Hypothetical types of biochemistry are forms of biochemistry speculated to be scientifically viable but not proven to exist at this time.[2] The kinds of living beings currently known on Earth all use carbon compounds for basic structural and metabolic functions, water as a solvent and DNA or RNA to define and control their form. If life exists on other planets or moons, it may be chemically similar; it is also possible that there are organisms with quite different chemistriesfor instance involving other classes of carbon compounds, compounds of another element, or another solvent in place of water.

The possibility of life-forms being based on "alternative" biochemistries is the topic of an ongoing scientific discussion, informed by what is known about extraterrestrial environments and about the chemical behaviour of various elements and compounds. It is also a common subject in science fiction.

The element silicon has been much discussed as a hypothetical alternative to carbon. Silicon is in the same group as carbon in the periodic table, and like carbon is tetravalent, although the silicon analogs of organic compounds are generally less stable. Hypothetical alternatives to water include ammonia, which, like water, is a polar molecule, and cosmically abundant; and non-polar hydrocarbon solvents such as methane and ethane, which are known to exist in liquid form on the surface of Titan.

Apart from the prospect of finding different forms of life on other planets or moons, Earth itself has been suggested as a place where a shadow biosphere of biochemically unfamiliar micro-organisms might have lived in the past, or may still exist today.[3][4]

Perhaps the least unusual alternative biochemistry would be one with differing chirality of its biomolecules. In known Earth-based life, amino acids are almost universally of the L form and sugars are of the D form. Molecules of opposite chirality have identical chemical properties to their mirrored forms, so life that used D amino acids or L sugars may be possible; molecules of such a chirality, however, would be incompatible with organisms using the opposing chirality molecules. Amino acids whose chirality is opposite to the norm are found on Earth, and these substances are generally thought to result from decay of organisms of normal chirality. However, physicist Paul Davies speculates that some of them might be products of "anti-chiral" life.[5]

It is questionable, however, whether such a biochemistry would be truly alien. Although it would certainly be an alternative stereochemistry, molecules that are overwhelmingly found in one enantiomer throughout the vast majority of organisms can nonetheless often be found in another enantiomer in different (often basal) organisms such as in comparisons between members of Archea and other domains,[citation needed] making it an open topic whether an alternative stereochemistry is truly novel.

On Earth, all known living things have a carbon-based structure and system. Scientists have speculated about the pros and cons of using atoms other than carbon to form the molecular structures necessary for life, but no one has proposed a theory employing such atoms to form all the necessary structures. However, as Carl Sagan argued, it is very difficult to be certain whether a statement that applies to all life on Earth will turn out to apply to all life throughout the universe.[6] Sagan used the term "carbon chauvinism" for such an assumption.[7] Carl Sagan regarded silicon and germanium as conceivable alternatives to carbon;[7] but, on the other hand, he noted that carbon does seem more chemically versatile and is more abundant in the cosmos.[8]

The silicon atom has been much discussed as the basis for an alternative biochemical system, because silicon has many chemical properties similar to those of carbon and is in the same group of the periodic table, the carbon group. Like carbon, silicon can create molecules that are sufficiently large to carry biological information.[9]

However, silicon has several drawbacks as an alternative to carbon. Silicon, unlike carbon, lacks the ability to form chemical bonds with diverse types of atoms as is necessary for the chemical versatility required for metabolism. Elements creating organic functional groups with carbon include hydrogen, oxygen, nitrogen, phosphorus, sulfur, and metals such as iron, magnesium, and zinc. Silicon, on the other hand, interacts with very few other types of atoms.[9] Moreover, where it does interact with other atoms, silicon creates molecules that have been described as "monotonous compared with the combinatorial universe of organic macromolecules".[9] This is because silicon atoms are much bigger, having a larger mass and atomic radius, and so have difficulty forming double bonds (the double bonded carbon is part of the carbonyl group, a fundamental motif of bio-organic chemistry).

Silanes, which are chemical compounds of hydrogen and silicon that are analogous to the alkane hydrocarbons, are highly reactive with water, and long-chain silanes spontaneously decompose. Molecules incorporating polymers of alternating silicon and oxygen atoms instead of direct bonds between silicon, known collectively as silicones, are much more stable. It has been suggested that silicone-based chemicals would be more stable than equivalent hydrocarbons in a sulfuric-acid-rich environment, as is found in some extraterrestrial locations.[10]

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