Overview

Clear writing and illustrationsClear explanations of difficult conceptsClear communication of the ways in biochemistry is currently understood and practiced. For over 35 years, in edition after bestselling edition, Principles of Biochemistry has put those defining principles into practice, guiding students through a coherent introduction to the essentials of biochemistry without overwhelming them.

The new edition brings this remarkable text into a new era. Like its predecessors, Lehninger Principles of Biochemistry, Sixth Edition strikes a careful balance of current science and enduring concepts, incorporating a tremendous amount of new findings, but only those that help illustrate biochemistrys foundational principles. With this edition, students will encounter new information emerging from high throughput DNA sequencing, x-ray crystallography, and the manipulation of genes and gene expression, and other techniques. In addition, students will see how contemporary biochemistry has shifted away from exploring metabolic pathways in isolation to focusing on interactions among pathways. They will also get an updated understanding of the relevance of biochemistry to the study of human disease (especially diabetes) as well as the important role of evolutionary theory in biochemical research.

These extensive content changes, as well as new art and powerful new learning technologies make this edition of Lehninger Principles of Biochemistry the most impressive yet.

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1.The Foundations of Biochemistry 1.1 Cellular Foundations 1.2 Chemical Foundations Box 11 Molecular Weight, Molecular Mass, and Their Correct Units Box 12 Louis Pasteur and Optical Activity: In Vino, Veritas1.3 Physical Foundations Box 13 Entropy: Things Fall Apart 1.4 Genetic Foundations

2.Water 2.1 Weak Interactions inAqueousSystems 2.2Ionization of Water, Weak Acids, and Weak Bases 2.3 Buffering agains pH Changes inBiological Systems Box 2-1 Medicine:On Being One's Own Rabbit (Don't Try This at Home!) 2.4 Water as a Reactant 2.5 The Fitness of Aqueous Environment for Living Organisms 3. Amino Acids, Peptides, and Proteins 3.1 Amino Acids Box 3-1 Methods:Absorption of Light by Molecules:The Lambert-Beer Law 3.2 Peptides and Proteins 3.3 Working with Proteins 3.4 The Structure of Proteins: Primary Structure Box 32 Consensus Sequences and Sequence Logos

4. The Three-Dimensional Structure of Proteins 4.1 Overview of Protein Structure 4.2 Protein Secondary Structure Box 41 Methods: Knowing the Right Hand from the Left 4.3 Protein Tertiary and Quaternary Structures Box 42 Permanent Waving Is Biochemical Engineering Box 43 Why Sailors, Explorers, and College Students Should Eat Their Fresh Fruits and Vegetables Box 44 The Protein Data Bank Box 45 Methods: Methods for Determining the Three-Dimensional Structure of a Protein 4.4 Protein Denaturation and Folding Box 46 Medicine: Death by Misfolding: The Prion Diseases

5. Protein Function 5.1 Reversible Binding of a Protein to a Ligand: Oxygen-Binding Proteins Box 51 Medicine: Carbon Monoxide: A Stealthy Killer 5.2 Complementary Interactions between Proteins and Ligands: The Immune System and Immunoglobulins 5.3 Protein Interactions Modulated by Chemical Energy: Actin, Myosin, and Molecular Motors

6. Enzymes 6.1 An Introduction to Enzymes 6.2 How Enzymes Work 6.3 Enzyme Kinetics as an Approach to Understanding Mechanism Box 61 Transformations of the Michaelis-Menten Equation: The Double-Reciprocal Plot Box 62 Kinetic Tests for Determining Inhibition Mechanisms Box 63 Curing African Sleeping Sickness with a Biochemical Trojan Horse 6.4 Examples of Enzymatic Reactions 6.5 Regulatory Enzymes

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Lehninger Principles of Biochemistry / Edition 6 by David ...