This NASA Research Announcement (NRA) solicits hypothesis-driven research proposals for 1) Ground-Based Research Designed to Lead to Space Flight, 2) Rapid Turn-Around Space Flight Experiments 3) ISS Flight Experiments and 4) New Space Biology Investigations. NASA Space Biology experiments have one or more of the following primary goals: 1) to effectively use microgravity and the other characteristics of the space environment to enhance our understanding of basic biological processes; 2) to develop the scientific and technological foundations for a safe, productive human presence in space for extended periods and in preparation for exploration; and 3) to apply this knowledge and technology to improve our nation's competitiveness, education, and the quality of life on Earth. NASA Space Biology experiments will be designed to discover how space flight affects a diverse group of microorganisms, plants, and animals; study the effects of gravity (g) across the g-spectrum, i.e., from micro- to hyper-gravity; and characterize the biological effects of radiation, magnetic fields, and the interaction amongst species in the unusual environments of space and spacecraft.

The full text of the solicitation is available on the NASA Research Opportunities homepage at http://nspires.nasaprs.com under menu listing "Open Solicitations." Potential applicants are urged to access this site well in advance of the proposal due date to familiarize themselves with its structure and to register in the NSPIRES system. Proposals must be submitted electronically.

Step-1 proposals are due on October 31, 2012 at 5 PM Eastern Time, and invited Step-2 proposals are due on December 19, 2012 at 5 PM Eastern Time. Proposals must be submitted electronically by an authorized official of the proposing organization. Proposers can use either NSPIRES (see URL above) or Grants.gov (http://www.grants.gov) for proposal submission. NASA's selection of research projects will be guided by recommendations of the National Research Council's 2011 Decadal Survey Report, "Recapturing a Future for Space Exploration: Life and Physical Sciences Research for a New Era" (http://www.nap.edu/catalog/13048.html).

All categories of U.S. institutions are eligible to submit proposals in response to this NRA. Principal Investigators (PIs) may collaborate with investigators from universities, Federal Government laboratories, the private sector, state and local government laboratories and other countries.

Every organization that intends to submit a proposal in response to this NRA must be registered with NSPIRES, and such registration must identify the authorized organizational representative(s) who will submit the electronic proposal. Instructions on how to register in NSPIRES will be described in the NRA. Each electronic proposal system places requirements on the registration of principal investigators and other participants (e.g. co-investigators). Potential proposers and proposing organizations are urged to access the system(s) well in advance of the proposal due date(s) of interest to familiarize themselves with its structure and enter the requested information. Questions in regards to responding to this NRA may be addressed to the contacts referenced in the full solicitation document.

This is a broad agency announcement as specified in FAR 6.102 (d)(2). Notwithstanding the posting of this opportunity at FedBizOpps.gov, nspires.nasaprs.com, or Grants.gov, NASA reserves the right to determine the appropriate award instrument for each proposal selected pursuant to this announcement.

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Release of NASA Research Announcement NNH12ZTT001N "Research Opportunities in Space Biology"