The University of Helsinki as research-oriented university offers a stimulating and international environment. The Faculty of Medicine of the University of Helsinki, together with Helsinki University Central Hospital, The Helsinki Institute of Life Science, and the Institute for Molecular Medicine Finland forms the Academic Medical Center Helsinki. This medical campus ranks among the 10 best medical centers at European level and the 50 best centers in the world. More info on the Faculty or Medicine and AMCH can be found here:

https://www.helsinki.fi/en/faculty-of-medicinehttps://www.helsinki.fi/en/meilahti-campus

Faculty of Medicine, Jackson laboratory, invites applications for a position of Doctoral Student / Research Assistant in mitochondrial biology and signalling for a fixed-term

The focus of the lab is to unravel fundamental signalling pathways and mechanisms controlling mitochondrial function. We are particularly interested in how mitochondria adapt signalling to metabolic cues in models of dysfunction including primary mitochondrial patient cell lines, cancer and associated disorders. We aim to exploit this knowledge on basic principles of mitochondrial signalling and subsequent metabolic susceptibilities in cellular models to help devise novel treatments of diseases that stem from misregulated mitochondrial function.

In this role the candidate will have the unique opportunity to drive an exciting project addressing limiting metabolic pathways in models of mitochondrial dysfunction by genome-wide CRISPR screening and mitochondrial structural analysis. The successful candidate will have access to a wide range of methodologies with work consisting in preparation of cell models, construction of libraries, and analysis of metabolic, proteomic and microscopic data at the cellular level.

We are looking for a highly motivated independent researcher with prime analytical skills driven by a passion for science. We expect you to formulate your own hypotheses, propose experimental design to address them, and take advantage of the laboratory and research communitys intellectual and skill resources to advance the knowledge of the field. The appointee is expected to publish in top-level international peer reviewed scientific journals. In addition, she/he is also expected to potentially take part on the other research tasks such as ones related to ongoing studies and preparation of grant applications. The specific responsibilities will vary according to the level of expertise of the candidate.

The ideal candidate has an extensive background in standard molecular cell biological methods, ideally encompassing genetic and microscopic techniques and/or bioinformatics (NGS data). Expertise in biochemistry and molecular biology is a pre-requisite for this position. Additional expertise for research projects involving human subjects, primary cell culture would be highly desirable. The ideal candidate is an adaptable team-player and has excellent communication and organizational skills and a strong command in written and spoken English and should be familiar with the constraints related to translational research.

This position will provide multiple opportunities for collaborations with potential lab visits abroad and cross-disciplinary scientific exchange, where the candidate will receive extensive training in cutting-edge technology. An aptitude to drive and maintain intra and inter team collaborations will be highly appreciated. In return, the candidate is offered access to an extensive variety of methodology and advanced techniques, appropriate supervision and help in career development.

More information about the lab, including the latest research and news, can be found here:http://www.jacksonlab.org

The position is initially limited to 2 years with a possibility of extension starting from September 2020. The contract of employment includes a probationary period of 6 months. Salary will be based on the Universities salary scheme for teaching and research personnel composed of both task specific and personal performance components.

The position will remain open until a suitable candidate will be recruited.

Please submit: CV, list of publications, motivation letter including a description of your research interests, and the names and telephone numbers of at least two referees.

Please submit your application, together with the required attachments, through the University of Helsinki electronic recruitment system by clicking on the Apply for job button. Internal applicants (i.e., current employees of the University of Helsinki) submit their applications through the SAP HR portal.

For further information, please contact Christopher B. Jackson, Ph.D., docent:christopher.jackson@helsinki.fi

Due date

31.08.2020 23:59 EEST

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Doctoral Student/Research Assistant in Mitochondrial Biology and Signalling job with UNIVERSITY OF HELSINKI | 218596 - Times Higher Education (THE)