Neuralinks wildly anticipated demo last Friday left me with more questions than answers. With a presentation teeming with promises and vision but scant on data, the event nevertheless lived up to its main goal as a memorable recruitment session to further the growth of the mysterious brain implant company.

Launched four years ago with the backing of Elon Musk, Neuralink has been working on futuristic neural interfaces that seamlessly listen in on the brains electrical signals, and at the same time, write into the brain with electrical pulses. Yet even by Silicon Valley standards, the company has kept a tight seal on its progress, conducting all manufacturing, research, and animal trials in-house.

A vision of marrying biological brains to artificial ones is hardly unique to Neuralink. The past decade has seen an explosion in brain-machine interfacessome implanted into the brain, some into peripheral nerves, or some that sit outside the skull like a helmet. The main idea behind all these contraptions is simple: the brain mostly operates on electrical signals. If we can tap into these enigmatic neural codesthe brains internal languagewe could potentially become the architects of our own minds.

Let people with paralysis walk again? Check and done. Control robotic limbs with their minds? Yup. Rewriting neural signals to battle depression? In humans right now. Recording the electrical activity behind simple memories and playing it back? Human trials ongoing. Linking up human minds into a BrainNet to collaborate on a Tetris-like game through the internet? Possible.

Given this backdrop, perhaps the most impressive part of the demonstration isnt lofty predictions of what brain-machine interfaces could potentially do one day. In some sense, were already there. Rather, what stood out was the redesigned Link device itself.

In Neuralinks coming out party last year, the company envisioned a wireless neural implant with a sleek ivory processing unit worn at the back of the ear. The electrodes of the implant itself are sewn into the brain with automated robotic surgery, relying on brain imaging techniques to avoid blood vessels and reduce brain bleeding.

The problem with that design, Musk said, is that it had multiple pieces and was complex. You still wouldnt look totally normal because theres a thing coming out of your ear.

The prototype at last weeks event came in a vastly different physical shell. About the size of a large coin, the device replaces a small chunk of your skull and sits flush with the surrounding skull matter. The electrodes, implanted inside the brain, connect with this topical device. When covered by hair, the implant is invisible.

Musk envisions an outpatient therapy where a robot can simultaneously remove a piece of the skull, sew the electrodes in, and replace the missing skull piece with the device. According to the team, the Link has similar physical properties and thickness as the skull, making the replacement a sort of copy-and-paste. Once inserted, the Link is then sealed to the skull with superglue.

I could have a Neuralink right now and you wouldnt know it, quipped Musk.

For a device that small, the team packed an admirable array of features into it. The Link device has over 1,000 channels, which can be individually activated. This is on par with Neuropixel, the crme de la crme of neural probes with 960 recording channels thats currently used widely in research, including by the Allen Institute for Brain Science.

Compared to the Utah Array, a legendary implant system used for brain stimulation in humans with only 256 electrodes, the Link has an obvious edge up in terms of pure electrode density.

Whats perhaps most impressive, however, is its onboard processing for neural spikesthe electrical pattern generated by neurons when they fire. Electrical signals are fairly chaotic in the brain, and filtering spikes from noise, as well as separating trains of electrical activity into spikes, normally requires quite a bit of processing power. This is why in the lab, neural spikes are usually recorded offline and processed using computers, rather than with on-board electronics.

The problem gets even more complicated when considering wireless data transfer from the implanted device to an external smartphone. Without accurate and efficient compression of those neural data, the transfer could tremendously lag, drain battery life, or heat up the device itselfsomething you dont want happening to a device stuck inside your skull.

To get around these problems, the team has been working on algorithms that use characteristic shapes of electrical patterns that look like spikes to efficiently identify individual neural firings. The data is processed on the chip inside the skull device. Recordings from each channel are filtered to root out obvious noise, and the spikes are then detected in real time. Because different types of neurons have their characteristic ways of spikingthat is, the shape of their spikes are diversethe chip can also be configured to detect the particular spikes youre looking for. This means that in theory the chip could be programmed to only capture the type of neuron activity youre interested infor example, to look at inhibitory neurons in the cortex and how they control neural information processing.

These processed spike data are then sent out to smartphones or other external devices through Bluetooth to enable wireless monitoring. Being able to do this efficiently has been a stumbling block in wireless brain implantsraw neural recordings are too massive for efficient transfer, and automated spike detection and compression of that data is difficult, but a necessary step to allow neural interfaces to finally cut the wire.

Link has other impressive features. For one, the battery life lasts all day, and the device can be charged at night using inductive charging. From my subsequent conversations with the team, it seems like there will be alignment lights to help track when the charger is aligned with the device. Whats more, the Link itself also has an internal temperature sensor to monitor for over-heating, and will automatically disconnect if the temperature rises above a certain thresholda very necessary safety measure so it doesnt overheat the surrounding skull tissue.

From the get-go of the demonstration, there was an undercurrent of tension between whats possible in neuroengineering versus whats needed to understand the brain.

Since its founding, Neuralink has always been fascinated with electrode numbers: boosting channel numbers on its devices and increasing the number of neurons that can be recorded at the same time.

