Lynda Chin is used to getting what she wants.

Chin, a physician who is the wife of Dr. Ronald DePinho, the president of the University of Texas M.D. Anderson Cancer Center, submitted a plan on March 12 seeking what would be the largest grant yet awarded by the Cancer Prevention and Research Institute of Texas, or CPRIT.

Chin had every reason to believe her seven-page application would win funding. She had received an $8 million enticement to move her cancer research lab from Boston to Houston last year after her husband accepted the M.D. Anderson position, and prospects for the success of her grant application seemed encouraging.

"We'll make it work," the cancer center's lead commercial grant officer had told her six days earlier.

But the same day it was submitted, Chin's application hit a snag.

"I don't think they are ready," Jerry Cobbs, the senior staff member who oversees commercialization grants for CPRIT, wrote his boss in an email after reviewing the application. He suggested consideration of the application be delayed.

Nevertheless, by the end of March, Chin had landed her grant - approximately $18 million for a single year.

A monthlong Houston Chronicle investigation suggests that CPRIT, a 3-year-old initiative backed by $3 billion in taxpayer funds, handled the grant application in a hasty manner designed to circumvent its own scientific reviewers.

Hundreds of internal emails obtained through a public records request shed new light on the forces at work in the application process - particularly the role of a Houston venture capitalist, Charles Tate, who invests in companies that commercialize drugs and who has ties to M.D. Anderson and to CPRIT.

The emails indicate that Tate, one of 11 members of CPRIT's oversight committee, was instrumental in shepherding Chin's proposal through the review process. He denied doing so.

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Anatomy of a grant: Emails indicate cancer agency sought to bypass scientific review