Clinical stage oncology company Prescient Therapeutics (ASX: PTX) has made plans to advance and accelerate its proprietary OmniCAR platform after unveiling two high-profile additions to its scientific advisory board.
In a statement to the market, the oncology company said it had appointed physician-scientist, Dr Marco Davila from the Moffitt Cancer Center and bioengineering expert Professor Andrew Tsourkas from the University of Pennsylvania, effective immediately.
The dual appointments are expected to bring unsurpassed expertise to Prescients ongoing development work on CAR-T therapies and binder protein engineering.
The company explained the rationale behind the move by stating that Dr Davila and Professor Tsourkas would bring deep complementary expertise to its operations and would compliment an existing team of highly credentialed personnel on the scientific board.
Currently, the broader team is comprised of CAR-T expert Professor Phil Darcy, hematologist and CAR-T researcher Professor H. Miles Prince and brain cancer specialist and cell therapy researcher Professor Don ORourke.
As a highly experienced clinical developer of CAR-T, Dr Davila is currently regarded as a leading figure in the field and is often invited to address global oncology conferences.
Dr Davila currently works at the Department of Blood and Marrow Transplantation at the Moffitt Cancer Center one of the largest cancer centres in the US treating patients with hematologic malignancies with various cell therapies.
Dr Davilas current research includes pre-clinical development and clinical translation of gene-engineered cell therapies, including CAR-T therapies, for patients with hematologic and solid tumour malignancies.
Moreover, Dr Davilas research has received widespread acclaim including generous grants and awards from the American Society of Hematology, Damon Runyon Cancer Research Foundation, the American Society of Clinical Oncology and the American Society for Clinical Investigation, respectively.
From my clinical experience with CAR-T therapies, as well as their pre-clinical development, I have seen both the early success of this revolutionary therapy in B cell malignancies and also the challenges in translating it to other cancers, said Dr Davila.
I am excited by the capabilities of OmniCAR to overcome many of these obstacles and bring gene-engineered cell therapies to many more patients. I am delighted to be appointed to Prescients SAB to help guide the development of OmniCAR, he added.
According to Prescient Therapeutics, OmniCAR is a universal immune receptor platform enabling controllable T-cell activity and multi-antigen targeting with a single cell product.
The company says it is the first of its kind: the first universal immune receptor allowing post-translational covalent loading of binders to T-cells.
As well as the addition of Dr Davila to its scientific board to help advance OmniCAR, Prescient is also bolstering its ranks from the University of Pennsylvania and an original co-founder of the technology.
Professor Tsourkas is a co-inventor of the patents developed at Penn and licensed by Prescient to form OmniCAR.
OmniCAR is based on technology first licensed from Penn as well as the so-called SpyTag/SpyCatcher binding system licensed from Oxford University. Given OmniCARs development path and close collaboration with Penns researchers, Prescient acquired the services of Professor Tsourkas as an organic fit.
Professor Tsourkas particular expertise in the conjugation of proteins is especially relevant to the development of OmniCARs binders, which involves incorporating SpyTag into antibodies and other antigen-binding molecules, the company said.
It has been wonderful to see the rapid progress of development of OmniCAR since Prescient licensed the underlying patent from Penn last year, said Professor Tsourkas.
The rapid, covalent nature of OmniCARs binding confers many unique capabilities and advantages over conventional CAR-T approaches. I look forward to assisting Prescient in the development of OmniCAR and its associated binders to address a variety of different cancers, Professor Tsourkas added.
Over the next 12 months, Prescient expects to expand the cohort read-out for its PTX-100 drug, as well as complete enrolment in the expansion cohort by Q3 2022. Prescient is confident of announcing several further value-adding milestones for each OmniCAR program throughout 2022.
In addition, Prescient has confirmed it expects to receive results for its PTX-200 Ph1b AML trial early next year with several cell therapy enhancements expected to come out of stealth mode in the first half of 2022.
