An article from the Scientist: "Based on new intelligence, oncologists are making informed battle plans to attack a particularly pernicious enemy - the cancer stem cell (CSC). Controversial though they are, cancer stem cells are an incredibly promising target. If treatment-resistant cancer, and the metastases that transplant the cancer throughout the body, could be attributed to the actions of a single cell type, it could explain many of the treatment failures and provide a novel way to attack the disease. The idea that cancers are driven by cells with 'embryonic features' is an old one. Many cancers regress to a less differentiated state, expressing proteins that are usually expressed only in the embryo or during early development. It is only in the past 20 years or so, however, that additional observations led to the hypothesis that these embryonic-like cells were a separate subpopulation that fueled tumor expansion, much the same way that stem cells churn out the cells that make up a particular organ. ... In the past 5 years there has been an exponential increase in CSC research. This research has helped to resolve a number of controversies regarding identification of these cells and their role in driving tumor growth and mediating treatment resistance. Despite these advances, the CSC field is still in its relative infancy, and many questions and challenges remain. More than a dozen biotechnology and pharmaceutical companies are now vigorously pursuing CSC research. As a result, a number of early-phase clinical trials targeting CSCs are in progress. These studies and the later-stage efficacy trials that follow them should indicate whether successful targeting of CSCs significantly improves outcomes in cancer patients. If this is found to be the case, it may usher in the beginning of a new era of cancer therapy."
Link: http://the-scientist.com/2012/04/01/are-cancer-stem-cells-ready-for-prime-time/
Source:
http://www.longevitymeme.org/newsletter/latest_rss_feed.cfm
- Vitamin K Delivers Kick to Cancer Risk [Last Updated On: August 17th, 2024] [Originally Added On: April 7th, 2010]
- Magnesium for Memory [Last Updated On: August 17th, 2024] [Originally Added On: April 7th, 2010]
- The Long Road Towards Prosthetic Nerves [Last Updated On: August 17th, 2024] [Originally Added On: April 9th, 2010]
- More on DAF-16 and Longevity in Nematodes [Last Updated On: August 17th, 2024] [Originally Added On: April 9th, 2010]
- Rapamycin and Alzheimer's Disease [Last Updated On: August 17th, 2024] [Originally Added On: April 9th, 2010]
- Rapamycin and Alzheimer's Disease [Last Updated On: August 17th, 2024] [Originally Added On: April 9th, 2010]
- Better Understanding Cytomegalovirus [Last Updated On: August 17th, 2024] [Originally Added On: April 9th, 2010]
- On Mitophagy and Aging [Last Updated On: August 17th, 2024] [Originally Added On: April 9th, 2010]
- A Trial of Giving Stem Cells Orders [Last Updated On: August 17th, 2024] [Originally Added On: April 9th, 2010]
- Methuselah Foundation Launches NewOrgan Prize [Last Updated On: August 17th, 2024] [Originally Added On: April 9th, 2010]
- The Contributions of Mitochondria to Longevity [Last Updated On: August 17th, 2024] [Originally Added On: April 9th, 2010]
- Dual Action Antibodies Versus Cancer [Last Updated On: August 17th, 2024] [Originally Added On: April 9th, 2010]
- Longevity and the End of Empire [Last Updated On: August 17th, 2024] [Originally Added On: April 9th, 2010]
- The Long Road Towards Prosthetic Nerves [Last Updated On: August 17th, 2024] [Originally Added On: April 10th, 2010]
- More on DAF-16 and Longevity in Nematodes [Last Updated On: August 17th, 2024] [Originally Added On: April 10th, 2010]
- Rapamycin and Alzheimer’s Disease [Last Updated On: August 17th, 2024] [Originally Added On: April 10th, 2010]
