Legions of women across America are going about their daily lives feeling out of sorts. "You feel flat and you feel tired, you haven't had a good night's sleep in two years [and you're] just going through the motions, trying to get through the day," Oprah says. "You feel like your life force is being sucked out of you."

The February issue of O, The Oprah Magazine delves into the root of this problem and possible fixes, and Oprah is taking the discussion even farther. "We're opening a national conversation about hormone replacement therapy," she says. "This is about your hormones being out of whack, and you don't even knowwe haven't had a language to talk about it yet." Hormone replacement therapy is relevant to women of all ages, Oprah says. "If you're a woman who's planning to live past the age of 35, at some point you're going to face hormone imbalance," she says. "All women need to be armed with this information."

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Is Hormone Replacement Therapy Right for You? - Oprah.com