For the first time in history, leading scientists and entrepreneurs believe theres a way to slow aging and maybe even reverseit.
The latest research on longevity suggests there is no reason that people born today cant live to at least 120 years old... perhaps even to 150 and beyond.
How would you change your life if you could live to 120 years old and remain healthy?
What would you do differently today?
Last week we explored the Longevity Mindset. Today and next week, Ill do a quick review of the latest advancements toward rewiring the biology of aging.
Every year, I take a group of my Abundance 360 Members on a Platinum Longevity Trip to meet with the cutting-edge researchers and companies. Following are some of the companies and technologies we observed that have the potential to increase your healthspan the amount of time you have to live a healthy and functional life, avoiding expensive end-of-life care.
Todays blog will be part one of a two-part series covering these developments.
Lets dive in
Over the past two decades, the cost of sequencing the human genome has dropped 100,000-fold: from $100 million per genome, to below $1,000 per genome (current estimates are as low as $300).
Genome sequencing can uncover disease susceptibilities years before symptoms present, allowing for personalized preventative care to begin sooner than ever before.
For example, the Cancer Genome Atlas Program at the NIH is currently using gene sequencing to decode the genetic underpinnings of 30 cancer types.
Perhaps the most impactful potential of low-cost genome sequencing is its ability to be used in what is called a liquid biopsy the ability to find free-flowing cancer DNA in your bloodstream that might indicate the existence of an undetected cancer in your body. And, as we know, finding cancer at stage-zero or stage-one is the key to survival.
There are two major companies we visited with during our Platinum Longevity Trip:
Cancer detection company GRAILanalyzes the mutated, fractionated DNA and RNA from cancer cells in your blood (from a simple blood draw) to diagnose over 50 cancer types in early stages. GRAIL recently received an $8 billion buy-out offer from biotech giant Illumina.
Freenometakes a similar approach to early cancer diagnosis from a real-time blood draw (called a liquid biopsy), initially focused on colon cancer. Freenomes multiomics platform analyzes fragments of DNA, RNA, and protein from the cancer and from the host response. This form of precision medicine bridges early detection and early intervention to boost human healthspan.
One of the most powerful technologies now available in the fight for longevity is called gene therapy a technology theorized in the 1980s that has taken almost 40 years to mature. Gene therapy allows scientists to use a vector (typically an Adeno Associated Virus) to carry a desired gene to a set of desired cells in an organism. Want a specific gene put into retinal cells, or bone marrow, or neurons? No problem, there's a gene therapy approach for that.
A new biotech start-up called Gordian Biotechnologyis using the convergence of gene therapy and single cell sequencing to run hundreds of thousands of independent experiments in a single animal to determine the therapeutic effects of specific gene additions on specific cells of interest. Because aging is such a multifactorial process, this approach can run thousands of parallel experiments to tackle the many complexities of age-related diseases simultaneously.
Next week, well learn about a company called Rejuvenate Bio, and an extraordinary researcher named Dr. David Sinclair who is using gene therapy to potentially rejuvenate animals with the ultimate goal of age reversal in humans.
In addition to Gene Therapy, the other incredible tool in our longevity research arsenal is CRISPR.
You may know CRISPR as the molecular scissors that can edit genes think CTRL X (cut) and CTRL V (paste). But beyond cutting and pasting, CRISPR can also be used to help find and identify a sequence of DNA in your cell, sort of a CTRL F functionality. This discovery is so important and transformative that the Nobel Prize was just awarded this month to Dr. Jennifer Doudna of Gladstone Institutes for its discovery.
Here are several other exciting CRISPR developments:
Gladstone-UCSF Institute of Genomic Immunologyis using CRISPR to edit the T-cells of the immune system that play critical roles in cancer, infection, and autoimmunity. CRISPR can delete mutated genes or add new DNA to reprogram the T-cells. This personalized approach takes advantage of the bodys own immune system to tackle complex diseases.
Rather than snipping and replacing genes, Mammoth Bioscienceshas programmed CRISPR proteins to locate and cleave target genes, acting as molecular shredders. The cleaved gene serves as a molecular readout if the target is successfully bound, enabling CRISPR to serve as a diagnostic tool. Additionally, the companys novel CRISPR proteins (cas14, casV) exist in the micro and nano scales, opening the door for new delivery systems at smaller scales than ever before.