- Better Understanding Cytomegalovirus [Last Updated On: August 17th, 2024] [Originally Added On: April 10th, 2010]
- On Mitophagy and Aging [Last Updated On: August 17th, 2024] [Originally Added On: April 10th, 2010]
- A Trial of Giving Stem Cells Orders [Last Updated On: August 17th, 2024] [Originally Added On: April 10th, 2010]
- Methuselah Foundation Launches NewOrgan Prize [Last Updated On: August 17th, 2024] [Originally Added On: April 10th, 2010]
- The Contributions of Mitochondria to Longevity [Last Updated On: August 17th, 2024] [Originally Added On: April 10th, 2010]
- Dual Action Antibodies Versus Cancer [Last Updated On: August 17th, 2024] [Originally Added On: April 10th, 2010]
- Longevity and the End of Empire [Last Updated On: August 17th, 2024] [Originally Added On: April 10th, 2010]
- Longevity Meme Newsletter, April 12 2010 [Last Updated On: August 17th, 2024] [Originally Added On: April 12th, 2010]
- Printing New Tissue Directly Onto the Body [Last Updated On: August 17th, 2024] [Originally Added On: April 12th, 2010]
- Reprogramming Autoimmune Disease [Last Updated On: August 17th, 2024] [Originally Added On: April 12th, 2010]
- Diet and Exercise Can Override the Genetic Disposition towards Obesity [Last Updated On: August 17th, 2024] [Originally Added On: April 12th, 2010]
- Your Heart Truly Loves Chocolate! [Last Updated On: August 17th, 2024] [Originally Added On: April 12th, 2010]
- CSC news roundup 2010-04-11 [Last Updated On: August 17th, 2024] [Originally Added On: April 13th, 2010]
- Longevity Meme Newsletter, April 12 2010 [Last Updated On: August 17th, 2024] [Originally Added On: April 13th, 2010]
- Printing New Tissue Directly Onto the Body [Last Updated On: August 17th, 2024] [Originally Added On: April 13th, 2010]
- Reprogramming Autoimmune Disease [Last Updated On: August 17th, 2024] [Originally Added On: April 13th, 2010]
- Diet and Exercise Can Override the Genetic Disposition towards Obesity [Last Updated On: August 17th, 2024] [Originally Added On: April 13th, 2010]
- Your Heart Truly Loves Chocolate! [Last Updated On: August 17th, 2024] [Originally Added On: April 13th, 2010]
- Trialing Stem Cells to Heal Heart Damage [Last Updated On: August 17th, 2024] [Originally Added On: April 13th, 2010]
- Selection Effects and Longevity Genes [Last Updated On: August 17th, 2024] [Originally Added On: April 13th, 2010]
- How Exercise Can Awaken Your Creative Genius Within [Last Updated On: August 17th, 2024] [Originally Added On: April 13th, 2010]
- Trialing Stem Cells to Heal Heart Damage [Last Updated On: August 17th, 2024] [Originally Added On: April 14th, 2010]
- Selection Effects and Longevity Genes [Last Updated On: August 17th, 2024] [Originally Added On: April 14th, 2010]
- How Exercise Can Awaken Your Creative Genius Within [Last Updated On: August 17th, 2024] [Originally Added On: April 14th, 2010]
- WILT, ALT, and Zscan4 [Last Updated On: August 17th, 2024] [Originally Added On: April 14th, 2010]
- Damage in Early Life Shortens Life Expectancy [Last Updated On: August 17th, 2024] [Originally Added On: April 14th, 2010]
- WILT, ALT, and Zscan4 [Last Updated On: August 17th, 2024] [Originally Added On: April 15th, 2010]
- Damage in Early Life Shortens Life Expectancy [Last Updated On: August 17th, 2024] [Originally Added On: April 15th, 2010]
- Synthetic Biology and the Extracellular Matrix [Last Updated On: August 17th, 2024] [Originally Added On: April 15th, 2010]
- The Tithonus Error as Prospection Error [Last Updated On: August 17th, 2024] [Originally Added On: April 15th, 2010]
- F.D.A. Says Millions Got Unapproved Drugs, Should the new bioequivalence and bioanalytical guidelines for 2010, be made more stringent [Last Updated On: August 17th, 2024] [Originally Added On: April 16th, 2010]
