1. Parkinson's disease
  2. Self regulation of normal LRRK2

Self regulation of normal LRRK2 by DFG-flip – Video

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Video Link: https://www.youtube.com/watch?v=Nl2D5HUUsHc



Self regulation of normal LRRK2 by DFG-flip
This video demonstrates molecular dynamics simulation of the Parkinson #39;s disease linked kinase called LRRK2. A typical kinase undergoes a duty cycle switching between "on" (DFG-in) and "off" (DFG-out) states regulating its own activity. The G2019S mutant however does not and stays in a perpetual "on" state that eventually eventually leads to Parkinson #39;s disease. See the video on the G2019S to see the differences between wild type and mutant.

By: Soumya Ray

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Self regulation of normal LRRK2 by DFG-flip - Video

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  1. Parkinson's disease
  2. Self regulation of normal LRRK2