Rivaroxaban in Antiphospholipid Syndrome – Annals of Internal Medicine

Vall d'Hebrn Research Institute, Barcelona, Spain (J.O., X.V., C.S., J.C.)

Miguel Servet Hospital, Zaragoza, Spain (L.S., M.P.)

Bellvitge University Hospital-IDIBELL, Barcelona, Spain (A.R.)

Sant Joan de Reus University Hospital, Reus, Spain (A.C.)

Granollers University Hospital, Granollers, Spain (J.C., V.O.)

Matar Hospital, Matar, Spain (M.M.)

Note: The corresponding author had full access to all data and final responsibility for the decision to submit the manuscript for publication.

Acknowledgment: The authors thank the Catalan Lupus Foundation and all the patients who participated in the trial; the investigators who recruited patients to the study; and the research staff who assisted with patient recruitment, data collection, biomarker measurements, and data management.

Financial Support: From Bayer Hispania.

Disclosures: Drs. Ordi-Ros and Corts-Hernndez report institutional support from Bayer Hispania to conduct the study. Dr. Ortiz-Santamaria reports personal fees and nonfinancial support from Pfizer, Janssen, Lilly, GSK, Novartis, Roche, and Abbott outside the submitted work. Authors not named here have disclosed no conflicts of interest. Disclosures can also be viewed at http://www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M19-0291.

Editors' Disclosures: Christine Laine, MD, MPH, Editor in Chief, reports that her spouse has stock options/holdings with Targeted Diagnostics and Therapeutics. Darren B. Taichman, MD, PhD, Executive Editor, reports that he has no financial relationships or interests to disclose. Cynthia D. Mulrow, MD, MSc, Senior Deputy Editor, reports that she has no relationships or interests to disclose. Jaya K. Rao, MD, MHS, Deputy Editor, reports that she has stock holdings/options in Eli Lilly and Pfizer. Catharine B. Stack, PhD, MS, Deputy Editor, Statistics, reports that she has stock holdings in Pfizer, Johnson & Johnson, and Colgate-Palmolive. Christina C. Wee, MD, MPH, Deputy Editor, reports employment with Beth Israel Deaconess Medical Center. Sankey V. Williams, MD, Deputy Editor, reports that he has no financial relationships or interests to disclose. Yu-Xiao Yang, MD, MSCE, Deputy Editor, reports that he has no financial relationships or interest to disclose.

Data Sharing Statement: The following data will be made available with publication: deidentified participant data (available from Dr. Josefina Corts-Hernndez; e-mail, fina.cortes@vhir.org). The following supporting documents will be made available with publication: informed consent form (available from Dr. Josefina Corts-Hernndez; e-mail, fina.cortes@vhir.org). These data will be made available to researchers whose proposed use of the data has been approved for a specified purpose, with investigator support, and with a signed data access agreement (no restrictions).

Corresponding Author: Josefina Corts-Hernndez, MD, PhD, Department of Internal Medicine, Rheumatology Research Group, Vall d'Hebrn University Hospital Research Institute, Passeig Vall d'Hebrn 119-129, 08035, Barcelona, Spain; e-mail, fina.cortes@vhir.org.

Current Author Addresses: Drs. Ordi-Ros, Vidal, and Sol: Vall d'Hebrn University Hospital Research Institute, Passeig Vall d'Hebrn 119-129, 08035, Barcelona, Spain.

Drs. Sez-Comet and Prez-Conesa: Servicio de Medicina Interna, Hospital Universitario Miguel Servet, Paseo Isabel La Catlica 9, 50009, Zaragoza, Spain.

Dr. Riera-Mestre: Internal Medicine Department, L'Hospitalet de Llobrega, Feixa llarga s/n, 08907, Barcelona, Spain.

Dr. Castro-Salom: Internal Medicine Department, Sant Joan de Reus University Hospital, Sant Joaquim 42 1-3, 43204, Reus, Spain.

Drs. Cuquet-Pedragosa and Ortiz-Sanatmaria: Granollers University Hospital, Avinguda Francesc Ribas s/n, 08402, Granollers, Spain.

Dr. Mauri-Plana: Department of Internal Medicine, Mataro Hospital, Carrer de Cirera, 230, 08304, Matar, Spain.

Dr. Corts-Hernndez: Department of Internal Medicine, Rheumatology Research Group, Vall d'Hebrn University Hospital Research Institute, Passeig Vall d'Hebrn 119-129, 08035, Barcelona, Spain.

Author Contributions: Conception and design: J. Ordi-Ros, M. Prez-Conesa, X. Vidal, J. Corts-Hernndez.

Analysis and interpretation of the data: J. Ordi-Ros, X. Vidal, A. Castro-Salom, C. Sol, J. Corts-Hernndez.

Drafting of the article: J. Ordi-Ros, L. Sez-Comet, X. Vidal, A. Riera-Mestre, C. Sol, J. Corts-Hernndez.

Critical revision for important intellectual content: J. Ordi-Ros, L. Sez-Comet, X. Vidal, A. Castro-Salom, J. Cuquet-Pedragosa, C. Sol, J. Corts-Hernndez.

Final approval of the article: J. Ordi-Ros, L. Sez-Comet, M. Prez-Conesa, X. Vidal, A. Riera-Mestre, A. Castro-Salom, J. Cuquet-Pedragosa, V. Ortiz-Santamaria, M. Mauri-Plana, C. Sol, J. Corts-Hernndez.

Provision of study materials or patients: J. Ordi-Ros, L. Sez-Comet, M. Prez-Conesa, A. Castro-Salom, V. Ortiz-Santamaria, J. Corts-Hernndez.

Statistical expertise: X. Vidal.

Obtaining of funding: J. Ordi-Ros, J. Corts-Hernndez.

Administrative, technical, or logistic support: J. Ordi-Ros, L. Sez-Comet, J. Corts-Hernndez.

Collection and assembly of data: J. Ordi-Ros, L. Sez-Comet, M. Prez-Conesa, X. Vidal, A. Riera-Mestre, A. Castro-Salom, J. Cuquet-Pedragosa, M. Mauri-Plana, J. Corts-Hernndez.