Crystal structure of the piRNA biogenesis factor Zucchini from mouse – Video

Video Link: https://www.youtube.com/watch?v=AYiicgVvbEM

Crystal structure of the piRNA biogenesis factor Zucchini from mouse
Animation of X-ray crystallographic structure determined for the protein mZuc (Zucchini / PLD6 from mouse) which has been implicated as a nuclease in piRNA biogenesis. The protein forms a homodimer which displays a narrow, positively-charged groove running through the active site which is capable of accommodating single-stranded nucleic acids. These data are available on the PDB with accession codes 4GGJ and 4GGK. The full research article is: The structural biochemistry of Zucchini implicates it as a nuclease in piRNA biogenesis. Ipsaro JJ, Haase AD, Knott SR, Joshua-Tor L, Hannon GJ. Nature. 2012 Nov 8;491(7423):279-83. doi: 10.1038/nature11502. Epub 2012 Oct 14.

By: jonipsaro

Original post:
Crystal structure of the piRNA biogenesis factor Zucchini from mouse - Video

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