Video Link: https://www.youtube.com/watch?v=A1DmURRbthY

cell origami
Cell Origami: Self-Folding of Three-Dimensional Cell-Laden Microstructures Driven by Cell Traction Force http://www.plosone.org scale bars in the movies: 50 um (micron) 3D cell-laden microstructures are produced by applying the principle of origami folding technique and cell traction force. The CTF is harnessed as a biological driving force to fold the microstructures. Cells stretch and adhere across multiple microplates. Upon detaching the microplates from a substrate, CTF causes the plates to lift and fold according to a prescribed pattern. We successfully produced various 3D cell-laden microstructures by just changing the geometry of the patterned 2D plates. We also achieved mass-production of the 3D cell-laden microstructures without causing damage to the cells. We believe that our methods will be useful for biotechnology applications that require analysis of cells in 3D configurations and for self-assembly of cell-based micro-medical devices.From:Kaori Kuribayashi-ShigetomiViews:8 0ratingsTime:00:51More inScience Technology

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