checking into Grey Sloan Memorial Hospital. Heartbreaking departures have allowed the shows diverse cast to explore some of the most pressing social issues of the day, including LGBTQ+ rights and the #MeToo movement, in some of the series most acclaimed storylines. Theres no denying Meredith Greys life has been agonizing, chaotic, and electrifying to watch.

Stacker has taken a more democratic approach to reveal the top 25 best Greys Anatomy episodes, using data from IMDb. Rankings are based on each episodes average IMDb rating, with ties broken by votes. The end result is a list of the best swoon-worthy declarations of love, heartbreaking tragedies, and moving moments of pure friendship that have kept fans glued to screens for more than a decade.

You may also like: 50 best episodes of 'Friends'

See more here:
Ranking the top 'Grey's Anatomy' episodes of all time - Crow River Media

We are almost two weeks removed now from the end of season 18 and, of course, we want to know more aboutGreys Anatomyseason 19! When is the next season of the landmark drama going to come out?

It goes without saying, but there is a lot to be excited for as we ponder over the future of this show. Take, for starters, the fact that there were multiple cliffhangers that hint at a very uncertain future for a number of familiar faces. Teddy and Owen, for example, could be in a different part of the world after fleeing Seattle. Meanwhile, Bailey quit her job after the residency program was shut down! All of a sudden, it feels to her like the work she put in more or less amounts to nothing.

Rest assured,Greys Anatomyseason 19 is on the fall schedule for ABC, and we will probably have a chance to get more news on it sooner rather than later. Just how long are we talking here? If we were to guess, the news will start pouring in when it comes to the middle of July. This is when weve seen the network announce premiere dates in advance, and there is little reason to think that theyd start changing things up all of a sudden here. They dont want to announce these datestooearly, after all, in fear that they would have to change them a little bit later. The most important thing to know is that your favorites are coming back, and they could be bringing some more great stuff across the board with them.

Once the premiere date is announced and filming begins later this summer, its our expectation that come early September, we could start getting a few teases as to what is actually coming up.

Related Be sure to get some more news when it comes to Greys Anatomy right now

Be sure to share right now in the attached comments! Once you do just that, remember to also stay put for other updates you will not want to miss. (Photo: ABC.)

Continue reading here:
Grey's Anatomy season 19 premiere date: When will news come out? - CarterMatt

Winter, as they say, is coming. If youre looking for a puffer jacket to keep yourself warm with a lighter impact on the environment, the team at Kathmandu has been working hard. The New Zealand-founded, certified B-Corp outdoor wear company recently launched its NXT-Level BioDown jacket, an innovative and award-winning piece of clothing made from a highly durable, biodegradable nylon.

While most jackets are made from polyester, Kathmandu chose nylon for its greater durability. It also decided to opt for nylon 66 (commonly used in friction bearings, carpets and luggage), a stronger version of its close cousin, nylon 6 (think toothbrush bristles) so that it will last and be worn longer.

Kathmandus scientists tweaked the polymer with a new ingredient designed to trigger biodegradation in an oxygen-free landfill environment. In a nutshell, the ingredient makes the discarded jacket attract microbes that form a biofilm on the material to help them break down those long chains of polymers. (But dont worry, your jacket wont start falling apart in the wash or while youre walking the dog in the rain only when it reaches oxygen-free landfill.*)

Hang on, isnt nylon derived from fossil fuel? Well, yes. Kathmandus Californian-born general manager of product, Robert Fry, says the decision to use nylon is all about playing the long game: producing a high-quality garment that will last longer, be more recyclable when technology catches up, and, in the meantime, biodegrade in three to five years under the right conditions.*

For us, the long-term goals around sustainability have to do with circularity more than anything else, Fry says from the companys Christchurch headquarters. And there are lots of principles of circularity, all of which were heavily invested in supporting, exploring, developing and innovating around, and theyre all in various states of go.

The problem Kathmandu faces is that much of the infrastructure required to close those circular systems isnt widely available in Australia yet. For example, we are still a long way away from widespread textile-to-textile chemical recycling, and the types of anaerobic, or oxygen-free, landfills required to make BioDowns innovative material biodegrade effectively are sparse.

The hope is that demand will ignite supply. Were doing our part to energise that infrastructure, so that as we introduce new products, new concepts into the marketplace, that theres an infrastructure in place that we can partner with, plug into and collaborate with, Fry says.

So, after youve worn your jacket for years, how does the breakdown of the material eventually happen?

Manu Rastogi, who heads Kathmandus innovation team and worked closely on the BioDown design, says: Biodegradation happens at the molecular level. Nylon 66 is made of carbon, hydrogen, oxygen and nitrogen. Microbes break down those molecular chains, whether that happens over hundreds of years or a few years, as in the case of BioDown. As the nylon is consumed by microbes, they release carbon dioxide and methane, and all that remains at the end is basically microbial poop.

Rastogi and his team went in search of best-practice landfills and found more than 20 biologically active sites in New Zealand. Although there are bioreactor landfills in Australia, our size and system of state governments means theyre not well documented, Rastogi says. Theres room for improvement.

Each state and territory also manages and prioritises waste differently. In suburban Sydney, roughly 40% of waste goes to Veolias Woodlawn Eco Precinct, an innovative, modern landfill facility that includes the necessary bioreactor landfill.

And if you look at whats happening globally, Rastogi says, thats where the landfill design and engineering is going: towards how do we harness carbon dioxide and methane and use that energy to generate electricity, so it doesnt go out in the atmosphere as greenhouse gases?

Adopting the build it and they will come philosophy, Rastogis team designed the jacket to be as recyclable as possible, too, making the zippers and inner lining from the same material. Insulating the jacket are duck down and feathers certified to the Responsible Down Standard, the global standard for ensuring best practices in animal welfare throughout the retail supply chain. And, by scanning in a QR code on the product, customers can trace the key conditions and source of the down in their jacket through the website Track My Down.

Other biodegradable, environmentally friendly details include labels made of cotton, hang tags made out of paper instead of plastic, and using natural bentonite clay instead of silica gel to absorb moisture during shipping.

In an imperfect world, its still vital for consumers and manufacturers to play their role and keep striving for a circular economy.

Fry says: We have to be responsible citizens of the planet and of our respective nations. Its morally incumbent upon us to do our best to make the world a better place. As Manu likes to say, we want to get from a place of doing less bad to doing more good.

Granted, the fully circular economy may be a while off yet, but its encouraging to see at least one company designing end-of-life responsibilities into its products from the very beginning.

Check out Kathmandus new NXT-Level BioDown jacket.

*Testing under ASTM D5511 indicates biodegradation of 86.6% after 3 years could occur in optimal conditions in some biologically active landfills without oxygen. Please ask your local council if this type of collection or waste disposal facilities exist for the product.

Excerpt from:
Anatomy of a jacket: how Kathmandu is rethinking sustainable clothing - The Guardian

Notorious for playing with energy and assertiveness that fuels their third-quarter runs, the Warriors did just that in Game 1 of the NBA Finals. They hung 38 points on the league's top-ranked defense while holding the Celtics to 24.

As a result, Golden State, a team yet to lose on its home floor in the playoffs, entered the final frame with a 12-point lead. Boston scored the last points of the third quarter, courtesy of a pair of Derrick White free throws, but a comeback required urgency, and there was little margin for error. Otherwise, the Celtics would spend the days leading into Game 2 kicking themselves for how they came out of the half.

Instead, they met the moment, landing a fourth-quarter haymaker, outscoring the Warriors 40-13 before the hosts added a three after both teams emptied their benches.

Jaylen Brown was at the center of that fourth-quarter takeover, getting them off to the fast start they needed, factoring into Boston's first seven points.

The play below, a three for Brown, also highlights the Celtics hunting Jordan Poole, who they'll target relentlessly throughout these Finals.

