We want to look & feel young again, and every year we spend hundreds of billions of dollars on beauty serums, cosmetic surgery, and exotic supplements in the hopes of appearing more vibrant, healthy, and desirable.
All of those products, procedures & pills only cover up the symptoms of aging they do nothing to address the cause. While medicine does help us to live longer, at best it has only slowed the ravages of time, and an aging population is driving demand for alternatives to the gradual decline into senescence.
Aging, once thought to be inevitable, is being challenged. For the first time in history, biomedical innovators are starting to view it in a disease model, and not as an inevitability of life and medical science is working to find a cure.
Here are three stories of people from different walks of life who share a singular goal theyre actively working to extend their own lifespans, and sharing what theyve learned on how to achieve it:
Dr. David Sinclair says the solution is to get your NAD+ levels up and hes offering detailed, practical advice on how to do it. In lengthy interviews with Joe Rogan & Rich Roll, as well as his recent book, he discusses the health benefits of intermittent fasting, limiting sugar & red meat, and eating plenty of vegetables but for Sinclair, thats only the beginning.
Sinclair is an award-winning Australian biologist, professor of genetics, and Founding Director of the Paul F. Glenn Laboratory for the Biological Mechanisms of Aging at Harvard University.
His team of 30+ scientists is deeply engaged in studying the mechanisms involved with aging & senescence, and treatments to potentially reverse them. One of the promising life-extension supplements theyve identified is Metformin an inexpensive blood sugar medication that may extend the human lifespan by as much as 10%.
In addition to Metformin, Sinclair is bullish on the prospects of NMN (nicotinamide monomucleotide) for life extension. This vitamin B-3 derivative converts easily into NAD+ inside your cells, which is claimed to improve cellular function and offer rejuvenating effects seen in human clinical trials.
Sinclair claims to have reversed aging in lab mice, and also claims to have knocked more than two decades off his biological age, as well as boasting online that he has the lung capacity, cholesterol and blood pressure of a young adult and the heart rate of an athlete.
If hes right, aging can reversed with NAD+ boosting supplements and thats a big step in a cure for aging and the diseases that come with it.
Others, like Elizabeth Parrish, the CEO of BioViva Sciences, have taken a different route: she underwent experimental gene therapy to lengthen her telomeres & reduce muscle wasting back in 2016, and claims her health has improved since the treatment.
According to Wikipedia, independent testing by SpectraCell Laboratories had revealed Elizabeth Parrishs leukocyte telomere length had been extended from 6.71kb to 7.33kb but in 2018, she reported further lengthening in her telomeres up to 8.12kb, along with an overall growth in muscle mass.
A telomere is a region of repetitive nucleotide sequences at the end of each chromosome that protects it from damage and telomeres get shorter as we age, leading to a variety of aging-related diseases. The initial 10% increase of Parrishs telomeres has been roughly compared to her cells becoming 20 years younger.
However, critics such as Dr. Bradley Johnson at the University of Pennsylvania have questioned her results, stating, Telomere length measurements typically have low precision with variation in measurements of around 10 percent, which is in the range of the reported telomere lengthening apparently experienced by Elizabeth Parrish.
Meet Jim Green, patient zero in a one man experiment in radical anti-aging. He lacks the Sinclair teams funding and cant bioengineer retroviral delivery systems like the Parrish team, but what he lacks in budget he makes up for in courage, innovation & perseverance.
A few years back, Jim decided to tackle aging head-on, and started doing intense research into published scientific papers on aging, cellular senescence, and supplements that led him to a rigorous health regime that he claims has literally reversed his aging.
Jims published a collection of links and notes to all of his papers online, and from talking with him personally several times I can tell you that hes been more than diligent about his research. Josh Mitteldorf also interviewed him recently, and in that interview Jim talked at length about his use of first a nutraceutical called TA-65 and later Astragalus Root Extract as a telomerase activator to give new life to old cells.
Jim has taken the hard road: consuming copious amounts of Astragalus extract along with countless other supplements and a daily exercise routine thats visibly reversed most signs of his aging including his seeing his gray hair regain its youthful color (no, he doesnt dye it, thats natural).
Rather than trying to hide the signs of aging with makeup or plastic surgery, innovators like Sinclair, Parrish & Green have taken action to turn back the clock in the hopes of not only living longer but also living better.
Sinclair has spoken numerous times about aging leading to a tragic loss of human capital & potential that up until now weve taken for granted, but if the research that these innovators are pursuing bears fruit, then it may no longer be our inevitable fate.
Whatever the results of their experiments may ultimately be, their research alone is a testament to our shared desire to stop the sands of time from passing & make the most of every moment that we have.
