- Researchers will further develop the Site-directed Enzyme Enhancement Therapy (SEE-Tx) technology for the treatment of rare genetic and neurodegenerative diseases
- The collaborative agreement unites resources from the Institute for Research in Biomedicine (IRB)-USI; Neurocentro -Ente Ospedaliero Cantonale (EOC) & GT GAIN Therapeutics, SA
LUGANO, Switzerland, Dec. 15, 2020 (GLOBE NEWSWIRE) -- GT Gain Therapeutics SA (Gain), a subsidiary of Gain Therapeutics, Inc.,a biotechnology company focused on redefining drug discovery by identifying and optimizing allosteric binding sites that have never before been targeted, along with the Institute for Research in Biomedicine (IRB, affiliated to USI Universit della Svizzera Italiana) and the Neurocentro announced today that Innosuisse, the Swiss Innovation Agency, has agreed to support the CHF 1.5M project by funding approximately CHF 850,000 to leverage these world class research organizations and promote continued innovation in the area of CNS diseases. The remaining support will come from Gain to cover the cost of related headcount expenses being dedicated to the project. The award specifically supports further investigation of the mechanisms of action of Gains proprietary STAR small molecule therapeutic candidates on lysosomal dysfunction and prion-like transmission of toxic forms of protein aggregates associated with neurodegenerative diseases.
Being recognized as an Innosuisse funded innovation project reinforces the support for our innovative approach and unites us with scientists and researchers as passionate as we are to discover new therapeutic approaches using our SEE-Tx target identification platform, said Manolo Bellotto, Ph.D., President and General Manager of Gain. The specific know-how in protein quality control by Prof. Molinari at the IRB and the expertise in neurosciences of Dr. Paganetti from Neurocentro will certainly contribute to a further understanding of the mechanism of action of our molecules in rare and genetic diseases, thus accelerating their development towards the clinic.
Dr.Maurizio Molinari, group leader of the Protein Folding and Quality Control research team from the IRB added, We are honored to be collaborating with the Gain team and to evaluate Gains novel therapeutic candidates as we work to advance new, innovative treatment options for rare lysosomal disorders and neurodegenerative diseases for which there are currently few treatment options. We are grateful to the Swiss Innovation Agency for their support and look forward to initiating this critical research program.
About Gain Therapeutics, Inc.
Gain Therapeutics, Inc. is redefining drug discovery with its SEE-Tx target identification platform. By identifying and optimizing allosteric binding sites that have never before been targeted, Gain is unlocking new treatment options for difficult-to-treat disorders characterized by protein misfolding. Gain was originally established in 2017 with the support of its founders and institutional investors such as TiVenture, 3B Future Health Fund (formerly known as Helsinn Investment Fund) and VitaTech. It has been awarded funding support from The Michael J. Fox Foundation for Parkinsons Research (MJFF) and The Silverstein Foundation for Parkinsons with GBA, as well as from the Eurostars-2 joint program with co-funding from the European Union Horizon 2020 research and Innosuisse. In July 2020, Gain Therapeutics, Inc. completed a share exchange with GT Gain Therapeutics SA., a Swiss corporation, whereby GT Gain Therapeutics SA became a wholly owned subsidiary of Gain Therapeutics, Inc. For more information, visit https://www.gaintherapeutics.com/
About the Institute for Research in Biomedicine (IRB)