With the recent breakthroughs in CRISPR and Gene Therapy technologies, a variety of strategies for reversing disease have been tried. Yet countlessexperiments remain, and thats where AI can help.
The explosion of novel imaging, sensing, and sequencing tools has unleashed an abundance of patient data.
But bringing together this information across millions of patients to form actionable insights can only be achieved with Artificial Intelligence.
One of the leading companies in this area is Insilico Medicine, which is leveraging AI in its end-to-end drug pipeline, extending healthy longevity through drug discovery and aging research.
In their comprehensive drug discovery engine, Insilico uses millions of samples and multiple data types to A) discover signatures of diseases, and B) identify the most promising targets for billions of molecules. These molecules either already exist or can be generated de novo with the desired set of parameters.
Insilico uses an AI technique called generative adversarial networks (GANs) to imagine novel molecular structures. With reinforcement learning, Insilicos system lets you generate a molecule with any of up to 20 different properties to hit a specified target.
Thanks to converging breakthroughs in machine learning, drug discovery and molecular biology, companies like Insilico can now do with 50 people what the pharmaceutical industry can barely do with an army of 5,000.
Another extraordinary company on the Longevity Platinum Trip was a company out of the Buck Institute called Edifice Health, which has developed the ability to determine your inflammatory age using advanced AI to score biomarkers of immune health. Inflammation is a leading contributor to most chronic illnesses, and greater awareness of this symptom will enhance preventative care. Even more important than measuring inflammatory age, Edifice Health is screening thousands of molecules to determine which can quell such inflammation.
An additional company out of the Buck Institute is Gerostate Alpha, a pharmaceutical company that is using large-scale AI to test millions of compounds for their ability to extend the life of a worm-like creature called the nematode. Once they get a hit in nematodes (rather short-lived creatures), they will then test the molecules in mice and eventually in humans. The company is testing millions of compounds in parallel, hoping to literally discover the pharmaceutical fountain of youth.
In next weeks blog, well continue to review other exciting companies on the cutting-edge of longevity science, diving more into gene therapy, senolytic medicines, vaccines, and stem cells.
If tracking the latest breakthroughs in longevity is something you desire If developing a Longevity Mindset is important to you, then consider joining my Abundance 360Mastermind.
Every year, my team and I select a group of 360 entrepreneurs and CEOs to coach over the course of a year-long program. A360 starts each January with a live event and continues every two months with Implementation Workshops, in which I personally coach members in small groups over Zoom. (In January 2021, you have a choice of live in-person or virtual participation. See the A360 website for more info.)
My mission is to help A360 members identify their massively transformative purpose, select their moonshot, and hone an Abundance, Exponential, and Longevity Mindset. Together we will actively select and reinforce your preferred mindsets.
To learn more and apply, visit abundance360.com
Read the original post:
100 years old will be the new 60 | Health & Wellness - CL Charlotte
- Scientists believe that aging might be optional - Mail Herald [Last Updated On: August 18th, 2024] [Originally Added On: November 18th, 2019]
- This Week in Running: November 18, 2019 - iRunFar [Last Updated On: August 18th, 2024] [Originally Added On: November 21st, 2019]
- Aging as a preventable disease and why living to 100 should be easy - Genetic Literacy Project [Last Updated On: August 18th, 2024] [Originally Added On: November 21st, 2019]