See the rest here:
The Race To Find A Cure For Aging - Medium
- Scientists believe that aging might be optional - Mail Herald [Last Updated On: August 18th, 2024] [Originally Added On: November 18th, 2019]
- This Week in Running: November 18, 2019 - iRunFar [Last Updated On: August 18th, 2024] [Originally Added On: November 21st, 2019]
- Aging as a preventable disease and why living to 100 should be easy - Genetic Literacy Project [Last Updated On: August 18th, 2024] [Originally Added On: November 21st, 2019]
- David Sinclair on Joe Rogan Podcast - chatting about NMN and ... [Last Updated On: August 18th, 2024] [Originally Added On: November 23rd, 2019]
- NMN and NAD Reverse Aging of Blood Vessels in New Study [Last Updated On: August 18th, 2024] [Originally Added On: November 23rd, 2019]
- #70 - David Sinclair, Ph.D.: How cellular reprogramming could ... [Last Updated On: August 18th, 2024] [Originally Added On: November 23rd, 2019]
- Lifespan: Why We Age_and Why We Don't Have To: David A ... [Last Updated On: August 18th, 2024] [Originally Added On: November 23rd, 2019]
- David Sinclair supplements and protocol explained NMN ... [Last Updated On: August 18th, 2024] [Originally Added On: November 23rd, 2019]
- David Sinclair's biological age was 58 after taking 1000 mg ... [Last Updated On: August 18th, 2024] [Originally Added On: November 23rd, 2019]
- David Sinclairs anti-aging science | Harvard Magazine [Last Updated On: August 18th, 2024] [Originally Added On: November 23rd, 2019]
- David Sinclair Supplements For Anti-Aging - What He Takes & Why [Last Updated On: August 18th, 2024] [Originally Added On: November 23rd, 2019]
- What Does David Sinclair Eat and Supplement? (2019 ... [Last Updated On: August 18th, 2024] [Originally Added On: November 23rd, 2019]
- #27 - David Sinclair, Ph.D.: Slowing aging sirtuins, NAD ... [Last Updated On: August 18th, 2024] [Originally Added On: November 23rd, 2019]
- Man with string of convictions in his native Poland came to Perth to set up drug den - The Courier [Last Updated On: August 18th, 2024] [Originally Added On: November 30th, 2019]
- Last surviving Viking-inspired boat that served a now- abandoned island goes up for auction - The Scotsman [Last Updated On: August 18th, 2024] [Originally Added On: November 30th, 2019]
- Dealer Jailed After Raid Uncovers 44k of Grugs - Daily Record [Last Updated On: August 18th, 2024] [Originally Added On: November 30th, 2019]
- Lazarus Effect: Sixteen-year study by Dr. Leis resulted in recovery from West Nile for Dr. Bush - Northside Sun [Last Updated On: August 18th, 2024] [Originally Added On: December 21st, 2019]
- OZY Takes You Ahead of the Curve in Science and Technology - OZY [Last Updated On: August 18th, 2024] [Originally Added On: December 29th, 2019]
- Hard work and dedication honored - Union Daily Times [Last Updated On: August 18th, 2024] [Originally Added On: January 23rd, 2020]
- Meet the people who think soaking in a frozen Minneapolis lake is the secret to good health - Minneapolis Star Tribune [Last Updated On: August 18th, 2024] [Originally Added On: January 24th, 2020]
- BOYS SWIMMING: Tigersharks top Waconia in conference dual - Crow River Media [Last Updated On: August 18th, 2024] [Originally Added On: January 25th, 2020]
- David Sinclair on NMN and Epigenetics | | LEAF [Last Updated On: August 18th, 2024] [Originally Added On: January 25th, 2020]
- Brave Cashel Community School get the better of St Augustine's to set-up a Munster hurling final clash with Doon - TipperaryLive.ie [Last Updated On: August 18th, 2024] [Originally Added On: January 28th, 2020]
- Diane Francis: Treating aging like a disease is the next big thing for science - Financial Post [Last Updated On: August 18th, 2024] [Originally Added On: January 28th, 2020]
- Letter: Yes to Green Growth | Opinion - Southern Pines Pilot [Last Updated On: August 18th, 2024] [Originally Added On: January 28th, 2020]
- Kelty Hearts 4-1 Caledonian Braves: Third straight defeat for Braves - Motherwell Times [Last Updated On: August 18th, 2024] [Originally Added On: February 6th, 2020]
- Is soaking in a frozen lake the secret to good health? - The Detroit News [Last Updated On: August 18th, 2024] [Originally Added On: February 12th, 2020]