The next possession demonstrates a problem Golden State had throughout Thursday's loss and will continue to have difficulty with this series. The Warriors lack high-level perimeter defenders.

As it relates to the following clip, Otto Porter, who played well overall in Game 1, is at a point in his career where it's hard for him to keep up with Jaylen Brown. The result is Brown driving by him, getting into the paint, occupying Klay Thompson's attention, and while Draymond Green knows what's coming, he can't prevent this alley-oop to Robert Williams.

Shortly after that, White attacked Klay Thompson off the dribble, getting deep into the paint. When White pivots, Porter sees him staring towards the left slot, persuading him to break that way before realizing the ball's going to Brown. And with White leading Brown further towards the corner, Brown gets a clean, in-rhythm look at a three that barely grazes the net.

The Celtics' comeback wasn't, nor could it have been, strictly a product of what they were accomplishing offensively. At the other end, Boston went smaller and started switching more frequently. The Celtics' big men also raised their pick-up point, meeting Stephen Curry higher up the floor as he came off screens.

Here, Al Horford's waiting for Curry above the three-point line, a shade below the pick from Kevon Looney. Horford and Jayson Tatum surround Curry, White tags the roller, Looney, and Horford uses his length to stay connected to Curry and Looney. Perhaps the latter could've gotten to the other side of the rim with more urgency, but the pass could still prove difficult. Instead, Curry rises for a floater as Tatum comes across his face to contest the shot.

As for the impact of Boston getting back to its preferred method of defending the pick-and-roll, which is switching on screens, one benefit was getting the ball out of Curry's hands.

In the play below, the Celtics don't switch the off-ball screen, which is really just Green grabbing his defender, Tatum. But when Curry shakes free of White, Tatum has no choice but to jump out to contest his potential shot. That results in Curry swinging the ball to Andrew Wiggins, who's plenty capable of making this three, but the Celtics will live with this shot.

And while Boston's defense was limiting Curry to four points in the final frame, its offense continued driving into the paint, moving the ball around, and chipping away at the deficit.

Here, Brown gets out of the corner and into the paint, prompting Porter to help wall off his drive as his man, White, drifts beyond the arc. Brown's strong with the ball and throws it on a line to White, who drills a right-wing three to bring the Celtics within one.

Scroll to Continue

White, who scored 21 points and was outstanding in this game, continued to play a critical role in Boston's comeback, cashing a three with Curry in his jersey, knotting the score at 103 with 5:40 remaining.

The next time down the floor, the Warriors are slow to match up in transition. Tatum swings the ball to White, who drives baseline off the catch, keeping Porter by the basket. It also forces Wiggins to zone two, accounting for Payton Pritchard and Horford.

The pass to Horford would've been more challenging, but Wiggins is splitting the difference between his two responsibilities, and he's too far in to break up the baseline pass. Pritchard then swings the ball to Horford, who's unbothered by Thompson coming over and getting his hand up, swishing a three to put the Celtics ahead 106-103.

Another instrumental aspect of Boston's comeback win was Golden State living up to its reputation for not taking care of the ball. In the fourth quarter, the Warriors committed four turnovers, two of the live-ball variety, leading to ten points for the Celtics.

And while overall, the hosts were more effective crashing the offensive glass, producing 26 second-chance points compared to 15 by Boston, none of those came in the fourth quarter before both teams emptied their benches. Conversely, as the Celtics rallied, they tacked on six points after securing an offensive rebound.

And with just under a minute to play, Tatum passed over a double team, giving Boston a four-on-three, where Brown drove baseline and found a cutting Horford, who provided the exclamation mark on the Celtics' 120-108 win in Game 1 of the NBA Finals.

Tatum played nearly the entire fourth quarter but didn't score, making the come-from-behind victory even more impressive. And despite his shot not falling, it didn't negatively affect him defensively, and he impacted the outcome with his facilitating.

Tatum finished with a game-high 13 assists. Nine of them were on Boston's 21 makes from beyond the arc, setting the record for the most by any player in a Finals game. It exemplified the Celtics' resiliency and their ability to figure out what's needed for them to walk out with a win.

Further Reading

It's Taken Al Horford 15 Years to Reach the NBA Finals; He's Wasting No Time Maximizing His Opportunity

Celtics, Jayson Tatum Discuss His Growth as a Facilitator After He Sets NBA Finals Record

Celtics' Resiliency on Display in Fourth Quarter of Game 1 of NBA Finals: 'We're battle-tested; we've been through a lot'

What Stood Out in Game 1 of the NBA Finals: Celtics' Take Series Opener with Fourth-Quarter Haymaker

Tony Parker Sizes Up the NBA Finals, Talks Ime Udoka and His Collaboration with MTN Dew LEGEND

As the Calls to Separate Them Grew Louder, Jayson Tatum and Jaylen Brown Grew Closer: 'two young, extremely competitive guys that just really want to win at all costs'

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The Anatomy of the Celtics' Fourth-Quarter Comeback in Game 1 of NBA Finals - Sports Illustrated

It didnt start with a retweet.

The controversy currently swirling around The Washington Post doesnt go back days. It goes back years.

If you want to truly understand how one of the most respected news organizations in the world is smack dab in the middle of a hot mess, you cant start with a high-profile reporter retweeting a sexist and homophobic tweet. You have to look at the history of the reporter who objected to that retweet and her relationship with the paper she works for, as well as the inconsistent social media policy of that paper.

And to do all that, you have to go back to at least 2018 when Brett Kavanaugh was a controversial nominee for the Supreme Court, controversial because of allegations of sexual assault and misconduct. Post reporter Felicia Sonmez, a politics breaking news reporter, was told by her editors that she could not cover stories involving Kavanaugh because they felt it was a conflict of interest. How? Because Sonmez had been open and public about being a survivor of sexual assault.

The Posts policy was considered unusual if not unheard of in journalism circles. Even Post media writer Paul Farhi wrote so.

Fast-forward to January 2020 and the day basketball star Kobe Bryant was killed in a helicopter crash. Soon after the news broke and tributes and remembrances poured in about Bryant, Sonmez used her Twitter feed to link to a 2016 Daily Beast story that recalled the 2003 rape allegations against Bryant. Marty Baron, who was the Posts well-known executive editor at the time, put Sonmez on paid administrative leave, saying Sonmez displayed poor judgment that undermined the work of her colleagues.

The leave soon ended after more than 300 Post staffers signed a letter in support of Sonmez.

But by this point, the seeds of resentment between Sonmez and Post leadership had seemingly been planted.

Now lets move to March 2021, when the Post finally reversed its decision and allowed Sonmez to write about stories involving sexual assault. But that decision was reversed only after Sonmez went on Twitter to voice her complaints about the Posts policy.

It came to a head a few months later, in July 2021, when Sonmez sued the Post and several current and former top editors, alleging that she had suffered discrimination and retaliation. Sonmezs suit said she had lost opportunities for career advancement and had experienced economic loss, humiliation, embarrassment, mental and emotional distress, and the deprivation of her rights to equal employment opportunities. She also claimed that she was retaliated against for speaking out publicly. (The lawsuit was dismissed in March of this year when a judge ruled that Sonmez had not demonstrated the paper showed discriminatory motive when it banned her from covering stories related to sexual harassment or misconduct. Sonmez is appealing that ruling.)

By this point, the situation was, at best, awkward between the paper and Sonmez. Questionable leadership decisions, including those from the now-retired Baron, a clunky social media policy and a reporter unafraid to go public with her criticism of the paper created a perfect storm that led us to last Friday and the controversy that is now captivating the media world, much to the delight of those who like to slam the so-called mainstream media.

