Artistic rendering of dengue virus immediately prior to the fusion of the viral lipid membrane (bottom) to the endosomal membrane of the host cell (top). Two dengue virus envelope protein trimers are shown (in surface representation) on either side of a nascent membrane fusion stalk. Completion of membrane fusion requires the alpha-helical stem regions (shown in worm representation) to anneal onto the core of the E trimers. The image is based on crystal structures of dengue virus E protein in the postfusion conformation determined in the Modis Laboratory. Image created by Janet Iwasa and Gal McGill, Digizyme, Inc.

Vinod Nayak, Moshe Dessau, Kaury Kucera, Karen Anthony, Michel Ledizet & Yorgo Modis (2009). Crystal structure of dengue type 1 envelope protein in the postfusion conformation and its implication for receptor binding, membrane fusion and antibody recognition. J. Virol., 83, 4338-44.

Yorgo Modis, Steven Ogata, David Clements & Stephen C. Harrison (2004). Structure of the dengue virus envelope protein after membrane fusion. Nature, 427, 313-319.

Image from the Modis lab.

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