Removing molecular 'garbage' may be key to successful aging, Clarke says

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Newswise Steven G. Clarke, a distinguished professor in the department of chemistry and biochemistry in UCLA's College of Letters and Science, has been named to UCLA's Elizabeth and Thomas Plott Chair in Gerontology.

The endowed chair, held for a five-year term, is intended for a scholar who conducts research and education activities related to aging and longevity in the areas of molecular biology, neuroscience and immunology.

An authority in his field, Clarke focuses on the biochemistry of the aging process and conducts research aimed at understanding, on a molecular level, how human functions are maintained during aging.

His research team has proposed that a major factor in the successful aging of all organisms is how well age-generated molecular "garbage" damaged proteins, nucleic acids, lipids and small molecules can either be repaired or eliminated from the body. His lab has analyzed protein-repair systems and novel types of enzymes that may contribute to reducing this buildup of damage in aging organisms.

Specifically, Clarke's team discovered and characterized the repair system involving the enzyme L-isoaspartyl methyltransferase, or PCMT. Early research on this enzyme's ability to repair defective proteins demonstrated that mice lacking sufficient PCMT had a significant increase in the number of damaged proteins in their tissues, particularly in the brain. Deficiencies in this enzyme have been linked to epilepsy and may also play a role in several degenerative diseases.

According to Clarke, understanding such pathways may help spur the future development of interventions to enhance these repair systems in the elderly, helping address declines in muscle strength, lung capacity, mental status, eye-lens clarity, heart output and other losses of function.

Clarke added that we may now be at the tip of the iceberg in our understanding of how many repair activities exist and how these activities may be manipulated for healthy living, particularly with diet and pharmaceuticals.

"I'm excited to accept the appointment to the Plott Chair and to continue our research in this critical field," said Clarke, who also directs UCLA's Cellular and Molecular Biology Training Program.

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UCLA Chemist Steven G. Clarke Named to Endowed Chair in Gerontology