So what happened Friday? Post reporter Dave Weigel retweeted a tweet from a social media personality that said, Every girl is bi. You just have to figure out if its polar or sexual.

Sonmez took a screenshot of the retweet and tweeted, Fantastic to work at a news outlet where retweets like this are allowed!

However, some argue that it wasnt allowed, not at all evidenced by the fact that within an hour of his retweet on Friday, Weigel deleted it and apologized for it, and by Monday was suspended from the paper for a month without pay.

Then again, was it Sonmezs tweet that spurred the Post to take swift action?

This also wasnt the first social media controversy the Post had this year. In a February tweet, Micah Gelman, senior editor and head of Post Video, misidentified Post video technician Breanna Muir as Breonna Taylor, the Black medical worker who was shot and killed by Louisville police officers in March 2020. Gelman apologized publicly and privately. Regarding this latest incident, Muir hit reply all on a staff note from executive editor Sally Buzbee and praised Sonmez for speaking out against harassment, discrimination and sexism.

A month before that, another Post editor, Lori Montgomery, tweeted then deleted a tweet that criticized an SFGate column about retiring Steelers quarterback Ben Roethlisberger. The column called Roethlisberger a jackass and mentioned how Roethlisberger had been accused of rape in the past. Montgomery tweeted, The only interesting thing about this column is how easily disproven and completely FOS it is.

Interestingly, Sonmez called out Montgomerys tweet, tweeting, Respectfully, @loriamontgomery, this @drewmagary column contains facts about sexual assault allegations against Ben Roethlisberger that the Washington Posts own story backs up.

Montgomery was given a verbal warning, and Sonmez has continued to call out on Twitter the inconsistencies of the Posts social media policy.

And so here we are this week with the paper known for the kind of dogged reporting that uncovered the Watergate scandal swept up in a quagmire that has included a suspension, two memos from the executive editor, countless contentious and accusatory tweets and a narrative that the Post has a hostile and toxic work environment. In the week where a House Select Committee investigates the events of Jan. 6 a story for which the Post won a prestigious Pulitzer Prize for Public Service the dominant story about the Post is this soap opera. It was even a topic on Wednesdays The View.

In the past 48 hours, the story has shifted slightly as more and more staffers are defending the Posts workplace and showing frustration with Sonmez not for calling out Weigels inappropriate retweet, but for continuing the conversation about it.

On Wednesday, I spoke to several well-established and respected journalists at the Post, both male and female, who wanted to make it clear: The Washington Post is a good place to work and not the toxic newsroom that this latest controversy might suggest. The Post staffers asked to speak on background and not have their names used, mostly because those who have publicly spoken up for the Post and questioned or challenged Sonmez have come under heavy criticism and been portrayed as insensitive.

I think a lot of people at the Post are frustrated with the way all of this is unfolding, one Post reporter told me. Obviously, a lot of people strongly feel that this doesnt represent the culture at the Post.

This source continued, Its frustrating to have this person make these assertions broadly about the Post and imply and amplify this idea that theres this great division and that the Post has this toxic work environment when that is not the case.

And yet another said it goes well beyond newsroom bickering.

This is affecting sourcing relationships, they said, adding that sources have told them that they are hesitant to talk to the Post right now because of all the drama.

Another staffer, a woman, said they had talked to several female staffers who said they felt Sonmez had taken it too far, but they didnt want to speak out because they didnt want to undermine Sonmez.

Its just an unwinnable situation for everyone involved, the staffer said.

Another unnamed staffer told Vanity Fairs Charlotte Klein, I think Felicia initially was right that was a gross Dave Weigel tweet, and we were all grateful she called attention to it. (The problem was in) continuing to make it an issue and go after more and more colleagues.

Of all the staffers I talked to Wednesday, not one defended Weigels retweet, although one did say they wish Sonmez had taken her complaints to editors and stayed off Twitter. I
t has been reported that Sonmez first complained about Weigels retweet on an internal Slack channel and that National editor Matea Gold, in the same Slack channel, wrote that The Post is committed to maintaining a respectful workplace for everyone and we do not tolerate demeaning language or actions. But Sonmez went to Twitter just minutes after her Slack message.

Over the weekend, Post staffer Jose A. Del Real accused Sonmez on Twitter of repeated and targeted public harassment of a colleague and suggested she was rallying the internet to attack (Weigel) for a mistake.

Buzbee stepped in on Sunday, sending out a brief memo to staff saying they were expected to treat each other with respect and kindness both in the newsroom and online.

One staffer told me Weigel has had a questionable history on social media, so his monthlong suspension might have been for an accumulation of poor decisions. It is also believed Weigel has been suspended once before for his social media use. Post officials would not discuss him or this matter.

Buzbee sent out another memo to staff on Tuesday this one much longer and much more sternly worded, writing in part, We do not tolerate colleagues attacking colleagues either face to face or online. Respect for others is critical to any civil society, including our newsroom. The newsroom social media policy points specifically to the need for collegiality.

Buzbee added, We know it takes bravery to call out problems. And we pledge to openly and honestly address problems brought to us. She also said the Post will update its social media policy.

Meanwhile, Sonmez continued tweeting, including lengthy threads about the Posts social media policy. Sonmez tweeted, In early 2020, @stevenjay and @loriamontgomery, then the Posts National and deputy National editors, commissioned an internal report on social media use in response to newsroom-wide outrage over my suspension. Two years later, nothing has changed.

Washington Post media writer Jeremy Barr wrote, The union that represents Post employees, the Washington Post Guild, has repeatedly lobbied for The Post to update the companys social media policies, which the guild has described as outdated and not sufficiently equitable, and repeated that call on Tuesday.

As Sonmez continued tweeting, Post staffer Lisa Rein tweeted at Sonmez on Tuesday night to Please stop. Sonmez replied, Please stop requesting that tweets from a colleague falsely accusing me of bullying and clout chasing be taken down?

Sonmez then added, Do you have any idea of the torrent of abuse Im facing right now? Sonmez then included screenshots of some of the nasty attacks she has been receiving online.

The social media melee picked up throughout the week with many high-profile staffers defending the Post.

White House bureau chief Ashley Parker tweeted, The Post is not perfect. No institution is. But Im proud to work here. I love coming to work (almost) every single day, and knowing that my colleagues are collegial, collaborative and fun humans not to mention talented journalists who are always striving to do better.

Reporter Amber Phillips tweeted, Working at The Washington Post, Im in awe almost every day how such talented journalists, from all backgrounds, can also be so collegial and thoughtful and caring. I love working here, and I love helping improve it.

Investigative political reporter Josh Dawsey tweeted, no institution is perfect, including the post. but the place is filled with many terrific people who are smart and collegial. im proud to work here.

Those are just a few examples, but there were enough that some wondered if it was a coordinated effort to defend the Post.

But a staffer told me on Wednesday, That was ridiculed by a lot of people as being some kind of contrived messaging operation, but I have no reason to believe it was anything other than an organic expression of how people feel about this newsroom.

Meanwhile, some Post staffers and others in the journalism world took to Twitter to stand by Sonmez, who tweeted, I often hear from colleagues who want to say something but are afraid to speak out. Knowing how the Post punished me for my own trauma and how a colleague publicly accused me of bullying for flagging a sexist tweet I dont blame them for being afraid of retaliation.

Sonmez was referring to her history with the Post.

Look, one staffer told me Wednesday, theres no question she was treated (crappy) in the past by the Post. What they did to her was wrong. But that and whats happening now are two different situations, in my opinion.

Another Post staffer said, That wasnt right, and most everybody I know at the Post was in her corner on that. They handled that poorly.

And some are questioning whether Post leadership is handling this situation as well as it can.

Its a real s show, one staffer said.

The Post is not commenting beyond a statement from Post communications chief Kris Coratti Kelly, who said, While we have not commented publicly, this is being addressed directly with the individuals involved.