The Institute for Research in Biomedicine was founded in 2000 with the clear and ambitious goal of advancing the study of human immunology, with particular emphasis on the mechanisms of host defense. The activities of the 13 research groups now extend beyond immunology to include the fields of DNA repair, rare diseases, structural and cell biology. Located in Bellinzona, capital of the Italian-speaking Canton of Ticino, the IRB is an affiliated institute of the USI Faculty of Biomedical Sciences. For more information, visit : http://www.irb.usi.ch
About Neurocentro -Ente Ospedaliero Cantonale (EOC)
The EOC multisite hospital is organized and managed as a modern company at the service of the patient. It has structures with clear segregations of functions and flexible management systems that foster innovation, accountability and simplification.Our approach favors a collegial and participatory management style. General management and hospital directors form the EOC Management Coordination Conference, physicians are directly involved in EOC management through the Clinical Coordination Conference. The other professional categories actively participate in the management of the EOC within inter-hospital groups.For more information, visit http://www.eoc.ch/en/Centri-specialistici/NSI/NSI.html
Forward-Looking Statements
Any statements in this release that are not historical facts may be considered to be forward-looking statements. Forward-looking statements are based on managements current expectations and are subject to risks and uncertainties which may cause results to differ materially and adversely from the statements contained herein. Such statements include, but are not limited to, statements regarding Gain Therapeutics, Inc. (Gain) expected use of the proceeds from the Series B financing round; the market opportunity for Gains product candidates; and the business strategies and development plans of Gain. Some of the potential risks and uncertainties that could cause actual results to differ from those predicted include Gains ability to: make commercially available its products and technologies in a timely manner or at all; enter into other strategic alliances, including arrangements for the development and distribution of its products; obtain intellectual property protection for its assets; accurately estimate its expenses and cash burn and raise additional funds when necessary. Undue reliance should not be placed on forward-looking statements, which speak only as of the date they are made. Except as required by law, Gain does not undertake any obligation to update any forward-looking statements to reflect new information, events or circumstances after the date they are made, or to reflect the occurrence of unanticipated events.
Gain Therapeutics Investor Contact:Daniel FerryLifeSci Advisors+1 617-430-7576daniel@lifesciadvisors.com
Gain Therapeutics Media Contact:Cait Williamson, Ph.D.LifeSci Communications+1 646-751-4366cait@lifescicomms.com
- Protein folding - Wikipedia [Last Updated On: August 18th, 2024] [Originally Added On: September 11th, 2019]
- Protein Folding: The Good, the Bad, and the Ugly - Science ... [Last Updated On: August 18th, 2024] [Originally Added On: September 13th, 2019]
- Protein Folding - Chemistry LibreTexts [Last Updated On: August 18th, 2024] [Originally Added On: September 14th, 2019]
- Protein Structure and Folding [Last Updated On: August 18th, 2024] [Originally Added On: September 19th, 2019]
- Structural Biochemistry/Proteins/Protein Folding ... [Last Updated On: August 18th, 2024] [Originally Added On: September 28th, 2019]
- Proteopathy - Wikipedia [Last Updated On: August 18th, 2024] [Originally Added On: October 1st, 2019]
- Folding@home - Wikipedia [Last Updated On: August 18th, 2024] [Originally Added On: October 1st, 2019]
- Denaturation and Protein Folding | Introduction to Chemistry [Last Updated On: August 18th, 2024] [Originally Added On: October 4th, 2019]
- Protein Folding - Anfinsen's Experiment ~ Biology Exams 4 U [Last Updated On: August 18th, 2024] [Originally Added On: October 4th, 2019]