- David Sinclair on Joe Rogan Podcast - chatting about NMN and ... [Last Updated On: August 18th, 2024] [Originally Added On: November 23rd, 2019]
- NMN and NAD Reverse Aging of Blood Vessels in New Study [Last Updated On: August 18th, 2024] [Originally Added On: November 23rd, 2019]
- #70 - David Sinclair, Ph.D.: How cellular reprogramming could ... [Last Updated On: August 18th, 2024] [Originally Added On: November 23rd, 2019]
- Lifespan: Why We Age_and Why We Don't Have To: David A ... [Last Updated On: August 18th, 2024] [Originally Added On: November 23rd, 2019]
- David Sinclair supplements and protocol explained NMN ... [Last Updated On: August 18th, 2024] [Originally Added On: November 23rd, 2019]
- David Sinclair's biological age was 58 after taking 1000 mg ... [Last Updated On: August 18th, 2024] [Originally Added On: November 23rd, 2019]
- David Sinclairs anti-aging science | Harvard Magazine [Last Updated On: August 18th, 2024] [Originally Added On: November 23rd, 2019]
- David Sinclair Supplements For Anti-Aging - What He Takes & Why [Last Updated On: August 18th, 2024] [Originally Added On: November 23rd, 2019]
- What Does David Sinclair Eat and Supplement? (2019 ... [Last Updated On: August 18th, 2024] [Originally Added On: November 23rd, 2019]
- #27 - David Sinclair, Ph.D.: Slowing aging sirtuins, NAD ... [Last Updated On: August 18th, 2024] [Originally Added On: November 23rd, 2019]
- Man with string of convictions in his native Poland came to Perth to set up drug den - The Courier [Last Updated On: August 18th, 2024] [Originally Added On: November 30th, 2019]
- Last surviving Viking-inspired boat that served a now- abandoned island goes up for auction - The Scotsman [Last Updated On: August 18th, 2024] [Originally Added On: November 30th, 2019]
- Dealer Jailed After Raid Uncovers 44k of Grugs - Daily Record [Last Updated On: August 18th, 2024] [Originally Added On: November 30th, 2019]
- Lazarus Effect: Sixteen-year study by Dr. Leis resulted in recovery from West Nile for Dr. Bush - Northside Sun [Last Updated On: August 18th, 2024] [Originally Added On: December 21st, 2019]
- OZY Takes You Ahead of the Curve in Science and Technology - OZY [Last Updated On: August 18th, 2024] [Originally Added On: December 29th, 2019]
- The Race To Find A Cure For Aging - Medium [Last Updated On: August 18th, 2024] [Originally Added On: January 1st, 2020]
- Hard work and dedication honored - Union Daily Times [Last Updated On: August 18th, 2024] [Originally Added On: January 23rd, 2020]
- Meet the people who think soaking in a frozen Minneapolis lake is the secret to good health - Minneapolis Star Tribune [Last Updated On: August 18th, 2024] [Originally Added On: January 24th, 2020]
- BOYS SWIMMING: Tigersharks top Waconia in conference dual - Crow River Media [Last Updated On: August 18th, 2024] [Originally Added On: January 25th, 2020]
- David Sinclair on NMN and Epigenetics | | LEAF [Last Updated On: August 18th, 2024] [Originally Added On: January 25th, 2020]
- Brave Cashel Community School get the better of St Augustine's to set-up a Munster hurling final clash with Doon - TipperaryLive.ie [Last Updated On: August 18th, 2024] [Originally Added On: January 28th, 2020]
- Diane Francis: Treating aging like a disease is the next big thing for science - Financial Post [Last Updated On: August 18th, 2024] [Originally Added On: January 28th, 2020]
- Letter: Yes to Green Growth | Opinion - Southern Pines Pilot [Last Updated On: August 18th, 2024] [Originally Added On: January 28th, 2020]
- Kelty Hearts 4-1 Caledonian Braves: Third straight defeat for Braves - Motherwell Times [Last Updated On: August 18th, 2024] [Originally Added On: February 6th, 2020]
- Is soaking in a frozen lake the secret to good health? - The Detroit News [Last Updated On: August 18th, 2024] [Originally Added On: February 12th, 2020]
- Letter:Deputy Is Vindicated | Opinion - Southern Pines Pilot [Last Updated On: August 18th, 2024] [Originally Added On: February 12th, 2020]