When reached Wednesday evening, Sonmez declined to comment.

What can Buzbee do now?

Its a really good question, one staffer said. I dont think theres any really good options here. Theres obviously a lot of hard feelings involving the person who is spearheading this. I dont know how this goes away. But I just want it known that the Post is a good place to work, and I think most of my colleagues feel that way.

Tom Jones is Poynters senior media writer. For the latest media news and analysis, delivered free to your inbox each and every weekday morning, sign up for his Poynter Report newsletter.

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Anatomy of a controversy: Inside the drama at The Washington Post - Poynter

Shes really living a lie in many ways, declares Michelle Dockery about her character in the Netflix limited series Anatomy of a Scandal. The series developed and written by Melissa James Gibson and Emmy-winning writer and producer David E. Kelley, follows a wife and mother (Sienna Miller) who struggles to support her husband (Rupert Friend), a British politician who has had an affair and is accused of rape. Dockery plays Kate Woodcroft, the prosecuting attorney who endures her own lingering trauma. Check out our exclusive video chat with the four-time Emmy nominee above. Spoilers for the full season ahead.

The character of Kate turns out to be more than a mere attorney. The audience eventually learns that Kates real name is Holly Berry, and that as a student, Kate/Holly was raped by the same politician Kate is presently prosecuting. Dockery says that the characters duality was one of the key attractions of the role. Shes changed her identity to bury her past, she says. I loved that there is this fantastic kind of journey throughout the story for her because she starts out as this quite closed off human being and very guarded, and then as the story goes on those layers begin to peel back.

SEE over 350 interviews with 2022 Emmy contenders

Because the show was filmed out of sequence, Dockery shot her emotional breakdown for the final episode very early in the filming and spent a great deal of time isolated from the rest of the cast. The actress argues that the circumstances helped in portraying her character. It worked out great because I could get all of that rage and emotion out in those final moments with Kate and then sort of work backwards, she explains. That separation from everybody was really good because Kates a lone wolf. Shes very private and she likes to be alone. So it was good to get into the character in that sense.

Dockery says that the entire production went to extraordinary lengths to tackle the issue of sexual violence in a way that is both honest and respectful to victims, including working with victims advocate groups throughout the United Kingdom. Its obviously a subject that is a really sensitive one, and we were all adamant that it was delivered in the most authentic way possible, she says. The actress describes how it was sometimes difficult to leave the character behind after filming certain scenes. Whenever I do something that is sort of guttural and emotional, I go home and Ill feel tired and its a little harder to shake off, she claims.

PREDICT the 2022 Emmy nominees by July 12

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Michelle Dockery (Anatomy of a Scandal) on playing a prosecutor: I could get all of that rage and emotion out [Exclusive Video Interview] - Gold Derby

"Grey's Anatomy" goes to great lengths to make sure that their medical scenes look as realistic as possible, meaning that they have to get creative with their props to make situations such as surgeries look authentic. If you're curious about the types of things they utilize for props, actor Sarah Drew, who has been playing Dr. April Kepner on "Grey's Anatomy" since 2009, has opened up about what filming those surgery scenes are like including what kind of props they have to work with. Speaking with the Miami Herald, Drew said, "We work with bovine organs, which is cow's organs. The smell is repulsive and makes us all gag. And we use an actual soldering tool to solder the organs. It smells like burning flesh. There's also a lot of silicone and blood matter red jello mixed with blood and chicken fat. It's pretty gross" (via RTE).

Along with making the props look realistic, there is great deal of attention paid to how the actors are moving and acting in a surgical setting to make sure that they don't do something that an actual doctor wouldn't. In September of 2021, LitHub published an oral history in which the cast and crew discuss how they pull off their most intricate medical scenes. Giacomo Gianniotti, who played Dr. Andrew DeLuca from 2015 to 2021, told an amusing anecdote as an example of the lengths they go to for accuracy: "My first surgery was a nightmare. There were so many things, general rules that I didn't know about sterilization, keeping everything clean. I was constantly dropping my hands in surgery and Linda Klein," the show's medical adviser technician, "would be like, 'Cut, cut, cut! Giacomo, what are you doing? You're dropping your hands! You're not sterile!'"

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What They Really Used For Organs During Surgeries In Grey's Anatomy - Looper

Netflix found a huge hit in its anthology thriller series Anatomy of a Scandal, so fans are understandably confused that the series is not getting picked up. However, the show was "canceled" instead, it was always planned as a limited series. The six episodes of Anatomy of a Scandal were all that were ever planned by its creators.

Anatomy of a Scandal is a Netflix original series that premiered on April 15, 2022. It is a drama with elements of true crime, politics and mystery all mixed together in the story of a British family torn apart by a highly publicized scandal. The show is based on a novel of the same name written by Sarah Vaughan, and Vaughan never wrote a sequel. With the story relayed in its entirety already, there's no reason for a second season to be made.

Vaughan wrote Anatomy of a Scandal and published it in 2018, drawing on her own experience as a political journalist and a student at Oxford. It was her third novel, separate from the first two books and the two that have followed it since. Vaughan has not hinted at any plans to make a sequel, and fans of the genre aren't necessarily clamoring for one, either. The story is self-contained, and thrillers of this kind do not typically get serialized in the world of publishing.

TV is a different story. Many acclaimed thriller adaptations have been extended past their source material, with TV writers teasing out the story and following the characters onto their next adventure. However, this is not always popular, with fans sometimes complaining that it's easy to tell when the original story runs out and the show is running on fumes. One of the most infamous recent examples was at Netflix 13 Reasons Why.

It would make sense that Netflix wants to avoid this pitfall when it comes to Anatomy of a Scandal, ending the show on a high note. It's also notable that the book and the show are both British. Short limited series are much more common in the U.K., and book adaptations are rarely extended there. Viewers would like be surprised if Anatomy of a Scandal broke that norm.

Fans who are disappointed to leave the Whitehouse family behind can always turn to Vaughan's book. It is available now in print, digital and audiobook format wherever books are sold. Otherwise, the series is streaming now on Netflix.

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'Anatomy of a Scandal': Why There Won't Be a Season 2 - PopCulture.com

Batman Forever costume sculptor Jose Fernandez has explained why the Batsuit had nipples.The suit infamously had the rather strange additions in both Batman Forever, starring Val Kilmer, and Batman & Robin, which starred George Clooney.

"With Val Kilmer's suit in Batman Forever, the nipples were one of those things that I added. It wasn't fetish to me, it was more informed by Roman armor like Centurions," Fernandez told MEL (via Screen Rant (opens in new tab)).

"And, in the comic books, the characters always looked like they were naked with spray paint on them it was all about anatomy, and I like to push anatomy," he continued. "I don't know exactly where my head was at back in the day, but that's what I remember. And so, I added the nipples. I had no idea there was going to end up being all this buzz about it."

Sadly, every version of the Batsuit since 97's Batman & Robin has done away with that particular design feature.

We'll next see Batman on the big screen in the upcoming The Flash, which, thanks to some multiversal shenanigans, will see the return of both Ben Affleck and Michael Keaton to the role. Keaton will also be playing Bruce Wayne again in the upcoming HBO Max movie Batgirl, which stars Leslie Grace as the titular Barbara Gordon.

The most recent cinematic incarnation of the Caped Crusader was Robert Pattinson's in The Batman, which has a sequel on the way.

If you're up to date on Batman Forever, check out our guide to all the upcoming superhero movies to get up to speed on what's next in the DCEU and MCU.

