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Sioux Falls made a cameo appearance Thursday night in the latest episode of the medical drama "Grey's Anatomy."

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GREY'S ANATOMY - "Hope for the Hopeless" - Richard performs his 10,000th surgery on a pair of bickering sisters (Nia Vardalos and Peri Gilpin) who come into the hospital for a liver transplant; Derek and Lexie take on a neuroblastoma case that has been previously deemed inoperable; Teddy and Cristina cross the line when they go against Owen's orders and try to steal a case from Alex and Dr. McQueen; Ellis Grey's shadow looms as Meredith searches for a specialty; meanwhile Adele is brought into the hospital after she is found wandering the streets, on Grey's Anatomy, THURSDAY, JANUARY 19 (9:00-10:02 p.m., ET) on the ABC Television Network. (Photo by Colleen Hayes/ABC via Getty Images) JAMES PICKENS JR., CHANDRA WILSON, ELLEN POMPEO(Photo: Colleen Hayes, ABC via Getty Images)

Sioux Falls made a cameo appearance Thursday night in the latest episode of the medical drama "Grey's Anatomy."

Without going into too much detail so as to not spoil the episode for those who've yet to watch, a pair of characters ends up at Joe Foss Field after a cross-country flight takes an unexpected turn.

"I don't even know what town we're in," one character says, standing on the tarmac with Sioux Falls police and fire vehicles in the background.

"Sioux Falls apparently," another replies.

Actress Ellen Pompeo, who plays Meredith Grey, tipped off fans that the show would feature South Dakota's biggest city in November. She posted an Instagram photo that led some to wonder whether they'd walk into a scene with Pompeo or creatorShonda Rhimes.

Local authorities and hospital spokespeople said the filming was done in Hollywood, not on location at Sioux Falls Regional Airport.

Follow Dana Ferguson on Twitter @bydanaferguson, call (605) 370-2493 or email dferguson@argusleader.com

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Sioux Falls makes cameo on 'Grey's Anatomy' - Sioux Falls Argus Leader