In the 16 years since Grey's Anatomy has been on the air, there has yet to be a group of interns that were as iconic as M.A.G.I.C..Although they were majorly competitive and got into some huge fights, Team M.A.G.I.C. was excessively loyal to one another. No matter what happened, their bond was completely unbreakable.

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However, this didn't mean they were all "friends" especially if fans take a closer look at Cristina and Izzie's relationship. Apart from Cristina saving Izzie's life, the pair had nothing in common. Don't believe it? Keep reading to discover 10 reasons why Cristina and Izzie aren't real friends.

One of the main reasons why Cristina and Izzie aren't real friends is due to their opposing personalities. Where Izzie is optimistic and happy, Cristina is dark and twisty. Izzie got emotionally involved with her patients and Cristina liked to keep an objective view. They were like chalk and cheese.

If fans watch the first five seasons again, they will find that Cristina and Izzie only hung out in group events. Any other time, Cristina was usually seen with Mere, and Izzie with George. Cristina and Izzie just didn't have that personal connection.

Another prime example as to why Izzie and Cristina weren't true friends was when Cristina helped Alex study for his intern exam. In "Grandma Got Run Over By a Reindeer," Cristina and the other internsfound out that Alex had failed his exam and decided to help him study.

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However, this all came about after they also discovered that Alex had cheated on Izzie, meaning they weren't meant to be speaking to him. As a result, Cristina agrees to tutor him in secret. When Izzie did find out, she was livid as it proved Cristina wasn't a friend you could count on. If there was no loyalty between them then they couldn't be very good friends.

In season 5, Cristina and Izzie ended up getting into a mini argument when the oncologistlearned that Cristina stole her apartment. In "Here Comes The Flood," Izzie founds out that she may be homeless after she walked in to see Derek measuring her room. She then began searching for a new apartment and subtly hinted to Cristina about becoming roommates.

However, Cristina didn't seem to pick up on Izzie's hints, and ended up putting an offer down with Callie. What's even worse is that Cristina didn't volunteer to help Izzie find another place. She could have given Izzie Burke's old apartment. Just goes to show Cristina didn't care about Izzie's personal problems.

Cristina and Izzie also proved they were never good friends when the cardiothoracic surgeon made jokes about Izzie's cancer. In "Goodbye," Izzie confided in Meredith and Cristina about the lack of intimacy between her and Alex. Instead of reassuring her, Cristina decided to inappropriately joke about them having cancer sex which upset Izzie greatly.

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Although Cristina's attitude derived from her relationship problems with Owen, this doesn't excuse how insensitive and rude she was being. Especially when she was making cruel jokes about a "friend" who was going through a tough time. If this was the support system Izzie had, she was better off without it. No one deserves to be treated this way.

The beginning of season 3 saw a division between Cristina and the other residents when she decided to help cover up Burke's tremor. However, their secret was soon uncovered when Cristina confessed all to the Chief after Burke allowed his injury to jeopardize one of their patients.

As a result, Cristina is frozen out by all of her colleagues including Izzie, who demanded she be punished. Considering what she did with Denny's LVAD, Izzie wasn't exactly in the position to judge someone. If anything, she should have been the one to stand up for Cristina since she knew how easy it was to make a mistake. The fact that she was baying for her blood proves why they weren't good friends.

Keeping with the previous entry, Izzie proved to be a terrible friend when she jeopardized Cristina's career for her own selfish gain. In "Deterioration of the Fight or Flight Response," Izzie cut Denny's LVAD wire and dragged the rest of the residents into her plan.

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For one, friends would never put each other in such a position where they feel like they have to compromise their morals and integrity. They also wouldn't make you jeopardize your career because they did something wrong. Izzie knew how much Cristina valued her career and yet she did all this anyway.

After Izzie cut Denny's LVAD, team M.A.G.I.C. banded together and refused to reveal what went down in Denny's room. However, Cristina seemed to have a change of heart when it came to her interrogation with the Chief.

As Webber tried to get to the bottom of the Duquette situation, he forbade any of the residents from entering the O.R., and questioned them one-on-one. What he didn't expect was for Cristina to say she would tell him what happened if he would tell her how she could get her edge. Nice to see how much Izzie's friendship was worth to her.

One of the more obvious entries on the list that proves why Cristina and Izzie aren't real friends is the fact that the oncologist left without saying goodbye. In "Invasion," Izzie was fired after she makes an error that compromised a patient's health. However, what no one expected was for her to skipped town and leave Alex a "Dear John" letter.

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For months, Izzie then proceeded to ghost everyone, including Cristina, who was worried about her not turning up for her treatment. While everyone understood that Izzie wasn't in the best place, she was wrong for not saying goodbye and for making her friends worry. If they were true friends, Izzie would have respected Cristina enough to say she was leaving.

Season 4 also saw Cristina and Izzie have a brief falling out when the cardiothoracic resident discovered Izzie had slept with George. As fans know, Izzie broke up George and Callie's marriage when they had a one-night stand. When this secret was discovered, Cristina was disgusted by Izzie's actions and berated her for sleeping with a married man.

However, Izzie retaliated by mentioning that Cristina's okay with Meredith doing it. Their relationship becomes further strained when Cristina becomes closer to Callie, and asks the orthopedic surgeon to move in with her. At this point, it's clear that Cristina wasn't very attached to the idea of becoming best friends with Izzie.

Ironically, Izzie made it clear that she and Cristina weren't friends when she chose to confide in her about her cancer diagnosis. After spending weeks deliberating what to do, Izzie decides to tell Cristina because she knew she would be objective and stoic ("I Will Follow You into the Dark").

When she first approached Cristina, Izzie told the cardiothoracic surgeon that she knows "she doesn't like her" but it was okay. The fact that she feels this is okay and Cristina doesn't deny it proves they are not friends. There is no emotional connection between them. Izzie basically confided in Cristina because she wanted "Dr. Yang's" professional opinion.

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A writer, reader and tv fanatic, Kayleigh enjoys reading movie news and your film reviews. She has attained an Undergraduate degree in Creative Writing and is also the creator of the film and television blog 'The Critics' Corner'.

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