PHILADELPHIA Rahul M. Kohli, MD, PhD, an assistant professor of Medicine and Biochemistry & Biophysics, is one of the recipients of a New Innovator Award from National Institutes of Health (NIH).

The NIH Directors New Innovator Award, totaling $1.5 million over five years, supports highly innovative research and creative, new investigators who exhibit strong potential to make great advances on a critical biomedical or behavioral research problem.

Kohlis lab will use the grant to study the enzymes that drive bacterial evolution, aiming to devise new methods to combat the emergence of drug-resistant bacteria.

The ability of pathogens to quickly build up resistance to the best available antibiotics leads to potentially devastating consequences to human health. Past responses to this concern have largely focused on modifying existing drugs, which can offer a brief reprieve, but eventually fosters more drug resistance. Kohlis research seeks to change the paradigm of attacking drug resistance, by targeting the very pathways that allow the pathogen to mutate.

Rather than focusing on drugs that kill bacteria, understanding and targeting bacterias ability to adapt could be an effective new approach to drug resistance, said Kohli. Given the clinical importance of the problem, Im excited about the opportunities we can pursue with this award.

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Penn Medicine Researcher Receives New Innovator Award from National Institutes of Health