Editor's Choice Academic Journal Main Category: Alzheimer's / Dementia Also Included In: Neurology / Neuroscience Article Date: 22 Mar 2012 - 8:00 PDT

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In the brain, oxidative impairment is linked to aging and is common in individuals with Alzheimer's disease (AD). Even though some studies have indicated that a diet rich in antioxidants may lower the risk of developing AD, results from antioxidant studies in AD have been mixed.

Douglas R. Galasko, M.D., of the University of California, San Diego, and his team enrolled 78 patients from the Alzheimer's Disease Cooperative Study (ADCS) Antioxidant Biomarker study in order to analyze alterations in cerebrospinal fluid (CSP) biomarkers associated to AD and oxidative stress, function and cognition.

The researchers assigned participants to one of three groups:

The researchers explained:

The researchers found that although participants in the E/C/ALA group saw a decrease of CSF F2-isoprostane levels, indicating a reduction of oxidative stress in the brain, the treatment raised caution regarding faster cognitive decline as evaluated by the Mini-Mental State Examination (MMSE).

The researchers said:

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Alzheimer's Disease - Antioxidants Have No Effect On Cerebrospinal Fluid Biomarkers