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Batman Forever costume designer explains why the Batsuit had nipples: "It was all about anatomy" - Gamesradar

Sarah Drew and Jesse Williams returned to Greys Anatomy for its Season 18 finale, thrilling fans with the reveal that their characters Jackson Avery and April Kepner had reunited. The fandom has been screaming for a Japril spinoff pretty much since Drew left the medical drama at the end of Season 14 (if not before that), and the yearning to see the couples life together in Boston is stronger than ever following their on-screen in-elevator kiss. The actors seem down for a spinoff, as well, as theyve consistently voiced their love for the characters, but Drew has an interesting idea about how shed want to differentiate their series from Greys Anatomy.

The idea of a spinoff featuring Jackson and April was actually one the actors pitched when they were both still on the show. Rather than giving them their own series, the writers turned their pitch into what is now known as Japril The Movie, a heartbreaking Season 12 episode. Sarah Drew returned for the Season 17 episode that announced Jesse Williams exit from Greys Anatomy, with April agreeing to accompany Jackson to Boston to continue co-parenting their daughter Harriet. Drew spoke with Tommy DiDario on Instagram about how she sees that story being continued:

In my dream world, it would be like a 10-episode kind of show where we could be somewhere that allows it to be a little darker, and a little grittier, a little sexier. That would be fun.

The Japril dynamic has been fun to watch, to say the least, but if they were the sole focus of the story, without the necessity of sharing screen time with a bevy of other Seattle surgeons, Jesse Williams and Sarah Drew would definitely have to dive deeper into Jackson and Aprils complexities much like they did for Japril The Movie. In that episode (officially Unbreak My Heart), Jackson served April with divorce papers, prompting a look at the highs and lows of their time together, with the episode ending with the reveal that April was pregnant again.

The history certainly exists for Sarah Drew and Jesse Williams to go darker and grittier with the characters. As far as sexier, lets just say its a good thing Jackson and April are doctors, because I feel some heart palpitations coming on.

The reason for their move to Boston for Jackson to take over his familys Catherine Fox Foundation to help provide better medical care to underserved communities would also lend itself to some interesting and important content. Drew said that would be fun to tackle:

And I think that's what's really fun about these two characters...they're both right now kind of really living in their purpose. And they're out to change the medical field and to fight for medical justice. We haven't seen that out in the world yet. So, I think it could lend itself to really interesting, fun stories to tell.

After his exit from the show in 2021, Jesse Williams said he and Sarah Drew would kill it if given the chance to do a spinoff, and Greys Anatomy star Ellen Pompeo also said she gets why fans want to see more, and shed watch them lead their own show. This seems to be an idea that fans (and the actors!) arent letting go of, so will somebody order this spinoff already?

In the meantime, you can relive all the Japril drama on streaming, with Seasons 1-17 of Greys Anatomy available to Netflix subscribers, while Season 18 is available in full with a Hulu subscription.

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Sarah Drew Would Totally Love A Japril Spinoff With Jesse Williams, And Knows How She'd Want It To Be Different From Grey's Anatomy - CinemaBlend

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ORYZON to Give Updates on Corporate Progress in November

Aftermath of Peshawar bombing in Pakistan: From Musharraf to Munir, the anatomy of a failed security policy  The Indian Express

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Aftermath of Peshawar bombing in Pakistan: From Musharraf to Munir, the anatomy of a failed security policy - The Indian Express

We describe a patient with multifocal recurrent hepatocellular carcinoma (HCC) who received proton beam therapy (PBT) and then underwent donation after brain dead (DBD) liver transplantation. The anatomy of the explanted diseased liver was examined pathologically post-transplantation. The patient was a 52-year-old male with hepatitis B virus infection and liver cirrhosis of Child-Pugh class B. Right lobe and caudate lobectomy were performed for primary HCC. However, three recurrent tumors appeared in the remnant liver in segments S2 (two sites) and S4, of sizes 23 mm, 10 mm, and 32 mm, respectively. Liver transplantation was required due to these multiple HCCs and liver cirrhosis, but the patient was ineligible for living donor liver transplantation (LDLT) based on Milan criteria. He was registered as a candidate on the waiting list for DBD transplantation. In consideration of the long waiting timefor a deceased donor transplant for more than one year, the progression of multiple recurrent HCCs, and the risk of death, the patient had limited treatment options other than PBT for poor liver function and multifocal HCCand eventually received 65 GyE/18 fractions of PBT. Eleven months after the start of PBT, the tumors remained progression-free and liver function did not deteriorate, allowing the patient to wait for liver transplantation. After transplantation, the histopathology of the explanted liver showed that the left lobe of the liver treated by PBT showed no evidence of solid tumors and tumor cells in visual and microscopic examinations. There was also no significant damage to normal liver tissue. This case demonstrates that PBT is a prospective option for patients with HCC with poor liver function, multiple tumors, and no other treatment options. PBT can achieve control or even complete response of HCC while maintaining liver function and may be an effective pre-transplant method for tumor downstaging and prolonging survival. PBT may enable more people to wait for a donor liver or to become eligible for liver transplantation.

Primary liver cancer is the fifth most common cancer and the third most common cause of cancer-related mortality worldwide [1-2]. Among live cancer cases, 85-90% are hepatocellular carcinoma (HCC) [3]. About 80% of liver cancers are also attributed to chronic hepatitis B and C [4]since these diseases are important risk factors for cirrhosis, which has a strong tendency to proceed to HCC. Patients with HCC can be managed by surgical resection, transcatheter arterial chemoembolization (TACE), radiofrequency ablation (RFA), and liver transplantation [5-6]. However, surgery is only preferable for solitary early-stage HCC, and partial resection is not recommended for multiple and recurrent cirrhotic HCC [7]. Among non-surgical approaches, RFA gives good therapeutic outcomes for solitary HCCbut not for multiple, large, and deeply located HCC [8]. Patients with cirrhosis leading to hepatic insufficiency should be carefully assessed for TACE because of the potential risk of liver failure or bleeding [9].

Liver transplantation is the optimal therapeutic option for liver cirrhosis and HCC [10], with excellent survival rates of >90% and >80% at one and five years, respectively [11]. Liver transplantation is mainly classified into living donor liver transplantation (LDLT) and donation after brain dead (DBD) liver transplantation [12]. In Japan and China, the Milan criteria are used to judge long-term eligibility for LDLT in patients with HCC [13-14]. However, the shortage of donor livers leads to long waiting periods for transplantation, and patients are in danger of death or tumor progression during this period, with a mortality rate of 11.3% [15]. Therefore, treating HCC during the pre-transplantation waiting period is necessary to reduce mortality and meet the criteria for transplantation.

Proton beam therapy (PBT) is an aggressive form of radiation therapy that offers advantages over photon-based radiation therapy through greater sparing of the normal liver surrounding the tumor due to its dosimetric properties based on the Bragg peak [16]. Thus, PBT reduces radiation-related hepatotoxicity while permitting escalation of the tumor dose [17]. At our center, we have shown the effectiveness of PBT for HCC, even in patients with cirrhosis and poor liver function, and we have found that PBT is tolerable and improves survival for patients with HCC with severe cirrhosis [18]. Here, we describe a case of multifocal HCC treated by PBT followed by DBD liver transplantation that showed a pathologically verified complete response to PBT with the disappearance of tumors.

The patient was a 52-year-old male with chronic hepatitis B infection complicated by severe cirrhosis. At the initial onset of HCC, resection of the right lobe and caudate lobe of the liver was performed. Fifteen months later, a tumor recurred in the S3 segment, for which internal yttrium-90 (Y90) irradiation was performed. Since then, the patient had received targeted drug therapy with lenvatinib and regorafenib, but this treatment was not effective. One and a half years later, the tumors progressed and the patient was diagnosed with multiple HCCs by contrast-enhanced magnetic resonance imaging (MRI). The arterial phase (Figure 1) showed three high signal intensity nodules in the left lobe of the liver: two HCCs in S2 and S4 (Figure 1a), with sizes of 23 mm and 32 mm, respectively, and a round-like HCC located in S2 (Figure 1b) close to the hepatic peritoneum, with a size of 10 mm. In the portal venous phase, all three nodules had low signal intensity with a lack of contrast. The patient had severe cirrhosis and high hepatobiliary enzyme parameters of aspartate aminotransferase (AST) 54 IU/L, alanine transaminase (ALT) 58 IU/L, alkaline phosphatase (ALP) 158 IU/L, andgamma-glutamyl transpeptidase (-GTP) 99 IU/L before PBT.