- Protein Structures: Primary, Secondary, Tertiary, Quaternary ... [Last Updated On: August 18th, 2024] [Originally Added On: October 4th, 2019]
- Protein Folding - an overview | ScienceDirect Topics [Last Updated On: August 18th, 2024] [Originally Added On: October 6th, 2019]
- Thermodynamics of spontaneous protein folding: role of ... [Last Updated On: August 18th, 2024] [Originally Added On: October 8th, 2019]
- Molecular Biology 02: 'Thermodynamics of protein folding' [Last Updated On: August 18th, 2024] [Originally Added On: October 8th, 2019]
- The Science Behind Foldit | Foldit [Last Updated On: August 18th, 2024] [Originally Added On: October 8th, 2019]
- Diseases Folding@home [Last Updated On: August 18th, 2024] [Originally Added On: October 8th, 2019]
- DeepMind timeline: The history of the UK's pioneering AI firm - Techworld.com [Last Updated On: August 18th, 2024] [Originally Added On: October 10th, 2019]
- Geroscience and it's Impact on the Human Healthspan: A podcast with John Newman - GeriPal - A Geriatrics and Palliative Care Blog [Last Updated On: August 18th, 2024] [Originally Added On: October 10th, 2019]
- Yumanity Therapeutics Initiates Phase 1 Clinical Trial of Lead Candidate YTX-7739 for the Treatment of Parkinson's Disease | Small Molecules | News... [Last Updated On: August 18th, 2024] [Originally Added On: October 10th, 2019]
- Tenure-Track or Tenure-Eligible Position in the Laboratory of Chemical Physics job with National Institutes of Health | 28302 - Chemical &... [Last Updated On: August 18th, 2024] [Originally Added On: October 10th, 2019]
- Food for the soul: Traditional gyza makers and eaters in Utsunomiya try to keep the dumplings rolling - The Japan Times [Last Updated On: August 18th, 2024] [Originally Added On: October 19th, 2019]
- UT molecular evolution professor named 2019 American Physical Society Fellow - UT The Daily Texan [Last Updated On: August 18th, 2024] [Originally Added On: October 19th, 2019]
- 9 must-have Instant Pot accessories for healthy eating - CNET [Last Updated On: August 18th, 2024] [Originally Added On: October 19th, 2019]
- Researchers Find Fish Wearing Natural 'Bullet-Proof Vest' to Thwart Piranhas in Amazon - News18 [Last Updated On: August 18th, 2024] [Originally Added On: October 19th, 2019]
- Christopher Dobson: chemist whose work on proteins advanced research into neurodegenerative diseases - The BMJ [Last Updated On: August 18th, 2024] [Originally Added On: October 19th, 2019]
- Two years in the making, Pizza Hut tests a round pizza box - Fast Company [Last Updated On: August 18th, 2024] [Originally Added On: October 23rd, 2019]
- Fava Is All About Balance - East Bay Express [Last Updated On: August 18th, 2024] [Originally Added On: October 23rd, 2019]
- Amazon fish wears nature's 'bullet-proof vest' to thwart piranhas - Reuters [Last Updated On: August 18th, 2024] [Originally Added On: October 23rd, 2019]
- RNA Folding Insights Lead to New Therapeutics and Synthetic Biology Technologies - Technology Networks [Last Updated On: August 18th, 2024] [Originally Added On: October 23rd, 2019]
- The Hidden Inactive Ingredient: Biological Products in Recombinant Pharmaceuticals - P&T Community [Last Updated On: August 18th, 2024] [Originally Added On: October 23rd, 2019]
- Insights into Parkinson's Onset May Lie in New Model of Cell Aging and Damage - Parkinson's News Today [Last Updated On: August 18th, 2024] [Originally Added On: October 23rd, 2019]
- Antibiotics with novel mechanism of action discovered - Drug Target Review [Last Updated On: August 18th, 2024] [Originally Added On: October 25th, 2019]
- The top AI lighthouse projects to watch in biopharma - FierceBiotech [Last Updated On: August 18th, 2024] [Originally Added On: October 25th, 2019]
- UCI vision scientist Krzysztof Palczewski elected to National Academy of Medicine - UCI News [Last Updated On: August 18th, 2024] [Originally Added On: October 26th, 2019]
