Deimination restores inner retinal visual function in murine demyelinating disease – Video




Deimination restores inner retinal visual function in murine demyelinating disease
Sanjoy Bhattarcharya and Vittorio Porciatti of the University of Miami discuss the role of deimination, a post-translational protein modification, in retinal function. Highlights: Highlights: Demyelinating diseases, including multiple sclerosis, are frequently accompanied by vision loss. Deimination is a protein modification that is impaired in the retinas of patients with demyelinating disease. Using a rat model of demyelinating disease, the researchers demonstrated that loss of deimination impaired retinal function. Restoration of deimination restored neurite outgrowth and retinal function, suggesting that deimination could be a therapeutic target. Article: http://www.jci.org

By: jclininvest

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Deimination restores inner retinal visual function in murine demyelinating disease - Video

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