Advertisement A protein called Sestrin might be responsible for many of the benefits of a good workout Photo by Kolar.io on Unsplash

| 2 min read | from UofM Medicine |

Whether it be a brisk walk around the park or high-intensity training at the gym, exercise does a body good. But what if you could harness the benefits of a good workout without ever moving a muscle?

Michigan Medicine researchers studying a class of naturally occurring protein called Sestrin have found that it can mimic many of exercises effects in flies and mice. The findings could eventually help scientists combat muscle wasting due to aging and other causes.

Researchers have previously observed that Sestrin accumulates in muscle following exercise, said Myungjin Kim, Ph.D., a research assistant professor in the Department of Molecular & Integrative Physiology. Kim, working with professor Jun Hee Lee, Ph.D. and a team of researchers wanted to know more about the proteins apparent link to exercise. Their first step was to encourage a bunch of flies to work out.

Taking advantage ofDrosophilaflies normal instinct to climb up and out of a test tube, their collaborators Robert Wessells, Ph.D. and Alyson Sujkowski of Wayne State University in Detroit developed a type of fly treadmill. Using it, the team trained the flies for three weeks and compared the running and flying ability of normal flies with that of flies bred to lack the ability to make Sestrin.

Flies can usually run around four to six hours at this point and the normal flies abilities improved over that period, says Lee. The flies without Sestrin did not improve with exercise.

Whats more, when they overexpressed Sestrin in the muscles of normal flies, essentially maxing out their Sestrin levels, they found those flies had abilities above and beyond the trained flies, even without exercise. In fact, flies with overexpressed Sestrin didnt develop more endurance when exercised.

The beneficial effects of Sestrin include more than just improved endurance. Mice without Sestrin lacked the improved aerobic capacity, improved respiration, and fat burning typically associated with exercise.

We propose that Sestrin can coordinate these biological activities by turning on or off different metabolic pathways, says Lee. This kind of combined effect is important for producing exercises effects.

Lee also helped another collaborator, Pura Muoz-Cnoves, Ph.D., of Pompeu Fabra University in Spain, to demonstrate that muscle-specific Sestrin can also help prevent atrophy in a muscle thats immobilized, such as the type that occurs when a limb is in a cast for a long period of time. This independent study again highlights that Sestrin alone is sufficient to produce many benefits of physical movement and exercise, says Lee.

Could Sestrin supplements be on the horizon? Not quite, says Lee. Sestrins are not small molecules, but we are working to find small molecule modulators of Sestrin.

Additionally, adds Kim, scientists still dont know how exercise produces Sestrin in the body. This is very critical for future study and could lead to a treatment for people who cannot exercise.

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