- Rett Syndrome Tied to Altered Protein Levels in Brain in Early Study - Rett Syndrome News [Last Updated On: August 18th, 2024] [Originally Added On: October 26th, 2019]
- Bulls-Eye: Imaging Technology Could Confirm When a Drug Is Going to the Right Place - On Cancer - Memorial Sloan Kettering [Last Updated On: August 18th, 2024] [Originally Added On: October 26th, 2019]
- Discover: Science is often wrong and that's actually a really good thing - Sudbury.com [Last Updated On: August 18th, 2024] [Originally Added On: November 2nd, 2019]
- IBM vs. Google and the Race to Quantum Supremacy - Citizen Truth [Last Updated On: August 18th, 2024] [Originally Added On: November 7th, 2019]
- Microprotein ID'd Affecting Protein Folding and Cell Stress Linked to Diseases Like Huntington's, Study Finds - Huntington's Disease News [Last Updated On: August 18th, 2024] [Originally Added On: November 7th, 2019]
- IBM vs. Google and the race to quantum supremacy - Salon [Last Updated On: August 18th, 2024] [Originally Added On: November 11th, 2019]
- That Junk DNA Is Full of Information! - Advanced Science News [Last Updated On: August 18th, 2024] [Originally Added On: November 16th, 2019]
- Argonne Researchers to Share Scientific Computing Insights at SC19 - HPCwire [Last Updated On: August 18th, 2024] [Originally Added On: November 16th, 2019]
- How to Make the Most of Your Old Tech - New York Magazine [Last Updated On: August 18th, 2024] [Originally Added On: November 16th, 2019]
- 2 tricked-out pies to be thankful for: pear with cranberries and pumpkin with ginger praline - The Gazette [Last Updated On: August 18th, 2024] [Originally Added On: November 17th, 2019]
- From Mediterranean Lentil Salad to Cinnamon Raisin Bread: Our Top 10 Vegan Recipes of the Day! - One Green Planet [Last Updated On: August 18th, 2024] [Originally Added On: November 22nd, 2019]
- What is Biophysical Analysis? - The John Innes Centre [Last Updated On: August 18th, 2024] [Originally Added On: November 22nd, 2019]
- Thermodynamic probes of instability: application to therapeutic proteins - European Pharmaceutical Review [Last Updated On: August 18th, 2024] [Originally Added On: November 22nd, 2019]
- In science, its better to be curious than correct - The Conversation CA [Last Updated On: August 18th, 2024] [Originally Added On: November 22nd, 2019]
- New Study Reveals US Airlines With the Healthiest Food Options - TravelPulse [Last Updated On: August 18th, 2024] [Originally Added On: November 29th, 2019]
- Study Reveals Hepatitis A Originated in Insects - Advanced Science News [Last Updated On: August 18th, 2024] [Originally Added On: November 29th, 2019]
- How Home-Baked Bread Is Defying the Industrial Food System - YES! Magazine [Last Updated On: August 18th, 2024] [Originally Added On: November 29th, 2019]
- Black Friday Is Absolutely Massive. Here Are a Bunch of Deals We Couldn't Call Out Individually - Gear Patrol [Last Updated On: August 18th, 2024] [Originally Added On: November 30th, 2019]
- A conserved ATP- and Scc2/4-dependent activity for cohesin in tethering DNA molecules - Science Advances [Last Updated On: August 18th, 2024] [Originally Added On: November 30th, 2019]
- Ancient Worm Reveals Way to Destroy Toxic Cells Potential New Therapy for Huntingtons and Parkinsons - SciTechDaily [Last Updated On: August 18th, 2024] [Originally Added On: December 11th, 2019]
- Biologics Market Size Expand at a CAGR of 3.9 With $399.5 Billion By 2025 - MENAFN.COM [Last Updated On: August 18th, 2024] [Originally Added On: December 11th, 2019]
- Exploring the Diversity of Parkinson's Proteins - Technology Networks [Last Updated On: August 18th, 2024] [Originally Added On: December 11th, 2019]
- Early detection of brain degeneration on the horizon with innovative sensor - UNM Newsroom [Last Updated On: August 18th, 2024] [Originally Added On: December 16th, 2019]