- Letter:Deputy Is Vindicated | Opinion - Southern Pines Pilot [Last Updated On: August 18th, 2024] [Originally Added On: February 12th, 2020]
- BOYS SWIMMING: Chargers take fifth at WCC Championships; look ahead to sections - Crow River Media [Last Updated On: August 18th, 2024] [Originally Added On: February 12th, 2020]
- Lifespan: The New Science Behind Anti-Aging and Longevity that Can Help You Live to 100 - Thrive Global [Last Updated On: August 18th, 2024] [Originally Added On: February 19th, 2020]
- Not fasting is killing us, but fasting can hurt us too. Here's what to do. - Mashable [Last Updated On: August 18th, 2024] [Originally Added On: February 21st, 2020]
- Anti-Aging Researcher David Sinclair Takes Metformin, NMN ... [Last Updated On: August 18th, 2024] [Originally Added On: February 22nd, 2020]
- Movers and Shakers Week Ending 2.28.20 - milehighcre.com [Last Updated On: August 18th, 2024] [Originally Added On: February 28th, 2020]
- Health inequality in England was bad. It has got worse - The Economist [Last Updated On: August 18th, 2024] [Originally Added On: February 28th, 2020]
- Southland couple join volunteers to help future proof Southland A&P Show - Stuff.co.nz [Last Updated On: August 18th, 2024] [Originally Added On: March 3rd, 2020]
- Pilot Wins Top Honors at Awards Ceremony | Business - Southern Pines Pilot [Last Updated On: August 18th, 2024] [Originally Added On: March 3rd, 2020]
- Flipping the switch on the ageing process - The Age [Last Updated On: August 18th, 2024] [Originally Added On: March 21st, 2020]
- 7 books to read while in coronavirus quarantine or isolation - The CEO Magazine [Last Updated On: August 18th, 2024] [Originally Added On: March 28th, 2020]
- Remembering loved ones who have passed away - the 68 death notices in North Staffordshire this week - Stoke-on-Trent Live [Last Updated On: August 18th, 2024] [Originally Added On: March 31st, 2020]
- Can canine coronavirus drug indomethacin be used in treating humans suffering from COVID-19? - MEAWW [Last Updated On: August 18th, 2024] [Originally Added On: April 11th, 2020]
- Is There Any Legitimate Health Advice in Gwyneth Paltrow's "Goop Lab"? - InsideHook [Last Updated On: August 18th, 2024] [Originally Added On: April 11th, 2020]
- Will Universities, Colleges, And Law School Campuses Be Open In Fall 2020? - Above the Law [Last Updated On: August 18th, 2024] [Originally Added On: April 11th, 2020]
- 'Refreshingly honest' dealer who ran Perth drug den will be sent home to Poland - The Courier [Last Updated On: August 18th, 2024] [Originally Added On: April 14th, 2020]
- Has Harvard's David Sinclair Found the Fountain of Youth? [Last Updated On: August 18th, 2024] [Originally Added On: April 20th, 2020]
- Carole Carson: Adventures in Aging Seven myths about getting older - The Union of Grass Valley [Last Updated On: August 18th, 2024] [Originally Added On: April 25th, 2020]
- Hide and Hedonism invite guests to a virtual wine dinner - Spear's WMS [Last Updated On: August 18th, 2024] [Originally Added On: May 1st, 2020]
- Budget realities from COVID-19 cut $40.6 million from Prince William budgets - Inside NoVA [Last Updated On: August 18th, 2024] [Originally Added On: May 1st, 2020]
- Drug Use is Transmitted from Old to Young - UPJ Athletics [Last Updated On: August 18th, 2024] [Originally Added On: May 16th, 2020]
- Fife woman breached Asbo by having illicit party at home during lockdown - The Courier [Last Updated On: August 18th, 2024] [Originally Added On: May 19th, 2020]
- A Harvard Geneticist Wants To Sell A Magical ... - HuffPost [Last Updated On: August 18th, 2024] [Originally Added On: June 9th, 2020]
- Jennifer Aniston: How The Morning Show felt like 20 years of therapy - The Detroit News [Last Updated On: August 18th, 2024] [Originally Added On: August 26th, 2020]
- Woods, Waters, and Wildlife: Buy Licenses Now! | FCT News - Freestonecountytimesonline [Last Updated On: August 18th, 2024] [Originally Added On: August 29th, 2020]
- Editorial: Five Birdies That Signal Good Work | Opinion | thepilot.com - Southern Pines Pilot [Last Updated On: August 18th, 2024] [Originally Added On: September 3rd, 2020]
- We all suffer when COVID-19 locks the elderly out of societal participation - The Investment Observer [Last Updated On: August 18th, 2024] [Originally Added On: September 18th, 2020]