Continue reading here:
Prescient Therapeutics bolsters scientific advisory board with CAR-T and bioengineering experts - Small Caps
- Where is medical device approval headed? The horse's mouth speaks... [Last Updated On: August 17th, 2024] [Originally Added On: May 3rd, 2010]
- Starting a medical device company? You are better off without some of these "VC"s! [Last Updated On: August 17th, 2024] [Originally Added On: May 4th, 2010]
- Silicon Valley Business of Engineering - A great event and resource for local medical device folks and others... [Last Updated On: August 17th, 2024] [Originally Added On: May 5th, 2010]
- MedTech: A great bioscience resource for folks in New York [Last Updated On: August 17th, 2024] [Originally Added On: May 7th, 2010]
- Blog brief: Inventables - a nice resource for your medical device projects [Last Updated On: August 17th, 2024] [Originally Added On: May 17th, 2010]
- Want to help out a biotech hackerspace AND learn about medical device regulations? Come to my class... [Last Updated On: August 17th, 2024] [Originally Added On: June 8th, 2010]
- A prototyping tip & a quick update [Last Updated On: August 17th, 2024] [Originally Added On: August 2nd, 2010]
- The Healthcare bill of rights is here... [Last Updated On: August 17th, 2024] [Originally Added On: October 11th, 2010]
- Come join me for a workshop on "The Rules of Brainstorming" [Last Updated On: August 17th, 2024] [Originally Added On: October 11th, 2010]
- DIYBio gets a little more local...Bangalore just got one - is there one in your area? [Last Updated On: August 17th, 2024] [Originally Added On: November 7th, 2010]
- Are you an entrepreneur? A job seeker? Where are your major hurdles coming from? [Last Updated On: August 17th, 2024] [Originally Added On: November 28th, 2010]
- The World Diabetes Day is here [Last Updated On: August 17th, 2024] [Originally Added On: November 28th, 2010]
- Healthgamescamp, San Francisco is tomorrow, barcamps and more... [Last Updated On: August 17th, 2024] [Originally Added On: December 13th, 2010]
- Healthgamescamp - liveblog: "It's crazy and wild and fun" [Last Updated On: August 17th, 2024] [Originally Added On: December 13th, 2010]
- Healthgamescamp - liveblog; part 2 - break time! [Last Updated On: August 17th, 2024] [Originally Added On: December 13th, 2010]
- Quick Post: Are others (guests) allowed to post on this blog? [Last Updated On: August 17th, 2024] [Originally Added On: December 19th, 2010]
- Entrepreneurship Opportunities: The Health 2.0 challenge for 2011 is announced [Last Updated On: August 17th, 2024] [Originally Added On: December 19th, 2010]
- A heartwarming story, a foundation and a few medical device challenges for the future [Last Updated On: August 17th, 2024] [Originally Added On: December 27th, 2010]
- What will your 2011 medical device design resolutions be? [Last Updated On: August 17th, 2024] [Originally Added On: January 2nd, 2011]
- Elan was recently asked: Your workers or your private jet..guess what they chose? [Last Updated On: August 17th, 2024] [Originally Added On: February 6th, 2011]
- Blog Briefs: A great resource: The National Academies Press makes all pdf books free! [Last Updated On: August 17th, 2024] [Originally Added On: June 12th, 2011]
- On Scott Brown's unfactual rant... [Last Updated On: August 17th, 2024] [Originally Added On: June 26th, 2011]
- There's trouble ahead for Pharma... [Last Updated On: August 17th, 2024] [Originally Added On: July 3rd, 2011]
- The Acne Apps Scandal - how a select few make everyone suffer... [Last Updated On: August 17th, 2024] [Originally Added On: September 18th, 2011]
- Faculty Interview | MIT Introduction to Bioengineering, Spri [Last Updated On: August 17th, 2024] [Originally Added On: October 10th, 2011]
- Destroying Humanity with Social [Last Updated On: August 17th, 2024] [Originally Added On: October 10th, 2011]
- Bioengineering- Clemson Graduate School [Last Updated On: August 17th, 2024] [Originally Added On: October 10th, 2011]