- BOYS SWIMMING: Chargers take fifth at WCC Championships; look ahead to sections - Crow River Media [Last Updated On: August 18th, 2024] [Originally Added On: February 12th, 2020]
- Lifespan: The New Science Behind Anti-Aging and Longevity that Can Help You Live to 100 - Thrive Global [Last Updated On: August 18th, 2024] [Originally Added On: February 19th, 2020]
- Not fasting is killing us, but fasting can hurt us too. Here's what to do. - Mashable [Last Updated On: August 18th, 2024] [Originally Added On: February 21st, 2020]
- Anti-Aging Researcher David Sinclair Takes Metformin, NMN ... [Last Updated On: August 18th, 2024] [Originally Added On: February 22nd, 2020]
- Movers and Shakers Week Ending 2.28.20 - milehighcre.com [Last Updated On: August 18th, 2024] [Originally Added On: February 28th, 2020]
- Health inequality in England was bad. It has got worse - The Economist [Last Updated On: August 18th, 2024] [Originally Added On: February 28th, 2020]
- Southland couple join volunteers to help future proof Southland A&P Show - Stuff.co.nz [Last Updated On: August 18th, 2024] [Originally Added On: March 3rd, 2020]
- Pilot Wins Top Honors at Awards Ceremony | Business - Southern Pines Pilot [Last Updated On: August 18th, 2024] [Originally Added On: March 3rd, 2020]
- Flipping the switch on the ageing process - The Age [Last Updated On: August 18th, 2024] [Originally Added On: March 21st, 2020]
- 7 books to read while in coronavirus quarantine or isolation - The CEO Magazine [Last Updated On: August 18th, 2024] [Originally Added On: March 28th, 2020]
- Remembering loved ones who have passed away - the 68 death notices in North Staffordshire this week - Stoke-on-Trent Live [Last Updated On: August 18th, 2024] [Originally Added On: March 31st, 2020]
- Can canine coronavirus drug indomethacin be used in treating humans suffering from COVID-19? - MEAWW [Last Updated On: August 18th, 2024] [Originally Added On: April 11th, 2020]
- Is There Any Legitimate Health Advice in Gwyneth Paltrow's "Goop Lab"? - InsideHook [Last Updated On: August 18th, 2024] [Originally Added On: April 11th, 2020]
- Will Universities, Colleges, And Law School Campuses Be Open In Fall 2020? - Above the Law [Last Updated On: August 18th, 2024] [Originally Added On: April 11th, 2020]
- 'Refreshingly honest' dealer who ran Perth drug den will be sent home to Poland - The Courier [Last Updated On: August 18th, 2024] [Originally Added On: April 14th, 2020]
- Has Harvard's David Sinclair Found the Fountain of Youth? [Last Updated On: August 18th, 2024] [Originally Added On: April 20th, 2020]
- Carole Carson: Adventures in Aging Seven myths about getting older - The Union of Grass Valley [Last Updated On: August 18th, 2024] [Originally Added On: April 25th, 2020]
- Hide and Hedonism invite guests to a virtual wine dinner - Spear's WMS [Last Updated On: August 18th, 2024] [Originally Added On: May 1st, 2020]
- Budget realities from COVID-19 cut $40.6 million from Prince William budgets - Inside NoVA [Last Updated On: August 18th, 2024] [Originally Added On: May 1st, 2020]
- Drug Use is Transmitted from Old to Young - UPJ Athletics [Last Updated On: August 18th, 2024] [Originally Added On: May 16th, 2020]
- Fife woman breached Asbo by having illicit party at home during lockdown - The Courier [Last Updated On: August 18th, 2024] [Originally Added On: May 19th, 2020]
- A Harvard Geneticist Wants To Sell A Magical ... - HuffPost [Last Updated On: August 18th, 2024] [Originally Added On: June 9th, 2020]
- Jennifer Aniston: How The Morning Show felt like 20 years of therapy - The Detroit News [Last Updated On: August 18th, 2024] [Originally Added On: August 26th, 2020]
- Woods, Waters, and Wildlife: Buy Licenses Now! | FCT News - Freestonecountytimesonline [Last Updated On: August 18th, 2024] [Originally Added On: August 29th, 2020]
- Editorial: Five Birdies That Signal Good Work | Opinion | thepilot.com - Southern Pines Pilot [Last Updated On: August 18th, 2024] [Originally Added On: September 3rd, 2020]
- We all suffer when COVID-19 locks the elderly out of societal participation - The Investment Observer [Last Updated On: August 18th, 2024] [Originally Added On: September 18th, 2020]
