Sara Ramirez

Arizona survived the deadly plane crash on Grey's Anatomy, but things aren't going to be easy for her and her wife Callie.

"It's very painful, it's very difficult and it's really heart-wrenching what happens," Sara Ramirez, who plays Callie, tells TVGuide.com.

On Thursday's episode, viewers will flash back to retrace the time between the rescue and the present. Though Arizona (Jessica Capshaw) specifically instructed Callie to save her leg, that didn't happen. Arizona is not only left distraught about her future, but also that her wife didn't keep her promise. Ramirez says that because of this, she's not sure how the couple can move on.

"Because they got married, because they have a child, certainly from Callie's perspective she's just trying to survive, she's trying to do what's right, [but] I'm really worried for them. I'm genuinely concerned about what's going to happen, how things are going to get better if they're going to get better."

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In the interview below, Ramirez warns viewers tuning into Thursday's episode: "Keep your Kleenex boxes nearby." Plus: Ramirez shares details about a new (platonic) relationship on the horizon for Callie.

Grey's Anatomy airs Thursdays at 9/8c on ABC.

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Grey's Anatomy's Ramirez: I'm Concerned About the Future of Callie and Arizona's Relationship