- Holiday cookies from around the world | Features - yoursun.com [Last Updated On: August 18th, 2024] [Originally Added On: December 22nd, 2019]
- The Art of Origami is Now A Key Tool That Helps Doctors Save Lives - Nature World News [Last Updated On: August 18th, 2024] [Originally Added On: December 23rd, 2019]
- Nanopores can identify the amino acids in proteins, the first step to sequencing - University of Illinois News [Last Updated On: August 18th, 2024] [Originally Added On: December 23rd, 2019]
- Wow your New Year's Eve guests with a puff pastry appetizer - KARE11.com [Last Updated On: August 18th, 2024] [Originally Added On: January 1st, 2020]
- The 10 most compelling product innovations of 2019 - Fast Company [Last Updated On: August 18th, 2024] [Originally Added On: January 1st, 2020]
- Our best recipes from 2019 | Food and cooking - STLtoday.com [Last Updated On: August 18th, 2024] [Originally Added On: January 1st, 2020]
- The best WIRED long reads of 2019 - Wired.co.uk [Last Updated On: August 18th, 2024] [Originally Added On: January 1st, 2020]
- Structure of Drosophila melanogaster ARC1 reveals a repurposed molecule with characteristics of retroviral Gag - Science Advances [Last Updated On: August 18th, 2024] [Originally Added On: January 1st, 2020]
- Gocycle to partner with nutrition brand Fuel10k to promote benefits of e-bikes - Bike Biz [Last Updated On: August 18th, 2024] [Originally Added On: January 16th, 2020]
- The Importance of Understanding TargetProtein Interactions in Drug Discovery - Technology Networks [Last Updated On: August 18th, 2024] [Originally Added On: January 16th, 2020]
- How DeepMind is unlocking the secrets of dopamine and protein folding with AI - VentureBeat [Last Updated On: August 18th, 2024] [Originally Added On: January 16th, 2020]
- How To Grow (Almost) Anything - Hackaday [Last Updated On: August 18th, 2024] [Originally Added On: January 19th, 2020]
- U of T's Peter Wittek, who will be remembered at Feb. 3 event, on why the future is quantum - News@UofT [Last Updated On: August 18th, 2024] [Originally Added On: January 19th, 2020]
- The DeepMind algorithm to solve two complex problems of biology - The Times Hub [Last Updated On: August 18th, 2024] [Originally Added On: January 19th, 2020]
- High Focus on Product Innovation & Development to Assist the Growth of the Folding Cartons Market between and . 2017 2025 Dagoretti News -... [Last Updated On: August 18th, 2024] [Originally Added On: January 24th, 2020]
- Folded, frozen, and faster: JUST Egg is now more convenient, and cheaper, to enjoy - FoodNavigator-USA.com [Last Updated On: August 18th, 2024] [Originally Added On: January 24th, 2020]
- Phyllo, cheese, heaven: Balkan women have been making these treats for centuries - The Gazette [Last Updated On: August 18th, 2024] [Originally Added On: January 26th, 2020]
- Phyllo, cheese, heaven: Balkan women have been making these treats for centuries - Waterbury Republican American [Last Updated On: August 18th, 2024] [Originally Added On: January 28th, 2020]
- The keto diet: Its highs and lows plus 5 recipes - The Gazette [Last Updated On: August 18th, 2024] [Originally Added On: February 12th, 2020]
- Study Shows How Soap Molecules Alter the Protein Structure - AZoM [Last Updated On: August 18th, 2024] [Originally Added On: February 12th, 2020]
- CryoEM of CBD Tau Suggests Another Unique Protofibril - Alzforum [Last Updated On: August 18th, 2024] [Originally Added On: February 16th, 2020]
- Working In Science Was A Brutal Education. Thats Why I Left. - BuzzFeed News [Last Updated On: August 18th, 2024] [Originally Added On: February 17th, 2020]
- The Evolution of the Eye, Demystified - Discovery Institute [Last Updated On: August 18th, 2024] [Originally Added On: February 28th, 2020]
- L-serine could be used to treat ALS, after promising study results - Drug Target Review [Last Updated On: August 18th, 2024] [Originally Added On: February 28th, 2020]