Fighting the pandemic will remain a top priority in 2021, not least for the biopharma companies working on the next generation of therapeutics and vaccines against COVID-19. But just because were in a pandemic doesnt mean all other diseases have stopped plaguing humanity. We asked executives which areas might see a resurgence this year, and neurology emerged as a popular horse to bet on.
Part of that interest could be down to Biogens once-failed Alzheimers disease candidate, aducanumab, which is slated for an FDA decision by March 7.
I think neurology will continue to be a big focus, at least in the first half of the year, while aducanumab is out there and all eyes are on the PDUFA, said Shehnaaz Suliman, M.D., president and chief operating officer of Alector, which is working on immuno-neurology approaches to neurodegenerative disease. There was a recent spate of high-priority deals done in the neuro spaceit signals appetite in Big Pharma and Big Biotech to do big value-creating deals.
RELATED: JPM: Alector, Annexon, Athira on what an aducanumab approval could mean for Alzheimer's R&D
Multiple executives agreed that aducanumab would not be a best-in-class drug but that its approval would give the whole field a boost, encouraging interest and investment in neurodegenerative disease R&D. Recent data for a similar drug, Eli Lillys donanemab, also offered hope.
I think its important to continue to go after neurology," said Doug Love, president and CEO of Annexon Biosciences. We are an aging population, and, of course, patients are going to have neurodegenerative disorders We need to think smart and branch out beyond Alzheimers. There are lots of neurodegenerative diseases. There are lots of kinds of dementia we can target.
Its a good time to pursue these indications, Love said, adding, As the field advances with various biomarkers, we will understand earlier in the disease process if drugs are working.
Another reason traditionally big indications like neurology and cardiology are getting more interest is the availability of genetic sequencing and the ability to slice those disease areas up into more manageable segments. It provides a regulatory path for companies working in those areas that previously did not exist, said Rahul Ballal, Ph.D., CEO of Imara, a company working on treatments for sickle cell disease and other blood disorders.
RELATED: JPM: Biogen bullish on Alzheimer's drug approval, sees Lilly data as positive despite AdComm rejection
For a long time, people have run away from those spaces for all the reasons you know: low probability of technical success, large, heterogeneous patient populations, Ballal said. And I think what biotech is doing thats really exciting within the neurodegenerative space and within cardiovascular disease is they are applying a rare disease approach to those diseases by finding patients within the very large swaths.
Whichever areas receive the most interest in 2021, the entire industry should make sure that treatments reach every patient who needs them, said Nessan Bermingham, CEO of Triplet Therapeutics.
We look at whats happening with the (COVID-19) vaccine and whats happening with the rollout of care for individuals who have gotten COVID-19, and the disparities are very clear, Bermingham said. In the U.S. and from a global standpoint, were only going to see those be further emphasized. This is something, as a biotech industry, we need to be very conscious of.
Biopharma companies should think about pricing, distribution and access not just of cutting-edge immuno-oncology meds and gene therapies but also of things like basic care, real-time feedback from doctors, diagnostics and imaging.
As we think about the disparities we face, weve not changed that, and arguably with new therapies coming out, weve actually made those disparities worse, Bermingham added. I think as an industry, we need to go back to the concept of healthcare democracy: that everyone has the right to healthcare.
