Difference between an ASTM and an ISO standard screws

Hi,

I am a Mechanical Engineering student in Singapore and would like to know what's the difference(s) between an ASTM bolt/screw and its' ISO counterpart?

For example, as a nearest comparison, the M50 (mm) x 60(mm) VS 2" x 60(mm) stainless steel bolt.

In ISO, the standard is A4-80 an

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