At the event, Musk said that his goal is to increase the number of recorded neurons by a factor of 100, then 1,000, then 10,000.

But heres the thing: as neuroscience is increasingly understanding the neural code behind our thought processes, its clear that more electrodes or more stimulated neurons isnt always better. Most neural circuits employ whats called sparse coding, in that only a handful of neurons, when stimulated in a way that mimics natural firing, can artificially trigger visual or olfactory sensations. With optogeneticsthe technique of stimulating neurons with lightscientists now know that its possible to incept memories by targeting just a few key neurons in a circuit. Sticking a ton of wires into the brain, which inevitably causes scarring, and zapping hundreds of thousands of neurons isnt necessarily going to help.

Unlike engineering, the solution to the brain isnt more channels or more implants. Rather, its deciphering the neural codeknowing what to stimulate, in what order, to produce what behavior. Its perhaps telling that despite claims of neural stimulation, the only data shown at the event were neurons firing from a section of a mouse brainusing two-photon microscopy to image neural activationafter zapping brain tissue with an electrode. What information, if any, is really being written into the brain? Without an idea of how neural circuits work and in what sequences, zapping the brain with electricityno matter how cool the device itself isis akin to banging on all the keys of a piano at once, rather than composing a beautiful melody.

Of course, the problem is far larger than Neuralink itself. Its perhaps the next frontier in solving the brains mysteries. To their credit, the Neuralink team has looked at potential damage to the brain from electrode insertion. A main problem with current electrodes is that the brain will eventually activate non-neuronal cells to form an insulating sheath around the electrode, sealing it off from the neurons it needs to record from. According to some employees I talked to, so far, for at least two months, the scarring around electrodes is minimal, although in the long run there may be scar tissue buildup at the scalp. This may make electrode threads difficult to removesomething that still needs to be optimized.

However, two months is only a fraction of what Musk is proposing: a decade-long implant, with hardware that can be updated.

The team may also have an answer there. Rather than removing the entire implant, it could potentially be useful to leave the threads inside the brain and only remove the top capthe Link device that contains the processing chip. The team is now trying the idea out, while exploring the possibility of a full-on removal and re-implant.

As a demonstration of feasibility, the team trotted out three adorable pigs: one without an implant, one with a Link, and one with the Link implanted and then removed. Gertrude, the pig currently with an implant in areas related to her snout, had her inner neural firings broadcasted as a series of electrical crackles as she roamed around her pen, sticking her snout into a variety of food and hay and bumping at her handler.

Pigs came as a surprise. Most reporters, myself included, were expecting non-human primates. However, pigs seem like a good choice. For one, their skulls have a similar density and thickness to human ones. For another, theyre smart cookies, meaning they can be trained to walk on a treadmill while the implant records from their motor cortex to predict the movement of each joint. Its feasible that the pigs could be trained on more complicated tests and behaviors to show that the implant is affecting their movements, preferences, or judgment.

For now, the team doesnt yet have publicly available data showing that targeted stimulation of the pigs cortexsay, motor cortexcan drive their muscles into action. (Part of this, I heard, is because of the higher stimulation intensity required, which is still being fine-tuned.)

Although pitched as a prototype, its clear that the Link remains experimental. The team is working closely with the FDA and was granted a breakthrough device designation in July, which could pave the way for a human trial for treating people with paraplegia and tetraplegia. Whether the trials will come by end of 2020, as Musk promised last year, however, remains to be seen.

Rather than other brain-machine interface companies, which generally focus on brain disorders, its clear that Musk envisions Link as something that can augment perfectly healthy humans. Given the need for surgical removal of part of your skull, its hard to say if its a convincing sell for the average person, even with Musks star power and his vision of augmenting natural sight, memory playback, or a third artificial layer of the brain that joins us with AI. And because the team only showed a highly condensed view of the pigs neural firingsrather than actual spike tracesits difficult to accurately gauge how sensitive the electrodes actually are.

Finally, for now the electrodes can only record from the cortexthe outermost layer of the brain. This leaves deeper brain circuits and their functions, including memory, addiction, emotion, and many types of mental illnesses off the table. While the team is confident that the electrodes can be extended in length to reach those deeper brain regions, its work for the future.

Neuralink has a long way to go. All that said, having someone with Musks impact championing a rapidly-evolving neurotechnology that could help people is priceless. One of the lasting conversations I had after the broadcast was someone asking me what its like to drill through skulls and see a living brain during surgery. I shrugged and said its just bone and tissue. He replied wistfully it would still be so cool to be able to see it though.

Its easy to forget the wonder that neuroscience brings to people when youve been in it for years or decades. Its easy to roll my eyes at Neuralinks data and think well neuroscientists have been listening in on live neurons firing inside animals and even humans for over a decade. As much as Im still skeptical about how Link compares to state-of-the-art neural probes developed in academia, Im impressed by how much a relatively small leadership team has accomplished in just the past year. Neuralink is only getting started, and aiming high. To quote Musk: Theres a tremendous amount of work to be done to go from here to a device that is widely available and affordable and reliable.

Image Credit: Neuralink

View original post here:

Neuralink's Wildly Anticipated New Brain Implant: the Hype vs. the Science - Singularity Hub