Go here to see the original:
Beyond COVID-19, where will biopharma focus in 2021? - FierceBiotech
- Serotonin Blocker May Build New Bone in Osteoporotic Mice by Decreasing GI Serotonin Levels [Last Updated On: August 17th, 2024] [Originally Added On: April 5th, 2010]
- The two current heavyweight world boxing champions both have PhDs, believe or not [Last Updated On: August 17th, 2024] [Originally Added On: April 6th, 2010]
- Video: Why submit your research to the BMJ? [Last Updated On: August 17th, 2024] [Originally Added On: April 6th, 2010]
- How does clinical evidence work? [Last Updated On: August 17th, 2024] [Originally Added On: April 7th, 2010]
- How To: Getting Smart During Your Daily Commute [Last Updated On: August 17th, 2024] [Originally Added On: April 7th, 2010]
- Scaring physicians aways from using social media [Last Updated On: August 17th, 2024] [Originally Added On: April 12th, 2010]
- Eradication of nasal colonization with S. aureus associated with a decrease in postoperative surgical-site infections [Last Updated On: August 17th, 2024] [Originally Added On: April 12th, 2010]
- Martina Navratilova Fighting Breast Cancer - ABC Video [Last Updated On: August 17th, 2024] [Originally Added On: April 12th, 2010]
- Are doctors ready for virtual visits? Telemedicine may not be accurate enough. [Last Updated On: August 17th, 2024] [Originally Added On: April 12th, 2010]
- Jamie Oliver at TED: Teach every child about food [Last Updated On: August 17th, 2024] [Originally Added On: April 12th, 2010]
- "Europeans Work to Live and Americans Live to Work" But Who is Happier? [Last Updated On: August 17th, 2024] [Originally Added On: April 12th, 2010]
- 29 Debates About the "Right Way" to Blog [Last Updated On: August 17th, 2024] [Originally Added On: April 12th, 2010]
- Johns Hopkins Medicine podcast now has a blog [Last Updated On: August 17th, 2024] [Originally Added On: April 13th, 2010]
- Health experts' tips for safe international travel [Last Updated On: August 17th, 2024] [Originally Added On: April 13th, 2010]
- How to use Google Docs Drawings for medical mind maps [Last Updated On: August 17th, 2024] [Originally Added On: April 14th, 2010]
- Australian grandmother beats off attacking shark - BBC [Last Updated On: August 17th, 2024] [Originally Added On: April 14th, 2010]
- Nonsurgical Weight Loss with a Liquid Meal Program - Mayo Clinic Video [Last Updated On: August 17th, 2024] [Originally Added On: April 15th, 2010]
- Vitamin D deficiency occurs frequently in COPD and correlates with severity [Last Updated On: August 17th, 2024] [Originally Added On: April 16th, 2010]
- Taking charge of your toddler's vaccination record is the best way to ensure they don't miss any shots [Last Updated On: August 17th, 2024] [Originally Added On: April 16th, 2010]
- The College of American Pathologists unveils a new patient website MyBiopsy.org [Last Updated On: August 17th, 2024] [Originally Added On: April 17th, 2010]
- Better Sleep, Better Learning? Obstructive sleep apnea can reduce a child’s IQ by 10 points [Last Updated On: August 17th, 2024] [Originally Added On: April 18th, 2010]
- Mobile Medicine via iPod/iPhone/iPad Apps [Last Updated On: August 17th, 2024] [Originally Added On: April 19th, 2010]
- AskaPatient.com - Medication Ratings and Health Care Opinions [Last Updated On: August 17th, 2024] [Originally Added On: April 21st, 2010]
- Standardized patient: Over the course of three days, I had 23 head-to-toe physicals from 23 medical students [Last Updated On: August 17th, 2024] [Originally Added On: April 22nd, 2010]
- 500 repetitions of 4 cardiac murmurs improved auscultatory proficiency of medical students [Last Updated On: August 17th, 2024] [Originally Added On: April 23rd, 2010]
- Rock legend Ronnie James Dio is fighting stomach cancer [Last Updated On: August 17th, 2024] [Originally Added On: April 23rd, 2010]