- Immetas Therapeutics Announces Series A Financing to Advance Research on Inflammation Pathways in Aging and Develop Therapeutics for Cancer and... [Last Updated On: August 18th, 2024] [Originally Added On: September 26th, 2020]
- DS4 to rock Morden live at The Sound Lounge - Your Local Guardian [Last Updated On: August 18th, 2024] [Originally Added On: September 26th, 2020]
- How newly unemployed over-50s can start-up again - The Guardian [Last Updated On: August 18th, 2024] [Originally Added On: October 8th, 2020]
- Brexit casts doubt over UK pension rights - Interactive Investor [Last Updated On: August 18th, 2024] [Originally Added On: October 16th, 2020]
- Cancer. How close are we to winning the war? - Switzer [Last Updated On: August 18th, 2024] [Originally Added On: October 16th, 2020]
- Where Sabrina the Teenage Witch cast are now - hit TV shows and unrecognisable star - Mirror Online [Last Updated On: August 18th, 2024] [Originally Added On: October 28th, 2020]
- Caledonian Braves can 'breathe a bit easier' after first win says boss Ricky Waddell - MSN UK [Last Updated On: August 18th, 2024] [Originally Added On: October 28th, 2020]
- Why Aren't We Talking More About Nutrition Amid COVID-19? - Anti Aging News [Last Updated On: August 18th, 2024] [Originally Added On: November 2nd, 2020]
- We should allow ourselves to be #pharmaproud - - pharmaphorum [Last Updated On: August 18th, 2024] [Originally Added On: November 19th, 2020]
- 6 Anti Aging Benefits of Metformin - The Shepherd of the Hills Gazette [Last Updated On: August 18th, 2024] [Originally Added On: November 19th, 2020]
- Hokitika father charged with murder initially claimed son fell out of bed - Stuff.co.nz [Last Updated On: August 18th, 2024] [Originally Added On: November 19th, 2020]
- Scientists Uncover Approach That Could Reverse Age-Related Vision Loss - Science Times [Last Updated On: August 18th, 2024] [Originally Added On: December 6th, 2020]
- HTLS 2020: A pill that can reverse ageing? Yes, it will be possible, says Dr Sinclair - Hindustan Times [Last Updated On: August 18th, 2024] [Originally Added On: December 6th, 2020]
- Reversing vision loss by turning back the aging clock - FierceBiotech [Last Updated On: August 18th, 2024] [Originally Added On: December 6th, 2020]
- Pill to reverse ageing in 30 years? Why not, says Harvard professor Dr David Sinclair - Hindustan Times [Last Updated On: August 18th, 2024] [Originally Added On: December 6th, 2020]
- Get younger reverse ageing and increase your health span - Have a Go News [Last Updated On: August 18th, 2024] [Originally Added On: December 8th, 2020]
- Over 50s Spending Spree Boosts Economy By Billions - Money International [Last Updated On: August 18th, 2024] [Originally Added On: January 20th, 2021]
- Hunger in Milwaukee and the World: What We Can Do About It - Wisconsin Public Radio News [Last Updated On: August 18th, 2024] [Originally Added On: February 15th, 2021]
- Woman's 'nasty' skin infection most likely caused by swimming in sea after shaving legs - Stuff.co.nz [Last Updated On: August 18th, 2024] [Originally Added On: August 3rd, 2021]
- David Sinclair | The Sinclair Lab [Last Updated On: August 18th, 2024] [Originally Added On: December 21st, 2021]
- David Sinclair Supplements List Deep Dive - Updated 2021 [Last Updated On: August 18th, 2024] [Originally Added On: December 21st, 2021]
- Don't Listen to Intermittent Fasting Influencers, The Science Doesn't Back It Up - InsideHook [Last Updated On: August 18th, 2024] [Originally Added On: April 27th, 2022]
- David Sinclair Post-2022 Canyons by UTMB 100k Interview - iRunFar [Last Updated On: August 18th, 2024] [Originally Added On: April 27th, 2022]
- Authorized Biography Of The Rolling Stones Charlie Watts Launched In London - uDiscover Music [Last Updated On: August 18th, 2024] [Originally Added On: September 24th, 2022]
- David Sinclair Supplements (2022 List) | Brands for Anti-Aging! [Last Updated On: August 18th, 2024] [Originally Added On: September 24th, 2022]