The patient was listed as a candidate for DBD liver transplantation for multiple HCCs and severe cirrhosis. However, the long waiting time before transplantation placed the patient at risk of death due to tumor progression and poor liver function, and he was no longer able to receive surgery, chemotherapy with sorafenib, or stereotactic body radiation therapy (SBRT). Therefore, he was referred to our center. At the first visit, liver function was Child-Pugh class B, corresponding to Alb 3.9 g/dl, T-Bil 2.0 mg/dl, and PT% 79.7%. He had no hepatic encephalopathy and no abdominal dropsy with a small amount of ascites. The spleen was moderately enlarged, with the largest dimension of 14 cm. The patient had a very low platelet count of 50109/L and suffered from esophageal varices, which indicated a high risk of rupture and bleeding.

A course of PBT was successfully performed and only grade 1 dermatitis was observed as acute radiation toxicity. Blood biochemical parameters related to liver function gradually decreased during PBT (Table 1). Nine months after the end of PBT, the tumor in S4 had disappeared on contrast-enhanced MRI (Figure 2a). The larger tumor in S2 showed a low-intensity internal signal area, and the smaller S2 tumor had disappeared (Figure 2). Liver structures remained intact without significant deformation, except for slight atrophy in the irradiated area of the tumor. Blood chemistry parameters before, during, and after PBT are shown in Table 1. Within 11 months after the end of PBT, the three tumors were completely controlled and the patient was in good condition to wait for liver transplantation, although cirrhosis was progressing very slowly. To date, after successful liver transplantation, there has still been no progression of tumors.

Before proton therapy for HCC, our Proton Beam Therapy Center usually implants a metal target near the tumor to assist with localization. Laser-targeting was used during patient position setting, followed by fluoroscopy to match bone structure and correction, and finally adjustment around the position of the target. Respiratory synchronization sensors and 3D tumor motion-monitoring techniques were also used. The clinical t
arget volume (CTV) was defined as the gross tumor volume (GTV) plus a margin of 5 to 10 mm in all directions. A margin of 5 mm was added to the tail axis to compensate for respiration-induced liver motion. A margin of 5 to 10 mm was added by expanding the multileaf collimator and adjusting the range shifter to cover the entire CTV, as shown in Figure 3.

The patient was administered once daily PBT for a total of 65 GyE/18 fractions. Initially, we performed0-33 GyE/10 fractions of PBT, and the tumors were observed to shrink in size. Therefore, for the final 32 GyE/8 fractions, the radiation coverage was reduced to a good fit for the tumors and the spread-out Bragg peak (SOBP) was shortened. At the end of PBT, the patient had only Grade 1 dermatitis with PS 0 and no other acute phase reactions. The dose distribution diagrams (Figure 3) show that the tumor in S4 was irradiated lateral to two gates of the proton beam in cross-sectional and coronal views (Figure 3a and Figure 3b)while the two tumor lesions in S2 were irradiated with one gate of the proton beam obliquely from above (Figure 3c and Figure 3d).

The patient had one HCC >3 cm before PBT, which exceeded the Milan criteria (one lesion <5 cm; three lesions each <3 cm), and thuswas not eligible for LDLT. However, he was registered as a candidate for DBD transplantation before PBT. At 11 months after the end of PBT, radiology showed no evidence of a tumor in the liver and no extrahepatic distant metastases or vascular invasion. The patient also had a good general condition. At this point, a donated liver became available and the patient underwent DBD liver transplantation in China.The pathological anatomy of the diseased liver showed that all three tumor lesionshad been replaced by fibrous nodules. Two grayish-white nodular masses on the cut surface of the diseased liver were found. Among them, the size of the larger one was 8.5*5.5*6.5 cm, which was adjacent to the peritoneum of the liver and the hepatic cutaneous margin. About 2 cm away from the large nodule, the small nodule was observed, which was 3*4*5 cm. The liver section was uniformly solid and moderate in character. Microscopic findings revealed normal hepatocytes in the nodules had been replaced by hyperplastic fibrous tissue and reactive small bile ducts with high infiltration of lymphocytes and neutrophils. No cancer cells were seen microscopically, and the tissue in the radiation area surrounding the tumorshad a normal structure and was only subtly damaged. The patient is currently in good health with normal liver function.

Liver transplantation is the best option for HCC because it allows the management of both the tumor and liver cirrhosis. The number of candidates for transplants for HCC has increased in recent years and this now accounts for 15-50% of all liver transplantations [19]. Over 60% of liver transplants are performed due to cirrhosis [20]. The Milan criteria are used to determine eligibility for LDLT worldwide, and among these criteria, the following conditions need to be met for eligibility: one lesion <5 cm or up to three lesions that are each <3 cm, no extrahepatic manifestations, and no evidence of gross vascular invasion [21]. In addition, Chinese and Japanese human organ transplant regulations indicate that LDLT must take place between individuals with consanguinity or clear family relationships. In contrast, DBD liver transplants are only available from voluntary private donations, and thus, it is unknown when a patient will receive a donor liver [22]. The huge gap between the demand for liver transplantations and the number of donors has led to significant morbidity and mortality of patients during the waiting period for transplantation [23]. A study in the United States showed that 51% of transplant candidates waited for more than oneyear for a liver transplant in 2018while data from 2016 indicated that about 44% of candidates on the liver transplant list did not receive a transplant within three years and 11.3% died during the waiting period [15]. For patients with HCC, only 25% survived after six months if managed without any treatment [24]. Among patients with multiple HCCs who were unable to receive treatment such as surgical resection or TACE, Ho et al. reported a one-year survival rate of 13.9% and median survival of only 2.8 months [25]. In our case, the patient had waited for more than one year for a donor liver. Without intervention during this time, he had a serious mortality risk. Thus, alternative therapeutic modalities had to be considered to prolong survival.

Radiation therapy for HCC is not the first recommended treatment in clinical practice. This is mostly due to the low tolerance of the liver to radiation, which can lead to radiation-induced liver disease (RILD), even at low doses [26]. SBRT and other conventional photon modalities are constrained by the radiation dose permitted to avoid adjacent organ damage since most of the liver is irradiated during treatment [27]. In contrast, PBT has a unique dose distribution defined by the Bragg peak, allowing the sparing of normal tissues and focusing the dose on the tumor area [28]. Sumiya et al. showed that PBT can protect against and prevent deterioration of liver function through accurate targeting, based on the almost constant levels of liver/biliary enzymes and total bilirubin (T-Bil) related to liver function during PBT, and minimal direct damage to the normal liver even in cases with abnormal pre-treatment enzyme levels [29]. A review at the University of Tsukuba [18] showed that PBT has superior therapeutic performance and encompasses a wide range of indications for HCC, including large tumors, tumor thrombosis, and cases with poor liver function. The five-year local control rates of PBT for HCC are consistently >80%, regardless of the radiation protocols used [18].