- Hockey-puck-on-a-rod test checks for concussion after head trauma [Last Updated On: August 17th, 2024] [Originally Added On: April 24th, 2010]
- Occupation may be a key factor in lung cancer [Last Updated On: August 17th, 2024] [Originally Added On: April 25th, 2010]
- FDA: High-dose simvastatin increases risk of muscle injury - caution with lower doses plus Amiodarone, Verapamil, Diltiazem [Last Updated On: August 17th, 2024] [Originally Added On: April 26th, 2010]
- Fish out of pills - Pharmaceuticals in drinking water [Last Updated On: August 17th, 2024] [Originally Added On: April 27th, 2010]
- 3-gram reduction in daily salt intake would decrease coronary heart disease, stroke, and death [Last Updated On: August 17th, 2024] [Originally Added On: April 27th, 2010]
- The men behind famous eponymous diseases [Last Updated On: August 17th, 2024] [Originally Added On: April 28th, 2010]
- Medical school letters of recommendation have formally been replaced by tweets [Last Updated On: August 17th, 2024] [Originally Added On: April 29th, 2010]
- "The doctor in literature: Private life" by Solomon Posen at Google Books [Last Updated On: August 17th, 2024] [Originally Added On: April 29th, 2010]
- High deductible health insurance can be bad for your health [Last Updated On: August 17th, 2024] [Originally Added On: April 30th, 2010]
- Should Doctors ‘Prescribe’ a Drink a Day? No. [Last Updated On: August 17th, 2024] [Originally Added On: May 1st, 2010]
- Turning medical residents away from copy-and-paste culture facilitated by EMR [Last Updated On: August 17th, 2024] [Originally Added On: May 2nd, 2010]
- Some nurses paid more than family doctors - CNN [Last Updated On: August 17th, 2024] [Originally Added On: May 2nd, 2010]
- Tiotropium for COPD: A good foundation therapy for most patients [Last Updated On: August 17th, 2024] [Originally Added On: May 2nd, 2010]
- Approach to evaluation and management of syncope in adults - BMJ Review [Last Updated On: August 17th, 2024] [Originally Added On: May 4th, 2010]
- U.S. Hospital Social Media List Includes More Than 600 Hospitals [Last Updated On: August 17th, 2024] [Originally Added On: May 4th, 2010]
- Can You Tell Your Life Story In 6 Words? [Last Updated On: August 17th, 2024] [Originally Added On: May 5th, 2010]
- How do you keep up with health news? [Last Updated On: August 17th, 2024] [Originally Added On: May 6th, 2010]
- Diet: For every 1% increase in omega-3 intake, HDL levels rose by 2.5 mg/dL [Last Updated On: August 17th, 2024] [Originally Added On: May 6th, 2010]
- Benefits and Dangers as Doctors Start to Use Social Media [Last Updated On: August 17th, 2024] [Originally Added On: May 7th, 2010]
- How to Subscribe to "What's New" Specialty Page of UpToDate? No Feed, No Problem for Google Reader [Last Updated On: August 17th, 2024] [Originally Added On: May 8th, 2010]
- High-risk profession: Suicide rate of U.S. doctors is one per day [Last Updated On: August 17th, 2024] [Originally Added On: May 8th, 2010]
- Video: A life cycle in 90 seconds [Last Updated On: August 17th, 2024] [Originally Added On: May 9th, 2010]
- Eating chocolate with high flavanol levels can protect the skin from UV light [Last Updated On: August 17th, 2024] [Originally Added On: May 10th, 2010]
- Barbara Walters, US TV Anchor, to Undergo Heart Surgery to Replace a "Faulty Valve" - Sounds Like Aortic Stenosis [Last Updated On: August 17th, 2024] [Originally Added On: May 11th, 2010]
- Can a Midday Nap Make You Smarter? Adults Who Nap for 90-minutes at 2 PM Learn and Perform Better at Tests [Last Updated On: August 17th, 2024] [Originally Added On: May 11th, 2010]
- 17% of food-related asphyxiations were caused by hot dogs - "the perfect plug for a child's airway" [Last Updated On: August 17th, 2024] [Originally Added On: May 12th, 2010]
- Bloggers, too much sitting can offset the benefits of regular exercise [Last Updated On: August 17th, 2024] [Originally Added On: May 13th, 2010]