- Immetas Therapeutics Announces Series A Financing to Advance Research on Inflammation Pathways in Aging and Develop Therapeutics for Cancer and... [Last Updated On: August 18th, 2024] [Originally Added On: September 26th, 2020]
- DS4 to rock Morden live at The Sound Lounge - Your Local Guardian [Last Updated On: August 18th, 2024] [Originally Added On: September 26th, 2020]
- How newly unemployed over-50s can start-up again - The Guardian [Last Updated On: August 18th, 2024] [Originally Added On: October 8th, 2020]
- 100 years old will be the new 60 | Health & Wellness - CL Charlotte [Last Updated On: August 18th, 2024] [Originally Added On: October 16th, 2020]
- Brexit casts doubt over UK pension rights - Interactive Investor [Last Updated On: August 18th, 2024] [Originally Added On: October 16th, 2020]
- Cancer. How close are we to winning the war? - Switzer [Last Updated On: August 18th, 2024] [Originally Added On: October 16th, 2020]
- Where Sabrina the Teenage Witch cast are now - hit TV shows and unrecognisable star - Mirror Online [Last Updated On: August 18th, 2024] [Originally Added On: October 28th, 2020]
- Caledonian Braves can 'breathe a bit easier' after first win says boss Ricky Waddell - MSN UK [Last Updated On: August 18th, 2024] [Originally Added On: October 28th, 2020]
- Why Aren't We Talking More About Nutrition Amid COVID-19? - Anti Aging News [Last Updated On: August 18th, 2024] [Originally Added On: November 2nd, 2020]
- We should allow ourselves to be #pharmaproud - - pharmaphorum [Last Updated On: August 18th, 2024] [Originally Added On: November 19th, 2020]
- 6 Anti Aging Benefits of Metformin - The Shepherd of the Hills Gazette [Last Updated On: August 18th, 2024] [Originally Added On: November 19th, 2020]
- Hokitika father charged with murder initially claimed son fell out of bed - Stuff.co.nz [Last Updated On: August 18th, 2024] [Originally Added On: November 19th, 2020]
- Scientists Uncover Approach That Could Reverse Age-Related Vision Loss - Science Times [Last Updated On: August 18th, 2024] [Originally Added On: December 6th, 2020]
- HTLS 2020: A pill that can reverse ageing? Yes, it will be possible, says Dr Sinclair - Hindustan Times [Last Updated On: August 18th, 2024] [Originally Added On: December 6th, 2020]
- Reversing vision loss by turning back the aging clock - FierceBiotech [Last Updated On: August 18th, 2024] [Originally Added On: December 6th, 2020]
- Pill to reverse ageing in 30 years? Why not, says Harvard professor Dr David Sinclair - Hindustan Times [Last Updated On: August 18th, 2024] [Originally Added On: December 6th, 2020]
- Get younger reverse ageing and increase your health span - Have a Go News [Last Updated On: August 18th, 2024] [Originally Added On: December 8th, 2020]
- Over 50s Spending Spree Boosts Economy By Billions - Money International [Last Updated On: August 18th, 2024] [Originally Added On: January 20th, 2021]
- Hunger in Milwaukee and the World: What We Can Do About It - Wisconsin Public Radio News [Last Updated On: August 18th, 2024] [Originally Added On: February 15th, 2021]
- Woman's 'nasty' skin infection most likely caused by swimming in sea after shaving legs - Stuff.co.nz [Last Updated On: August 18th, 2024] [Originally Added On: August 3rd, 2021]
- David Sinclair | The Sinclair Lab [Last Updated On: August 18th, 2024] [Originally Added On: December 21st, 2021]
- David Sinclair Supplements List Deep Dive - Updated 2021 [Last Updated On: August 18th, 2024] [Originally Added On: December 21st, 2021]
- Don't Listen to Intermittent Fasting Influencers, The Science Doesn't Back It Up - InsideHook [Last Updated On: August 18th, 2024] [Originally Added On: April 27th, 2022]
- David Sinclair Post-2022 Canyons by UTMB 100k Interview - iRunFar [Last Updated On: August 18th, 2024] [Originally Added On: April 27th, 2022]
- Authorized Biography Of The Rolling Stones Charlie Watts Launched In London - uDiscover Music [Last Updated On: August 18th, 2024] [Originally Added On: September 24th, 2022]
- David Sinclair Supplements (2022 List) | Brands for Anti-Aging! [Last Updated On: August 18th, 2024] [Originally Added On: September 24th, 2022]