In this case, the 52-year-old male patient had already received several treatment options, including surgery, chemotherapy, and internal irradiation due to HCC. As a consequence of severe cirrhosis and multiple recurrences of HCCs, these treatments could no longer be used to maintain liver function, so PBT seemed to be the only therapeutic option. After PBT, tumors were controlled, liver function did not deteriorate, and survival was extended [25], which allowed the patient to wait for a liver transplant safely. Thus, PBT in HCC cases not meeting the criteria for liver transplant may alleviate the tumor burden and downgrade the stage, and in turn, make the case consistent with the criteria [30]. Currently, the main methods for downstaging are local ablation therapy and TACE [31]. Chen et al. concluded that PBT for local management of HCC can be regarded as a bridging intervention for advanced aggressive HCC or as an option for downstaging of HCC to achieve criteria for transplantation, especially when other treatments are not available [27]. Thus, for patients not meeting transplant criteria, PBT may be considered a new approach for downstaging to enable more patients to become eligible for liver transplantation.

Our case illustrates that proton beam therapy is a promising new option for HCC with poor liver functionand multifocality, where other conventional treatments are not suitable. Proton beam therapy enables control of multiple HCCs, even to the point of complete tumor response, while preventing the deterioration ofliver function and allowing for prolonged patient survival. Furthermore, these findings suggest that proton beam therapy is a prospective pre-transplant modality. It might downstage the tumor, extend patient survival, and further allow more patients to wait for a donor liver or become eligible for liver transplantation, leading to more patients having access to radical treatment for HCC.

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Proton Beam Therapy for Multifocal Hepatocellular Carcinoma (HCC) Showing Complete Response in Pathological Anatomy After Liver Transplantation -...

Patrick Dempsey on Greys Anatomy Photo by Gale Adler/Abc-Tv/Kobal/Shutterstock

More MerDer scenes? After Patrick Dempseys highly emotional return toGreys Anatomylast year, fans are speculating whether his beloved character of Derek Shepherd could make future appearances on the show.

Not Wordle, just a sticky note, the official Twitter account for the long-running medical drama teased on Thursday, January 27, alongside 25 small blue boxes to resemble thepopular spelling game.

In Wordle, players have six tries to guess the daily correct word. After each incorrect guess, the game gives letter placement hints by color. Many players have taken to Twitter to share their progress using colored emoji squares.

After the series speculative tweet, many eagle-eyed fans were quick to note that the illustration resembled Dereks low-key Post-It note wedding to Meredith Grey (Ellen Pompeo) during season 7. Considering the comparison, many social media users started to believe it was a clue that theEnchantedactor, 56, could return to the ABC series.

Derek shepherd is alive Confirmation? one fan tweeted on Thursday, as another wrote, Derek is coming I know.

Greys which is set to return from its winter hiatus next month previously welcomed Dempseys character back during the season 17 premiere in a dream sequence as Meredith battled COVID-19. Throughout the season, the 52-year-old Massachusetts natives characterreconnected with her late friends and family, including McDreamy, sister Lexie (Chyler Leigh), George OMalley (T.R. Knight) and Mark Sloan (Eric Dane).

We all cried at the beginning and we hugged each other, Dempsey previously toldVarietyin April 2021 about his return, which was nearly six years after his 2015 exit from the show. It was really for us to get the message out there to wear a mask, take care of yourself.

After Derek reunited with his longtime love in four separate episodes including a dreamy wedding scene Dempsey wasnt ready to rule out another onscreen reunion.

Who knows? Never say never with this show, right? theValentines Dayactor told the outlet. Im glad we did it this year. And [showrunner] Krista Vernoff did a fantastic job telling the story. It was just a great way to give people some hope.

Both longtime fans of the series and former cast members couldnt help gushing over the Maine natives moving cameo.

I was actually thrilled and thought it was incredibly cleverthe way they brought people backduring [Merediths coma], Kate Walsh, who played Addison Montgomery on the ABC show and itsPrivate Practicespinoff, exclusively toldUs Weeklyin May 2021 about her former TV ex-husbands return. What a great device that was. Honestly, I thought it was just awesome and chilling and hugely moving and really cool to take a very kind of, I would say clich device of, you know, coma in the hospital drama, but then make it this amazing thing where youve got Pat andT.R., and didEric come back too? Its just so cool.

The midseason premiere ofGreys Anatomyairs on ABC Thursday, February 24, at 9 p.m. ET.

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Could It Be? Greys Anatomy Fans Are Freaking Out Over Potential Derek Shepherd Return - Us Weekly

News of the Anatomy of a Scandal billboards on Sunset Boulevard sits in my DMs while I shepherd my teens through the preschool chaos. Its the morning I drive my youngest to school. Have you seen my goggles? he calls, while I covertly flick to the Insta app on my phone and see that one of the executive producers of the Netflix show based on my thriller has sent me four messages. My heart trips. I may have written an international bestselling novel developed by the Big Little Lies dream team, but imposter syndrome rages; my default response that Im about to be found out. Only, there they are: photos of vast billboards depicting the series leads - Sienna Miller, Michelle Dockery, Rupert Friend, Naomi Scott, and Josette Simon looking suitably noirish against a hazy LA sky. Its the latest in a series of discombobulating moments, but I havent time to dwell on it. Come on, comes the cry from the hall. Were going to be late!

It's one degree and sleeting by the time I drop the boy and look at the image again, on a freezing dog walk. I fire off a tweet, and head along an East Anglian field, sleet driving into my face. Hands in my pockets, I can feel my phone vibrating with congratulatory messages from other authors. Take a selfie! suggests one. Jump on a plane! says another. I think of my to-do list: the articles to be written; the small matter of dog and children; covid just experienced, still clouding my brain. The scene is bleak: grey skies; ploughed-up brassicas; a biting wind whistling from Siberia, but I smile. I dont need to fly 5,400 miles to see the billboards in person. The six-part series based on my thriller about power, privilege and consent is being paraded along the road to Hollywoods studios. Its enough to know that its there.

It's been quite the journey. When I wrote it, back in 2016, I had no idea if anyone would want to publish it. A former news reporter and political correspondent on the Guardian, Id taken voluntary redundancy after my second baby, the childcare juggle/two-hour commute seeming insurmountable and financially impossible with a husband doing anti-social shifts. My first two novels didnt trouble the UK bestseller lists, but then came Anatomy, partly inspired by a phone call Id taken from Boris Johnson, back in late 2004, over his affair with Petronella Wyatt. Drawing on my time at Oxford, my experience at Westminster, and my court reporting, its been sold to 24 countries and was swiftly snapped up by Made Up Stories, 3dot Productions and David E Kelley. Four years later, its now one of the most watched shows on Netflix.

And its been a ride. Ill never forget going on set at the end of the third lockdown and meeting an Ugg-shodden Sienna, Michelle, and Josette (covid protocols meant the Shepperton studio in which they were filming the court scenes was freezing) or discussing consent and privilege with an emotionally intelligent Rupert Friend. Ive felt a quiet thrill hearing my lines voiced by these actors, while recognising that something fresh has been created: that my baby has developed way beyond my pages into something gripping to be screened in 190 countries; is no longer mine. Of course, there are changes its twistier and more sumptuous but Im thrilled it remains faithful to the tone of my thriller with its key themes of entitlement and consent. The cast have been doing sterling work, touring the US chat shows, and, in Siennas case, being frank about the parallels with her own life. Reading and listening to her speaking so passionately about its relevance is another pinch-me moment. It couldnt be more timely.

The Conservatives have helped with the marketing. That was my immediate, irreverent response to the recent allegations againstTory backbencher David Warburton. Whenever Ive worried that Anatomy might feel outdated, another politician does something abusive or entitled: Charlie Elphicke; Matt Hancock; the PM and Partygate; and now the MP for Somerton and Frome. It means rewriting a T2 front, originally slated for transmission day, but its a pleasure. A middle-aged man accused of sexually assaulting two younger women while his wife stands dutifully by him? Sounds rather familiar.