- Faculty Interview | MIT Introduction to Bioengineering, Spri - Video [Last Updated On: August 17th, 2024] [Originally Added On: October 13th, 2011]
- Grant to benefit Bioengineering research - Video [Last Updated On: August 17th, 2024] [Originally Added On: October 14th, 2011]
- BioEngineering Associates, Inc. - Mad River Bluffs Stabilization Project - Video [Last Updated On: August 17th, 2024] [Originally Added On: October 14th, 2011]
- BIO ENGINEERING - Video [Last Updated On: August 17th, 2024] [Originally Added On: October 15th, 2011]
- Cross-Species Hybridization and Bioengineering: We're Not in Kansas Anymore! - Alex Jones Tv 2/2 - Video [Last Updated On: August 17th, 2024] [Originally Added On: October 16th, 2011]
- Paul Root Wolpe: It's time to question bio-engineering - Video [Last Updated On: August 17th, 2024] [Originally Added On: October 19th, 2011]
- BioEngineering Insights 2009 - BioMaterials Part 2 - Video [Last Updated On: August 17th, 2024] [Originally Added On: October 22nd, 2011]
- Blog Action Day - Blogging for Food... [Last Updated On: August 17th, 2024] [Originally Added On: October 23rd, 2011]
- [KAIST-Bioengineering]Biomimetics - Video [Last Updated On: August 17th, 2024] [Originally Added On: October 24th, 2011]
- [KAIST Bioengineering] Bioengineering through movies - Video [Last Updated On: August 17th, 2024] [Originally Added On: October 26th, 2011]
- PhD Research in Belgium (Bioengineering at the University of Leuven) - Video [Last Updated On: August 17th, 2024] [Originally Added On: October 29th, 2011]
- Penn Bioengineering: Modeling Contractile Forces - Video [Last Updated On: August 17th, 2024] [Originally Added On: October 29th, 2011]
- Global 3000 | How One Bio-engineering Seed Producer is Dominating Markets - Video [Last Updated On: August 17th, 2024] [Originally Added On: October 31st, 2011]
- White House Awards UC San Diego Bioengineering Professor Shu Chien National Medal of Science - Video [Last Updated On: August 17th, 2024] [Originally Added On: October 31st, 2011]
- [KAIST BioEngineering] Olleh! BioEng! - Video [Last Updated On: August 17th, 2024] [Originally Added On: November 9th, 2011]
- Calling BS on the link between tax increases and medical device innovation... [Last Updated On: August 17th, 2024] [Originally Added On: January 1st, 2012]
- Stanford's Stephen Quake, Bioengineer - Video [Last Updated On: August 17th, 2024] [Originally Added On: January 1st, 2012]
- Plandai Biotechnology, Inc. Announces Appointment of World-Renowned Physicist to Chair Plandai Scientific Board [Last Updated On: August 17th, 2024] [Originally Added On: January 30th, 2012]
- Need muscle for a tough spot? Turn to fat stem cells [Last Updated On: August 17th, 2024] [Originally Added On: January 31st, 2012]
- India gets her own stem cell hosptial [Last Updated On: August 17th, 2024] [Originally Added On: February 5th, 2012]
- A marketable major [Last Updated On: August 17th, 2024] [Originally Added On: February 7th, 2012]
- US Navy here to talk biofuels [Last Updated On: August 17th, 2024] [Originally Added On: February 7th, 2012]
- Carlsberg-invested Chongqing Brewery to hire independent auditors [Last Updated On: August 17th, 2024] [Originally Added On: February 7th, 2012]
- Industry linkage beefs up livestock nutrition [Last Updated On: August 17th, 2024] [Originally Added On: February 13th, 2012]
- The Hertz Foundation Selects 50 Finalists for 2012-2013 Hertz Fellowship Supporting Gifted Young Leaders in Applied ... [Last Updated On: August 17th, 2024] [Originally Added On: February 13th, 2012]
- US Navy eyes Aussie biofuel research [Last Updated On: August 17th, 2024] [Originally Added On: February 13th, 2012]
- Researchers make breakthrough in stem cell research [Last Updated On: August 17th, 2024] [Originally Added On: February 14th, 2012]
- UQ researchers make breakthrough in stem cell research [Last Updated On: August 17th, 2024] [Originally Added On: February 14th, 2012]
