In its latest round of early human trials, a drug called divarasib has shown promising results in treating a specific form of bowel cancer, outshining existing alternatives.
In a new study published in the journal Nature Medicine, researchers at the Peter MacCallum Cancer Center in Australia found that when divarasib is combined with another cancer treatment called cetuximab, 62 percent of patients with tumors caused by a mutation in the KRAS gene experienced a positive outcome, which means that their tumors were either completely eradicated or reduced in size.
When used on its own, previous research found the pill yields a still impressive 35.9 percent positive response rate, notes NewAtlas, and is overall 20 times more effective than other treatments that also target the same cancer.
Despite the promising results, it's a very targeted drug that will only be effective for a small proportion of colon cancer patients. The mutation, KRAS G12C, affects a protein that controls cell division and occurs only in four percent of colon or rectal (colorectal) cancer cases, according to the researchers.
However, because KRAS G12C cancer is commonly tested for and has such a poor prognosis, doctors could quickly identify the patients that would benefit from divarasib, providing immediate — and potentially life-saving — relief.
"The median progression-free survival for patients in the study" — the amount of time during or after the treatment they were able to live without the cancer getting worse — "was just over eight months and the treatment was well tolerated with manageable side effects," said study lead author Jayesh Desai, a medical oncologist at the Peter MacCallum Cancer Center, in a statement.
"While this is not a head-to-head trial, the response rates are better than what we have seen with other treatments that work on the KRAS G12C mutation pathway," he added, referring to trials that directly compare different therapies.
Existing treatments for KRAS G12C bowel cancer such as chemotherapy and immunotherapy provided only modest results. Their main drawback is that they're non-selective, targeting the whole body rather than homing in on the deadly tumors — a problem that divarasib seemingly promises to circumvent.
"We are very hopeful that this combination of divarasib with cetuximab will translate into better outcomes for our colorectal cancer patients," Desai said.
More on cancer: Scientists Intrigued by Clever Trick That Makes Cancer Cells Self-Destruct
The post Anti-Cancer Pill Shows Promising Results in Human Experiment appeared first on Futurism.
Link:
Anti-Cancer Pill Shows Promising Results in Human Experiment
- Futurist Serata featuring artist Luca Buvoli at Brown (Nov. 20) [Last Updated On: November 7th, 2009] [Originally Added On: November 7th, 2009]
- FUTUR1SM00GGI [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- ‘Futurism on Film’ Series this month in NYC [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Schedule of Futurist Events in NYC (PERFORMA 09: Nov 1-22) [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- ‘Futurismo/Futurizm: The Futurist Avant-Garde in Italy and Russia’ (Nov. 13 + 14) [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- ‘Beyond Futurism: F.T. Marinetti, Writer’ conference at Columbia (Nov. 12+13) [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Futurism and Cars at the Museo Nicolis [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- MoMA Film Series Marks Centenary of Futurism with Films [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- ‘Bergson+Futurism. Speed in thought’ - Madrid (Nov. 5) [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- ‘The Future in Five Senses: Echoes of Italian Futurism in New York Architecture and Design’ Nov. 16th NYC [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- New World-Wide Climate Treaty in 2010 More Likely [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Tar Sands CCS Myth Shattered [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Smart Grid and Smart Meters Get Big Grants [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Pollution Makes Methane Even More Dangerous [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Climate Change Bill Hearing Video [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- New Satellite to Monitor Water and Plant Growth [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Spiritual Battle Awaits the Deniers and Skeptics [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Effects of Climate Change are Observed World-Wide [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Get Yer Global Warming Science Here [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- TckTckTck Wake up Call — Delay Kills [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Canada’s Awful Gold Rush [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Climate Change Talks Spark Global Backlash by Businesses [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- World May Need Extra Year for Climate Treaty [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Senator Boxer Moves Climate Bill Despite Republican Obstructionism [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Lights out for incandescent lights? [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Sutures from Bacteria [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Remote-Controlled Pigeons [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Apple Announces iPhone Release Date [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- UK Government Envisions a Grim Future [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Top