GIGLIO ISLAND, Italy (AP) Stranded on a tiny Italian island, a cancer researcher grew increasingly alarmed to hear that one, and then three more visitors had fallen ill with COVID-19.

Paola Muti braced for a rapid spread of the coronavirus to the 800 closely-knit islanders, many of whom she knows well. Her mother was born on Giglio Island and she often stays at the family home with its charming view of the sea through the parlors windows.

But days passed and none of Giglios islanders developed any COVID-19 symptoms even though the conditions seemed favorable for the disease to spread like wildfire.

The Gigliesi, as the residents are known, socialize in the steep alleys near the port or on the granite steps that serve as narrow streets in the hilltop Castle neighborhood, with densely packed homes built against the remnants of a fortress erected centuries ago to protect against pirates.

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Dr. Armando Schiaffino, the islands sole physician for around 40 years, shared Mutis worry that there would be a local outbreak.

Every time an ordinary childhood illness, like scarlet fever, measles or chicken pox strikes, within a very few days practically all get infected on Giglio, he said in an interview in his office near the port.

Muti, a breast cancer researcher at the University of Milan where she is an epidemiology professor, decided to try to find out why it wasnt happening this time.

Were residents perhaps infected but didnt show symptoms? Was it something genetic? Something else? Or just plain luck?

Dr. Schiaffino came to me and told me, Hey, look, Paola, this is incredible. In this full pandemic, with all the cases that came to the island, nobody is sick. So I said to myself: Right, here we can do a study, no? I am here, Muti said.

By then, Muti was trapped on the island by Italys strict lockdown rules. What was especially puzzling to her was that many of the islanders had had close contact with the visitors.

Giglios first known COVID-19 case was a man in his 60s who arrived on Feb. 18 a couple of days before Italys first native case would be diagnosed in the north. The man came to Giglio for a relatives funeral, and had been coughing all the way though the service, Muti said.

The virus is mainly spread through droplets when someone coughs, sneezes or talks. The man headed back on the ferry the same day to the mainland and died three weeks later in a hospital.

On March 5, four days before the national lockdown was declared, three more visitors came from the mainland and would test positive on the island. One of them was a German man from northern Italy, the initial epicenter of Europes outbreak. He socialized for several days with longtime friends in Giglio, including in public eateries. After a week, due to a bad cough, he was tested on the island and the result was positive. He self-isolated in a house on Giglio.

There were other known cases, including an islander who had lived in Australia for two years before slipping back onto Giglio in mid-March during lockdown to see his parents. Three days after arriving on Giglio, he developed a mild fever and tested positive, Muti said. He self-isolated at his parents home.

No other case has surfaced on Giglio, including since lockdown was lifted in early June, and tourists from throughout Italy have been arriving.

Giglio is part of Tuscany, and its health office quickly sent over kits to test for antibodies to see if others may have had COVID-19. In late April, just before the first lockdown travel restrictions would be eased, the islanders had their blood tested, lining up outside the islands school and doctors office.

Of the 800 or so year-round residents, 723 volunteered to be tested.

We all wanted to do it, to be tranquil about any possible infection, but also to help science, said Simone Madaro, who had been working at the cemetery while the infected man had gathered with fellow mourners.

The Rev. Lorenzo Pasquotti, the priest who conducted the service for around 50 mourners, and who himself was tested recalled: After the funeral, there were greetings, hugging and kissing, as is the custom. Then came the procession to the cemetery, where there were more hugs and kisses.

Of the islanders tested, only one was found to have antibodies, an elderly Gigliese man who had sailed on the same ferry to the island with the German visitor, Muti said.

Intrigued about why the virus didnt seem to interact with the islands native population, Muti hadnt reached any conclusions by the time she was preparing to leave the island this month. She plans to write up up her study for eventual publication.

Its possible, Muti guessed, that islanders werent exposed to enough COVID-19 to get infected.

That possibility was also voiced by Massimo Andreoni, head of infectious diseases at Romes Tor Vergata hospital. He noted some patients are simply less capable of spreading the disease for reasons that are still unclear.

Chance might have played a role, said Daniel Altmann, a professor of immunology at Imperial College London. It could be something more or less trivial nobody got infected because through good luck there was little contact, he said in an email exchange.

Or, Altmann also noted that it could be something important and exotic, such as a genetic variant common among the islands population.

With many of the Gigliesi intermarrying through generations, Muti would like to do a genetic study someday if she could obtain funding.

Giglio lies in pristine waters in a protected regional marine sanctuary, and the islanders voice relief that they live in a natural environment they like to think is good for health, whatever Mutis study might determine.

As an island, as the environment goes, were OK, no? said Domenico Pignatelli, as the elderly man kept company with friends in chairs placed on a stony street atop Giglio.

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Luck? Genetics? Italian island spared from COVID outbreak - The Associated Press