Weve grabbed a few days in north Cornwall, though the idea of my taking a holiday at the most exciting point of my career is clearly stupid. Nevertheless, its wonderful to be here. The historian A.L. Rowse described the county as the land of my content and I feel similarly about the spot Ive been visiting since I was a child, and from where my mums family hail. My literary claim to fame used to be that a distant relative, one Hilda Jelbert, was DH Lawrences 14-year-old maid at Zennor. After scouring Padstow Tesco, where Anatomy of a Scandal is on the front of two magazines, inside several others, and the Times, I realise thats about to change.

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How a phone call from Boris inspired me to write Anatomy of a Scandal - The Spectator

For many people, the prospect of an anatomy lab full of corpses is disconcerting. But for first-year medical students, it can be exciting

"I remember the first time we walked in, you just get this sense of how big the moment is," said Alyssa Yock, who is studying at UNM medical school and tells me that all the reading in the world is no substitute for the slow, careful work of dissection of a real person.

"You know, you see things in a book, and you expect it to look like that," she said. "But when you get into a lab, you see that people are different, it's not always going to be how it is in the book."

But during the last two years, along with difficulties having students assembling safely in labs, the medical school has received fewer donations of people who had decided to give their bodies when they die.

Amy Rosenbaum, director of UNMs Anatomical Donations Program, explains why.

"Unfortunately, the pandemic shut us down for a while, we had to close," she said. "But the other aspect was that because of the pandemic, we can't take COVID-positive donorsSo that has really limited our pool.

It is a sensitive subject but Rosenbaum wants to remind people that the school is accepting donations and people can sign up to the program.

"It's really hard to advertise this, it's kind of a taboo subject," she said. "But there is a need. And I think that that's what we're trying to get out, is that there is a need for donation here."

The problem exists across the country. An article in the BMC Medical Education journal found that many schools nationwide stopped accepting donations during the pandemic, and about 80% of course directors said the pandemic affected the quality of learning, with many citing the absence of dissection as a problem.

Anatomy lecturer Julie Jordan says during the worst virus surges, the school explored online teaching options but would prefer not to rely on them

"We did use a virtual anatomy program that was cadaver based," she said. "It was pretty good. But it was ultimately really frustrating too, because you could only do so much with moving it around, and really investigating structures and function of the body."

Student Devin Maez learned online in his first year, during the worst of the pandemic, but assisted in the dissection lab in his second year and was grateful for the opportunity.

"There's something innately beautiful about learning hands on, that you don't get in a book," he said.

At the end of the course, the students learn more about their donors. Alyssa Yocky learned she had dissected a woman who had worked as a teacher, and as a nurse during wartime.

"I went in with one of my lab mates and we went and held her hand and it was like, I started to cry," she said. She hadn't expected to feel so emotional but was struck by, "just how much I learned from her and just thanking her for being such a great teacher."

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A shortage of cadavers at the anatomy lab - KUNM

January 29, (THEWILL) A Professor of Anatomy at the University of Ilorin, Moyosore Salihu Ajao, has decried the scarcity of cadavers (human dead bodies) for the study of anatomy and practical classes in medical institutions in Nigeria.

Professor Ajao made this known while speaking at the 214th Inaugural Lecture of the university, expressing that the shortage affects the students.

Emphasising that the challenge is more difficult because dead bodies are not sold in the market in any part of the world, Ajao explained that the study of human anatomy cannot be fully understood from written descriptions of dimensional pictures or plastic models.

Prof. Ajao citing one of his investigations, explained that there are different causes of scarcity in the Nigerian Medical Institutions which reflects a poor ratio of students to cadavers during the studies in medical schools in Nigeria.

Despite the lack of materials for the study of medicine, Professor Ajao said there is increasing pressure to produce more doctors in Nigeria.

The first major challenge I noticed on my assumption of office as a young lecturer in the department of anatomy was the chronic shortages of cadavers in the department and after a quick check on other universities, I discovered that we are not alone in the struggle to get bodies fit enough for dissection at practicals.

The National Universities Commission recommends an average of eight students per body in Nigeria.

They are never sold in the market in any part of the world. Since human anatomy is the science that is concerned with the structures of the human body, these structures cannot be fully understood from written descriptions to dimensional pictures or plastic models.

The dissection of the human body (cadavers) is the basis for understanding the structure and functions of the human body for several centuries. In other words, to fully understand the importance of cadavers to man is far and beyond what we should overlook.

One of my studies revealed that about 12 to 15 students used a body against the International Standard that recommends a maximum of six students to one body. The National Universities Commission recommends an average of eight students per body in Nigeria.

The pressure to produce more doctors keeps mounting every year while the provision of facilities including cadaver supplies are limited in the country, he said.

The issue of human dead bodies for study of anatomy has generated a history of conflict in human society.

THEWILL reports that about 200 years ago, there were riots in America and attacks on high profile figures in England and Scotland.

The attacks, according to THEWILLs findings, were not sparked by hunger, poverty or a yearning for political reform. Instead it was public repulsion on realising that bodies of the recently dead had been stolen from graveyards, obtained by deception from hospitals, or worse, and spirited away. Their destination? Dissection in the name of the medical sciences that were blossoming at the time.

In an attempt to end this situation, the UK passed the Anatomy Act of 1832. This meant that anatomists, rather than having to rely on grave robbers, had legal access to the unclaimed corpses of people who had died in workhouses or in prison, supplemented in later years by those who died in mental hospitals. Supply met growing demand and public anger abated.

But the probably unintended and unforeseen result was to make poverty the sole criterion for dissection. It also set in stone the legitimacy of using unclaimed bodies for educational and research purposes, something that dominated anatomical practice in many countries until the 1950s or later.

However, unclaimed bodies continue to constitute the source of cadavers in some countries, as many are passed to state anatomy boards.

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Shortage Of Dead Bodies Affecting Anatomy Study In Schools Prof Ajao - thewillnigeria

GREYS ANATOMY - Hotter Than Hell Seattles favorite redhead returns and graces the Grey Sloan halls with her experience and expertise as she attempts to help Richard teach the newest crop of residents. Meanwhile, Meredith has a decision to make, and Link confides in Teddy on an all-new episode of Greys Anatomy, THURSDAY, OCT. 14 (9:00-10:01 p.m. EDT), on ABC. (ABC/Eric McCandless)CAMILLA LUDDINGTON

Women of the Movement has come to an end. That means were back to the usual TGIT lineup, right? Whats going on with Greys Anatomy tonight?

We have some bad news. WhileWomen of the Movement aired its series finale last week, were not getting back to the usual TGIT lineup. ABC is keepingGreys Anatomy off the air for a little longer, so there isnt a new episode on tonight, Thursday, Jan. 27. As we mentioned, there wouldnt be any new episodes ofGreys Anatomy on in January 2022.

There isnt even a rerun on tonight. ABC is airingTruth and Lies: The Last Gangster starting at 8/7c. It will take up the first two hours of the night. This series looks into the Gambino mob family and is perfect for those who are fascinated by mobsters.

Whats with the lack of new episode tonight? This is partly due to the pandemic. The show doesnt have enough episodes in the can to air a few before the Winter Olympics.

The Winter Olympics is also playing a part. Rather than bring shows back for a few weeks and then take them off the air for the Winter Olympics, ABC has opted for other programming in the run-up to the February sporting event.

Were still looking at the series returning with new episodes at the end of February 2022. The official release date is Thursday, Feb. 24.

The series will return with a two-hour crossover event withStation 19. We last left a doctors life in the balance. Owen was in a car that went over a cliff edge, and its not clear if he will live or die. Well get to see Ben Warren and the other firefighters of Station 19 go out to save him.

Greys Anatomy airs Thursdays at 9/8c on ABC. Catch up on the season so far on Hulu.

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Is a new episode of Greys Anatomy on tonight? (January 27) - Hidden Remote