Ten Emerging Technologies for the Environment [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- DIY Mobile Networks [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Stem-Cell Treatment Cures Type 1 Diabetes [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Is Tesla Getting the Electric Car Right? [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- The Future of TV News [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Bruce Sterling on Earth-Friendly Pervasive Computing [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- First Step Toward Organ Regeneration in Humans [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- IBM's "Five in Five" [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Outsourced Journalism [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Is True Global Democracy the Next Great Political Movement? [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- The Risks of Autonomous Robots [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Microsoft Introduces "Tabletop" PC [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Britain Piloting First Biofueled Train [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Self-Healing Plastic [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Bird Population Falls Over Past 40 Years [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- The iPhone Revolution? [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- The End of "Cheap Food"? [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- How to Stop -- Or Live With -- Global Warming [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- MIT Demonstrates "Wireless Electricity" [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Unintended Consequences of Biofuels [Last Updated On: November 8th, 2009] [Originally Added On: November 8th, 2009]
- Time to Focus on the Big Picture in Copenhagen [Last Updated On: December 12th, 2009] [Originally Added On: December 12th, 2009]
- Protests in Copenhagen [Last Updated On: December 12th, 2009] [Originally Added On: December 12th, 2009]
- Mario Guido Dal Monte exhibit [Last Updated On: December 13th, 2009] [Originally Added On: December 13th, 2009]
- Futurism News Bulletin, xvi [Last Updated On: December 13th, 2009] [Originally Added On: December 13th, 2009]
- Viva il Futurismo! (video trailer) [Last Updated On: December 13th, 2009] [Originally Added On: December 13th, 2009]
- 3 exhibits in Gorizia! [Last Updated On: December 13th, 2009] [Originally Added On: December 13th, 2009]
- Forthcoming: ‘Antidiets of the Avant-garde’ by Cecilia Novero [Last Updated On: December 13th, 2009] [Originally Added On: December 13th, 2009]
- Pubblicità e propaganda. Ceramica e grafica futuriste at the Wolfsoniana [Last Updated On: December 13th, 2009] [Originally Added On: December 13th, 2009]
- Balla’s home scheduled to open in 2010 [Last Updated On: December 13th, 2009] [Originally Added On: December 13th, 2009]
- Futurismo a Savona [Last Updated On: December 13th, 2009] [Originally Added On: December 13th, 2009]
- ‘Zang Sud Sud’, Cosenza [Last Updated On: December 13th, 2009] [Originally Added On: December 13th, 2009]
- Conference in Rome (Dec. 10) [Last Updated On: December 13th, 2009] [Originally Added On: December 13th, 2009]
- Climate Hackergate: A Well-Orchestrated Campaign of Harassment [Last Updated On: December 13th, 2009] [Originally Added On: December 13th, 2009]
- The Sad Story of Cap and Trade [Last Updated On: December 13th, 2009] [Originally Added On: December 13th, 2009]
- How to Waste Trillions on Capturing Carbon [Last Updated On: December 13th, 2009] [Originally Added On: December 13th, 2009]
- Smack the Email Hack Attack [Last Updated On: December 13th, 2009] [Originally Added On: December 13th, 2009]
- EPA About to Declare CO2 a Public Danger [Last Updated On: December 13th, 2009] [Originally Added On: December 13th, 2009]
- Copenhagen Summit Starts with Virtually There Media [Last Updated On: December 13th, 2009] [Originally Added On: December 13th, 2009]
- Climate Scientist Gets Blunt on Trading Scheme [Last Updated On: December 13th, 2009] [Originally Added On: December 13th, 2009]
- One Climate Change Editorial in 56 Newspapers, 45 Countries [Last Updated On: December 13th, 2009] [Originally Added On: December 13th, 2009]
- This Decade Will be Hottest Ever on Record [Last Updated On: December 13th, 2009] [Originally Added On: December 13th, 2009]
- Divide and Conquer [Last Updated On: December 13th, 2009] [Originally Added On: December 13th, 2009]
- Leave the Coal in the Hole! [Last Updated On: December 13th, 2009] [Originally Added On: December 13th, 2009]
- COP15: Two Agreements Coming [Last Updated On: December 13th, 2009] [Originally Added On: December 13th, 2009]
- Climate and Copenhagen News December 10 [Last Updated On: December 13th, 2009] [Originally Added On: December 13th, 2009]
- Sea Level Already Rising on Atlantic Coast [Last Updated On: December 13th, 2009] [Originally Added On: December 13th, 2009]
- ‘Umbria Veloce’ in Perugia [Last Updated On: December 14th, 2009] [Originally Added On: December 14th, 2009]
- An Instable CO2-Filled Ocean [Last Updated On: December 14th, 2009] [Originally Added On: December 14th, 2009]
- ‘Futurismi a Ravenna’ opens Dec. 19 [Last Updated On: December 15th, 2009] [Originally Added On: December 15th, 2009]
- ‘Futurism and the Technological Imagination’ – 30% discount until Jan. 15 [Last Updated On: December 15th, 2009] [Originally Added On: December 15th, 2009]
- Protecting Our Lungs at Copenhagen [Last Updated On: December 15th, 2009] [Originally Added On: December 15th, 2009]