"Dear Fellow Nerium Shareholders,

We are at a critical juncture for the shareholders of Nerium Biotechnology, Inc. ("Nerium" or the "Company"). Failure to take action and vote for change will have significant consequences.

Your vote will impact the future of the Company and you have the opportunity to effect positive change by voting FOR the nominees proposed by the Shareholders Group.

A more detailed version of this letter is available on our website at: http://www.nbishareholders.com

The Shareholders Group has proposed six new highly qualified directors to be elected at the Company's upcoming Annual General Meeting of Nerium shareholders to be held on June 29, 2017. Shareholders can support change by voting their YELLOW form of proxy (the "YELLOW Proxy") in support of the directors proposed by the Shareholders Group (the "Shareholders' Nominees").

Critical Reasons to Replace Current Board and Management:

The decision to replace the current Board and Management is never easy, especially for those of you who have long-term personal relationships with some of the individuals involved. However, there comes a time when personal feelings must be set aside and action must be taken. In our opinion, the time has come for a change to the manner in which the Company is managed and operated. The case for taking action is compelling and has only become more so over the course of the last several weeks.

You have likely received the Shareholders Group's Proxy Circular (the "Shareholders Group Circular") and Yellow Proxy, which provides shareholders the opportunity to vote for change and a viable future for our Company. The Shareholders Group Circular, Yellow Proxy, and letter to shareholders can also be found on our website at http://www.nbishareholders.com. We have laid out, in detail, the many reasons why the current Board and Management must be replaced, as well as our plan for the Company going forward. The Shareholders Group's plan for the Company is based on a simple and much desired premise saving our Company in order to ultimately return value to shareholders.

The Shareholders Group believes that shareholders must take immediate action, or face the prospect of the Company ceasing to be a going concern in the near future.

Even prior to these new, very disturbing revelations, the Shareholders Group had clearly articulated the case for replacing the current Board and Management. It is no longer a debate it is a necessity.

The current Board and Management have had ten years to do right by shareholders. It is time for a change the very future of our investment depends on it.

The Shareholders' Nominees pledge to ensure that the Company is operated in a transparent manner, conducts good corporate governance, communicates regularly with shareholders, and discloses all important decisions, transactions or events.

In conclusion, the Shareholders Group believes that replacing the Board is critical to stabilize Nerium. The time is NOW, to effect positive change. Vote to save our Company by submitting your YELLOW Proxy in favor of the Shareholders' Nominees.

Sincerely Yours,

/s/ Brad BuscherBrad Buscher

On behalf of the Nerium Biotechnology, Inc. Shareholders Group

Your vote is extremely important. Every vote counts to save the Company.

Time is of the essence. Vote via email or fax to ensure your vote is received in a timely manner."

The above letter has also been mailed to Nerium shareholders and a more detailed letter, along with materials relating to the meeting, can be found on the Shareholders Group's website at http://www.nbishareholders.com

Time is Limited. You are encouraged to submit your YELLOW Proxy by EMAIL OR FAX in advance of the deadline at 8:00 a.m. (Eastern Time) on June 27, 2017

DO NOT use the proxy provided by Management. Shareholders are urged to discard that proxy and follow the instructions on the YELLOW Proxy. If you have already voted using Management's proxy form but wish to support the Shareholders Group, simply vote using the YELLOW Proxy. A later dated YELLOW Proxy will supersede a previously submitted vote.

Shareholders who require assistance with voting or have questions should immediately contact Laurel Hill Advisory Group at 1-877-452-7184 toll-free (416-304-0211 collect), or by email at assistance@laurelhill.com.

About the Shareholders Group

The Shareholders Group is comprised of a number of shareholders of Nerium Biotechnology, Inc. who collectively own or control more than 2.3 million shares of the Company's common stock. The Shareholders Group was formed in June of 2016 for the sole purpose of removing the Company's current management team and replacing them with individuals who will act in accordance with their fiduciary duty to the Company and its shareholders.

Further Information or Assistance

For more information or if you require assistance with voting, please contact the proxy solicitation agent for the Shareholders Group:

Laurel Hill Advisory GroupNorth America Toll Free: 1-877-452-7184Collect Calls Outside North America: 1-416-304-0211 Email: assistance@laurelhill.com

SOURCE The Shareholders Group of Nerium

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Shareholders Group of Nerium Biotechnology, Inc. announces important reminder to vote for much needed change to ... - PR Newswire (press release)