What’s the News: Researchers at the Scripps Research Institute have now created a vaccine that prevents a heroin high in rats. The vaccine, detailed in a recent study in the Journal of Medicinal Chemistry, stimulates antibodies that can stop not only heroin but also its derivative psychoactive compounds from reaching the brain.

How the Heck:

Developing a vaccine for heroin addiction has been a goal of research for some time, but a major issue has been that the drug quickly metabolizes into 6-acetylmorphine, morphine, and the much less active 3-monoacetylmorphine, so any vaccine must work against all four of the compounds.
This research team solved the problem by creating a drug cocktail that slowly degrades in the body, all the while exposing the immune system to the different psychoactive metabolites of heroin. They also created a control vaccine that only targeted morphine.
When the researchers injected several booster shots of the dynamic vaccine into ...