Saba Ale Ebrahim,1,* Amirhossein Ashtari,2,* Maysam Zamani Pedram,3 5,* Nader Ale Ebrahim,6,* Amir Sanati-Nezhad4,5,*

1School of Electrical Engineering, Iran University of Science and Technology, Tehran, Iran; 2Department of Electrical Engineering, Politecnico di Milano, Milan, Italy; 3Faculty of Electrical Engineering, K. N. Toosi University of Technology, Tehran, Iran; 4Department of Mechanical and Manufacturing Engineering, University of Calgary, Calgary, Alberta T2N 1N4, Canada; 5Center for Bioengineering Research and Education, Biomedical Engineering Program, University of Calgary, Calgary, Alberta T2N 1N4, Canada; 6Research and Technology Department, Alzahra University, Vanak, Tehran, Iran

*These authors contributed equally to this work

Correspondence: Maysam Zamani Pedram; Amir Sanati-Nezhad Email mzpedram@kntu.ac.ir; amir.sanatinezhad@ucalgary.ca

Background: Exosomes are small vesicles produced by almost all cells in the body and found in all biofluids. Cancer cell-derived exosomes are known to have distinct, measurable signatures, applicable for early cancer diagnosis. Despite the present bibliometric studies on Cancer detection and Nanoparticles, no single study exists to deal with Exosome bibliometric study.Methods: This bibliometric work investigated the publication trends of Exosomes nanoparticles and its application in cancer detection, for the literature from 2008 to July 2019. The data were collected from the Web of Science Core Collection. There were variant visual maps generated to show annual publication, most- relevant authors, sources, countries, topics and keywords. The network analysis of these studies was investigated to evaluate the research trends in the field of exosomes. In addition, the data were qualitatively analyzed according to 22 top-cited articles, illustrating the frequently used subjects and methods in exosomes research area.Results: The results showed that the documents in this field have improved the citation rate. The top-relevant papers are mostly published in Scientific Reports journal which has lost its popularity after 2017, while today, Analytical Chemistry is leading in publishing the most articles related to exosomes. The documents containing keywords of plasma, cells, cancer, biomarkers, and vesicles as keywords plus, are more likely to be published in PLoS One journal. The clustering of the keywords network showed that the keyword theme of extracellular vesicles has the highest centrality rate. In global research, USA is the most corresponding country, followed by China, Korea and Australia. Based on the qualitative analysis, the published documents with at least 50 citations have used exosome release, cargo, detection, purification and secretion, as their targets and applied cell culture or isolation as their methods.Conclusion: The bibliometric study on exosomes nanoparticles for cancer detection provides a clear vision of the future research direction and identifies the potential opportunities and challenges. This may lead new researchers to select the proper subfields in exosome-related research fields.

Keywords: exosomes, cancer detection, nanoparticles, microvesicles, bibliometrics, research productivity

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Publication Trends in Exosomes Nanoparticles for Cancer Detection | IJN - Dove Medical Press