- Farm-raised salmon has 16 times the polychlorinated biphenyls (PCBs) as wild-caught salmon [Last Updated On: August 17th, 2024] [Originally Added On: May 13th, 2010]
- Back and forth: Study fails to show link previously found between virus and chronic fatigue syndrome [Last Updated On: August 17th, 2024] [Originally Added On: May 14th, 2010]
- Warfarin Sensitivity Genotype Test - Mayo Clinic Video [Last Updated On: August 17th, 2024] [Originally Added On: May 14th, 2010]
- Childhood diabetes associated with increasing birth weight - 7% increase in risk for every 1000 g in weight [Last Updated On: August 17th, 2024] [Originally Added On: May 15th, 2010]
- The Barefoot Professor says barefoot running could minimize injuries [Last Updated On: August 17th, 2024] [Originally Added On: May 15th, 2010]
- Açaí, a Global "Super Fruit", Is Regular Dinner Meal in Brazil [Last Updated On: August 17th, 2024] [Originally Added On: May 16th, 2010]
- A NYTimes skeptic doubts that decreasing salt intake would have any benefits (it may even hurt) [Last Updated On: August 17th, 2024] [Originally Added On: May 17th, 2010]
- TED video: CIO of Cleveland Clinic talks about electronic medical records (EMR) [Last Updated On: August 17th, 2024] [Originally Added On: May 18th, 2010]
- Hospitalist evolution? "Extensivist" = hospitalist who prevents readmissions by seeing patients after discharge [Last Updated On: August 17th, 2024] [Originally Added On: May 18th, 2010]
- Video: Cleveland Clinic Model of Medicine [Last Updated On: August 17th, 2024] [Originally Added On: May 19th, 2010]
- What is the oldest medical blog? [Last Updated On: August 17th, 2024] [Originally Added On: May 19th, 2010]
- 7.2% Decrease in Work Hours of U.S. Physicians Between 1996 and 2008 [Last Updated On: August 17th, 2024] [Originally Added On: May 20th, 2010]
- Osteoporosis Drug Lasofoxifene May "Fight" Several Diseases But Increases Risk of Blood Clots [Last Updated On: August 17th, 2024] [Originally Added On: May 21st, 2010]
- Sign of the times [Last Updated On: August 17th, 2024] [Originally Added On: May 21st, 2010]
- Antibiotic use for respiratory infections could be reduced by 40% by procalcitonin (PCT) test [Last Updated On: August 17th, 2024] [Originally Added On: May 22nd, 2010]
- "Blogging fame does not pay the bills" [Last Updated On: August 17th, 2024] [Originally Added On: May 22nd, 2010]
- Health benefits of chocolate [Last Updated On: August 17th, 2024] [Originally Added On: May 23rd, 2010]
- Metabolic pathway plays a role in susceptibility to stuttering [Last Updated On: August 17th, 2024] [Originally Added On: May 23rd, 2010]
- Physically fit students score higher on tests than their less fit peers [Last Updated On: August 17th, 2024] [Originally Added On: May 24th, 2010]
- Room-temperature plasma gases may replace hand disinfectants [Last Updated On: August 17th, 2024] [Originally Added On: May 25th, 2010]
- New Treatment Effective in Killing Head Lice - benzyl alcohol lotion 5% (Ulesfia) [Last Updated On: August 17th, 2024] [Originally Added On: May 25th, 2010]
- Doctors use Facebook pages to connect with patients [Last Updated On: August 17th, 2024] [Originally Added On: May 26th, 2010]
- TED Talks: A new strategy in the war on cancer [Last Updated On: August 17th, 2024] [Originally Added On: May 26th, 2010]
- Oral Tolvaptan (Samsca) Is Safe and Effective in Chronic Hyponatremia [Last Updated On: August 17th, 2024] [Originally Added On: May 26th, 2010]
- Medical blog content and relationship with blogger credentials and blog host [Last Updated On: August 17th, 2024] [Originally Added On: May 27th, 2010]
- Doctors should blog with their real name - agree or disagree? [Last Updated On: August 17th, 2024] [Originally Added On: May 29th, 2010]
- "I'm a Medicare doctor. Here's what I make" [Last Updated On: August 17th, 2024] [Originally Added On: May 29th, 2010]