- Synthetic Biology and the Extracellular Matrix [Last Updated On: August 17th, 2024] [Originally Added On: April 16th, 2010]
- The Tithonus Error as Prospection Error [Last Updated On: August 17th, 2024] [Originally Added On: April 16th, 2010]
- Towards an Artificial Pancreas [Last Updated On: August 17th, 2024] [Originally Added On: April 16th, 2010]
- Immortality Isn't Unethical [Last Updated On: August 17th, 2024] [Originally Added On: April 16th, 2010]
- Immortality Isn't Unethical [Last Updated On: August 17th, 2024] [Originally Added On: April 16th, 2010]
- Alcohol in Adolescence: A Cancerous Combination? [Last Updated On: August 17th, 2024] [Originally Added On: April 16th, 2010]
- Green Tea for Weight Loss [Last Updated On: August 17th, 2024] [Originally Added On: April 16th, 2010]
- Towards an Artificial Pancreas [Last Updated On: August 17th, 2024] [Originally Added On: April 17th, 2010]
- Immortality Isn’t Unethical [Last Updated On: August 17th, 2024] [Originally Added On: April 17th, 2010]
- Alcohol in Adolescence: A Cancerous Combination? [Last Updated On: August 17th, 2024] [Originally Added On: April 17th, 2010]
- Green Tea for Weight Loss [Last Updated On: August 17th, 2024] [Originally Added On: April 17th, 2010]
- On Calorie Restriction Research [Last Updated On: August 17th, 2024] [Originally Added On: April 17th, 2010]
- AGE Precursor Methylglyoxal Also an Issue? [Last Updated On: August 17th, 2024] [Originally Added On: April 17th, 2010]
- On Calorie Restriction Research [Last Updated On: August 17th, 2024] [Originally Added On: April 18th, 2010]
- AGE Precursor Methylglyoxal Also an Issue? [Last Updated On: August 17th, 2024] [Originally Added On: April 18th, 2010]
- Longevity Meme Newsletter, April 19 2010 [Last Updated On: August 17th, 2024] [Originally Added On: April 19th, 2010]
- Let Them Eat Wheat [Last Updated On: August 17th, 2024] [Originally Added On: April 19th, 2010]
- An Appetite for Alzheimer’s Avoidance [Last Updated On: August 17th, 2024] [Originally Added On: April 19th, 2010]
- Steps Towards Controlling Regeneration [Last Updated On: August 17th, 2024] [Originally Added On: April 20th, 2010]
- Another View of What to Do About Aging [Last Updated On: August 17th, 2024] [Originally Added On: April 20th, 2010]
- Rare flowers and common herbal supplements get unmasked with plant DNA barcoding [Last Updated On: August 17th, 2024] [Originally Added On: April 21st, 2010]
- Steps Towards Controlling Regeneration [Last Updated On: August 17th, 2024] [Originally Added On: April 21st, 2010]
- Another View of What to Do About Aging [Last Updated On: August 17th, 2024] [Originally Added On: April 21st, 2010]
- Stopping Metastasis [Last Updated On: August 17th, 2024] [Originally Added On: April 21st, 2010]
- Humanity+ Summit at Harvard [Last Updated On: August 17th, 2024] [Originally Added On: April 21st, 2010]
- Stopping Metastasis [Last Updated On: August 17th, 2024] [Originally Added On: April 22nd, 2010]
- Humanity+ Summit at Harvard [Last Updated On: August 17th, 2024] [Originally Added On: April 22nd, 2010]
- An Update on Scent and Longevity [Last Updated On: August 17th, 2024] [Originally Added On: April 22nd, 2010]
- Tissue Engineered Skin Progresses [Last Updated On: August 17th, 2024] [Originally Added On: April 22nd, 2010]
- Because Someone Has to State the Obvious [Last Updated On: August 17th, 2024] [Originally Added On: April 23rd, 2010]
- Deciphering Regeneration [Last Updated On: August 17th, 2024] [Originally Added On: April 23rd, 2010]
- Politics and Historical Aspirations to Engineered Longevity [Last Updated On: August 17th, 2024] [Originally Added On: April 24th, 2010]
- Exercise and Alzheimer's Disease [Last Updated On: August 17th, 2024] [Originally Added On: April 24th, 2010]