- Brand Marvel Worldwide Consumer Products Corporation Update [Last Updated On: August 17th, 2024] [Originally Added On: February 14th, 2012]
- U.S. and Canadian Scientists Form a Global Alliance for Nano-Bio-Electronics in Order to Rapidly Find Solutions for ... [Last Updated On: August 17th, 2024] [Originally Added On: February 14th, 2012]
- Speaker to discuss Honor Code at UPUA meeting [Last Updated On: August 17th, 2024] [Originally Added On: February 15th, 2012]
- Understand the Lessons Learned from the FDA QbD Pilot Programme - Case Study Merck Serono [Last Updated On: August 17th, 2024] [Originally Added On: February 15th, 2012]
- Lewis: Fully caffeinated professor dreams up business [Last Updated On: August 17th, 2024] [Originally Added On: February 15th, 2012]
- Titan Spine Acquires Additional Patent Protection for its Spinal Implant Surface Technologies [Last Updated On: August 17th, 2024] [Originally Added On: February 15th, 2012]
- Histogenics to Present at 7th Annual New York Stem Cell Summit [Last Updated On: August 17th, 2024] [Originally Added On: February 16th, 2012]
- Microchip successfully delivers bone-loss drug: study [Last Updated On: August 17th, 2024] [Originally Added On: February 16th, 2012]
- Microchip delivers drug; can it replace shots? [Last Updated On: August 17th, 2024] [Originally Added On: February 16th, 2012]
- Bioengineering company bringing ideas to Huntington [Last Updated On: August 17th, 2024] [Originally Added On: February 18th, 2012]
- UCLA Discovery that Migrating Cells "Turn Right' has Implications for Engineering Tissues, Organs [Last Updated On: August 17th, 2024] [Originally Added On: February 18th, 2012]
- After scrapping bigger plans, HP says webOS still has an open-source future [Last Updated On: August 17th, 2024] [Originally Added On: February 19th, 2012]
- Discovery that migrating cells 'turn right' has implications for engineering tissues, organs [Last Updated On: August 17th, 2024] [Originally Added On: February 19th, 2012]
- Biotechnology and Bioengineering: Cell stamping from PEG-oleyl surfaces - Video [Last Updated On: August 17th, 2024] [Originally Added On: February 21st, 2012]
- American Oriental Bioengineering Inc. Announces Plans for Reverse Stock Split of its Common Stock [Last Updated On: August 17th, 2024] [Originally Added On: February 22nd, 2012]
- Injectable gel could repair tissue damaged by heart attack [Last Updated On: August 17th, 2024] [Originally Added On: February 22nd, 2012]
- World’s First Lab-Engineered Burger Just Months Away [Last Updated On: August 17th, 2024] [Originally Added On: February 22nd, 2012]
- For UC Berkeley’s New Helios Energy Research Facility: Firespray’s Ductwork Solves Lab Construction Challenge [Last Updated On: August 17th, 2024] [Originally Added On: February 22nd, 2012]
- IBM and IBN Treating MRSA With Nanotechnology and Nanomedicine in February's Edition of Healthcare Global [Last Updated On: August 17th, 2024] [Originally Added On: February 22nd, 2012]
- Injectable gel could repair damaged cardiac tissue [Last Updated On: August 17th, 2024] [Originally Added On: February 22nd, 2012]
- DNA2.0 Partners with Cosmo Bio to Deliver Bioengineering Solutions to Japanese Researchers [Last Updated On: August 17th, 2024] [Originally Added On: February 23rd, 2012]
- Three UI professors win Sloan fellowships [Last Updated On: August 17th, 2024] [Originally Added On: February 23rd, 2012]
- IBM and IBN Treating MRSA with Nanotechnology and Nanomedicine in February’s Edition of Healthcare Global [Last Updated On: August 17th, 2024] [Originally Added On: February 23rd, 2012]
- Now, injectable gel that could repair tissue damaged by heart attack [Last Updated On: August 17th, 2024] [Originally Added On: February 23rd, 2012]
- India's drug discovery innovation prognosis is "poor". Is anyone surprised? [Last Updated On: August 17th, 2024] [Originally Added On: February 26th, 2012]